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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for TLR10 |
Gene summary |
Gene information | Gene symbol | TLR10 | Gene ID | 81793 |
Gene name | toll like receptor 10 | |
Synonyms | CD290 | |
Cytomap | 4p14 | |
Type of gene | protein-coding | |
Description | toll-like receptor 10 | |
Modification date | 20200313 | |
UniProtAcc | ||
Context |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for TLR10 |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for TLR10 |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_123762 | chr4 | 38772239:38775652:38775775:38775963:38782921:38782990 | 38775775:38775963 |
exon_skip_158398 | chr4 | 38773125:38775652:38776110:38776426:38782921:38782989 | 38776110:38776426 |
exon_skip_158901 | chr4 | 38773125:38775652:38775775:38775963:38776110:38776197 | 38775775:38775963 |
exon_skip_263730 | chr4 | 38773125:38775652:38775775:38775963:38782921:38782989 | 38775775:38775963 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for TLR10 |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000622002 | 38775775 | 38775963 | 3UTR-3UTR |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000622002 | 38775775 | 38775963 | 3UTR-3UTR |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000308973 | 38775775 | 38775963 | 3UTR-3UTR |
ENST00000622002 | 38775775 | 38775963 | 3UTR-3UTR |
ENST00000613579 | 38776110 | 38776426 | 3UTR-3UTR |
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Infer the effects of exon skipping event on protein functional features for TLR10 |
p-ENSG00000174123_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in TLR10 |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
Mayo | ENST00000622002 | 38775775 | 38775963 | hsa-miR-4251 | chr4:38775871-38775878 | 8mer-1a | chr4:38775863-38775883 | 160.00 | -23.44 |
Mayo | ENST00000622002 | 38775775 | 38775963 | hsa-miR-6769b-3p | chr4:38775876-38775883 | 8mer-1a | chr4:38775863-38775883 | 160.00 | -23.44 |
Mayo | ENST00000613579 | 38776110 | 38776426 | hsa-miR-7152-5p | chr4:38776131-38776138 | 8mer-1a | chr4:38776117-38776138 | 148.00 | -12.99 |
Mayo | ENST00000613579 | 38776110 | 38776426 | hsa-miR-196a-3p | chr4:38776256-38776263 | 8mer-1a | chr4:38776247-38776266 | 157.00 | -22.27 |
Mayo | ENST00000613579 | 38776110 | 38776426 | hsa-miR-1228-3p | chr4:38776246-38776253 | 8mer-1a | chr4:38776243-38776263 | 158.00 | -20.18 |
Mayo | ENST00000613579 | 38776110 | 38776426 | hsa-miR-4699-5p | chr4:38776345-38776352 | 8mer-1a | chr4:38776338-38776362 | 143.00 | -19.92 |
Mayo | ENST00000622002 | 38775775 | 38775963 | hsa-miR-3922-3p | chr4:38775922-38775929 | 8mer-1a | chr4:38775916-38775940 | 160.00 | -19.93 |
Mayo | ENST00000613579 | 38776110 | 38776426 | hsa-miR-4715-3p | chr4:38776185-38776192 | 8mer-1a | chr4:38776171-38776192 | 159.00 | -20.52 |
Mayo | ENST00000622002 | 38775775 | 38775963 | hsa-miR-627-5p | chr4:38775927-38775934 | 8mer-1a | chr4:38775916-38775940 | 160.00 | -19.93 |
Mayo | ENST00000622002 | 38775775 | 38775963 | hsa-miR-3176 | chr4:38775922-38775929 | 8mer-1a | chr4:38775916-38775940 | 160.00 | -19.93 |
Mayo | ENST00000613579 | 38776110 | 38776426 | hsa-miR-4516 | chr4:38776265-38776272 | 8mer-1a | chr4:38776257-38776276 | 152.00 | -21.08 |
Mayo | ENST00000622002 | 38775775 | 38775963 | hsa-miR-3183 | chr4:38775876-38775883 | 8mer-1a | chr4:38775863-38775883 | 160.00 | -23.44 |
Mayo | ENST00000622002 | 38775775 | 38775963 | hsa-miR-4723-3p | chr4:38775876-38775883 | 8mer-1a | chr4:38775863-38775883 | 160.00 | -23.44 |
Mayo | ENST00000613579 | 38776110 | 38776426 | hsa-miR-196a-1-3p | chr4:38776356-38776363 | 8mer-1a | chr4:38776343-38776363 | 140.00 | -5.05 |
Mayo | ENST00000613579 | 38776110 | 38776426 | hsa-miR-4736 | chr4:38776321-38776328 | 8mer-1a | chr4:38776314-38776333 | 154.00 | -18.72 |
Mayo | ENST00000613579 | 38776110 | 38776426 | hsa-miR-21-3p | chr4:38776283-38776290 | 8mer-1a | chr4:38776281-38776310 | 153.00 | -20.18 |
Mayo | ENST00000613579 | 38776110 | 38776426 | hsa-miR-122b-3p | chr4:38776283-38776290 | 8mer-1a | chr4:38776281-38776310 | 153.00 | -20.18 |
Mayo | ENST00000613579 | 38776110 | 38776426 | hsa-miR-4434 | chr4:38776265-38776272 | 8mer-1a | chr4:38776257-38776276 | 152.00 | -21.08 |
Mayo | ENST00000613579 | 38776110 | 38776426 | hsa-miR-5703 | chr4:38776265-38776272 | 8mer-1a | chr4:38776257-38776276 | 152.00 | -21.08 |
Mayo | ENST00000622002 | 38775775 | 38775963 | hsa-miR-4777-3p | chr4:38775856-38775863 | 8mer-1a | chr4:38775855-38775880 | 155.00 | -21.09 |
Mayo | ENST00000622002 | 38775775 | 38775963 | hsa-miR-3921 | chr4:38775873-38775880 | 8mer-1a | chr4:38775863-38775883 | 160.00 | -23.44 |
Mayo | ENST00000613579 | 38776110 | 38776426 | hsa-miR-4452 | chr4:38776393-38776400 | 8mer-1a | chr4:38776380-38776407 | 152.00 | -20.49 |
Mayo | ENST00000622002 | 38775775 | 38775963 | hsa-miR-302a-5p | chr4:38775903-38775910 | 8mer-1a | chr4:38775894-38775913 | 157.00 | -19.38 |
Mayo | ENST00000613579 | 38776110 | 38776426 | hsa-miR-3140-3p | chr4:38776190-38776197 | 8mer-1a | chr4:38776180-38776201 | 142.00 | -18.74 |
Mayo | ENST00000613579 | 38776110 | 38776426 | hsa-miR-1305 | chr4:38776229-38776236 | 8mer-1a | chr4:38776226-38776250 | 161.00 | -15.44 |
Mayo | ENST00000622002 | 38775775 | 38775963 | hsa-miR-4279 | chr4:38775879-38775886 | 8mer-1a | chr4:38775867-38775888 | 143.00 | -16.45 |
Mayo | ENST00000613579 | 38776110 | 38776426 | hsa-miR-6831-3p | chr4:38776287-38776294 | 8mer-1a | chr4:38776281-38776310 | 153.00 | -20.18 |
Mayo | ENST00000613579 | 38776110 | 38776426 | hsa-miR-7159-5p | chr4:38776388-38776395 | 8mer-1a | chr4:38776375-38776395 | 163.00 | -19.36 |
Mayo | ENST00000613579 | 38776110 | 38776426 | hsa-miR-7161-3p | chr4:38776303-38776310 | 8mer-1a | chr4:38776281-38776310 | 153.00 | -20.18 |
Mayo | ENST00000613579 | 38776110 | 38776426 | hsa-miR-653-3p | chr4:38776326-38776333 | 8mer-1a | chr4:38776314-38776333 | 154.00 | -18.72 |
Mayo | ENST00000622002 | 38775775 | 38775963 | hsa-miR-4653-5p | chr4:38775873-38775880 | 8mer-1a | chr4:38775863-38775883 | 160.00 | -23.44 |
Mayo | ENST00000613579 | 38776110 | 38776426 | hsa-miR-2052 | chr4:38776126-38776133 | 8mer-1a | chr4:38776117-38776138 | 148.00 | -12.99 |
Mayo | ENST00000613579 | 38776110 | 38776426 | hsa-miR-8084 | chr4:38776219-38776226 | 8mer-1a | chr4:38776215-38776236 | 155.00 | -11.77 |
Mayo | ENST00000613579 | 38776110 | 38776426 | hsa-miR-4474-3p | chr4:38776339-38776346 | 8mer-1a | chr4:38776322-38776346 | 149.00 | -21.14 |
Mayo | ENST00000613579 | 38776110 | 38776426 | hsa-miR-4291 | chr4:38776417-38776424 | 8mer-1a | chr4:38776407-38776424 | 144.00 | -13.00 |
Mayo | ENST00000613579 | 38776110 | 38776426 | hsa-miR-7114-5p | chr4:38776269-38776276 | 8mer-1a | chr4:38776257-38776276 | 152.00 | -21.08 |
Mayo | ENST00000622002 | 38775775 | 38775963 | hsa-miR-6858-3p | chr4:38775828-38775835 | 8mer-1a | chr4:38775825-38775845 | 152.00 | -20.44 |
MSBB | ENST00000622002 | 38775775 | 38775963 | hsa-miR-4251 | chr4:38775871-38775878 | 8mer-1a | chr4:38775863-38775883 | 160.00 | -23.44 |
MSBB | ENST00000622002 | 38775775 | 38775963 | hsa-miR-6769b-3p | chr4:38775876-38775883 | 8mer-1a | chr4:38775863-38775883 | 160.00 | -23.44 |
MSBB | ENST00000622002 | 38775775 | 38775963 | hsa-miR-3922-3p | chr4:38775922-38775929 | 8mer-1a | chr4:38775916-38775940 | 160.00 | -19.93 |
