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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for CPEB4 |
 Gene summary |
| Gene information | Gene symbol | CPEB4 | Gene ID | 80315 |
| Gene name | cytoplasmic polyadenylation element binding protein 4 | |
| Synonyms | CPE-BP4|hCPEB-4 | |
| Cytomap | 5q35.2 | |
| Type of gene | protein-coding | |
| Description | cytoplasmic polyadenylation element-binding protein 4CPE-binding protein 4 | |
| Modification date | 20200313 | |
| UniProtAcc | A0A590UJI5, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for CPEB4 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000113742
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| STG | UP | ENST00000520867.5 | CPEB4-208:protein_coding:CPEB4 | 1.567218e+01 | 2.253417e+01 | 4.611856e-26 | 9.950080e-23 |
| CB | UP | ENST00000522336.5 | CPEB4-209:protein_coding:CPEB4 | 1.675134e+01 | 8.375265e-01 | 6.003926e-04 | 3.367169e-03 |
| CB | UP | ENST00000519467.1 | CPEB4-206:protein_coding:CPEB4 | 3.953011e+00 | 1.789236e+00 | 8.551344e-03 | 3.057689e-02 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for CPEB4 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_143795 | chr5 | 173932450:173932500:173943026:173943049:173944967:173945092 | 173943026:173943049 |
| exon_skip_193967 | chr5 | 173910523:173910604:173932450:173932500:173944967:173945092 | 173932450:173932500 |
| exon_skip_258763 | chr5 | 173890677:173890858:173910523:173910604:173944967:173945092 | 173910523:173910604 |
| exon_skip_28863 | chr5 | 173910523:173910604:173943026:173943049:173944967:173945092 | 173943026:173943049 |
| exon_skip_49213 | chr5 | 173918216:173918254:173943026:173943049:173944967:173945092 | 173943026:173943049 |
| exon_skip_64384 | chr5 | 173910523:173910604:173932450:173932500:173943026:173943049 | 173932450:173932500 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
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| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
| exon_skip_28863 | Mayo_TC | 1.637805e-01 | 2.819298e-01 | -1.181493e-01 | 7.906715e-07 |
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Open reading frame (ORF) annotation in the exon skipping event for CPEB4 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000265085 | 173932450 | 173932500 | In-frame |
| ENST00000265085 | 173943026 | 173943049 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000265085 | 173932450 | 173932500 | In-frame |
| ENST00000265085 | 173943026 | 173943049 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000265085 | 173932450 | 173932500 | In-frame |
| ENST00000265085 | 173943026 | 173943049 | In-frame |
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Infer the effects of exon skipping event on protein functional features for CPEB4 |
p-ENSG00000113742_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000265085 | 9500 | 729 | 173932450 | 173932500 | 2663 | 2712 | 403 | 419 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000265085 | 9500 | 729 | 173932450 | 173932500 | 2663 | 2712 | 403 | 419 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000265085 | 9500 | 729 | 173932450 | 173932500 | 2663 | 2712 | 403 | 419 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q17RY0 | 403 | 419 | 403 | 419 | Alternative sequence | ID=VSP_022041;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11214970,ECO:0000303|PubMed:15489334;Dbxref=PMID:11214970,PMID:15489334 |
| Q17RY0 | 403 | 419 | 404 | 428 | Alternative sequence | ID=VSP_022042;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| Q17RY0 | 403 | 419 | 1 | 729 | Chain | ID=PRO_0000269264;Note=Cytoplasmic polyadenylation element-binding protein 4 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q17RY0 | 403 | 419 | 403 | 419 | Alternative sequence | ID=VSP_022041;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11214970,ECO:0000303|PubMed:15489334;Dbxref=PMID:11214970,PMID:15489334 |
| Q17RY0 | 403 | 419 | 404 | 428 | Alternative sequence | ID=VSP_022042;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| Q17RY0 | 403 | 419 | 1 | 729 | Chain | ID=PRO_0000269264;Note=Cytoplasmic polyadenylation element-binding protein 4 |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q17RY0 | 403 | 419 | 403 | 419 | Alternative sequence | ID=VSP_022041;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11214970,ECO:0000303|PubMed:15489334;Dbxref=PMID:11214970,PMID:15489334 |
| Q17RY0 | 403 | 419 | 404 | 428 | Alternative sequence | ID=VSP_022042;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| Q17RY0 | 403 | 419 | 1 | 729 | Chain | ID=PRO_0000269264;Note=Cytoplasmic polyadenylation element-binding protein 4 |
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3'-UTR located exon skipping events that lost miRNA binding sites in CPEB4 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for CPEB4 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for CPEB4 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for CPEB4 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for CPEB4 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | NUP42 | exon_skip_28863 | 5.786443e-01 | 1.084197e-14 |
| CB | NUP42 | exon_skip_143795 | 5.358486e-01 | 7.539263e-12 |
| FL | SRSF2 | exon_skip_28863 | 5.032917e-01 | 1.586297e-11 |
| FL | NUP42 | exon_skip_28863 | 4.111010e-01 | 8.069365e-08 |
| FL | SRSF1 | exon_skip_28863 | 4.180443e-01 | 4.618894e-08 |
| FL | SRSF9 | exon_skip_28863 | 4.542534e-01 | 2.035204e-09 |
| FL | SRSF2 | exon_skip_143795 | 4.577193e-01 | 1.669903e-09 |
| FL | SRSF9 | exon_skip_143795 | 4.584946e-01 | 1.555025e-09 |
| HCC | RBM5 | exon_skip_28863 | -5.651702e-01 | 2.924572e-23 |
| HCC | RBM5 | exon_skip_143795 | -5.704281e-01 | 6.277212e-24 |
| IFG | RBMS3 | exon_skip_193967 | 5.259782e-01 | 4.833416e-03 |
| IFG | RBM5 | exon_skip_28863 | 4.021244e-01 | 4.170205e-02 |
| TC | SRSF2 | exon_skip_28863 | 5.136029e-01 | 1.008172e-10 |
| TC | NUP42 | exon_skip_28863 | 7.022962e-01 | 5.797600e-22 |
| TC | SRSF2 | exon_skip_143795 | 4.373159e-01 | 5.276992e-08 |
| TC | NUP42 | exon_skip_143795 | 6.654438e-01 | 1.664006e-19 |
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RelatedDrugs for CPEB4 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CPEB4 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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