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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for GDPD5 |
 Gene summary |
| Gene information | Gene symbol | GDPD5 | Gene ID | 81544 |
| Gene name | glycerophosphodiester phosphodiesterase domain containing 5 | |
| Synonyms | GDE2|PP1665 | |
| Cytomap | 11q13.4-q13.5 | |
| Type of gene | protein-coding | |
| Description | glycerophosphodiester phosphodiesterase domain-containing protein 5glycerophosphodiester phosphodiesterase 2 | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for GDPD5 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000158555
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | DOWN | ENST00000533805.5 | GDPD5-215:protein_coding:GDPD5 | 1.196445e+02 | -9.574507e-01 | 5.013356e-08 | 1.182227e-06 |
| CB | DOWN | ENST00000533784.5 | GDPD5-214:protein_coding:GDPD5 | 2.457210e+02 | -1.746052e+00 | 2.181978e-04 | 1.433671e-03 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for GDPD5 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_154606 | chr11 | 75444413:75444495:75448492:75448649:75448977:75449122 | 75448492:75448649 |
| exon_skip_221943 | chr11 | 75444413:75444495:75448492:75448649:75448977:75449027 | 75448492:75448649 |
| exon_skip_23713 | chr11 | 75436936:75437048:75439340:75439354:75439879:75439961 | 75439340:75439354 |
| exon_skip_240318 | chr11 | 75456757:75456816:75457693:75457786:75462786:75462889 | 75457693:75457786 |
| exon_skip_268569 | chr11 | 75462786:75462889:75477619:75477795:75490237:75490289 | 75477619:75477795 |
| exon_skip_270906 | chr11 | 75452816:75452970:75455204:75455354:75456757:75456816 | 75455204:75455354 |
| exon_skip_279543 | chr11 | 75442363:75442581:75443136:75443286:75444413:75444495 | 75443136:75443286 |
| exon_skip_43291 | chr11 | 75436936:75437048:75439879:75439961:75441163:75441310 | 75439879:75439961 |
| exon_skip_62610 | chr11 | 75457693:75457786:75462786:75462889:75477619:75477795 | 75462786:75462889 |
| exon_skip_64026 | chr11 | 75477619:75477795:75479244:75479488:75490237:75490289 | 75479244:75479488 |
| exon_skip_8846 | chr11 | 75449517:75449610:75449885:75449983:75456757:75456816 | 75449885:75449983 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
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| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
| exon_skip_23713 | Mayo_TC | 5.219512e-01 | 6.487143e-01 | -1.267631e-01 | 7.906715e-07 |
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Open reading frame (ORF) annotation in the exon skipping event for GDPD5 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000336898 | 75477619 | 75477795 | 3UTR-3CDS |
| ENST00000529721 | 75479244 | 75479488 | 3UTR-3UTR |
| ENST00000336898 | 75449885 | 75449983 | In-frame |
| ENST00000529721 | 75449885 | 75449983 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000529721 | 75479244 | 75479488 | 3UTR-3UTR |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000336898 | 75477619 | 75477795 | 3UTR-3CDS |
| ENST00000529721 | 75479244 | 75479488 | 3UTR-3UTR |
| ENST00000336898 | 75439879 | 75439961 | Frame-shift |
| ENST00000529721 | 75439879 | 75439961 | Frame-shift |
| ENST00000336898 | 75443136 | 75443286 | Frame-shift |
| ENST00000529721 | 75443136 | 75443286 | Frame-shift |
| ENST00000336898 | 75457693 | 75457786 | Frame-shift |
| ENST00000529721 | 75457693 | 75457786 | Frame-shift |
| ENST00000336898 | 75462786 | 75462889 | Frame-shift |
| ENST00000529721 | 75462786 | 75462889 | Frame-shift |
| ENST00000336898 | 75449885 | 75449983 | In-frame |
| ENST00000529721 | 75449885 | 75449983 | In-frame |
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Infer the effects of exon skipping event on protein functional features for GDPD5 |
p-ENSG00000158555_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000336898 | 3540 | 605 | 75449885 | 75449983 | 1214 | 1311 | 125 | 157 |
| ENST00000529721 | 3239 | 605 | 75449885 | 75449983 | 913 | 1010 | 125 | 157 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000336898 | 3540 | 605 | 75449885 | 75449983 | 1214 | 1311 | 125 | 157 |
| ENST00000529721 | 3239 | 605 | 75449885 | 75449983 | 913 | 1010 | 125 | 157 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q8WTR4 | 125 | 157 | 1 | 245 | Alternative sequence | ID=VSP_020813;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q8WTR4 | 125 | 157 | 1 | 245 | Alternative sequence | ID=VSP_020813;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q8WTR4 | 125 | 157 | 1 | 218 | Alternative sequence | ID=VSP_020814;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| Q8WTR4 | 125 | 157 | 1 | 218 | Alternative sequence | ID=VSP_020814;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| Q8WTR4 | 125 | 157 | 1 | 138 | Alternative sequence | ID=VSP_020815;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| Q8WTR4 | 125 | 157 | 1 | 138 | Alternative sequence | ID=VSP_020815;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| Q8WTR4 | 125 | 157 | 40 | 158 | Alternative sequence | ID=VSP_020816;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12975309;Dbxref=PMID:12975309 |
| Q8WTR4 | 125 | 157 | 40 | 158 | Alternative sequence | ID=VSP_020816;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12975309;Dbxref=PMID:12975309 |
| Q8WTR4 | 125 | 157 | 1 | 605 | Chain | ID=PRO_0000251941;Note=Glycerophosphodiester phosphodiesterase domain-containing protein 5 |
| Q8WTR4 | 125 | 157 | 1 | 605 | Chain | ID=PRO_0000251941;Note=Glycerophosphodiester phosphodiesterase domain-containing protein 5 |
| Q8WTR4 | 125 | 157 | 25 | 571 | Disulfide bond | Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Q8WTR4 | 125 | 157 | 25 | 571 | Disulfide bond | Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Q8WTR4 | 125 | 157 | 111 | 125 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q8WTR4 | 125 | 157 | 111 | 125 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q8WTR4 | 125 | 157 | 147 | 160 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q8WTR4 | 125 | 157 | 147 | 160 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q8WTR4 | 125 | 157 | 126 | 146 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q8WTR4 | 125 | 157 | 126 | 146 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q8WTR4 | 125 | 157 | 1 | 245 | Alternative sequence | ID=VSP_020813;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q8WTR4 | 125 | 157 | 1 | 245 | Alternative sequence | ID=VSP_020813;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q8WTR4 | 125 | 157 | 1 | 218 | Alternative sequence | ID=VSP_020814;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| Q8WTR4 | 125 | 157 | 1 | 218 | Alternative sequence | ID=VSP_020814;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| Q8WTR4 | 125 | 157 | 1 | 138 | Alternative sequence | ID=VSP_020815;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| Q8WTR4 | 125 | 157 | 1 | 138 | Alternative sequence | ID=VSP_020815;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| Q8WTR4 | 125 | 157 | 40 | 158 | Alternative sequence | ID=VSP_020816;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12975309;Dbxref=PMID:12975309 |
