|
||||||
|
 | |
| |
| |
| Open reading frame (ORF) annotation in the exon skipping event |
| |
| 3'-UTR located exon skipping events lost miRNA binding sites |
| |
| |
| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| |
| |
|
Gene summary for EDC3 |
 Gene summary |
| Gene information | Gene symbol | EDC3 | Gene ID | 80153 |
| Gene name | enhancer of mRNA decapping 3 | |
| Synonyms | LSM16|MRT50|YJDC|YJEFN2|hYjeF_N2-15q23 | |
| Cytomap | 15q24.1 | |
| Type of gene | protein-coding | |
| Description | enhancer of mRNA-decapping protein 3LSM16 homolog (EDC3, S. cerevisiae)enhancer of mRNA decapping 3 homologyjeF N-terminal domain-containing protein 2yjeF domain containingyjeF domain-containing protein 1 | |
| Modification date | 20200327 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
Top |
Gene structures and expression levels for EDC3 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
ENSG00000179151
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
 |
Top |
Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for EDC3 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
 |
| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_125904 | chr15 | 74675031:74675142:74676941:74677022:74695880:74695987 | 74676941:74677022 |
| exon_skip_130308 | chr15 | 74675031:74675142:74687091:74687179:74695880:74695936 | 74687091:74687179 |
| exon_skip_15294 | chr15 | 74640561:74640619:74655733:74656068:74671455:74671599 | 74655733:74656068 |
| exon_skip_172089 | chr15 | 74675031:74675142:74676941:74677022:74687091:74687179 | 74676941:74677022 |
| exon_skip_192459 | chr15 | 74656020:74656068:74674961:74675142:74695880:74695936 | 74674961:74675142 |
| exon_skip_204669 | chr15 | 74675031:74675142:74676941:74677022:74695880:74695936 | 74676941:74677022 |
| exon_skip_219266 | chr15 | 74676941:74677022:74687091:74687179:74695880:74695936 | 74687091:74687179 |
| exon_skip_50856 | chr15 | 74671662:74671774:74674961:74675142:74687091:74687179 | 74674961:74675142 |
| exon_skip_60292 | chr15 | 74632733:74632946:74635409:74635626:74640466:74640619 | 74635409:74635626 |
| exon_skip_7233 | chr15 | 74676941:74677022:74687091:74687179:74695880:74695987 | 74687091:74687179 |
| exon_skip_87315 | chr15 | 74656020:74656068:74671455:74671774:74674961:74675142 | 74671455:74671774 |
| exon_skip_9558 | chr15 | 74655733:74656068:74671455:74671774:74674961:74675142 | 74671455:74671774 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
Top |
Open reading frame (ORF) annotation in the exon skipping event for EDC3 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000426797 | 74676941 | 74677022 | 3UTR-3UTR |
| ENST00000568176 | 74687091 | 74687179 | 3UTR-3UTR |
| ENST00000315127 | 74671455 | 74671774 | Frame-shift |
| ENST00000426797 | 74671455 | 74671774 | Frame-shift |
| ENST00000568176 | 74671455 | 74671774 | Frame-shift |
| ENST00000315127 | 74655733 | 74656068 | In-frame |
| ENST00000426797 | 74655733 | 74656068 | In-frame |
| ENST00000568176 | 74655733 | 74656068 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000568176 | 74674961 | 74675142 | 3UTR-3CDS |
| ENST00000426797 | 74676941 | 74677022 | 3UTR-3UTR |
| ENST00000568176 | 74687091 | 74687179 | 3UTR-3UTR |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000568176 | 74674961 | 74675142 | 3UTR-3CDS |
| ENST00000426797 | 74676941 | 74677022 | 3UTR-3UTR |
| ENST00000568176 | 74687091 | 74687179 | 3UTR-3UTR |
| ENST00000315127 | 74635409 | 74635626 | Frame-shift |
| ENST00000426797 | 74635409 | 74635626 | Frame-shift |
| ENST00000568176 | 74635409 | 74635626 | Frame-shift |
| ENST00000315127 | 74671455 | 74671774 | Frame-shift |
| ENST00000426797 | 74671455 | 74671774 | Frame-shift |
| ENST00000568176 | 74671455 | 74671774 | Frame-shift |
| ENST00000315127 | 74655733 | 74656068 | In-frame |
| ENST00000426797 | 74655733 | 74656068 | In-frame |
| ENST00000568176 | 74655733 | 74656068 | In-frame |
Top |
