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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for MYO15B |
 Gene summary |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for MYO15B |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000266714
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| PG | UP | ENST00000581612.1 | MYO15B-219:retained_intron:MYO15B | 7.733055e+00 | 9.650307e-01 | 2.001770e-06 | 1.513606e-04 |
| PG | UP | ENST00000584516.5 | MYO15B-227:nonsense_mediated_decay:MYO15B | 2.801982e+01 | 1.068474e+00 | 5.807810e-06 | 3.370647e-04 |
| PG | UP | ENST00000580724.1 | MYO15B-218:retained_intron:MYO15B | 6.614887e+00 | 9.022807e-01 | 6.328689e-06 | 3.577896e-04 |
| PG | UP | ENST00000581866.1 | MYO15B-220:retained_intron:MYO15B | 3.661314e+00 | 9.618780e-01 | 6.844640e-05 | 2.076974e-03 |
| CB | DOWN | ENST00000580262.2 | MYO15B-215:nonsense_mediated_decay:MYO15B | 7.527448e+01 | -8.264280e-01 | 2.035128e-10 | 1.151781e-08 |
| CB | DOWN | ENST00000577948.5 | MYO15B-205:nonsense_mediated_decay:MYO15B | 1.320976e+01 | -1.068372e+00 | 9.552362e-04 | 4.970833e-03 |
| CB | DOWN | ENST00000580096.5 | MYO15B-214:nonsense_mediated_decay:MYO15B | 9.577296e+00 | -8.046053e-01 | 6.142563e-03 | 2.331665e-02 |
| CB | DOWN | ENST00000580414.5 | MYO15B-216:nonsense_mediated_decay:MYO15B | 4.638874e+00 | -1.480409e+00 | 6.291119e-03 | 2.377120e-02 |
| TC | DOWN | ENST00000580262.2 | MYO15B-215:nonsense_mediated_decay:MYO15B | 5.334529e+01 | -8.677644e-01 | 5.654857e-11 | 1.196707e-08 |
| TC | DOWN | ENST00000583140.5 | MYO15B-224:protein_coding:MYO15B | 9.432661e+01 | -8.088110e-01 | 1.093241e-08 | 9.708754e-07 |
| TC | DOWN | ENST00000610429.1 | MYO15B-229:retained_intron:MYO15B | 4.415256e+00 | -8.120086e-01 | 1.542231e-04 | 2.274993e-03 |
| TC | DOWN | ENST00000578005.4 | MYO15B-207:retained_intron:MYO15B | 3.545808e+00 | -9.492575e-01 | 2.148265e-04 | 2.962377e-03 |
| TC | DOWN | ENST00000578300.1 | MYO15B-209:retained_intron:MYO15B | 2.747415e+00 | -8.566916e-01 | 6.583019e-04 | 7.138056e-03 |
| TC | DOWN | ENST00000577948.5 | MYO15B-205:nonsense_mediated_decay:MYO15B | 3.795893e+00 | -1.151742e+00 | 5.729341e-03 | 3.707509e-02 |
| TC | DOWN | ENST00000582012.3 | MYO15B-221:nonsense_mediated_decay:MYO15B | 9.232941e-01 | -1.138122e+00 | 6.725936e-03 | 4.177320e-02 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for MYO15B |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_101128 | chr17 | 75622004:75622080:75623781:75623854:75624015:75624064 | 75623781:75623854 |
| exon_skip_102578 | chr17 | 75603188:75603312:75605504:75605621:75605864:75606021 | 75605504:75605621 |
| exon_skip_110958 | chr17 | 75620332:75620357:75621031:75621176:75621345:75621372 | 75621031:75621176 |
| exon_skip_113473 | chr17 | 75603032:75603077:75603188:75603312:75605504:75605621 | 75603188:75603312 |
| exon_skip_117012 | chr17 | 75613705:75613777:75613981:75614033:75614199:75614360 | 75613981:75614033 |
| exon_skip_120350 | chr17 | 75602830:75602945:75603032:75603077:75610166:75610259 | 75603032:75603077 |
| exon_skip_135733 | chr17 | 75596813:75596899:75601438:75601563:75602517:75602594 | 75601438:75601563 |
| exon_skip_14626 | chr17 | 75590626:75590689:75590907:75591016:75591172:75591246 | 75590907:75591016 |
| exon_skip_165814 | chr17 | 75592238:75592301:75592428:75592541:75592679:75592840 | 75592428:75592541 |
| exon_skip_182418 | chr17 | 75594475:75594588:75594701:75594759:75594840:75594972 | 75594701:75594759 |
| exon_skip_191010 | chr17 | 75590341:75590385:75590626:75590689:75591172:75591246 | 75590626:75590689 |
| exon_skip_201181 | chr17 | 75596768:75596899:75600631:75600680:75601438:75601563 | 75600631:75600680 |
| exon_skip_203016 | chr17 | 75616885:75616961:75617085:75617304:75617810:75617915 | 75617085:75617304 |
| exon_skip_204428 | chr17 | 75596820:75596899:75601438:75601563:75602517:75602594 | 75601438:75601563 |
| exon_skip_22501 | chr17 | 75612815:75612893:75612974:75613209:75613293:75613471 | 75612974:75613209 |
| exon_skip_237716 | chr17 | 75620332:75620357:75620467:75621176:75621345:75621372 | 75620467:75621176 |
| exon_skip_250667 | chr17 | 75619358:75619476:75619681:75619799:75619879:75620020 | 75619681:75619799 |
| exon_skip_254723 | chr17 | 75619358:75619476:75619681:75619723:75619800:75620020 | 75619681:75619723 |
| exon_skip_259035 | chr17 | 75624175:75624269:75624370:75624447:75624543:75624639 | 75624370:75624447 |
| exon_skip_269577 | chr17 | 75596813:75596899:75600606:75600680:75601438:75601563 | 75600606:75600680 |
| exon_skip_287694 | chr17 | 75614961:75615042:75615240:75615338:75615503:75615600 | 75615240:75615338 |
| exon_skip_3262 | chr17 | 75596820:75596899:75600631:75600680:75601438:75601563 | 75600631:75600680 |
| exon_skip_38648 | chr17 | 75620332:75620357:75620467:75620636:75621031:75621176 | 75620467:75620636 |
| exon_skip_56544 | chr17 | 75592238:75592301:75592464:75592541:75592679:75592840 | 75592464:75592541 |
| exon_skip_56887 | chr17 | 75605867:75606021:75606933:75607003:75610166:75610259 | 75606933:75607003 |
| exon_skip_58455 | chr17 | 75615863:75615884:75616069:75616147:75616312:75616381 | 75616069:75616147 |
| exon_skip_82029 | chr17 | 75605929:75606021:75606933:75607003:75610166:75610259 | 75606933:75607003 |
| exon_skip_87625 | chr17 | 75596813:75596899:75600631:75600680:75601438:75601563 | 75600631:75600680 |
| exon_skip_9342 | chr17 | 75591616:75591712:75591977:75592080:75592238:75592301 | 75591977:75592080 |
| exon_skip_96648 | chr17 | 75601438:75601563:75602517:75602594:75602830:75602945 | 75602517:75602594 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for MYO15B |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000633867 | 75600631 | 75600680 | Frame-shift |
| ENST00000633867 | 75603188 | 75603312 | Frame-shift |
| ENST00000633867 | 75605504 | 75605621 | Frame-shift |
| ENST00000633867 | 75612974 | 75613209 | Frame-shift |
| ENST00000633867 | 75617085 | 75617304 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000633867 | 75624370 | 75624447 | 3UTR-3UTR |
| ENST00000633867 | 75600631 | 75600680 | Frame-shift |
| ENST00000633867 | 75605504 | 75605621 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000633867 | 75620467 | 75621176 | 3UTR-3CDS |
| ENST00000633867 | 75624370 | 75624447 | 3UTR-3UTR |
| ENST00000633867 | 75600631 | 75600680 | Frame-shift |
| ENST00000633867 | 75603188 | 75603312 | Frame-shift |
| ENST00000633867 | 75605504 | 75605621 | Frame-shift |
| ENST00000633867 | 75612974 | 75613209 | Frame-shift |
| ENST00000633867 | 75616069 | 75616147 | Frame-shift |
| ENST00000633867 | 75617085 | 75617304 | Frame-shift |
| ENST00000633867 | 75619681 | 75619799 | Frame-shift |
| ENST00000633867 | 75602517 | 75602594 | In-frame |
| ENST00000633867 | 75615240 | 75615338 | In-frame |
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Infer the effects of exon skipping event on protein functional features for MYO15B |
p-ENSG00000266714_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000633867 | 6340 | 1530 | 75602517 | 75602594 | 476 | 552 | 158 | 184 |
| ENST00000633867 | 6340 | 1530 | 75615240 | 75615338 | 2466 | 2563 | 822 | 854 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q96JP2 | 158 | 184 | 1 | 1530 | Chain | ID=PRO_0000292047;Note=Unconventional myosin-XVB |
| Q96JP2 | 158 | 184 | 1 | 335 | Domain | Note=Myosin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00782 |
| Q96JP2 | 822 | 854 | 1 | 1530 | Chain | ID=PRO_0000292047;Note=Unconventional myosin-XVB |
| Q96JP2 | 822 | 854 | 820 | 865 | Compositional bias | Note=Met/Pro-rich |
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3'-UTR located exon skipping events that lost miRNA binding sites in MYO15B |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for MYO15B |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for MYO15B |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for MYO15B |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
| CB | exon_skip_56544 | rs736521 | chr17:75592461 | 1.008526e-08 | 6.350487e-06 |
| CB | exon_skip_56544 | rs820254 | chr17:75594355 | 4.814938e-05 | 9.550040e-03 |
| CB | exon_skip_56544 | rs820259 | chr17:75597493 | 4.857269e-05 | 9.611491e-03 |
| TC | exon_skip_56544 | rs736521 | chr17:75592461 | 6.155412e-11 | 6.329731e-08 |
| TC | exon_skip_56544 | rs820254 | chr17:75594355 | 8.190580e-06 | 2.094835e-03 |
| TC | exon_skip_56544 | rs820259 | chr17:75597493 | 8.190580e-06 | 2.094835e-03 |
| DLPFC | exon_skip_117012 | rs820256 | chr17:75594749 | 3.257826e-05 | 3.171311e-03 |
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Correlation with RNA binding proteins (RBPs) for MYO15B |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for MYO15B |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MYO15B |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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