| Q8WTR4 | 125 | 157 | 40 | 158 | Alternative sequence | ID=VSP_020816;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12975309;Dbxref=PMID:12975309 |
| Q8WTR4 | 125 | 157 | 1 | 605 | Chain | ID=PRO_0000251941;Note=Glycerophosphodiester phosphodiesterase domain-containing protein 5 |
| Q8WTR4 | 125 | 157 | 1 | 605 | Chain | ID=PRO_0000251941;Note=Glycerophosphodiester phosphodiesterase domain-containing protein 5 |
| Q8WTR4 | 125 | 157 | 25 | 571 | Disulfide bond | Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Q8WTR4 | 125 | 157 | 25 | 571 | Disulfide bond | Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Q8WTR4 | 125 | 157 | 111 | 125 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q8WTR4 | 125 | 157 | 111 | 125 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q8WTR4 | 125 | 157 | 147 | 160 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q8WTR4 | 125 | 157 | 147 | 160 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q8WTR4 | 125 | 157 | 126 | 146 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q8WTR4 | 125 | 157 | 126 | 146 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
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3'-UTR located exon skipping events that lost miRNA binding sites in GDPD5 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
| Mayo | ENST00000529721 | 75479244 | 75479488 | hsa-miR-4685-5p | chr11:75479371-75479378 | 8mer-1a | chr11:75479353-75479378 | 172.00 | -36.41 |
| Mayo | ENST00000529721 | 75479244 | 75479488 | hsa-miR-4687-3p | chr11:75479436-75479443 | 8mer-1a | chr11:75479418-75479445 | 146.00 | -29.83 |
| Mayo | ENST00000529721 | 75479244 | 75479488 | hsa-miR-612 | chr11:75479270-75479277 | 8mer-1a | chr11:75479251-75479277 | 165.00 | -26.37 |
| Mayo | ENST00000529721 | 75479244 | 75479488 | hsa-miR-6860 | chr11:75479270-75479277 | 8mer-1a | chr11:75479251-75479277 | 165.00 | -26.37 |
| Mayo | ENST00000529721 | 75479244 | 75479488 | hsa-miR-544a | chr11:75479467-75479474 | 8mer-1a | chr11:75479453-75479474 | 153.00 | -14.43 |
| Mayo | ENST00000529721 | 75479244 | 75479488 | hsa-miR-1266-5p | chr11:75479414-75479421 | 8mer-1a | chr11:75479405-75479428 | 164.00 | -30.25 |
| Mayo | ENST00000529721 | 75479244 | 75479488 | hsa-miR-4518 | chr11:75479414-75479421 | 8mer-1a | chr11:75479405-75479428 | 164.00 | -30.25 |
| Mayo | ENST00000529721 | 75479244 | 75479488 | hsa-miR-328-3p | chr11:75479421-75479428 | 8mer-1a | chr11:75479405-75479428 | 164.00 | -30.25 |
| Mayo | ENST00000529721 | 75479244 | 75479488 | hsa-miR-5189-5p | chr11:75479270-75479277 | 8mer-1a | chr11:75479251-75479277 | 165.00 | -26.37 |
| Mayo | ENST00000529721 | 75479244 | 75479488 | hsa-miR-3187-5p | chr11:75479270-75479277 | 8mer-1a | chr11:75479251-75479277 | 165.00 | -26.37 |
