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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for TAF15 |
Gene summary |
Gene information | Gene symbol | TAF15 | Gene ID | 8148 |
Gene name | TATA-box binding protein associated factor 15 | |
Synonyms | Npl3|RBP56|TAF2N|TAFII68 | |
Cytomap | 17q12 | |
Type of gene | protein-coding | |
Description | TATA-binding protein-associated factor 2NRBP56/CSMF fusionTAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDaTATA box binding protein (TBP)-associated factor, RNA polymerase II, N, 68kD (RNA-binding protein 56)TATA box-bin | |
Modification date | 20200313 | |
UniProtAcc | A0A075B7C1, | |
Context |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
TAF15 | GO:0048255 | mRNA stabilization | 27378374 |
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Gene structures and expression levels for TAF15 |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
CB | UP | ENST00000604360.5 | TAF15-208:lncRNA:TAF15 | 9.753469e+00 | 1.193294e+00 | 6.092369e-08 | 1.396737e-06 |
CB | DOWN | ENST00000604694.1 | TAF15-210:protein_coding:TAF15 | 1.204730e+02 | -1.904863e+00 | 1.399899e-06 | 1.995291e-05 |
CB | UP | ENST00000603967.1 | TAF15-206:protein_coding:TAF15 | 4.086300e+00 | 9.213970e-01 | 5.490393e-03 | 2.126932e-02 |
TC | DOWN | ENST00000604694.1 | TAF15-210:protein_coding:TAF15 | 5.572608e+01 | -1.808212e+00 | 1.547431e-06 | 5.731244e-05 |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for TAF15 |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_124854 | chr17 | 35844280:35844368:35844477:35845038:35846906:35847192 | 35844477:35845038 |
exon_skip_159570 | chr17 | 35838424:35838553:35842367:35842459:35844077:35844158 | 35842367:35842459 |
exon_skip_206690 | chr17 | 35809506:35809576:35809972:35810063:35817240:35817317 | 35809972:35810063 |
exon_skip_219958 | chr17 | 35809506:35809576:35809972:35810063:35817716:35817755 | 35809972:35810063 |
exon_skip_225666 | chr17 | 35824158:35824198:35833907:35833941:35834566:35834598 | 35833907:35833941 |
exon_skip_238068 | chr17 | 35809972:35810063:35817240:35817317:35817716:35817755 | 35817240:35817317 |
exon_skip_261982 | chr17 | 35820024:35820075:35820164:35820248:35820332:35820437 | 35820164:35820248 |
exon_skip_26785 | chr17 | 35824078:35824198:35833907:35833941:35834566:35834598 | 35833907:35833941 |
exon_skip_269805 | chr17 | 35820024:35820075:35820164:35820239:35820332:35820437 | 35820164:35820239 |
exon_skip_40082 | chr17 | 35809484:35809576:35809972:35810063:35817716:35817755 | 35809972:35810063 |
exon_skip_71494 | chr17 | 35809562:35809576:35809972:35810063:35817716:35817755 | 35809972:35810063 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for TAF15 |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000605844 | 35820164 | 35820248 | Frame-shift |
ENST00000605844 | 35833907 | 35833941 | Frame-shift |
ENST00000605844 | 35842367 | 35842459 | In-frame |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000605844 | 35820164 | 35820248 | Frame-shift |
ENST00000605844 | 35833907 | 35833941 | Frame-shift |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000605844 | 35820164 | 35820248 | Frame-shift |
ENST00000605844 | 35833907 | 35833941 | Frame-shift |
ENST00000605844 | 35844477 | 35845038 | Frame-shift |
ENST00000605844 | 35842367 | 35842459 | In-frame |
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Infer the effects of exon skipping event on protein functional features for TAF15 |
p-ENSG00000270647_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000605844 | 2208 | 592 | 35842367 | 35842459 | 1030 | 1121 | 305 | 335 |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000605844 | 2208 | 592 | 35842367 | 35842459 | 1030 | 1121 | 305 | 335 |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Q92804 | 305 | 335 | 304 | 308 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2MMY |
Q92804 | 305 | 335 | 314 | 316 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2MMY |
Q92804 | 305 | 335 | 1 | 592 | Chain | ID=PRO_0000081749;Note=TATA-binding protein-associated factor 2N |
Q92804 | 305 | 335 | 320 | 590 | Compositional bias | Note=Arg/Gly-rich |
Q92804 | 305 | 335 | 234 | 320 | Domain | Note=RRM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176 |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Q92804 | 305 | 335 | 304 | 308 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2MMY |
Q92804 | 305 | 335 | 314 | 316 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2MMY |
Q92804 | 305 | 335 | 1 | 592 | Chain | ID=PRO_0000081749;Note=TATA-binding protein-associated factor 2N |
Q92804 | 305 | 335 | 320 | 590 | Compositional bias | Note=Arg/Gly-rich |
Q92804 | 305 | 335 | 234 | 320 | Domain | Note=RRM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176 |
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3'-UTR located exon skipping events that lost miRNA binding sites in TAF15 |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for TAF15 |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for TAF15 |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TAF15 |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for TAF15 |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
CB | NUP42 | exon_skip_269805 | 5.594152e-01 | 2.625963e-14 |
CB | NUP42 | exon_skip_261982 | 5.896057e-01 | 2.919266e-16 |
CB | NUP42 | exon_skip_225666 | 5.748172e-01 | 2.312889e-15 |
CB | PABPC5 | exon_skip_225666 | 4.186110e-01 | 3.993697e-08 |
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RelatedDrugs for TAF15 |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TAF15 |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |