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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for SHOC2 |
 Gene summary |
| Gene information | Gene symbol | SHOC2 | Gene ID | 8036 |
| Gene name | SHOC2 leucine rich repeat scaffold protein | |
| Synonyms | SIAA0862|SOC2|SUR8 | |
| Cytomap | 10q25.2 | |
| Type of gene | protein-coding | |
| Description | leucine-rich repeat protein SHOC-2soc-2 suppressor of clear homolog | |
| Modification date | 20200313 | |
| UniProtAcc | Q9UQ13, X6RI37, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for SHOC2 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000108061
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | UP | ENST00000489390.1 | SHOC2-205:lncRNA:SHOC2 | 2.656215e+00 | 1.904839e+00 | 2.479706e-03 | 1.101738e-02 |
| CB | DOWN | ENST00000451838.1 | SHOC2-203:protein_coding:SHOC2 | 4.156832e+02 | -8.740400e-01 | 2.640476e-03 | 1.160852e-02 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for SHOC2 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_141201 | chr10 | 110964851:110965061:110985628:110985765:111000415:111000545 | 110985628:110985765 |
| exon_skip_22401 | chr10 | 111009248:111009385:111009713:111009830:111011610:111011670 | 111009713:111009830 |
| exon_skip_243739 | chr10 | 110919603:110919657:110951608:110951792:110964125:110964524 | 110951608:110951792 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for SHOC2 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000369452 | 111009713 | 111009830 | Frame-shift |
| ENST00000369452 | 110985628 | 110985765 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000369452 | 110985628 | 110985765 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000369452 | 111009713 | 111009830 | Frame-shift |
| ENST00000369452 | 110985628 | 110985765 | In-frame |
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Infer the effects of exon skipping event on protein functional features for SHOC2 |
p-ENSG00000108061_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000369452 | 3960 | 582 | 110985628 | 110985765 | 1050 | 1186 | 235 | 280 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000369452 | 3960 | 582 | 110985628 | 110985765 | 1050 | 1186 | 235 | 280 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000369452 | 3960 | 582 | 110985628 | 110985765 | 1050 | 1186 | 235 | 280 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9UQ13 | 235 | 280 | 234 | 279 | Alternative sequence | ID=VSP_038188;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q9UQ13 | 235 | 280 | 1 | 582 | Chain | ID=PRO_0000097737;Note=Leucine-rich repeat protein SHOC-2 |
| Q9UQ13 | 235 | 280 | 216 | 237 | Repeat | Note=LRR 6 |
| Q9UQ13 | 235 | 280 | 239 | 260 | Repeat | Note=LRR 7 |
| Q9UQ13 | 235 | 280 | 262 | 283 | Repeat | Note=LRR 8 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9UQ13 | 235 | 280 | 234 | 279 | Alternative sequence | ID=VSP_038188;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q9UQ13 | 235 | 280 | 1 | 582 | Chain | ID=PRO_0000097737;Note=Leucine-rich repeat protein SHOC-2 |
| Q9UQ13 | 235 | 280 | 216 | 237 | Repeat | Note=LRR 6 |
| Q9UQ13 | 235 | 280 | 239 | 260 | Repeat | Note=LRR 7 |
| Q9UQ13 | 235 | 280 | 262 | 283 | Repeat | Note=LRR 8 |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9UQ13 | 235 | 280 | 234 | 279 | Alternative sequence | ID=VSP_038188;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q9UQ13 | 235 | 280 | 1 | 582 | Chain | ID=PRO_0000097737;Note=Leucine-rich repeat protein SHOC-2 |
| Q9UQ13 | 235 | 280 | 216 | 237 | Repeat | Note=LRR 6 |
| Q9UQ13 | 235 | 280 | 239 | 260 | Repeat | Note=LRR 7 |
| Q9UQ13 | 235 | 280 | 262 | 283 | Repeat | Note=LRR 8 |
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3'-UTR located exon skipping events that lost miRNA binding sites in SHOC2 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for SHOC2 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for SHOC2 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for SHOC2 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for SHOC2 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| IFG | PCBP2 | exon_skip_265679 | 4.580971e-01 | 2.437565e-02 |
| IFG | ESRP2 | exon_skip_265679 | 5.861300e-01 | 2.613642e-03 |
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RelatedDrugs for SHOC2 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SHOC2 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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