| Mayo | ENST00000529721 | 75479244 | 75479488 | hsa-miR-516b-5p | chr11:75479327-75479334 | 8mer-1a | chr11:75479319-75479341 | 170.00 | -25.85 |
| Mayo | ENST00000529721 | 75479244 | 75479488 | hsa-miR-1285-3p | chr11:75479270-75479277 | 8mer-1a | chr11:75479251-75479277 | 165.00 | -26.37 |
| Mayo | ENST00000529721 | 75479244 | 75479488 | hsa-miR-1289 | chr11:75479324-75479331 | 8mer-1a | chr11:75479319-75479341 | 170.00 | -25.85 |
| Mayo | ENST00000529721 | 75479244 | 75479488 | hsa-miR-6826-3p | chr11:75479430-75479437 | 8mer-1a | chr11:75479416-75479437 | 160.00 | -24.90 |
| Mayo | ENST00000529721 | 75479244 | 75479488 | hsa-miR-3918 | chr11:75479412-75479419 | 8mer-1a | chr11:75479405-75479428 | 164.00 | -30.25 |
| Mayo | ENST00000529721 | 75479244 | 75479488 | hsa-miR-6837-5p | chr11:75479371-75479378 | 8mer-1a | chr11:75479353-75479378 | 172.00 | -36.41 |
| Mayo | ENST00000529721 | 75479244 | 75479488 | hsa-miR-6857-3p | chr11:75479336-75479343 | 8mer-1a | chr11:75479319-75479343 | 158.00 | -29.21 |
| MSBB | ENST00000529721 | 75479244 | 75479488 | hsa-miR-4685-5p | chr11:75479371-75479378 | 8mer-1a | chr11:75479353-75479378 | 172.00 | -36.41 |
| MSBB | ENST00000529721 | 75479244 | 75479488 | hsa-miR-4687-3p | chr11:75479436-75479443 | 8mer-1a | chr11:75479418-75479445 | 146.00 | -29.83 |
| MSBB | ENST00000529721 | 75479244 | 75479488 | hsa-miR-612 | chr11:75479270-75479277 | 8mer-1a | chr11:75479251-75479277 | 165.00 | -26.37 |
| MSBB | ENST00000529721 | 75479244 | 75479488 | hsa-miR-6860 | chr11:75479270-75479277 | 8mer-1a | chr11:75479251-75479277 | 165.00 | -26.37 |
| MSBB | ENST00000529721 | 75479244 | 75479488 | hsa-miR-544a | chr11:75479467-75479474 | 8mer-1a | chr11:75479453-75479474 | 153.00 | -14.43 |
| MSBB | ENST00000529721 | 75479244 | 75479488 | hsa-miR-1266-5p | chr11:75479414-75479421 | 8mer-1a | chr11:75479405-75479428 | 164.00 | -30.25 |
| MSBB | ENST00000529721 | 75479244 | 75479488 | hsa-miR-4518 | chr11:75479414-75479421 | 8mer-1a | chr11:75479405-75479428 | 164.00 | -30.25 |
| MSBB | ENST00000529721 | 75479244 | 75479488 | hsa-miR-328-3p | chr11:75479421-75479428 | 8mer-1a | chr11:75479405-75479428 | 164.00 | -30.25 |
| MSBB | ENST00000529721 | 75479244 | 75479488 | hsa-miR-5189-5p | chr11:75479270-75479277 | 8mer-1a | chr11:75479251-75479277 | 165.00 | -26.37 |
| MSBB | ENST00000529721 | 75479244 | 75479488 | hsa-miR-3187-5p | chr11:75479270-75479277 | 8mer-1a | chr11:75479251-75479277 | 165.00 | -26.37 |
| MSBB | ENST00000529721 | 75479244 | 75479488 | hsa-miR-516b-5p | chr11:75479327-75479334 | 8mer-1a | chr11:75479319-75479341 | 170.00 | -25.85 |
| MSBB | ENST00000529721 | 75479244 | 75479488 | hsa-miR-1285-3p | chr11:75479270-75479277 | 8mer-1a | chr11:75479251-75479277 | 165.00 | -26.37 |
| MSBB | ENST00000529721 | 75479244 | 75479488 | hsa-miR-1289 | chr11:75479324-75479331 | 8mer-1a | chr11:75479319-75479341 | 170.00 | -25.85 |
| MSBB | ENST00000529721 | 75479244 | 75479488 | hsa-miR-6826-3p | chr11:75479430-75479437 | 8mer-1a | chr11:75479416-75479437 | 160.00 | -24.90 |
| MSBB | ENST00000529721 | 75479244 | 75479488 | hsa-miR-3918 | chr11:75479412-75479419 | 8mer-1a | chr11:75479405-75479428 | 164.00 | -30.25 |
| MSBB | ENST00000529721 | 75479244 | 75479488 | hsa-miR-6837-5p | chr11:75479371-75479378 | 8mer-1a | chr11:75479353-75479378 | 172.00 | -36.41 |
