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![]() | Open reading frame (ORF) annotation in the exon skipping event |
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![]() | 3'-UTR located exon skipping events lost miRNA binding sites |
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![]() | Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for LAS1L |
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Gene information | Gene symbol | LAS1L | Gene ID | 81887 |
Gene name | LAS1 like ribosome biogenesis factor | |
Synonyms | Las1|Las1-like|WTS|dJ475B7.2 | |
Cytomap | Xq12 | |
Type of gene | protein-coding | |
Description | ribosomal biogenesis protein LAS1Lprotein LAS1 homolog | |
Modification date | 20200313 | |
UniProtAcc | Q9Y4W2, R4GNF7, | |
Context |
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Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for LAS1L |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
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Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
CB | DOWN | ENST00000374804.9 | LAS1L-201:protein_coding:LAS1L | 2.097714e+01 | -2.137488e+00 | 1.378611e-03 | 6.764053e-03 |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for LAS1L |
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Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_11929 | chrX | 65532561:65532630:65533610:65533735:65534480:65534754 | 65533610:65533735 |
exon_skip_119805 | chrX | 65524965:65525050:65528260:65528369:65529212:65529258 | 65528260:65528369 |
exon_skip_140804 | chrX | 65531357:65531438:65532561:65532630:65534480:65534754 | 65532561:65532630 |
exon_skip_151722 | chrX | 65531357:65531438:65532561:65532630:65533610:65533709 | 65532561:65532630 |
exon_skip_17702 | chrX | 65524965:65525050:65528260:65528369:65529212:65529254 | 65528260:65528369 |
exon_skip_238782 | chrX | 65524247:65524262:65524564:65524614:65524965:65525050 | 65524564:65524614 |
exon_skip_242524 | chrX | 65512583:65512901:65514823:65514973:65517987:65518465 | 65514823:65514973 |
exon_skip_280252 | chrX | 65524965:65525050:65529212:65529258:65529594:65529878 | 65529212:65529258 |
exon_skip_281762 | chrX | 65524056:65524262:65524564:65524614:65524965:65525050 | 65524564:65524614 |
exon_skip_35432 | chrX | 65531357:65531438:65532561:65532630:65533610:65533735 | 65532561:65532630 |
exon_skip_50674 | chrX | 65524056:65524262:65524564:65524614:65524965:65525046 | 65524564:65524614 |
exon_skip_65025 | chrX | 65532561:65532630:65533610:65533735:65534480:65534572 | 65533610:65533735 |
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Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
exon_skip_85149 | ROSMAP_DLPFC | 4.303653e-01 | 5.421429e-01 | -1.117776e-01 | 2.579105e-06 |
exon_skip_281762 | Mayo_CB | 3.558537e-01 | 5.371429e-01 | -1.812892e-01 | 1.807559e-09 |
exon_skip_85149 | Mayo_TC | 3.037805e-01 | 4.220513e-01 | -1.182708e-01 | 1.387550e-06 |
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Open reading frame (ORF) annotation in the exon skipping event for LAS1L |
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ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000374811 | 65528260 | 65528369 | Frame-shift |
ENST00000374811 | 65532561 | 65532630 | Frame-shift |
ENST00000374811 | 65524564 | 65524614 | In-frame |
ENST00000374811 | 65533610 | 65533735 | In-frame |
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ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000374811 | 65528260 | 65528369 | Frame-shift |
ENST00000374811 | 65524564 | 65524614 | In-frame |
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ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000374811 | 65514823 | 65514973 | Frame-shift |
ENST00000374811 | 65528260 | 65528369 | Frame-shift |
ENST00000374811 | 65532561 | 65532630 | Frame-shift |
ENST00000374811 | 65524564 | 65524614 | In-frame |
ENST00000374811 | 65533610 | 65533735 | In-frame |
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Infer the effects of exon skipping event on protein functional features for LAS1L |
p-ENSG00000001497_img4.png![]() |
