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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for ZC3H14 |
 Gene summary |
| Gene information | Gene symbol | ZC3H14 | Gene ID | 79882 |
| Gene name | zinc finger CCCH-type containing 14 | |
| Synonyms | MRT56|MSUT-2|NY-REN-37|SUT2|UKp68 | |
| Cytomap | 14q31.3 | |
| Type of gene | protein-coding | |
| Description | zinc finger CCCH domain-containing protein 14mammalian suppressor of tau pathology-2nuclear protein UKp68renal carcinoma antigen NY-REN-37 | |
| Modification date | 20200313 | |
| UniProtAcc | A0A087WTC9, A0A3B3IT62, | |
| Context | - 32589834(Targeting Pathological Tau by Small Molecule Inhibition of the poly(A):MSUT2 RNA-protein Interaction) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for ZC3H14 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000100722
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | UP | ENST00000554602.5 | ZC3H14-209:protein_coding:ZC3H14 | 9.551828e+00 | 8.641295e-01 | 9.048173e-07 | 1.376762e-05 |
| CB | UP | ENST00000302216.12 | ZC3H14-202:protein_coding:ZC3H14 | 1.210119e+02 | 1.182752e+00 | 1.018240e-05 | 1.070227e-04 |
| CB | UP | ENST00000553495.5 | ZC3H14-207:nonsense_mediated_decay:ZC3H14 | 9.721623e-01 | 1.504418e+00 | 3.985049e-04 | 2.378720e-03 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for ZC3H14 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_108728 | chr14 | 88596734:88596808:88601924:88602083:88602828:88602900 | 88601924:88602083 |
| exon_skip_112403 | chr14 | 88563134:88563169:88563651:88563693:88568039:88568153 | 88563651:88563693 |
| exon_skip_143914 | chr14 | 88574291:88574346:88574430:88574522:88574693:88574853 | 88574430:88574522 |
| exon_skip_144320 | chr14 | 88577985:88578140:88596734:88596808:88601924:88602083 | 88596734:88596808 |
| exon_skip_163721 | chr14 | 88573711:88573758:88574291:88574346:88574693:88574853 | 88574291:88574346 |
| exon_skip_198093 | chr14 | 88563653:88563693:88568039:88568153:88571084:88571124 | 88568039:88568153 |
| exon_skip_204707 | chr14 | 88563651:88563693:88567858:88567916:88568039:88568153 | 88567858:88567916 |
| exon_skip_231542 | chr14 | 88572578:88573007:88573611:88573758:88574291:88574346 | 88573611:88573758 |
| exon_skip_24522 | chr14 | 88563653:88563693:88567858:88568153:88571084:88571124 | 88567858:88568153 |
| exon_skip_248483 | chr14 | 88572578:88573007:88574693:88574853:88575840:88575940 | 88574693:88574853 |
| exon_skip_250704 | chr14 | 88602035:88602083:88602828:88603045:88607243:88607363 | 88602828:88603045 |
| exon_skip_253825 | chr14 | 88609727:88609803:88610834:88610940:88611745:88611810 | 88610834:88610940 |
| exon_skip_280678 | chr14 | 88573693:88573758:88574291:88574346:88574693:88574853 | 88574291:88574346 |
| exon_skip_45810 | chr14 | 88574813:88574853:88575840:88575940:88577985:88578140 | 88575840:88575940 |
| exon_skip_49698 | chr14 | 88577985:88578140:88596734:88596808:88607243:88607363 | 88596734:88596808 |
| exon_skip_50248 | chr14 | 88563651:88563693:88567858:88568153:88571084:88571124 | 88567858:88568153 |
| exon_skip_50651 | chr14 | 88568039:88568153:88571084:88571124:88572030:88572113 | 88571084:88571124 |
| exon_skip_78372 | chr14 | 88602035:88602083:88602828:88603060:88607243:88607363 | 88602828:88603060 |
| exon_skip_9040 | chr14 | 88563026:88563169:88563651:88563693:88568039:88568153 | 88563651:88563693 |
| exon_skip_97511 | chr14 | 88563651:88563693:88568039:88568153:88571084:88571124 | 88568039:88568153 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
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| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
| exon_skip_49698 | MSBB_IFG | 5.226667e-01 | 4.136364e-01 | 1.090303e-01 | 3.228745e-02 |
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Open reading frame (ORF) annotation in the exon skipping event for ZC3H14 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000251038 | 88563651 | 88563693 | Frame-shift |
| ENST00000251038 | 88568039 | 88568153 | Frame-shift |
| ENST00000251038 | 88571084 | 88571124 | Frame-shift |
| ENST00000251038 | 88601924 | 88602083 | Frame-shift |
| ENST00000251038 | 88602828 | 88603060 | Frame-shift |