| MSBB | ENST00000529721 | 75479244 | 75479488 | hsa-miR-6857-3p | chr11:75479336-75479343 | 8mer-1a | chr11:75479319-75479343 | 158.00 | -29.21 |
| ROSMAP | ENST00000529721 | 75479244 | 75479488 | hsa-miR-4685-5p | chr11:75479371-75479378 | 8mer-1a | chr11:75479353-75479378 | 172.00 | -36.41 |
| ROSMAP | ENST00000529721 | 75479244 | 75479488 | hsa-miR-4687-3p | chr11:75479436-75479443 | 8mer-1a | chr11:75479418-75479445 | 146.00 | -29.83 |
| ROSMAP | ENST00000529721 | 75479244 | 75479488 | hsa-miR-612 | chr11:75479270-75479277 | 8mer-1a | chr11:75479251-75479277 | 165.00 | -26.37 |
| ROSMAP | ENST00000529721 | 75479244 | 75479488 | hsa-miR-6860 | chr11:75479270-75479277 | 8mer-1a | chr11:75479251-75479277 | 165.00 | -26.37 |
| ROSMAP | ENST00000529721 | 75479244 | 75479488 | hsa-miR-544a | chr11:75479467-75479474 | 8mer-1a | chr11:75479453-75479474 | 153.00 | -14.43 |
| ROSMAP | ENST00000529721 | 75479244 | 75479488 | hsa-miR-1266-5p | chr11:75479414-75479421 | 8mer-1a | chr11:75479405-75479428 | 164.00 | -30.25 |
| ROSMAP | ENST00000529721 | 75479244 | 75479488 | hsa-miR-4518 | chr11:75479414-75479421 | 8mer-1a | chr11:75479405-75479428 | 164.00 | -30.25 |
| ROSMAP | ENST00000529721 | 75479244 | 75479488 | hsa-miR-328-3p | chr11:75479421-75479428 | 8mer-1a | chr11:75479405-75479428 | 164.00 | -30.25 |
| ROSMAP | ENST00000529721 | 75479244 | 75479488 | hsa-miR-5189-5p | chr11:75479270-75479277 | 8mer-1a | chr11:75479251-75479277 | 165.00 | -26.37 |
| ROSMAP | ENST00000529721 | 75479244 | 75479488 | hsa-miR-3187-5p | chr11:75479270-75479277 | 8mer-1a | chr11:75479251-75479277 | 165.00 | -26.37 |
| ROSMAP | ENST00000529721 | 75479244 | 75479488 | hsa-miR-516b-5p | chr11:75479327-75479334 | 8mer-1a | chr11:75479319-75479341 | 170.00 | -25.85 |
| ROSMAP | ENST00000529721 | 75479244 | 75479488 | hsa-miR-1285-3p | chr11:75479270-75479277 | 8mer-1a | chr11:75479251-75479277 | 165.00 | -26.37 |
| ROSMAP | ENST00000529721 | 75479244 | 75479488 | hsa-miR-1289 | chr11:75479324-75479331 | 8mer-1a | chr11:75479319-75479341 | 170.00 | -25.85 |
| ROSMAP | ENST00000529721 | 75479244 | 75479488 | hsa-miR-6826-3p | chr11:75479430-75479437 | 8mer-1a | chr11:75479416-75479437 | 160.00 | -24.90 |
| ROSMAP | ENST00000529721 | 75479244 | 75479488 | hsa-miR-3918 | chr11:75479412-75479419 | 8mer-1a | chr11:75479405-75479428 | 164.00 | -30.25 |
| ROSMAP | ENST00000529721 | 75479244 | 75479488 | hsa-miR-6837-5p | chr11:75479371-75479378 | 8mer-1a | chr11:75479353-75479378 | 172.00 | -36.41 |
| ROSMAP | ENST00000529721 | 75479244 | 75479488 | hsa-miR-6857-3p | chr11:75479336-75479343 | 8mer-1a | chr11:75479319-75479343 | 158.00 | -29.21 |
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SNVs in the skipped exons for GDPD5 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for GDPD5 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for GDPD5 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for GDPD5 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| TC | FUS | exon_skip_23713 | 4.146753e-01 | 1.088089e-07 |
| TC | ESRP1 | exon_skip_23713 | 4.004366e-01 | 3.192757e-07 |
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RelatedDrugs for GDPD5 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for GDPD5 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
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