|
Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for ZFAND1 |
Gene summary |
Gene information | Gene symbol | ZFAND1 | Gene ID | 79752 |
Gene name | zinc finger AN1-type containing 1 | |
Synonyms | - | |
Cytomap | 8q21.13 | |
Type of gene | protein-coding | |
Description | AN1-type zinc finger protein 1zinc finger AN1-type-containing protein 1zinc finger, AN1-type domain 1 | |
Modification date | 20200313 | |
UniProtAcc | ||
Context |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
Top |
Gene structures and expression levels for ZFAND1 |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
PG | DOWN | ENST00000523096.5 | ZFAND1-221:protein_coding:ZFAND1 | 3.651822e+01 | -1.008287e+00 | 1.617556e-03 | 2.056487e-02 |
CB | UP | ENST00000517450.5 | ZFAND1-203:protein_coding:ZFAND1 | 1.674836e+01 | 1.065115e+00 | 1.343400e-09 | 5.552972e-08 |
CB | UP | ENST00000521287.5 | ZFAND1-214:protein_coding:ZFAND1 | 6.405977e+01 | 8.841325e-01 | 1.082742e-06 | 1.604600e-05 |
CB | UP | ENST00000520635.5 | ZFAND1-212:protein_coding:ZFAND1 | 1.166282e+00 | 1.313631e+00 | 9.589263e-03 | 3.358414e-02 |
TC | UP | ENST00000517450.5 | ZFAND1-203:protein_coding:ZFAND1 | 6.568692e+00 | 8.623609e-01 | 3.944571e-05 | 7.686634e-04 |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
Top |
Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for ZFAND1 |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_162686 | chr8 | 81703099:81703124:81708788:81708829:81713918:81714039 | 81708788:81708829 |
exon_skip_167410 | chr8 | 81714987:81715114:81718182:81718224:81721249:81721282 | 81718182:81718224 |
exon_skip_188592 | chr8 | 81703099:81703124:81708788:81708829:81713918:81714031 | 81708788:81708829 |
exon_skip_279864 | chr8 | 81702969:81703103:81713918:81714039:81714804:81714895 | 81713918:81714039 |
exon_skip_48198 | chr8 | 81703099:81703124:81713918:81714039:81714804:81714895 | 81713918:81714039 |
exon_skip_49945 | chr8 | 81714987:81715114:81717249:81717288:81718182:81718224 | 81717249:81717288 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
exon_skip_49945 | ROSMAP_DLPFC | 2.487500e-01 | 3.519444e-01 | -1.031944e-01 | 2.413695e-02 |
Top |
Open reading frame (ORF) annotation in the exon skipping event for ZFAND1 |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000220669 | 81717249 | 81717288 | Frame-shift |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000220669 | 81713918 | 81714039 | Frame-shift |
ENST00000220669 | 81717249 | 81717288 | Frame-shift |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000220669 | 81713918 | 81714039 | Frame-shift |
ENST00000220669 | 81717249 | 81717288 | Frame-shift |
Top |
Infer the effects of exon skipping event on protein functional features for ZFAND1 |
p-ENSG00000104231_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Top |
3'-UTR located exon skipping events that lost miRNA binding sites in ZFAND1 |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
Top |
SNVs in the skipped exons for ZFAND1 |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
Top |
AD stage-associated exon skippint events for ZFAND1 |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
Top |
Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ZFAND1 |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
HCC | exon_skip_49945 | rs2142316 | chr8:81652967 | 7.803553e-04 | 4.813645e-02 |
Top |
Correlation with RNA binding proteins (RBPs) for ZFAND1 |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
CB | CNOT4 | exon_skip_49945 | -4.771031e-01 | 2.331783e-10 |
HCC | HNRNPF | exon_skip_49945 | -4.163359e-01 | 7.185273e-13 |
IFG | TRNAU1AP | exon_skip_162686 | -4.010289e-01 | 3.815991e-02 |
STG | SRSF11 | exon_skip_49945 | 4.167566e-01 | 1.203425e-04 |
TC | ELAVL4 | exon_skip_188592 | 5.158513e-01 | 2.933596e-12 |
TC | RALYL | exon_skip_188592 | 5.379872e-01 | 2.196113e-13 |
Top |
RelatedDrugs for ZFAND1 |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for ZFAND1 |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |