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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for MLLT10 |
 Gene summary |
| Gene information | Gene symbol | MLLT10 | Gene ID | 8028 |
| Gene name | MLLT10 histone lysine methyltransferase DOT1L cofactor | |
| Synonyms | AF10 | |
| Cytomap | 10p12.31 | |
| Type of gene | protein-coding | |
| Description | protein AF-10ALL1-fused gene from chromosome 10 proteinmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10type I AF10 proteintype III AF10 prot | |
| Modification date | 20200313 | |
| UniProtAcc | A0A494C038, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| MLLT10 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 17868029 |
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Gene structures and expression levels for MLLT10 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000078403
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| PG | DOWN | ENST00000430455.2 | MLLT10-207:nonsense_mediated_decay:MLLT10 | 8.668762e-01 | -8.896064e-01 | 4.946004e-04 | 8.778001e-03 |
| CB | UP | ENST00000651405.1 | MLLT10-224:lncRNA:MLLT10 | 2.097622e+00 | 8.987453e-01 | 1.449448e-03 | 7.056442e-03 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for MLLT10 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_116922 | chr10 | 21538833:21538912:21586294:21586348:21595331:21595378 | 21586294:21586348 |
| exon_skip_125368 | chr10 | 21682225:21682257:21712230:21712340:21713772:21713922 | 21712230:21712340 |
| exon_skip_127913 | chr10 | 21651673:21651768:21663750:21663843:21670449:21670704 | 21663750:21663843 |
| exon_skip_134160 | chr10 | 21538833:21538912:21571975:21572026:21586294:21586348 | 21571975:21572026 |
| exon_skip_134496 | chr10 | 21681333:21681376:21682225:21682257:21713772:21713922 | 21682225:21682257 |
| exon_skip_14201 | chr10 | 21617134:21617207:21651673:21651768:21670449:21670665 | 21651673:21651768 |
| exon_skip_144618 | chr10 | 21538833:21538912:21557621:21557824:21586294:21586348 | 21557621:21557824 |
| exon_skip_15550 | chr10 | 21651673:21651768:21668917:21669052:21670449:21670601 | 21668917:21669052 |
| exon_skip_173129 | chr10 | 21732899:21733087:21733504:21733592:21733768:21733981 | 21733504:21733592 |
| exon_skip_173135 | chr10 | 21682225:21682257:21688491:21688538:21713772:21713922 | 21688491:21688538 |
| exon_skip_182176 | chr10 | 21673641:21673919:21681332:21681376:21713772:21713922 | 21681332:21681376 |
| exon_skip_186784 | chr10 | 21681332:21681376:21682225:21682257:21713772:21713922 | 21682225:21682257 |
| exon_skip_198426 | chr10 | 21534749:21534804:21538833:21538912:21586294:21586348 | 21538833:21538912 |
| exon_skip_219274 | chr10 | 21682225:21682257:21712230:21712340:21713772:21713950 | 21712230:21712340 |
| exon_skip_220433 | chr10 | 21557621:21557824:21586294:21586348:21595331:21595378 | 21586294:21586348 |
| exon_skip_243680 | chr10 | 21571985:21572026:21586294:21586348:21595331:21595440 | 21586294:21586348 |
| exon_skip_244215 | chr10 | 21595331:21595440:21612348:21612451:21614831:21614924 | 21612348:21612451 |
| exon_skip_244893 | chr10 | 21614831:21614924:21617112:21617207:21651673:21651768 | 21617112:21617207 |
| exon_skip_255250 | chr10 | 21651673:21651768:21663750:21663843:21670449:21670665 | 21663750:21663843 |
| exon_skip_267045 | chr10 | 21586294:21586348:21595331:21595440:21612348:21612451 | 21595331:21595440 |
| exon_skip_273210 | chr10 | 21670449:21670704:21673641:21673919:21681332:21681376 | 21673641:21673919 |
| exon_skip_283676 | chr10 | 21688491:21688538:21708588:21708657:21713772:21713950 | 21708588:21708657 |
| exon_skip_35197 | chr10 | 21670449:21670704:21673350:21673919:21681332:21681376 | 21673350:21673919 |
| exon_skip_46893 | chr10 | 21651673:21651768:21663750:21663843:21670449:21670601 | 21663750:21663843 |
| exon_skip_59695 | chr10 | 21726244:21726355:21727856:21727928:21730900:21731054 | 21727856:21727928 |
| exon_skip_89138 | chr10 | 21538833:21538912:21541263:21541361:21586294:21586348 | 21541263:21541361 |
| exon_skip_95542 | chr10 | 21651673:21651768:21668917:21669052:21670449:21670665 | 21668917:21669052 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for MLLT10 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000377072 | 21538833 | 21538912 | Frame-shift |
| ENST00000377072 | 21586294 | 21586348 | Frame-shift |
| ENST00000377072 | 21595331 | 21595440 | Frame-shift |
| ENST00000377072 | 21617112 | 21617207 | In-frame |
| ENST00000377072 | 21688491 | 21688538 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000377072 | 21586294 | 21586348 | Frame-shift |
| ENST00000377072 | 21595331 | 21595440 | Frame-shift |
| ENST00000377072 | 21617112 | 21617207 | In-frame |
| ENST00000377072 | 21673350 | 21673919 | In-frame |
| ENST00000377072 | 21688491 | 21688538 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000377072 | 21538833 | 21538912 | Frame-shift |
| ENST00000377072 | 21586294 | 21586348 | Frame-shift |
| ENST00000377072 | 21595331 | 21595440 | Frame-shift |
| ENST00000377072 | 21612348 | 21612451 | Frame-shift |
| ENST00000377072 | 21727856 | 21727928 | Frame-shift |
| ENST00000377072 | 21733504 | 21733592 | Frame-shift |
| ENST00000377072 | 21617112 | 21617207 | In-frame |
| ENST00000377072 | 21651673 | 21651768 | In-frame |
| ENST00000377072 | 21673350 | 21673919 | In-frame |
| ENST00000377072 | 21688491 | 21688538 | In-frame |
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Infer the effects of exon skipping event on protein functional features for MLLT10 |
p-ENSG00000078403_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in MLLT10 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for MLLT10 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for MLLT10 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for MLLT10 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for MLLT10 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for MLLT10 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MLLT10 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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