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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for CAMK2G |
 Gene summary |
| Gene information | Gene symbol | CAMK2G | Gene ID | 818 |
| Gene name | calcium/calmodulin dependent protein kinase II gamma | |
| Synonyms | CAMK|CAMK-II|CAMKG|MRD59 | |
| Cytomap | 10q22.2 | |
| Type of gene | protein-coding | |
| Description | calcium/calmodulin-dependent protein kinase type II subunit gammacaMK-II subunit gammacalcium/calmodulin-dependent protein kinase (CaM kinase) II gamma | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
Top |
Gene structures and expression levels for CAMK2G |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000148660
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
 |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| PCC | UP | ENST00000351293.7 | CAMK2G-204:protein_coding:CAMK2G | 4.849177e+02 | 8.046975e-01 | 3.015760e-05 | 2.729300e-03 |
| TC | UP | ENST00000433289.5 | CAMK2G-208:protein_coding:CAMK2G | 6.898565e+00 | 9.152785e-01 | 6.550627e-04 | 7.110219e-03 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for CAMK2G |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_108680 | chr10 | 73817479:73817554:73819532:73819645:73821682:73821730 | 73819532:73819645 |
| exon_skip_123883 | chr10 | 73821682:73821730:73824040:73824084:73837468:73837511 | 73824040:73824084 |
| exon_skip_132492 | chr10 | 73847225:73847347:73847988:73848082:73848526:73848609 | 73847988:73848082 |
| exon_skip_134285 | chr10 | 73815201:73815247:73817023:73817117:73817479:73817554 | 73817023:73817117 |
| exon_skip_159800 | chr10 | 73817479:73817554:73818209:73818895:73819532:73819614 | 73818209:73818895 |
| exon_skip_165362 | chr10 | 73821682:73821730:73824040:73824084:73825321:73825347 | 73824040:73824084 |
| exon_skip_167759 | chr10 | 73824040:73824084:73825321:73825347:73837468:73837511 | 73825321:73825347 |
| exon_skip_174572 | chr10 | 73821682:73821730:73824040:73824084:73825279:73825347 | 73824040:73824084 |
| exon_skip_206164 | chr10 | 73847988:73848082:73848526:73848609:73849013:73849115 | 73848526:73848609 |
| exon_skip_214314 | chr10 | 73821682:73821730:73824040:73824084:73828089:73828121 | 73824040:73824084 |
| exon_skip_217314 | chr10 | 73817479:73817554:73819532:73819617:73821682:73821730 | 73819532:73819617 |
| exon_skip_226790 | chr10 | 73837468:73837511:73839539:73839601:73842169:73842211 | 73839539:73839601 |
| exon_skip_235771 | chr10 | 73825321:73825347:73828089:73828121:73837468:73837511 | 73828089:73828121 |
| exon_skip_240015 | chr10 | 73821682:73821730:73824040:73824084:73828089:73828120 | 73824040:73824084 |
| exon_skip_245245 | chr10 | 73824040:73824084:73828089:73828121:73837468:73837511 | 73828089:73828121 |
| exon_skip_55843 | chr10 | 73824040:73824084:73825279:73825347:73837468:73837511 | 73825279:73825347 |
| exon_skip_5699 | chr10 | 73824040:73824084:73825279:73825347:73828089:73828121 | 73825279:73825347 |
| exon_skip_6300 | chr10 | 73872989:73873083:73873390:73873523:73874397:73874461 | 73873390:73873523 |
| exon_skip_65109 | chr10 | 73824040:73824084:73825279:73825347:73828089:73828120 | 73825279:73825347 |
| exon_skip_78572 | chr10 | 73860830:73860889:73872989:73873083:73874397:73874461 | 73872989:73873083 |
| exon_skip_84308 | chr10 | 73852254:73852319:73853192:73853246:73860830:73860854 | 73853192:73853246 |
| exon_skip_88579 | chr10 | 73849261:73849333:73852254:73852319:73853192:73853246 | 73852254:73852319 |
| exon_skip_92498 | chr10 | 73872989:73873083:73873390:73873523:73874397:73874554 | 73873390:73873523 |
| exon_skip_94869 | chr10 | 73842458:73842541:73847225:73847347:73847988:73848012 | 73847225:73847347 |
| exon_skip_99699 | chr10 | 73821682:73821730:73824040:73824084:73825279:73825341 | 73824040:73824084 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
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| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
| exon_skip_226790 | MSBB_STG | 4.114493e-01 | 5.429167e-01 | -1.314674e-01 | 3.173720e-03 |
| exon_skip_226790 | MSBB_PG | 3.067391e-01 | 4.296491e-01 | -1.229100e-01 | 2.098377e-04 |
| exon_skip_108680 | Mayo_CB | 2.507317e-01 | 3.661039e-01 | -1.153722e-01 | 1.722196e-09 |
| exon_skip_17487 | Mayo_CB | 3.941558e-01 | 6.660714e-01 | -2.719156e-01 | 1.807559e-09 |
| exon_skip_167759 | Mayo_CB | 2.140741e-01 | 3.285507e-01 | -1.144767e-01 | 8.097718e-07 |
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Open reading frame (ORF) annotation in the exon skipping event for CAMK2G |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000423381 | 73817023 | 73817117 | Frame-shift |
| ENST00000423381 | 73847988 | 73848082 | Frame-shift |
| ENST00000423381 | 73853192 | 73853246 | Frame-shift |
| ENST00000423381 | 73872989 | 73873083 | Frame-shift |
| ENST00000423381 | 73824040 | 73824084 | In-frame |
| ENST00000423381 | 73825279 | 73825347 | In-frame |
| ENST00000423381 | 73828089 | 73828121 | In-frame |
| ENST00000423381 | 73847225 | 73847347 | In-frame |
| ENST00000423381 | 73848526 | 73848609 | In-frame |
| ENST00000423381 | 73852254 | 73852319 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000423381 | 73817023 | 73817117 | Frame-shift |
| ENST00000423381 | 73847988 | 73848082 | Frame-shift |
| ENST00000423381 | 73853192 | 73853246 | Frame-shift |
| ENST00000423381 | 73825279 | 73825347 | In-frame |
| ENST00000423381 | 73828089 | 73828121 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000423381 | 73847988 | 73848082 | Frame-shift |
| ENST00000423381 | 73853192 | 73853246 | Frame-shift |
| ENST00000423381 | 73824040 | 73824084 | In-frame |
| ENST00000423381 | 73825279 | 73825347 | In-frame |
| ENST00000423381 | 73828089 | 73828121 | In-frame |
| ENST00000423381 | 73847225 | 73847347 | In-frame |
| ENST00000423381 | 73848526 | 73848609 | In-frame |
| ENST00000423381 | 73852254 | 73852319 | In-frame |
Top |
Infer the effects of exon skipping event on protein functional features for CAMK2G |
p-ENSG00000148660_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000423381 | 3841 | 558 | 73852254 | 73852319 | 406 | 470 | 92 | 113 |
| ENST00000423381 | 3841 | 558 | 73848526 | 73848609 | 648 | 730 | 172 | 200 |
| ENST00000423381 | 3841 | 558 | 73847225 | 73847347 | 827 | 948 | 232 | 272 |
| ENST00000423381 | 3841 | 558 | 73828089 | 73828121 | 1121 | 1152 | 330 | 340 |
| ENST00000423381 | 3841 | 558 | 73825279 | 73825347 | 1154 | 1221 | 341 | 363 |