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ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000374811 | 2456 | 734 | 65533610 | 65533735 | 278 | 402 | 79 | 120 |
ENST00000374811 | 2456 | 734 | 65524564 | 65524614 | 1084 | 1133 | 347 | 364 |
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ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000374811 | 2456 | 734 | 65524564 | 65524614 | 1084 | 1133 | 347 | 364 |
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ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000374811 | 2456 | 734 | 65533610 | 65533735 | 278 | 402 | 79 | 120 |
ENST00000374811 | 2456 | 734 | 65524564 | 65524614 | 1084 | 1133 | 347 | 364 |
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UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Q9Y4W2 | 79 | 120 | 79 | 120 | Alternative sequence | ID=VSP_015178;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
Q9Y4W2 | 79 | 120 | 1 | 734 | Chain | ID=PRO_0000211559;Note=Ribosomal biogenesis protein LAS1L |
Q9Y4W2 | 347 | 364 | 292 | 734 | Alternative sequence | ID=VSP_015180;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2 |
Q9Y4W2 | 347 | 364 | 348 | 365 | Alternative sequence | ID=VSP_015181;Note=In isoform 2 and isoform 3. DGQTEVQRGEGTDPKSHK->E;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
Q9Y4W2 | 347 | 364 | 1 | 734 | Chain | ID=PRO_0000211559;Note=Ribosomal biogenesis protein LAS1L |
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UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Q9Y4W2 | 347 | 364 | 292 | 734 | Alternative sequence | ID=VSP_015180;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2 |
Q9Y4W2 | 347 | 364 | 348 | 365 | Alternative sequence | ID=VSP_015181;Note=In isoform 2 and isoform 3. DGQTEVQRGEGTDPKSHK->E;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
Q9Y4W2 | 347 | 364 | 1 | 734 | Chain | ID=PRO_0000211559;Note=Ribosomal biogenesis protein LAS1L |
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UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Q9Y4W2 | 79 | 120 | 79 | 120 | Alternative sequence | ID=VSP_015178;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
Q9Y4W2 | 79 | 120 | 1 | 734 | Chain | ID=PRO_0000211559;Note=Ribosomal biogenesis protein LAS1L |
Q9Y4W2 | 347 | 364 | 292 | 734 | Alternative sequence | ID=VSP_015180;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2 |
Q9Y4W2 | 347 | 364 | 348 | 365 | Alternative sequence | ID=VSP_015181;Note=In isoform 2 and isoform 3. DGQTEVQRGEGTDPKSHK->E;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
Q9Y4W2 | 347 | 364 | 1 | 734 | Chain | ID=PRO_0000211559;Note=Ribosomal biogenesis protein LAS1L |
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3'-UTR located exon skipping events that lost miRNA binding sites in LAS1L |
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Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for LAS1L |
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Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for LAS1L |
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AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for LAS1L |
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Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for LAS1L |
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Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
CB | SAMD4A | exon_skip_85149 | -4.378908e-01 | 7.825222e-09 |
CB | PCBP4 | exon_skip_85149 | 6.215447e-01 | 2.286422e-18 |
CB | RBM45 | exon_skip_85149 | 5.539491e-01 | 3.616810e-14 |
CB | NUP42 | exon_skip_85149 | 4.066969e-01 | 1.040266e-07 |
CB | CNOT4 | exon_skip_281762 | -5.623048e-01 | 1.230847e-14 |
CB | TRA2A | exon_skip_281762 | -5.743213e-01 | 2.474691e-15 |
CB | HNRNPA2B1 | exon_skip_281762 | -5.810123e-01 | 9.842919e-16 |
CB | HNRNPF | exon_skip_281762 | -4.312021e-01 | 1.393503e-08 |
CB | RBM6 | exon_skip_119805 | -6.441800e-01 | 5.177600e-20 |
CB | RBM4 | exon_skip_119805 | -4.591896e-01 | 1.143997e-09 |
CB | RBM6 | exon_skip_218798 | -4.144980e-01 | 5.581308e-08 |
CB | PCBP4 | exon_skip_218798 | 4.033112e-01 | 1.356349e-07 |
CB | TRA2A | exon_skip_218798 | -5.401073e-01 | 2.021662e-13 |
CB | HNRNPA2B1 | exon_skip_218798 | -4.336234e-01 | 1.132437e-08 |
CB | SRSF4 | exon_skip_218798 | -4.221386e-01 | 2.986373e-08 |
CB | RBM4 | exon_skip_218798 | -6.458943e-01 | 3.836054e-20 |
CB | TRA2A | exon_skip_280252 | -4.770818e-01 | 2.666956e-10 |
DLPFC | DAZAP1 | exon_skip_85149 | 6.350901e-01 | 8.818679e-39 |
DLPFC | SRSF2 | exon_skip_85149 | 5.747524e-01 | 1.713650e-30 |
DLPFC | ELAVL4 | exon_skip_85149 | 5.197090e-01 | 2.696826e-24 |
DLPFC | RBM25 | exon_skip_85149 | 5.068237e-01 | 5.303600e-23 |
DLPFC | SFPQ | exon_skip_85149 | 5.445662e-01 | 5.936511e-27 |
DLPFC | ZNF638 | exon_skip_85149 | 5.014219e-01 | 1.781558e-22 |
DLPFC | RBM28 | exon_skip_85149 | 4.854024e-01 | 5.722061e-21 |
DLPFC | RBM6 | exon_skip_85149 | 4.347468e-01 | 1.078521e-16 |
DLPFC | TIA1 | exon_skip_85149 | 5.596646e-01 | 1.117607e-28 |
DLPFC | RBM5 | exon_skip_85149 | 6.457913e-01 | 1.896218e-40 |
DLPFC | MATR3 | exon_skip_85149 | 4.047188e-01 | 1.776845e-14 |
DLPFC | TRNAU1AP | exon_skip_85149 | 4.873045e-01 | 3.826208e-21 |
DLPFC | PCBP4 | exon_skip_85149 | 6.803169e-01 | 2.582474e-46 |
DLPFC | TRA2A | exon_skip_85149 | 4.345174e-01 | 1.123601e-16 |
DLPFC | KHDRBS2 | exon_skip_85149 | 4.515713e-01 | 4.908895e-18 |
DLPFC | SNRPA | exon_skip_85149 | 5.475462e-01 | 2.753734e-27 |
DLPFC | SF1 | exon_skip_85149 | 6.169366e-01 | 4.252914e-36 |
DLPFC | KHDRBS3 | exon_skip_85149 | 4.826661e-01 | 1.016471e-20 |
DLPFC | RBM24 | exon_skip_85149 | 4.336832e-01 | 1.303690e-16 |
DLPFC | FUBP1 | exon_skip_85149 | 4.689844e-01 | 1.666434e-19 |
DLPFC | ENOX1 | exon_skip_85149 | 4.597467e-01 | 1.027203e-18 |
DLPFC | KHSRP | exon_skip_85149 | 6.145191e-01 | 9.395481e-36 |
DLPFC | HNRNPA0 | exon_skip_85149 | 4.696026e-01 | 1.472579e-19 |
DLPFC | PUM1 | exon_skip_85149 | 4.104569e-01 | 6.966171e-15 |
DLPFC | HNRNPDL | exon_skip_85149 | 5.103016e-01 | 2.403152e-23 |
DLPFC | RBM45 | exon_skip_85149 | 4.568914e-01 | 1.782344e-18 |
DLPFC | PUF60 | exon_skip_85149 | 5.709814e-01 | 4.967922e-30 |
DLPFC | HNRNPD | exon_skip_85149 | 5.111955e-01 | 1.957828e-23 |
DLPFC | NUP42 | exon_skip_85149 | 4.698750e-01 | 1.394339e-19 |
DLPFC | RALYL | exon_skip_85149 | 4.695247e-01 | 1.495716e-19 |
DLPFC | SNRNP70 | exon_skip_85149 | 6.986079e-01 | 9.224250e-50 |
DLPFC | HNRNPL | exon_skip_85149 | 5.391835e-01 | 2.332197e-26 |
DLPFC | CELF1 | exon_skip_85149 | 6.087777e-01 | 6.006621e-35 |
DLPFC | RBM23 | exon_skip_85149 | 4.096645e-01 | 7.936194e-15 |
DLPFC | CPEB1 | exon_skip_85149 | 5.171781e-01 | 4.890172e-24 |
DLPFC | EWSR1 | exon_skip_85149 | 5.682458e-01 | 1.066113e-29 |
DLPFC | SRSF1 | exon_skip_85149 | 4.372100e-01 | 6.934150e-17 |
DLPFC | FUS | exon_skip_85149 | 6.551905e-01 | 5.717374e-42 |
DLPFC | SRSF4 | exon_skip_85149 | 4.490537e-01 | 7.880143e-18 |
DLPFC | SRSF9 | exon_skip_85149 | 4.354101e-01 | 9.579091e-17 |
DLPFC | SRSF5 | exon_skip_85149 | 6.416867e-01 | 8.420593e-40 |
DLPFC | YBX2 | exon_skip_85149 | 6.515591e-01 | 2.244506e-41 |
DLPFC | SART3 | exon_skip_85149 | 6.051505e-01 | 1.902178e-34 |
DLPFC | NOVA1 | exon_skip_85149 | 6.401842e-01 | 1.445030e-39 |
IFG | RBM25 | exon_skip_119805 | -4.478087e-01 | 3.213010e-02 |
IFG | RBM6 | exon_skip_119805 | -4.904571e-01 | 1.749952e-02 |
IFG | PCBP4 | exon_skip_119805 | -4.527678e-01 | 3.004839e-02 |
IFG | PCBP2 | exon_skip_119805 | -6.436940e-01 | 9.195042e-04 |
IFG | SF1 | exon_skip_119805 | -4.780593e-01 | 2.103920e-02 |
PCC | ILF2 | exon_skip_119805 | 4.010320e-01 | 1.620257e-09 |
TC | RBMS2 | exon_skip_85149 | -4.934405e-01 | 3.367275e-11 |
TC | MSI1 | exon_skip_85149 | -4.274908e-01 | 1.720705e-08 |
TC | SAMD4A | exon_skip_85149 | -5.287185e-01 | 6.652526e-13 |
TC | PTBP1 | exon_skip_85149 | -4.529269e-01 | 1.814612e-09 |
TC | HNRNPF | exon_skip_85149 | -5.063910e-01 | 8.399101e-12 |
TC | NOVA1 | exon_skip_85149 | 4.657161e-01 | 5.450392e-10 |
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RelatedDrugs for LAS1L |
![]() (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for LAS1L |
![]() (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |