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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for FBXO11 |
 Gene summary |
| Gene information | Gene symbol | FBXO11 | Gene ID | 80204 |
| Gene name | F-box protein 11 | |
| Synonyms | FBX11|IDDFBA|PRMT9|UBR6|UG063H01|VIT1 | |
| Cytomap | 2p16.3 | |
| Type of gene | protein-coding | |
| Description | F-box only protein 11protein arginine N-methyltransferase 9ubiquitin protein ligase E3 component n-recognin 6vitiligo-associated protein 1vitiligo-associated protein VIT-1 | |
| Modification date | 20200327 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| FBXO11 | GO:0006464 | cellular protein modification process | 16487488 |
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Gene structures and expression levels for FBXO11 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000138081
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for FBXO11 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_100937 | chr2 | 47832349:47832486:47832572:47832678:47832769:47832880 | 47832572:47832678 |
| exon_skip_109588 | chr2 | 47809600:47809707:47810316:47810426:47813234:47813377 | 47810316:47810426 |
| exon_skip_110439 | chr2 | 47818960:47819078:47820362:47820456:47822218:47822303 | 47820362:47820456 |
| exon_skip_140806 | chr2 | 47813791:47813867:47818779:47818864:47818956:47819078 | 47818779:47818864 |
| exon_skip_159185 | chr2 | 47834579:47834711:47834788:47834871:47835872:47835962 | 47834788:47834871 |
| exon_skip_197928 | chr2 | 47818956:47819078:47820362:47820456:47822218:47822303 | 47820362:47820456 |
| exon_skip_204832 | chr2 | 47808195:47808247:47808329:47808427:47809158:47809185 | 47808329:47808427 |
| exon_skip_250 | chr2 | 47832964:47833070:47834579:47834711:47834788:47834871 | 47834579:47834711 |
| exon_skip_283686 | chr2 | 47809600:47809707:47810316:47810426:47813234:47813284 | 47810316:47810426 |
| exon_skip_32739 | chr2 | 47818779:47818864:47818956:47819078:47820362:47820456 | 47818956:47819078 |
| exon_skip_36968 | chr2 | 47810316:47810426:47813234:47813377:47813791:47813867 | 47813234:47813377 |
| exon_skip_44270 | chr2 | 47834788:47834871:47835872:47836001:47838859:47839000 | 47835872:47836001 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for FBXO11 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000403359 | 47818779 | 47818864 | Frame-shift |
| ENST00000403359 | 47820362 | 47820456 | Frame-shift |
| ENST00000403359 | 47832572 | 47832678 | Frame-shift |
| ENST00000403359 | 47810316 | 47810426 | In-frame |
| ENST00000403359 | 47818956 | 47819078 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000403359 | 47832572 | 47832678 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000403359 | 47818779 | 47818864 | Frame-shift |
| ENST00000403359 | 47820362 | 47820456 | Frame-shift |
| ENST00000403359 | 47832572 | 47832678 | Frame-shift |
| ENST00000403359 | 47834579 | 47834711 | Frame-shift |
| ENST00000403359 | 47835872 | 47836001 | Frame-shift |
| ENST00000403359 | 47808329 | 47808427 | In-frame |
| ENST00000403359 | 47810316 | 47810426 | In-frame |
| ENST00000403359 | 47813234 | 47813377 | In-frame |
| ENST00000403359 | 47818956 | 47819078 | In-frame |
| ENST00000403359 | 47834788 | 47834871 | In-frame |
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Infer the effects of exon skipping event on protein functional features for FBXO11 |
p-ENSG00000138081_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000403359 | 4072 | 927 | 47818956 | 47819078 | 1871 | 1992 | 599 | 639 |
| ENST00000403359 | 4072 | 927 | 47810316 | 47810426 | 2301 | 2410 | 742 | 779 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000403359 | 4072 | 927 | 47834788 | 47834871 | 791 | 873 | 239 | 266 |
| ENST00000403359 | 4072 | 927 | 47818956 | 47819078 | 1871 | 1992 | 599 | 639 |
| ENST00000403359 | 4072 | 927 | 47813234 | 47813377 | 2157 | 2299 | 694 | 742 |
| ENST00000403359 | 4072 | 927 | 47810316 | 47810426 | 2301 | 2410 | 742 | 779 |
| ENST00000403359 | 4072 | 927 | 47808329 | 47808427 | 2629 | 2726 | 852 | 884 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q86XK2 | 599 | 639 | 212 | 927 | Alternative sequence | ID=VSP_008861;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10531037;Dbxref=PMID:10531037 |
| Q86XK2 | 599 | 639 | 1 | 927 | Chain | ID=PRO_0000273574;Note=F-box only protein 11 |
| Q86XK2 | 599 | 639 | 579 | 601 | Repeat | Note=PbH1 9 |
| Q86XK2 | 599 | 639 | 602 | 624 | Repeat | Note=PbH1 10 |
| Q86XK2 | 599 | 639 | 625 | 647 | Repeat | Note=PbH1 11 |
| Q86XK2 | 599 | 639 | 632 | 632 | Sequence conflict | Note=R->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q86XK2 | 742 | 779 | 212 | 927 | Alternative sequence | ID=VSP_008861;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10531037;Dbxref=PMID:10531037 |
| Q86XK2 | 742 | 779 | 670 | 927 | Alternative sequence | ID=VSP_008862;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2 |
| Q86XK2 | 742 | 779 | 744 | 770 | Alternative sequence | ID=VSP_008863;Note=In isoform 2. LLEENDIFRNAQAGVLISTNSHPILRK->IVVNFALVKNPVFHYSSISLMINDIAN;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q86XK2 | 742 | 779 | 771 | 927 | Alternative sequence | ID=VSP_008864;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q86XK2 | 742 | 779 | 1 | 927 | Chain | ID=PRO_0000273574;Note=F-box only protein 11 |
| Q86XK2 | 742 | 779 | 740 | 762 | Repeat | Note=PbH1 16 |
| Q86XK2 | 742 | 779 | 763 | 785 | Repeat | Note=PbH1 17 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q86XK2 | 239 | 266 | 212 | 927 | Alternative sequence | ID=VSP_008861;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10531037;Dbxref=PMID:10531037 |
| Q86XK2 | 239 | 266 | 1 | 927 | Chain | ID=PRO_0000273574;Note=F-box only protein 11 |
| Q86XK2 | 239 | 266 | 239 | 239 | Sequence conflict | Note=L->S;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q86XK2 | 599 | 639 | 212 | 927 | Alternative sequence | ID=VSP_008861;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10531037;Dbxref=PMID:10531037 |
| Q86XK2 | 599 | 639 | 1 | 927 | Chain | ID=PRO_0000273574;Note=F-box only protein 11 |
| Q86XK2 | 599 | 639 | 579 | 601 | Repeat | Note=PbH1 9 |
| Q86XK2 | 599 | 639 | 602 | 624 | Repeat | Note=PbH1 10 |
| Q86XK2 | 599 | 639 | 625 | 647 | Repeat | Note=PbH1 11 |
| Q86XK2 | 599 | 639 | 632 | 632 | Sequence conflict | Note=R->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q86XK2 | 694 | 742 | 212 | 927 | Alternative sequence | ID=VSP_008861;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10531037;Dbxref=PMID:10531037 |
| Q86XK2 | 694 | 742 | 670 | 927 | Alternative sequence | ID=VSP_008862;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2 |
| Q86XK2 | 694 | 742 | 1 | 927 | Chain | ID=PRO_0000273574;Note=F-box only protein 11 |
| Q86XK2 | 694 | 742 | 715 | 715 | Natural variant | ID=VAR_070076;Note=Found in a patient with lymphoma%3B strongly diminishes ubiquitin-mediated degradation of BCL6. K->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22113614;Dbxref=PMID:22113614 |
| Q86XK2 | 694 | 742 | 715 | 715 | Natural variant | ID=VAR_070077;Note=Found in a patient with lymphoma%3B almost abolishes ubiquitin-mediated degradation of BCL6. K->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22113614;Dbxref=PMID:22113614 |
| Q86XK2 | 694 | 742 | 694 | 716 | Repeat | Note=PbH1 14 |
| Q86XK2 | 694 | 742 | 717 | 739 | Repeat | Note=PbH1 15 |
| Q86XK2 | 694 | 742 | 740 | 762 | Repeat | Note=PbH1 16 |
| Q86XK2 | 742 | 779 | 212 | 927 | Alternative sequence | ID=VSP_008861;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10531037;Dbxref=PMID:10531037 |
| Q86XK2 | 742 | 779 | 670 | 927 | Alternative sequence | ID=VSP_008862;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2 |
| Q86XK2 | 742 | 779 | 744 | 770 | Alternative sequence | ID=VSP_008863;Note=In isoform 2. LLEENDIFRNAQAGVLISTNSHPILRK->IVVNFALVKNPVFHYSSISLMINDIAN;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q86XK2 | 742 | 779 | 771 | 927 | Alternative sequence | ID=VSP_008864;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q86XK2 | 742 | 779 | 1 | 927 | Chain | ID=PRO_0000273574;Note=F-box only protein 11 |
| Q86XK2 | 742 | 779 | 740 | 762 | Repeat | Note=PbH1 16 |
| Q86XK2 | 742 | 779 | 763 | 785 | Repeat | Note=PbH1 17 |
| Q86XK2 | 852 | 884 | 212 | 927 | Alternative sequence | ID=VSP_008861;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10531037;Dbxref=PMID:10531037 |
| Q86XK2 | 852 | 884 | 670 | 927 | Alternative sequence | ID=VSP_008862;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2 |
| Q86XK2 | 852 | 884 | 771 | 927 | Alternative sequence | ID=VSP_008864;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q86XK2 | 852 | 884 | 845 | 856 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VMD |
| Q86XK2 | 852 | 884 | 878 | 884 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VMD |
| Q86XK2 | 852 | 884 | 1 | 927 | Chain | ID=PRO_0000273574;Note=F-box only protein 11 |
| Q86XK2 | 852 | 884 | 866 | 872 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VMD |
| Q86XK2 | 852 | 884 | 833 | 904 | Zinc finger | Note=UBR-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00508 |
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3'-UTR located exon skipping events that lost miRNA binding sites in FBXO11 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for FBXO11 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for FBXO11 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for FBXO11 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for FBXO11 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for FBXO11 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FBXO11 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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