| ENST00000423381 | 3841 | 558 | 73824040 | 73824084 | 1223 | 1266 | 364 | 378 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000423381 | 3841 | 558 | 73828089 | 73828121 | 1121 | 1152 | 330 | 340 |
| ENST00000423381 | 3841 | 558 | 73825279 | 73825347 | 1154 | 1221 | 341 | 363 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000423381 | 3841 | 558 | 73852254 | 73852319 | 406 | 470 | 92 | 113 |
| ENST00000423381 | 3841 | 558 | 73848526 | 73848609 | 648 | 730 | 172 | 200 |
| ENST00000423381 | 3841 | 558 | 73847225 | 73847347 | 827 | 948 | 232 | 272 |
| ENST00000423381 | 3841 | 558 | 73828089 | 73828121 | 1121 | 1152 | 330 | 340 |
| ENST00000423381 | 3841 | 558 | 73825279 | 73825347 | 1154 | 1221 | 341 | 363 |
| ENST00000423381 | 3841 | 558 | 73824040 | 73824084 | 1223 | 1266 | 364 | 378 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q13555 | 92 | 113 | 1 | 558 | Chain | ID=PRO_0000086101;Note=Calcium/calmodulin-dependent protein kinase type II subunit gamma |
| Q13555 | 92 | 113 | 14 | 272 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| Q13555 | 92 | 113 | 98 | 103 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2V7O |
| Q13555 | 92 | 113 | 110 | 129 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2V7O |
| Q13555 | 172 | 200 | 1 | 558 | Chain | ID=PRO_0000086101;Note=Calcium/calmodulin-dependent protein kinase type II subunit gamma |
| Q13555 | 172 | 200 | 14 | 272 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| Q13555 | 172 | 200 | 178 | 180 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2V7O |
| Q13555 | 172 | 200 | 183 | 187 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2V7O |
| Q13555 | 172 | 200 | 194 | 209 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2V7O |
| Q13555 | 232 | 272 | 1 | 558 | Chain | ID=PRO_0000086101;Note=Calcium/calmodulin-dependent protein kinase type II subunit gamma |
| Q13555 | 232 | 272 | 14 | 272 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| Q13555 | 232 | 272 | 237 | 240 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2V7O |
| Q13555 | 232 | 272 | 243 | 252 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2V7O |
| Q13555 | 232 | 272 | 263 | 266 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2V7O |
| Q13555 | 232 | 272 | 270 | 273 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2V7O |
| Q13555 | 232 | 272 | 257 | 259 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2V7O |
| Q13555 | 330 | 340 | 331 | 364 | Alternative sequence | ID=VSP_013350;Note=In isoform 3%2C isoform 7 and isoform 10. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:7557101,ECO:0000303|PubMed:8449910;Dbxref=PMID:7557101,PMID:8449910 |
| Q13555 | 330 | 340 | 331 | 341 | Alternative sequence | ID=VSP_013349;Note=In isoform 2%2C isoform 8%2C isoform 9 and isoform 11. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:7557101,ECO:0000303|PubMed:9060999;Dbxref=PMID:7557101,PMID:9060999 |
| Q13555 | 330 | 340 | 1 | 558 | Chain | ID=PRO_0000086101;Note=Calcium/calmodulin-dependent protein kinase type II subunit gamma |
| Q13555 | 330 | 340 | 334 | 334 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11730 |
| Q13555 | 341 | 363 | 331 | 364 | Alternative sequence | ID=VSP_013350;Note=In isoform 3%2C isoform 7 and isoform 10. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:7557101,ECO:0000303|PubMed:8449910;Dbxref=PMID:7557101,PMID:8449910 |