Infer the effects of exon skipping event on protein functional features for EDC3 |
p-ENSG00000179151_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000315127 | 3780 | 508 | 74655733 | 74656068 | 667 | 1001 | 161 | 273 |
| ENST00000426797 | 2110 | 508 | 74655733 | 74656068 | 948 | 1282 | 161 | 273 |
| ENST00000568176 | 1842 | 508 | 74655733 | 74656068 | 713 | 1047 | 161 | 273 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000315127 | 3780 | 508 | 74655733 | 74656068 | 667 | 1001 | 161 | 273 |
| ENST00000426797 | 2110 | 508 | 74655733 | 74656068 | 948 | 1282 | 161 | 273 |
| ENST00000568176 | 1842 | 508 | 74655733 | 74656068 | 713 | 1047 | 161 | 273 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q96F86 | 161 | 273 | 270 | 272 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3D3K |
| Q96F86 | 161 | 273 | 270 | 272 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3D3K |
| Q96F86 | 161 | 273 | 270 | 272 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3D3K |
| Q96F86 | 161 | 273 | 1 | 508 | Chain | ID=PRO_0000119054;Note=Enhancer of mRNA-decapping protein 3 |
| Q96F86 | 161 | 273 | 1 | 508 | Chain | ID=PRO_0000119054;Note=Enhancer of mRNA-decapping protein 3 |
| Q96F86 | 161 | 273 | 1 | 508 | Chain | ID=PRO_0000119054;Note=Enhancer of mRNA-decapping protein 3 |
| Q96F86 | 161 | 273 | 192 | 228 | Domain | Note=DFDF;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00845 |
| Q96F86 | 161 | 273 | 192 | 228 | Domain | Note=DFDF;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00845 |
| Q96F86 | 161 | 273 | 192 | 228 | Domain | Note=DFDF;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00845 |
| Q96F86 | 161 | 273 | 206 | 210 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WAX |
| Q96F86 | 161 | 273 | 206 | 210 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WAX |
| Q96F86 | 161 | 273 | 206 | 210 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WAX |
| Q96F86 | 161 | 273 | 215 | 225 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WAX |
| Q96F86 | 161 | 273 | 215 | 225 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WAX |
| Q96F86 | 161 | 273 | 215 | 225 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WAX |
| Q96F86 | 161 | 273 | 161 | 161 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:19690332,PMID:20068231,PMID:23186163 |
| Q96F86 | 161 | 273 | 161 | 161 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:19690332,PMID:20068231,PMID:23186163 |
| Q96F86 | 161 | 273 | 161 | 161 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:19690332,PMID:20068231,PMID:23186163 |
| Q96F86 | 161 | 273 | 204 | 204 | Mutagenesis | Note=Abolishes interaction with DDX6%3B when associated with A-206. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19285948;Dbxref=PMID:19285948 |
| Q96F86 | 161 | 273 | 204 | 204 | Mutagenesis | Note=Abolishes interaction with DDX6%3B when associated with A-206. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19285948;Dbxref=PMID:19285948 |
| Q96F86 | 161 | 273 | 204 | 204 | Mutagenesis | Note=Abolishes interaction with DDX6%3B when associated with A-206. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19285948;Dbxref=PMID:19285948 |
| Q96F86 | 161 | 273 | 206 | 206 | Mutagenesis | Note=Abolishes interaction with DDX6%3B when associated with A-204. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19285948;Dbxref=PMID:19285948 |
| Q96F86 | 161 | 273 | 206 | 206 | Mutagenesis | Note=Abolishes interaction with DDX6%3B when associated with A-204. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19285948;Dbxref=PMID:19285948 |
| Q96F86 | 161 | 273 | 206 | 206 | Mutagenesis | Note=Abolishes interaction with DDX6%3B when associated with A-204. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19285948;Dbxref=PMID:19285948 |