| ENST00000251038 | 88610834 | 88610940 | Frame-shift |
| ENST00000251038 | 88596734 | 88596808 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000251038 | 88563651 | 88563693 | Frame-shift |
| ENST00000251038 | 88568039 | 88568153 | Frame-shift |
| ENST00000251038 | 88571084 | 88571124 | Frame-shift |
| ENST00000251038 | 88601924 | 88602083 | Frame-shift |
| ENST00000251038 | 88596734 | 88596808 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000251038 | 88563651 | 88563693 | Frame-shift |
| ENST00000251038 | 88568039 | 88568153 | Frame-shift |
| ENST00000251038 | 88571084 | 88571124 | Frame-shift |
| ENST00000251038 | 88574693 | 88574853 | Frame-shift |
| ENST00000251038 | 88575840 | 88575940 | Frame-shift |
| ENST00000251038 | 88601924 | 88602083 | Frame-shift |
| ENST00000251038 | 88602828 | 88603060 | Frame-shift |
| ENST00000251038 | 88610834 | 88610940 | Frame-shift |
| ENST00000251038 | 88596734 | 88596808 | In-frame |
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Infer the effects of exon skipping event on protein functional features for ZC3H14 |
p-ENSG00000100722_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000251038 | 18298 | 736 | 88596734 | 88596808 | 1506 | 1579 | 427 | 451 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000251038 | 18298 | 736 | 88596734 | 88596808 | 1506 | 1579 | 427 | 451 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000251038 | 18298 | 736 | 88596734 | 88596808 | 1506 | 1579 | 427 | 451 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q6PJT7 | 427 | 451 | 1 | 454 | Alternative sequence | ID=VSP_033162;Note=In isoform 8. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1 |
| Q6PJT7 | 427 | 451 | 427 | 582 | Alternative sequence | ID=VSP_033166;Note=In isoform 3 and isoform 10. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|Ref.2;Dbxref=PMID:14702039 |
| Q6PJT7 | 427 | 451 | 427 | 451 | Alternative sequence | ID=VSP_033167;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.8 |
| Q6PJT7 | 427 | 451 | 1 | 736 | Chain | ID=PRO_0000331311;Note=Zinc finger CCCH domain-containing protein 14 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q6PJT7 | 427 | 451 | 1 | 454 | Alternative sequence | ID=VSP_033162;Note=In isoform 8. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1 |
| Q6PJT7 | 427 | 451 | 427 | 582 | Alternative sequence | ID=VSP_033166;Note=In isoform 3 and isoform 10. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|Ref.2;Dbxref=PMID:14702039 |
| Q6PJT7 | 427 | 451 | 427 | 451 | Alternative sequence | ID=VSP_033167;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.8 |
| Q6PJT7 | 427 | 451 | 1 | 736 | Chain | ID=PRO_0000331311;Note=Zinc finger CCCH domain-containing protein 14 |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q6PJT7 | 427 | 451 | 1 | 454 | Alternative sequence | ID=VSP_033162;Note=In isoform 8. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1 |
| Q6PJT7 | 427 | 451 | 427 | 582 | Alternative sequence | ID=VSP_033166;Note=In isoform 3 and isoform 10. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|Ref.2;Dbxref=PMID:14702039 |
| Q6PJT7 | 427 | 451 | 427 | 451 | Alternative sequence | ID=VSP_033167;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.8 |
| Q6PJT7 | 427 | 451 | 1 | 736 | Chain | ID=PRO_0000331311;Note=Zinc finger CCCH domain-containing protein 14 |
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3'-UTR located exon skipping events that lost miRNA binding sites in ZC3H14 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for ZC3H14 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for ZC3H14 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ZC3H14 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for ZC3H14 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| IFG | FUBP3 | exon_skip_144320 | -4.970060e-01 | 9.793718e-03 |
| IFG | RBMS3 | exon_skip_49698 | 4.405781e-01 | 2.427964e-02 |
| IFG | HNRNPD | exon_skip_49698 | 4.304597e-01 | 2.815276e-02 |
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RelatedDrugs for ZC3H14 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZC3H14 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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