| Q13555 | 341 | 363 | 331 | 341 | Alternative sequence | ID=VSP_013349;Note=In isoform 2%2C isoform 8%2C isoform 9 and isoform 11. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:7557101,ECO:0000303|PubMed:9060999;Dbxref=PMID:7557101,PMID:9060999 |
| Q13555 | 341 | 363 | 341 | 363 | Alternative sequence | ID=VSP_032700;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| Q13555 | 341 | 363 | 351 | 364 | Alternative sequence | ID=VSP_036027;Note=In isoform 9. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7557101;Dbxref=PMID:7557101 |
| Q13555 | 341 | 363 | 1 | 558 | Chain | ID=PRO_0000086101;Note=Calcium/calmodulin-dependent protein kinase type II subunit gamma |
| Q13555 | 341 | 363 | 349 | 349 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18691976;Dbxref=PMID:18691976 |
| Q13555 | 341 | 363 | 352 | 352 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:19369195;Dbxref=PMID:18691976,PMID:19369195 |
| Q13555 | 364 | 378 | 331 | 364 | Alternative sequence | ID=VSP_013350;Note=In isoform 3%2C isoform 7 and isoform 10. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:7557101,ECO:0000303|PubMed:8449910;Dbxref=PMID:7557101,PMID:8449910 |
| Q13555 | 364 | 378 | 351 | 364 | Alternative sequence | ID=VSP_036027;Note=In isoform 9. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7557101;Dbxref=PMID:7557101 |
| Q13555 | 364 | 378 | 1 | 558 | Chain | ID=PRO_0000086101;Note=Calcium/calmodulin-dependent protein kinase type II subunit gamma |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q13555 | 330 | 340 | 331 | 364 | Alternative sequence | ID=VSP_013350;Note=In isoform 3%2C isoform 7 and isoform 10. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:7557101,ECO:0000303|PubMed:8449910;Dbxref=PMID:7557101,PMID:8449910 |
| Q13555 | 330 | 340 | 331 | 341 | Alternative sequence | ID=VSP_013349;Note=In isoform 2%2C isoform 8%2C isoform 9 and isoform 11. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:7557101,ECO:0000303|PubMed:9060999;Dbxref=PMID:7557101,PMID:9060999 |
| Q13555 | 330 | 340 | 1 | 558 | Chain | ID=PRO_0000086101;Note=Calcium/calmodulin-dependent protein kinase type II subunit gamma |
| Q13555 | 330 | 340 | 334 | 334 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11730 |
| Q13555 | 341 | 363 | 331 | 364 | Alternative sequence | ID=VSP_013350;Note=In isoform 3%2C isoform 7 and isoform 10. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:7557101,ECO:0000303|PubMed:8449910;Dbxref=PMID:7557101,PMID:8449910 |
| Q13555 | 341 | 363 | 331 | 341 | Alternative sequence | ID=VSP_013349;Note=In isoform 2%2C isoform 8%2C isoform 9 and isoform 11. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:7557101,ECO:0000303|PubMed:9060999;Dbxref=PMID:7557101,PMID:9060999 |
| Q13555 | 341 | 363 | 341 | 363 | Alternative sequence | ID=VSP_032700;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| Q13555 | 341 | 363 | 351 | 364 | Alternative sequence | ID=VSP_036027;Note=In isoform 9. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7557101;Dbxref=PMID:7557101 |
| Q13555 | 341 | 363 | 1 | 558 | Chain | ID=PRO_0000086101;Note=Calcium/calmodulin-dependent protein kinase type II subunit gamma |
| Q13555 | 341 | 363 | 349 | 349 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18691976;Dbxref=PMID:18691976 |
| Q13555 | 341 | 363 | 352 | 352 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:19369195;Dbxref=PMID:18691976,PMID:19369195 |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q13555 | 92 | 113 | 1 | 558 | Chain | ID=PRO_0000086101;Note=Calcium/calmodulin-dependent protein kinase type II subunit gamma |
| Q13555 | 92 | 113 | 14 | 272 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| Q13555 | 92 | 113 | 98 | 103 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2V7O |
| Q13555 | 92 | 113 | 110 | 129 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2V7O |
| Q13555 | 172 | 200 | 1 | 558 | Chain | ID=PRO_0000086101;Note=Calcium/calmodulin-dependent protein kinase type II subunit gamma |
| Q13555 | 172 | 200 | 14 | 272 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| Q13555 | 172 | 200 | 178 | 180 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2V7O |
| Q13555 | 172 | 200 | 183 | 187 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2V7O |
| Q13555 | 172 | 200 | 194 | 209 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2V7O |
| Q13555 | 232 | 272 | 1 | 558 | Chain | ID=PRO_0000086101;Note=Calcium/calmodulin-dependent protein kinase type II subunit gamma |
| Q13555 | 232 | 272 | 14 | 272 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| Q13555 | 232 | 272 | 237 | 240 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2V7O |
| Q13555 | 232 | 272 | 243 | 252 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2V7O |
| Q13555 | 232 | 272 | 263 | 266 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2V7O |
| Q13555 | 232 | 272 | 270 | 273 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2V7O |
| Q13555 | 232 | 272 | 257 | 259 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2V7O |
| Q13555 | 330 | 340 | 331 | 364 | Alternative sequence | ID=VSP_013350;Note=In isoform 3%2C isoform 7 and isoform 10. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:7557101,ECO:0000303|PubMed:8449910;Dbxref=PMID:7557101,PMID:8449910 |
| Q13555 | 330 | 340 | 331 | 341 | Alternative sequence | ID=VSP_013349;Note=In isoform 2%2C isoform 8%2C isoform 9 and isoform 11. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:7557101,ECO:0000303|PubMed:9060999;Dbxref=PMID:7557101,PMID:9060999 |
| Q13555 | 330 | 340 | 1 | 558 | Chain | ID=PRO_0000086101;Note=Calcium/calmodulin-dependent protein kinase type II subunit gamma |
| Q13555 | 330 | 340 | 334 | 334 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11730 |
| Q13555 | 341 | 363 | 331 | 364 | Alternative sequence | ID=VSP_013350;Note=In isoform 3%2C isoform 7 and isoform 10. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:7557101,ECO:0000303|PubMed:8449910;Dbxref=PMID:7557101,PMID:8449910 |
| Q13555 | 341 | 363 | 331 | 341 | Alternative sequence | ID=VSP_013349;Note=In isoform 2%2C isoform 8%2C isoform 9 and isoform 11. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:7557101,ECO:0000303|PubMed:9060999;Dbxref=PMID:7557101,PMID:9060999 |
| Q13555 | 341 | 363 | 341 | 363 | Alternative sequence | ID=VSP_032700;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| Q13555 | 341 | 363 | 351 | 364 | Alternative sequence | ID=VSP_036027;Note=In isoform 9. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7557101;Dbxref=PMID:7557101 |