| Q96F86 | 161 | 273 | 191 | 296 | Region | Note=Required for interaction with DDX6;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Q96F86 | 161 | 273 | 191 | 296 | Region | Note=Required for interaction with DDX6;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Q96F86 | 161 | 273 | 191 | 296 | Region | Note=Required for interaction with DDX6;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q96F86 | 161 | 273 | 270 | 272 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3D3K |
| Q96F86 | 161 | 273 | 270 | 272 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3D3K |
| Q96F86 | 161 | 273 | 270 | 272 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3D3K |
| Q96F86 | 161 | 273 | 1 | 508 | Chain | ID=PRO_0000119054;Note=Enhancer of mRNA-decapping protein 3 |
| Q96F86 | 161 | 273 | 1 | 508 | Chain | ID=PRO_0000119054;Note=Enhancer of mRNA-decapping protein 3 |
| Q96F86 | 161 | 273 | 1 | 508 | Chain | ID=PRO_0000119054;Note=Enhancer of mRNA-decapping protein 3 |
| Q96F86 | 161 | 273 | 192 | 228 | Domain | Note=DFDF;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00845 |
| Q96F86 | 161 | 273 | 192 | 228 | Domain | Note=DFDF;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00845 |
| Q96F86 | 161 | 273 | 192 | 228 | Domain | Note=DFDF;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00845 |
| Q96F86 | 161 | 273 | 206 | 210 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WAX |
| Q96F86 | 161 | 273 | 206 | 210 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WAX |
| Q96F86 | 161 | 273 | 206 | 210 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WAX |
| Q96F86 | 161 | 273 | 215 | 225 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WAX |
| Q96F86 | 161 | 273 | 215 | 225 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WAX |
| Q96F86 | 161 | 273 | 215 | 225 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2WAX |
| Q96F86 | 161 | 273 | 161 | 161 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:19690332,PMID:20068231,PMID:23186163 |
| Q96F86 | 161 | 273 | 161 | 161 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:19690332,PMID:20068231,PMID:23186163 |
| Q96F86 | 161 | 273 | 161 | 161 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:19690332,PMID:20068231,PMID:23186163 |
| Q96F86 | 161 | 273 | 204 | 204 | Mutagenesis | Note=Abolishes interaction with DDX6%3B when associated with A-206. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19285948;Dbxref=PMID:19285948 |
| Q96F86 | 161 | 273 | 204 | 204 | Mutagenesis | Note=Abolishes interaction with DDX6%3B when associated with A-206. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19285948;Dbxref=PMID:19285948 |
| Q96F86 | 161 | 273 | 204 | 204 | Mutagenesis | Note=Abolishes interaction with DDX6%3B when associated with A-206. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19285948;Dbxref=PMID:19285948 |
| Q96F86 | 161 | 273 | 206 | 206 | Mutagenesis | Note=Abolishes interaction with DDX6%3B when associated with A-204. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19285948;Dbxref=PMID:19285948 |
| Q96F86 | 161 | 273 | 206 | 206 | Mutagenesis | Note=Abolishes interaction with DDX6%3B when associated with A-204. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19285948;Dbxref=PMID:19285948 |
| Q96F86 | 161 | 273 | 206 | 206 | Mutagenesis | Note=Abolishes interaction with DDX6%3B when associated with A-204. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19285948;Dbxref=PMID:19285948 |
| Q96F86 | 161 | 273 | 191 | 296 | Region | Note=Required for interaction with DDX6;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Q96F86 | 161 | 273 | 191 | 296 | Region | Note=Required for interaction with DDX6;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Q96F86 | 161 | 273 | 191 | 296 | Region | Note=Required for interaction with DDX6;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
Top |
3'-UTR located exon skipping events that lost miRNA binding sites in EDC3 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
| Mayo | ENST00000568176 | 74687091 | 74687179 | hsa-miR-6747-3p | chr15:74687120-74687127 | 8mer-1a | chr15:74687108-74687131 | 164.00 | -23.50 |
| Mayo | ENST00000426797 | 74676941 | 74677022 | hsa-miR-6755-3p | chr15:74676969-74676976 | 8mer-1a | chr15:74676954-74676976 | 161.00 | -15.89 |
| Mayo | ENST00000426797 | 74676941 | 74677022 | hsa-miR-4697-3p | chr15:74676966-74676973 | 8mer-1a | chr15:74676954-74676976 | 161.00 | -15.89 |
| Mayo | ENST00000426797 | 74676941 | 74677022 | hsa-miR-4310 | chr15:74676980-74676987 | 8mer-1a | chr15:74676976-74676996 | 156.00 | -19.83 |
| Mayo | ENST00000426797 | 74676941 | 74677022 | hsa-miR-7157-5p | chr15:74676980-74676987 | 8mer-1a | chr15:74676976-74676996 | 156.00 | -19.83 |
| Mayo | ENST00000568176 | 74687091 | 74687179 | hsa-miR-4452 | chr15:74687145-74687152 | 8mer-1a | chr15:74687130-74687152 | 189.00 | -31.72 |
| Mayo | ENST00000426797 | 74676941 | 74677022 | hsa-miR-5004-3p | chr15:74676957-74676964 | 8mer-1a | chr15:74676954-74676976 | 161.00 | -15.89 |
| Mayo | ENST00000568176 | 74687091 | 74687179 | hsa-miR-3690 | chr15:74687139-74687146 | 8mer-1a | chr15:74687130-74687152 | 189.00 | -31.72 |
| MSBB | ENST00000568176 | 74687091 | 74687179 | hsa-miR-6747-3p | chr15:74687120-74687127 | 8mer-1a | chr15:74687108-74687131 | 164.00 | -23.50 |
| MSBB | ENST00000426797 | 74676941 | 74677022 | hsa-miR-6755-3p | chr15:74676969-74676976 | 8mer-1a | chr15:74676954-74676976 | 161.00 | -15.89 |
| MSBB | ENST00000426797 | 74676941 | 74677022 | hsa-miR-4697-3p | chr15:74676966-74676973 | 8mer-1a | chr15:74676954-74676976 | 161.00 | -15.89 |
| MSBB | ENST00000426797 | 74676941 | 74677022 | hsa-miR-4310 | chr15:74676980-74676987 | 8mer-1a | chr15:74676976-74676996 | 156.00 | -19.83 |
| MSBB | ENST00000426797 | 74676941 | 74677022 | hsa-miR-7157-5p | chr15:74676980-74676987 | 8mer-1a | chr15:74676976-74676996 | 156.00 | -19.83 |
| MSBB | ENST00000568176 | 74687091 | 74687179 | hsa-miR-4452 | chr15:74687145-74687152 | 8mer-1a | chr15:74687130-74687152 | 189.00 | -31.72 |
| MSBB | ENST00000426797 | 74676941 | 74677022 | hsa-miR-5004-3p | chr15:74676957-74676964 | 8mer-1a | chr15:74676954-74676976 | 161.00 | -15.89 |
| MSBB | ENST00000568176 | 74687091 | 74687179 | hsa-miR-3690 | chr15:74687139-74687146 | 8mer-1a | chr15:74687130-74687152 | 189.00 | -31.72 |
| ROSMAP | ENST00000568176 | 74687091 | 74687179 | hsa-miR-6747-3p | chr15:74687120-74687127 | 8mer-1a | chr15:74687108-74687131 | 164.00 | -23.50 |
| ROSMAP | ENST00000426797 | 74676941 | 74677022 | hsa-miR-6755-3p | chr15:74676969-74676976 | 8mer-1a | chr15:74676954-74676976 | 161.00 | -15.89 |
| ROSMAP | ENST00000426797 | 74676941 | 74677022 | hsa-miR-4697-3p | chr15:74676966-74676973 | 8mer-1a | chr15:74676954-74676976 | 161.00 | -15.89 |
| ROSMAP | ENST00000426797 | 74676941 | 74677022 | hsa-miR-4310 | chr15:74676980-74676987 | 8mer-1a | chr15:74676976-74676996 | 156.00 | -19.83 |
| ROSMAP | ENST00000426797 | 74676941 | 74677022 | hsa-miR-7157-5p | chr15:74676980-74676987 | 8mer-1a | chr15:74676976-74676996 | 156.00 | -19.83 |
| ROSMAP | ENST00000568176 | 74687091 | 74687179 | hsa-miR-4452 | chr15:74687145-74687152 | 8mer-1a | chr15:74687130-74687152 | 189.00 | -31.72 |
| ROSMAP | ENST00000426797 | 74676941 | 74677022 | hsa-miR-5004-3p | chr15:74676957-74676964 | 8mer-1a | chr15:74676954-74676976 | 161.00 | -15.89 |
| ROSMAP | ENST00000568176 | 74687091 | 74687179 | hsa-miR-3690 | chr15:74687139-74687146 | 8mer-1a | chr15:74687130-74687152 | 189.00 | -31.72 |
Top |
SNVs in the skipped exons for EDC3 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
Top |
AD stage-associated exon skippint events for EDC3 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
Top |
Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for EDC3 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
Top |
Correlation with RNA binding proteins (RBPs) for EDC3 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
Top |
RelatedDrugs for EDC3 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for EDC3 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|