MSBB | ENST00000622002 | 38775775 | 38775963 | hsa-miR-627-5p | chr4:38775927-38775934 | 8mer-1a | chr4:38775916-38775940 | 160.00 | -19.93 |
MSBB | ENST00000622002 | 38775775 | 38775963 | hsa-miR-3176 | chr4:38775922-38775929 | 8mer-1a | chr4:38775916-38775940 | 160.00 | -19.93 |
MSBB | ENST00000622002 | 38775775 | 38775963 | hsa-miR-3183 | chr4:38775876-38775883 | 8mer-1a | chr4:38775863-38775883 | 160.00 | -23.44 |
MSBB | ENST00000622002 | 38775775 | 38775963 | hsa-miR-4723-3p | chr4:38775876-38775883 | 8mer-1a | chr4:38775863-38775883 | 160.00 | -23.44 |
MSBB | ENST00000622002 | 38775775 | 38775963 | hsa-miR-4777-3p | chr4:38775856-38775863 | 8mer-1a | chr4:38775855-38775880 | 155.00 | -21.09 |
MSBB | ENST00000622002 | 38775775 | 38775963 | hsa-miR-3921 | chr4:38775873-38775880 | 8mer-1a | chr4:38775863-38775883 | 160.00 | -23.44 |
MSBB | ENST00000622002 | 38775775 | 38775963 | hsa-miR-302a-5p | chr4:38775903-38775910 | 8mer-1a | chr4:38775894-38775913 | 157.00 | -19.38 |
MSBB | ENST00000622002 | 38775775 | 38775963 | hsa-miR-4279 | chr4:38775879-38775886 | 8mer-1a | chr4:38775867-38775888 | 143.00 | -16.45 |
MSBB | ENST00000622002 | 38775775 | 38775963 | hsa-miR-4653-5p | chr4:38775873-38775880 | 8mer-1a | chr4:38775863-38775883 | 160.00 | -23.44 |
MSBB | ENST00000622002 | 38775775 | 38775963 | hsa-miR-6858-3p | chr4:38775828-38775835 | 8mer-1a | chr4:38775825-38775845 | 152.00 | -20.44 |
ROSMAP | ENST00000622002 | 38775775 | 38775963 | hsa-miR-4251 | chr4:38775871-38775878 | 8mer-1a | chr4:38775863-38775883 | 160.00 | -23.44 |
ROSMAP | ENST00000622002 | 38775775 | 38775963 | hsa-miR-6769b-3p | chr4:38775876-38775883 | 8mer-1a | chr4:38775863-38775883 | 160.00 | -23.44 |
ROSMAP | ENST00000622002 | 38775775 | 38775963 | hsa-miR-3922-3p | chr4:38775922-38775929 | 8mer-1a | chr4:38775916-38775940 | 160.00 | -19.93 |
ROSMAP | ENST00000622002 | 38775775 | 38775963 | hsa-miR-627-5p | chr4:38775927-38775934 | 8mer-1a | chr4:38775916-38775940 | 160.00 | -19.93 |
ROSMAP | ENST00000622002 | 38775775 | 38775963 | hsa-miR-3176 | chr4:38775922-38775929 | 8mer-1a | chr4:38775916-38775940 | 160.00 | -19.93 |
ROSMAP | ENST00000622002 | 38775775 | 38775963 | hsa-miR-3183 | chr4:38775876-38775883 | 8mer-1a | chr4:38775863-38775883 | 160.00 | -23.44 |
ROSMAP | ENST00000622002 | 38775775 | 38775963 | hsa-miR-4723-3p | chr4:38775876-38775883 | 8mer-1a | chr4:38775863-38775883 | 160.00 | -23.44 |
ROSMAP | ENST00000622002 | 38775775 | 38775963 | hsa-miR-4777-3p | chr4:38775856-38775863 | 8mer-1a | chr4:38775855-38775880 | 155.00 | -21.09 |
ROSMAP | ENST00000622002 | 38775775 | 38775963 | hsa-miR-3921 | chr4:38775873-38775880 | 8mer-1a | chr4:38775863-38775883 | 160.00 | -23.44 |
ROSMAP | ENST00000622002 | 38775775 | 38775963 | hsa-miR-302a-5p | chr4:38775903-38775910 | 8mer-1a | chr4:38775894-38775913 | 157.00 | -19.38 |
ROSMAP | ENST00000622002 | 38775775 | 38775963 | hsa-miR-4279 | chr4:38775879-38775886 | 8mer-1a | chr4:38775867-38775888 | 143.00 | -16.45 |
ROSMAP | ENST00000622002 | 38775775 | 38775963 | hsa-miR-4653-5p | chr4:38775873-38775880 | 8mer-1a | chr4:38775863-38775883 | 160.00 | -23.44 |
ROSMAP | ENST00000622002 | 38775775 | 38775963 | hsa-miR-6858-3p | chr4:38775828-38775835 | 8mer-1a | chr4:38775825-38775845 | 152.00 | -20.44 |
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SNVs in the skipped exons for TLR10 |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for TLR10 |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TLR10 |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for TLR10 |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for TLR10 |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TLR10 |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |