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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for ZNF322 |
Gene summary |
Gene information | Gene symbol | ZNF322 | Gene ID | 79692 |
Gene name | zinc finger protein 322 | |
Synonyms | HCG12|ZNF322A|ZNF388|ZNF489 | |
Cytomap | 6p22.2 | |
Type of gene | protein-coding | |
Description | zinc finger protein 322HLA complex group 12zinc finger protein 322Azinc finger protein 388zinc finger protein 489 | |
Modification date | 20200313 | |
UniProtAcc | C9JP13, Q6U7Q0, | |
Context |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for ZNF322 |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
PG | UP | ENST00000622479.4 | ZNF322-208:protein_coding:ZNF322 | 2.642378e+00 | 4.598690e+00 | 5.413029e-03 | 4.827446e-02 |
CB | UP | ENST00000465674.5 | ZNF322-204:lncRNA:ZNF322 | 1.212170e+00 | 1.864535e+00 | 1.254376e-02 | 4.179279e-02 |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for ZNF322 |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_225979 | chr6 | 26638640:26638728:26643659:26643728:26658558:26658646 | 26643659:26643728 |
exon_skip_258468 | chr6 | 26658558:26658646:26658777:26658851:26659441:26659689 | 26658777:26658851 |
exon_skip_291441 | chr6 | 26638476:26638728:26643659:26643728:26658558:26658646 | 26643659:26643728 |
exon_skip_570 | chr6 | 26658558:26658646:26658777:26658851:26659441:26659685 | 26658777:26658851 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for ZNF322 |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000415922 | 26643659 | 26643728 | 3UTR-3UTR |
ENST00000622479 | 26643659 | 26643728 | 3UTR-3UTR |
ENST00000622479 | 26658777 | 26658851 | 3UTR-3UTR |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000622479 | 26658777 | 26658851 | 3UTR-3UTR |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000415922 | 26643659 | 26643728 | 3UTR-3UTR |
ENST00000622479 | 26643659 | 26643728 | 3UTR-3UTR |
ENST00000622479 | 26658777 | 26658851 | 3UTR-3UTR |
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Infer the effects of exon skipping event on protein functional features for ZNF322 |
p-ENSG00000181315_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in ZNF322 |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
Mayo | ENST00000622479 | 26643659 | 26643728 | hsa-miR-4307 | chr6:26643677-26643684 | 8mer-1a | chr6:26643662-26643686 | 157.00 | -17.75 |
Mayo | ENST00000622479 | 26658777 | 26658851 | hsa-miR-4722-5p | chr6:26658804-26658811 | 8mer-1a | chr6:26658788-26658811 | 154.00 | -21.40 |
Mayo | ENST00000622479 | 26658777 | 26658851 | hsa-miR-4736 | chr6:26658818-26658825 | 8mer-1a | chr6:26658816-26658837 | 147.00 | -19.44 |
Mayo | ENST00000622479 | 26643659 | 26643728 | hsa-miR-567 | chr6:26643679-26643686 | 8mer-1a | chr6:26643662-26643686 | 157.00 | -17.75 |
MSBB | ENST00000622479 | 26658777 | 26658851 | hsa-miR-4722-5p | chr6:26658804-26658811 | 8mer-1a | chr6:26658788-26658811 | 154.00 | -21.40 |
MSBB | ENST00000622479 | 26658777 | 26658851 | hsa-miR-4736 | chr6:26658818-26658825 | 8mer-1a | chr6:26658816-26658837 | 147.00 | -19.44 |
ROSMAP | ENST00000622479 | 26643659 | 26643728 | hsa-miR-4307 | chr6:26643677-26643684 | 8mer-1a | chr6:26643662-26643686 | 157.00 | -17.75 |
ROSMAP | ENST00000622479 | 26658777 | 26658851 | hsa-miR-4722-5p | chr6:26658804-26658811 | 8mer-1a | chr6:26658788-26658811 | 154.00 | -21.40 |
ROSMAP | ENST00000622479 | 26658777 | 26658851 | hsa-miR-4736 | chr6:26658818-26658825 | 8mer-1a | chr6:26658816-26658837 | 147.00 | -19.44 |
ROSMAP | ENST00000622479 | 26643659 | 26643728 | hsa-miR-567 | chr6:26643679-26643686 | 8mer-1a | chr6:26643662-26643686 | 157.00 | -17.75 |
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SNVs in the skipped exons for ZNF322 |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for ZNF322 |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ZNF322 |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for ZNF322 |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for ZNF322 |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZNF322 |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |