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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for ZNF611 |
 Gene summary |
| Gene information | Gene symbol | ZNF611 | Gene ID | 81856 |
| Gene name | zinc finger protein 611 | |
| Synonyms | - | |
| Cytomap | 19q13.41 | |
| Type of gene | protein-coding | |
| Description | zinc finger protein 611 | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for ZNF611 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000213020
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | UP | ENST00000601643.5 | ZNF611-217:protein_coding:ZNF611 | 1.392588e+00 | 1.572640e+00 | 2.786144e-03 | 1.213788e-02 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for ZNF611 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_113059 | chr19 | 52711207:52711304:52714015:52714141:52715832:52715913 | 52714015:52714141 |
| exon_skip_123292 | chr19 | 52706777:52706864:52711207:52711304:52714015:52714110 | 52711207:52711304 |
| exon_skip_179030 | chr19 | 52715832:52715913:52716111:52716233:52728730:52728786 | 52716111:52716233 |
| exon_skip_198881 | chr19 | 52706777:52706864:52711207:52711304:52714015:52714141 | 52711207:52711304 |
| exon_skip_2006 | chr19 | 52706777:52706864:52707469:52707542:52711207:52711304 | 52707469:52707542 |
| exon_skip_202244 | chr19 | 52706777:52706864:52707421:52707542:52711207:52711304 | 52707421:52707542 |
| exon_skip_209979 | chr19 | 52706777:52706864:52714015:52714141:52715832:52715913 | 52714015:52714141 |
| exon_skip_21145 | chr19 | 52728730:52728831:52729906:52730005:52735001:52735011 | 52729906:52730005 |
| exon_skip_228791 | chr19 | 52706777:52706864:52707392:52707538:52714015:52714141 | 52707392:52707538 |
| exon_skip_235779 | chr19 | 52707469:52707542:52711207:52711304:52714015:52714110 | 52711207:52711304 |
| exon_skip_269480 | chr19 | 52714015:52714141:52715832:52715913:52728730:52728786 | 52715832:52715913 |
| exon_skip_294064 | chr19 | 52706777:52706864:52707469:52707542:52715832:52715913 | 52707469:52707542 |
| exon_skip_39598 | chr19 | 52706777:52706864:52707421:52707542:52715832:52715913 | 52707421:52707542 |
| exon_skip_68913 | chr19 | 52706777:52706864:52708177:52708326:52714015:52714141 | 52708177:52708326 |
| exon_skip_69673 | chr19 | 52707469:52707542:52711207:52711304:52714015:52714141 | 52711207:52711304 |
| exon_skip_82225 | chr19 | 52706777:52706864:52715832:52715913:52735001:52735011 | 52715832:52715913 |
| exon_skip_94739 | chr19 | 52706777:52706864:52707392:52707538:52714015:52714110 | 52707392:52707538 |
| exon_skip_96879 | chr19 | 52715832:52715913:52728730:52728831:52735001:52735011 | 52728730:52728831 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for ZNF611 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000319783 | 52716111 | 52716233 | 3UTR-3UTR |
| ENST00000540744 | 52728730 | 52728831 | 3UTR-3UTR |
| ENST00000543227 | 52729906 | 52730005 | 3UTR-3UTR |
| ENST00000319783 | 52714015 | 52714141 | Frame-shift |
| ENST00000540744 | 52714015 | 52714141 | Frame-shift |
| ENST00000543227 | 52714015 | 52714141 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000540744 | 52715832 | 52715913 | 3UTR-3CDS |
| ENST00000543227 | 52715832 | 52715913 | 3UTR-3CDS |
| ENST00000319783 | 52716111 | 52716233 | 3UTR-3UTR |
| ENST00000540744 | 52728730 | 52728831 | 3UTR-3UTR |
| ENST00000543227 | 52729906 | 52730005 | 3UTR-3UTR |
| ENST00000319783 | 52714015 | 52714141 | Frame-shift |
| ENST00000540744 | 52714015 | 52714141 | Frame-shift |
| ENST00000543227 | 52714015 | 52714141 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000319783 | 52716111 | 52716233 | 3UTR-3UTR |
| ENST00000540744 | 52728730 | 52728831 | 3UTR-3UTR |
| ENST00000543227 | 52729906 | 52730005 | 3UTR-3UTR |
| ENST00000319783 | 52714015 | 52714141 | Frame-shift |
| ENST00000540744 | 52714015 | 52714141 | Frame-shift |
| ENST00000543227 | 52714015 | 52714141 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for ZNF611 |
p-ENSG00000213020_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in ZNF611 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
| Mayo | ENST00000543227 | 52729906 | 52730005 | hsa-miR-3913-3p | chr19:52729926-52729933 | 8mer-1a | chr19:52729923-52729948 | 159.00 | -22.79 |
| Mayo | ENST00000540744 | 52728730 | 52728831 | hsa-miR-7106-5p | chr19:52728794-52728801 | 8mer-1a | chr19:52728779-52728803 | 162.00 | -32.60 |
| Mayo | ENST00000540744 | 52728730 | 52728831 | hsa-miR-1233-3p | chr19:52728756-52728763 | 8mer-1a | chr19:52728752-52728770 | 159.00 | -22.74 |
| Mayo | ENST00000319783 | 52716111 | 52716233 | hsa-miR-6882-3p | chr19:52716139-52716146 | 8mer-1a | chr19:52716138-52716158 | 155.00 | -21.83 |
| Mayo | ENST00000540744 | 52728730 | 52728831 | hsa-miR-6126 | chr19:52728769-52728776 | 8mer-1a | chr19:52728768-52728789 | 163.00 | -25.65 |
| Mayo | ENST00000319783 | 52716111 | 52716233 | hsa-miR-3179 | chr19:52716172-52716179 | 8mer-1a | chr19:52716162-52716183 | 163.00 | -24.78 |
| Mayo | ENST00000319783 | 52716111 | 52716233 | hsa-miR-423-5p | chr19:52716221-52716228 | 8mer-1a | chr19:52716214-52716231 | 146.00 | -19.07 |
| Mayo | ENST00000319783 | 52716111 | 52716233 | hsa-miR-3184-5p | chr19:52716221-52716228 | 8mer-1a | chr19:52716214-52716231 | 146.00 | -19.07 |
| Mayo | ENST00000543227 | 52729906 | 52730005 | hsa-miR-4999-5p | chr19:52729960-52729967 | 8mer-1a | chr19:52729947-52729967 | 171.00 | -24.01 |
| Mayo | ENST00000540744 | 52728730 | 52728831 | hsa-miR-6807-5p | chr19:52728782-52728789 | 8mer-1a | chr19:52728779-52728803 | 162.00 | -32.60 |
| Mayo | ENST00000319783 | 52716111 | 52716233 | hsa-miR-3909 | chr19:52716213-52716220 | 8mer-1a | chr19:52716209-52716226 | 159.00 | -31.94 |
| Mayo | ENST00000319783 | 52716111 | 52716233 | hsa-miR-6889-3p | chr19:52716181-52716188 | 8mer-1a | chr19:52716167-52716188 | 141.00 | -22.42 |
| Mayo | ENST00000319783 | 52716111 | 52716233 | hsa-miR-6529-3p | chr19:52716181-52716188 | 8mer-1a | chr19:52716167-52716188 | 141.00 | -22.42 |
| Mayo | ENST00000319783 | 52716111 | 52716233 | hsa-miR-7976 | chr19:52716177-52716184 | 8mer-1a | chr19:52716165-52716185 | 146.00 | -19.57 |
| Mayo | ENST00000540744 | 52728730 | 52728831 | hsa-miR-1236-3p | chr19:52728821-52728828 | 8mer-1a | chr19:52728807-52728828 | 144.00 | -12.92 |