| Q13555 | 341 | 363 | 1 | 558 | Chain | ID=PRO_0000086101;Note=Calcium/calmodulin-dependent protein kinase type II subunit gamma |
| Q13555 | 341 | 363 | 349 | 349 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18691976;Dbxref=PMID:18691976 |
| Q13555 | 341 | 363 | 352 | 352 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:19369195;Dbxref=PMID:18691976,PMID:19369195 |
| Q13555 | 364 | 378 | 331 | 364 | Alternative sequence | ID=VSP_013350;Note=In isoform 3%2C isoform 7 and isoform 10. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:7557101,ECO:0000303|PubMed:8449910;Dbxref=PMID:7557101,PMID:8449910 |
| Q13555 | 364 | 378 | 351 | 364 | Alternative sequence | ID=VSP_036027;Note=In isoform 9. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7557101;Dbxref=PMID:7557101 |
| Q13555 | 364 | 378 | 1 | 558 | Chain | ID=PRO_0000086101;Note=Calcium/calmodulin-dependent protein kinase type II subunit gamma |
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3'-UTR located exon skipping events that lost miRNA binding sites in CAMK2G |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for CAMK2G |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for CAMK2G |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
| ADstage | MSBB | IFG | exon_skip_235771 | -4.273770e-01 | 2.330327e-02 | chr10 | - | 73825321 | 73825347 | 73828089 | 73828121 | 73837468 | 73837511 |
| ADstage | MSBB | STG | exon_skip_226790 | -3.029057e-01 | 3.164640e-03 | chr10 | - | 73837468 | 73837511 | 73839539 | 73839601 | 73842169 | 73842211 |
| ADstage | ROSMAP | PCC | exon_skip_226790 | -3.124423e-01 | 2.980000e-06 | chr10 | - | 73837468 | 73837511 | 73839539 | 73839601 | 73842169 | 73842211 |
| CDR | MSBB | IFG | exon_skip_235771 | -5.313259e-01 | 3.620655e-03 | chr10 | - | 73825321 | 73825347 | 73828089 | 73828121 | 73837468 | 73837511 |
| CDR | MSBB | IFG | exon_skip_226790 | -4.256004e-01 | 2.394682e-02 | chr10 | - | 73837468 | 73837511 | 73839539 | 73839601 | 73842169 | 73842211 |
| CDR | MSBB | STG | exon_skip_226790 | -4.518016e-01 | 5.470000e-06 | chr10 | - | 73837468 | 73837511 | 73839539 | 73839601 | 73842169 | 73842211 |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for CAMK2G |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for CAMK2G |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | TARDBP | exon_skip_49494 | -4.473444e-01 | 3.387825e-09 |
| CB | ELAVL1 | exon_skip_49494 | -4.403312e-01 | 6.319827e-09 |
| CB | SAMD4A | exon_skip_49494 | -4.628551e-01 | 8.106495e-10 |
| CB | CNOT4 | exon_skip_49494 | -4.518303e-01 | 2.256725e-09 |
| CB | FXR2 | exon_skip_49494 | -4.425855e-01 | 5.180027e-09 |
| CB | PCBP1 | exon_skip_49494 | -4.257381e-01 | 2.212276e-08 |
| CB | PCBP4 | exon_skip_49494 | 5.621839e-01 | 1.250459e-14 |
| CB | HNRNPA2B1 | exon_skip_49494 | -4.572087e-01 | 1.375728e-09 |
| CB | RBM45 | exon_skip_49494 | 4.477589e-01 | 3.263816e-09 |
| CB | RBM23 | exon_skip_49494 | -4.732129e-01 | 2.995292e-10 |
| CB | SRSF4 | exon_skip_49494 | -4.966089e-01 | 2.785415e-11 |
| CB | HNRNPF | exon_skip_49494 | -4.337797e-01 | 1.117311e-08 |
| CB | RBM4 | exon_skip_49494 | -5.420448e-01 | 1.596418e-13 |
| CB | RBM6 | exon_skip_108680 | -4.516647e-01 | 2.291062e-09 |
| CB | CNOT4 | exon_skip_108680 | -6.478260e-01 | 2.729774e-20 |
| CB | MBNL1 | exon_skip_108680 | -4.417079e-01 | 5.597996e-09 |
| CB | FXR2 | exon_skip_108680 | -5.434863e-01 | 1.337868e-13 |
| CB | PCBP1 | exon_skip_108680 | -5.844762e-01 | 6.056495e-16 |
| CB | TRA2A | exon_skip_108680 | -6.123187e-01 | 9.818563e-18 |
| CB | HNRNPL | exon_skip_108680 | -4.442349e-01 | 4.474424e-09 |
| CB | SRSF1 | exon_skip_108680 | -4.913647e-01 | 4.818794e-11 |
| CB | RBM4 | exon_skip_108680 | -7.903615e-01 | 3.127275e-35 |
| CB | CNOT4 | exon_skip_240015 | -5.298232e-01 | 2.237097e-12 |
| CB | RBM45 | exon_skip_240015 | 6.010197e-01 | 2.694478e-16 |
| CB | CNOT4 | exon_skip_17487 | -5.237819e-01 | 9.835696e-11 |
| CB | PCBP1 | exon_skip_17487 | -4.308451e-01 | 2.258144e-07 |
| CB | RBM45 | exon_skip_17487 | 7.914587e-01 | 8.595109e-30 |
| CB | NUP42 | exon_skip_17487 | 5.928633e-01 | 5.550927e-14 |
| CB | PABPC1 | exon_skip_17487 | 4.327569e-01 | 1.968946e-07 |
| CB | PABPC4 | exon_skip_17487 | 4.539754e-01 | 4.060142e-08 |
| CB | CNOT4 | exon_skip_236382 | -5.752906e-01 | 2.168109e-15 |
| CB | PCBP1 | exon_skip_236382 | -5.379463e-01 | 2.626224e-13 |
| CB | RBM45 | exon_skip_236382 | 5.371047e-01 | 2.906456e-13 |
| CB | EIF4G2 | exon_skip_236382 | -4.414834e-01 | 5.710000e-09 |
| CB | NUP42 | exon_skip_55843 | 5.479287e-01 | 7.720039e-14 |
| CB | NUP42 | exon_skip_167759 | 5.643821e-01 | 5.416327e-14 |
| CB | NUP42 | exon_skip_245245 | 6.059715e-01 | 4.140497e-17 |
| CB | NUP42 | exon_skip_235771 | 5.255905e-01 | 1.131577e-12 |
| CB | RBM6 | exon_skip_226790 | -4.682926e-01 | 4.826574e-10 |
| CB | HNRNPK | exon_skip_226790 | 4.253527e-01 | 2.284880e-08 |
| DLPFC | SRSF11 | exon_skip_217314 | 5.400974e-01 | 2.297464e-27 |
| DLPFC | RBM5 | exon_skip_217314 | 4.014516e-01 | 1.028596e-14 |
| DLPFC | PUF60 | exon_skip_217314 | 4.630901e-01 | 1.235861e-19 |
| DLPFC | SRSF2 | exon_skip_196648 | 5.984581e-01 | 6.653468e-25 |
| DLPFC | RBM5 | exon_skip_196648 | 5.236288e-01 | 1.935059e-18 |
| DLPFC | PCBP1 | exon_skip_196648 | 5.369823e-01 | 1.774479e-19 |
| DLPFC | HNRNPK | exon_skip_196648 | 4.745788e-01 | 5.372422e-15 |
| DLPFC | PCBP2 | exon_skip_196648 | 4.581051e-01 | 5.866336e-14 |
| DLPFC | ENOX1 | exon_skip_196648 | 5.388800e-01 | 1.252726e-19 |
| DLPFC | PPRC1 | exon_skip_196648 | 5.945107e-01 | 1.609988e-24 |
| DLPFC | NUP42 | exon_skip_196648 | 4.981017e-01 | 1.404833e-16 |
| DLPFC | EIF4G2 | exon_skip_196648 | 4.403906e-01 | 6.671311e-13 |
| DLPFC | CELF1 | exon_skip_196648 | 6.223148e-01 | 2.434404e-27 |
| DLPFC | PABPC1 | exon_skip_196648 | 4.753911e-01 | 4.759084e-15 |
| DLPFC | PABPC4 | exon_skip_196648 | 5.443197e-01 | 4.561008e-20 |
| DLPFC | SRSF5 | exon_skip_196648 | 5.374640e-01 | 1.624728e-19 |
| DLPFC | YBX2 | exon_skip_196648 | 5.398514e-01 | 1.047323e-19 |
| DLPFC | SART3 | exon_skip_196648 | 6.500530e-01 | 1.888157e-30 |
| DLPFC | CELF1 | exon_skip_1321 | -4.166204e-01 | 1.867668e-15 |
| DLPFC | YBX2 | exon_skip_1321 | -4.168409e-01 | 1.799077e-15 |
| FL | SRSF2 | exon_skip_245245 | 4.002122e-01 | 6.757706e-09 |
| HCC | EIF4G2 | exon_skip_55843 | -4.279576e-01 | 1.387640e-13 |
| HCC | ZNF326 | exon_skip_245245 | -4.588373e-01 | 1.277832e-15 |
| HCC | RBM5 | exon_skip_245245 | -4.197107e-01 | 4.486181e-13 |
| HCC | RBM6 | exon_skip_226790 | -6.246194e-01 | 6.092062e-31 |
| HCC | CNOT4 | exon_skip_226790 | -4.230842e-01 | 2.786714e-13 |
| HCC | PCBP1 | exon_skip_226790 | -4.054573e-01 | 3.165634e-12 |
| HCC | EIF4G2 | exon_skip_226790 | -5.641964e-01 | 2.402450e-24 |
| HCC | ZC3H10 | exon_skip_226790 | -5.996420e-01 | 4.799922e-28 |
| IFG | EIF4B | exon_skip_108680 | 4.739046e-01 | 1.084795e-02 |
| IFG | YBX2 | exon_skip_5699 | -4.182596e-01 | 2.676132e-02 |
| IFG | YBX2 | exon_skip_1321 | -4.290627e-01 | 2.270579e-02 |
| IFG | RBM6 | exon_skip_226790 | -6.957246e-01 | 3.950477e-05 |
| IFG | CNOT4 | exon_skip_226790 | -4.475528e-01 | 1.693585e-02 |
| IFG | PCBP2 | exon_skip_226790 | -4.969853e-01 | 7.135089e-03 |
| PCC | ZNF326 | exon_skip_235771 | -4.273186e-01 | 6.559278e-11 |
| PCC | RBM6 | exon_skip_226790 | -4.966969e-01 | 8.546605e-15 |
| PG | MBNL1 | exon_skip_108680 | -4.738657e-01 | 1.055713e-12 |
| PG | FXR2 | exon_skip_108680 | -4.323074e-01 | 1.321707e-10 |
| PG | HNRNPK | exon_skip_108680 | -4.222966e-01 | 3.849237e-10 |
| PG | HNRNPL | exon_skip_108680 | -4.443762e-01 | 3.474617e-11 |
| PG | SRSF1 | exon_skip_108680 | -4.236807e-01 | 3.327288e-10 |
| PG | SRSF2 | exon_skip_235771 | 4.221880e-01 | 2.636057e-09 |
| PG | NUP42 | exon_skip_235771 | 4.011554e-01 | 1.826094e-08 |
| PG | PCBP1 | exon_skip_226790 | 4.988339e-01 | 1.155070e-13 |
| PG | HNRNPK | exon_skip_226790 | 4.530317e-01 | 2.931745e-11 |
| STG | SRSF2 | exon_skip_235771 | 4.355326e-01 | 3.100909e-05 |
| STG | PCBP1 | exon_skip_226790 | 4.258295e-01 | 2.086408e-05 |
| STG | HNRNPK | exon_skip_226790 | 5.358536e-01 | 3.111563e-08 |
| STG | EIF4G2 | exon_skip_226790 | 4.171038e-01 | 3.193318e-05 |
| TC | PCBP4 | exon_skip_49494 | 4.474639e-01 | 3.759158e-09 |
| TC | FXR2 | exon_skip_108680 | -4.503232e-01 | 2.907889e-09 |
| TC | RBM4 | exon_skip_108680 | -5.924269e-01 | 2.419757e-16 |
| TC | NUP42 | exon_skip_1321 | -4.343759e-01 | 2.796799e-08 |
| TC | CELF1 | exon_skip_1321 | -4.280616e-01 | 4.651706e-08 |
| TC | SRSF2 | exon_skip_245245 | 6.067494e-01 | 7.404788e-17 |
| TC | NUP42 | exon_skip_245245 | 7.392209e-01 | 6.964874e-28 |
| TC | SRSF2 | exon_skip_235771 | 5.412406e-01 | 1.476342e-13 |
| TC | NUP42 | exon_skip_235771 | 6.748699e-01 | 1.307804e-22 |
| TC | CNOT4 | exon_skip_226790 | 4.383861e-01 | 6.715370e-09 |
| TC | MBNL1 | exon_skip_226790 | 4.920836e-01 | 3.881594e-11 |
| TC | PCBP1 | exon_skip_226790 | 4.418241e-01 | 4.955704e-09 |
| TC | HNRNPK | exon_skip_226790 | 5.088889e-01 | 6.382276e-12 |
| TC | PPRC1 | exon_skip_226790 | 5.231559e-01 | 1.273224e-12 |
| TC | EIF4G2 | exon_skip_226790 | 4.650768e-01 | 5.795034e-10 |
| TC | EWSR1 | exon_skip_226790 | 4.896764e-01 | 4.987270e-11 |
| TC | SRSF5 | exon_skip_226790 | 5.249719e-01 | 1.031412e-12 |
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RelatedDrugs for CAMK2G |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Q13555 | approved | DB06616 | Bosutinib | small molecule | Q13555 |
| Q13555 | approved|investigational | DB12010 | Fostamatinib | small molecule | Q13555 |
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RelatedDiseases for CAMK2G |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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