| Mayo | ENST00000319783 | 52716111 | 52716233 | hsa-miR-4286 | chr19:52716146-52716153 | 8mer-1a | chr19:52716143-52716163 | 155.00 | -27.84 |
| Mayo | ENST00000319783 | 52716111 | 52716233 | hsa-miR-6852-3p | chr19:52716213-52716220 | 8mer-1a | chr19:52716209-52716226 | 159.00 | -31.94 |
| Mayo | ENST00000319783 | 52716111 | 52716233 | hsa-miR-455-3p | chr19:52716161-52716168 | 8mer-1a | chr19:52716154-52716174 | 161.00 | -25.01 |
| MSBB | ENST00000543227 | 52729906 | 52730005 | hsa-miR-3913-3p | chr19:52729926-52729933 | 8mer-1a | chr19:52729923-52729948 | 159.00 | -22.79 |
| MSBB | ENST00000540744 | 52728730 | 52728831 | hsa-miR-7106-5p | chr19:52728794-52728801 | 8mer-1a | chr19:52728779-52728803 | 162.00 | -32.60 |
| MSBB | ENST00000540744 | 52728730 | 52728831 | hsa-miR-1233-3p | chr19:52728756-52728763 | 8mer-1a | chr19:52728752-52728770 | 159.00 | -22.74 |
| MSBB | ENST00000319783 | 52716111 | 52716233 | hsa-miR-6882-3p | chr19:52716139-52716146 | 8mer-1a | chr19:52716138-52716158 | 155.00 | -21.83 |
| MSBB | ENST00000540744 | 52728730 | 52728831 | hsa-miR-6126 | chr19:52728769-52728776 | 8mer-1a | chr19:52728768-52728789 | 163.00 | -25.65 |
| MSBB | ENST00000319783 | 52716111 | 52716233 | hsa-miR-3179 | chr19:52716172-52716179 | 8mer-1a | chr19:52716162-52716183 | 163.00 | -24.78 |
| MSBB | ENST00000319783 | 52716111 | 52716233 | hsa-miR-423-5p | chr19:52716221-52716228 | 8mer-1a | chr19:52716214-52716231 | 146.00 | -19.07 |
| MSBB | ENST00000319783 | 52716111 | 52716233 | hsa-miR-3184-5p | chr19:52716221-52716228 | 8mer-1a | chr19:52716214-52716231 | 146.00 | -19.07 |
| MSBB | ENST00000543227 | 52729906 | 52730005 | hsa-miR-4999-5p | chr19:52729960-52729967 | 8mer-1a | chr19:52729947-52729967 | 171.00 | -24.01 |
| MSBB | ENST00000540744 | 52728730 | 52728831 | hsa-miR-6807-5p | chr19:52728782-52728789 | 8mer-1a | chr19:52728779-52728803 | 162.00 | -32.60 |
| MSBB | ENST00000319783 | 52716111 | 52716233 | hsa-miR-3909 | chr19:52716213-52716220 | 8mer-1a | chr19:52716209-52716226 | 159.00 | -31.94 |
| MSBB | ENST00000319783 | 52716111 | 52716233 | hsa-miR-6889-3p | chr19:52716181-52716188 | 8mer-1a | chr19:52716167-52716188 | 141.00 | -22.42 |
| MSBB | ENST00000319783 | 52716111 | 52716233 | hsa-miR-6529-3p | chr19:52716181-52716188 | 8mer-1a | chr19:52716167-52716188 | 141.00 | -22.42 |
| MSBB | ENST00000319783 | 52716111 | 52716233 | hsa-miR-7976 | chr19:52716177-52716184 | 8mer-1a | chr19:52716165-52716185 | 146.00 | -19.57 |
| MSBB | ENST00000540744 | 52728730 | 52728831 | hsa-miR-1236-3p | chr19:52728821-52728828 | 8mer-1a | chr19:52728807-52728828 | 144.00 | -12.92 |
| MSBB | ENST00000319783 | 52716111 | 52716233 | hsa-miR-4286 | chr19:52716146-52716153 | 8mer-1a | chr19:52716143-52716163 | 155.00 | -27.84 |
| MSBB | ENST00000319783 | 52716111 | 52716233 | hsa-miR-6852-3p | chr19:52716213-52716220 | 8mer-1a | chr19:52716209-52716226 | 159.00 | -31.94 |
| MSBB | ENST00000319783 | 52716111 | 52716233 | hsa-miR-455-3p | chr19:52716161-52716168 | 8mer-1a | chr19:52716154-52716174 | 161.00 | -25.01 |
| ROSMAP | ENST00000543227 | 52729906 | 52730005 | hsa-miR-3913-3p | chr19:52729926-52729933 | 8mer-1a | chr19:52729923-52729948 | 159.00 | -22.79 |
| ROSMAP | ENST00000540744 | 52728730 | 52728831 | hsa-miR-7106-5p | chr19:52728794-52728801 | 8mer-1a | chr19:52728779-52728803 | 162.00 | -32.60 |
| ROSMAP | ENST00000540744 | 52728730 | 52728831 | hsa-miR-1233-3p | chr19:52728756-52728763 | 8mer-1a | chr19:52728752-52728770 | 159.00 | -22.74 |
| ROSMAP | ENST00000319783 | 52716111 | 52716233 | hsa-miR-6882-3p | chr19:52716139-52716146 | 8mer-1a | chr19:52716138-52716158 | 155.00 | -21.83 |
| ROSMAP | ENST00000540744 | 52728730 | 52728831 | hsa-miR-6126 | chr19:52728769-52728776 | 8mer-1a | chr19:52728768-52728789 | 163.00 | -25.65 |
| ROSMAP | ENST00000319783 | 52716111 | 52716233 | hsa-miR-3179 | chr19:52716172-52716179 | 8mer-1a | chr19:52716162-52716183 | 163.00 | -24.78 |
| ROSMAP | ENST00000319783 | 52716111 | 52716233 | hsa-miR-423-5p | chr19:52716221-52716228 | 8mer-1a | chr19:52716214-52716231 | 146.00 | -19.07 |
| ROSMAP | ENST00000319783 | 52716111 | 52716233 | hsa-miR-3184-5p | chr19:52716221-52716228 | 8mer-1a | chr19:52716214-52716231 | 146.00 | -19.07 |
| ROSMAP | ENST00000543227 | 52729906 | 52730005 | hsa-miR-4999-5p | chr19:52729960-52729967 | 8mer-1a | chr19:52729947-52729967 | 171.00 | -24.01 |
| ROSMAP | ENST00000540744 | 52728730 | 52728831 | hsa-miR-6807-5p | chr19:52728782-52728789 | 8mer-1a | chr19:52728779-52728803 | 162.00 | -32.60 |
| ROSMAP | ENST00000319783 | 52716111 | 52716233 | hsa-miR-3909 | chr19:52716213-52716220 | 8mer-1a | chr19:52716209-52716226 | 159.00 | -31.94 |
| ROSMAP | ENST00000319783 | 52716111 | 52716233 | hsa-miR-6889-3p | chr19:52716181-52716188 | 8mer-1a | chr19:52716167-52716188 | 141.00 | -22.42 |
| ROSMAP | ENST00000319783 | 52716111 | 52716233 | hsa-miR-6529-3p | chr19:52716181-52716188 | 8mer-1a | chr19:52716167-52716188 | 141.00 | -22.42 |
| ROSMAP | ENST00000319783 | 52716111 | 52716233 | hsa-miR-7976 | chr19:52716177-52716184 | 8mer-1a | chr19:52716165-52716185 | 146.00 | -19.57 |
| ROSMAP | ENST00000540744 | 52728730 | 52728831 | hsa-miR-1236-3p | chr19:52728821-52728828 | 8mer-1a | chr19:52728807-52728828 | 144.00 | -12.92 |
| ROSMAP | ENST00000319783 | 52716111 | 52716233 | hsa-miR-4286 | chr19:52716146-52716153 | 8mer-1a | chr19:52716143-52716163 | 155.00 | -27.84 |
| ROSMAP | ENST00000319783 | 52716111 | 52716233 | hsa-miR-6852-3p | chr19:52716213-52716220 | 8mer-1a | chr19:52716209-52716226 | 159.00 | -31.94 |
| ROSMAP | ENST00000319783 | 52716111 | 52716233 | hsa-miR-455-3p | chr19:52716161-52716168 | 8mer-1a | chr19:52716154-52716174 | 161.00 | -25.01 |
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SNVs in the skipped exons for ZNF611 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for ZNF611 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ZNF611 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
| HCC | exon_skip_21145 | rs12980139 | chr19:52682852 | 1.458414e-05 | 1.750469e-03 |
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Correlation with RNA binding proteins (RBPs) for ZNF611 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for ZNF611 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZNF611 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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