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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for BAG6 |
 Gene summary |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| BAG6 | GO:0002429 | immune response-activating cell surface receptor signaling pathway | 18852879 |
| BAG6 | GO:0006915 | apoptotic process | 14960581 |
| BAG6 | GO:0018393 | internal peptidyl-lysine acetylation | 17403783 |
| BAG6 | GO:0030101 | natural killer cell activation | 18852879 |
| BAG6 | GO:0030433 | ubiquitin-dependent ERAD pathway | 23129660|24981174 |
| BAG6 | GO:0071712 | ER-associated misfolded protein catabolic process | 23129660|24981174 |
| BAG6 | GO:0071816 | tail-anchored membrane protein insertion into ER membrane | 20676083|25535373 |
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Gene structures and expression levels for BAG6 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000204463
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | DOWN | ENST00000464126.1 | BAG6-258:lncRNA:BAG6 | 2.493832e+02 | -1.112059e+00 | 2.632787e-03 | 1.157912e-02 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for BAG6 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_104090 | chr6 | 31644082:31644194:31644525:31644602:31644946:31645069 | 31644525:31644602 |
| exon_skip_116592 | chr6 | 31646394:31646523:31647591:31647826:31648677:31648751 | 31647591:31647826 |
| exon_skip_124319 | chr6 | 31644317:31644414:31644525:31644602:31644946:31645041 | 31644525:31644602 |
| exon_skip_144521 | chr6 | 31640199:31640306:31640385:31640528:31640645:31640704 | 31640385:31640528 |
| exon_skip_164299 | chr6 | 31643890:31643977:31644082:31644194:31644946:31645198 | 31644082:31644194 |
| exon_skip_165579 | chr6 | 31643113:31643115:31643890:31643977:31644082:31644194 | 31643890:31643977 |
| exon_skip_170956 | chr6 | 31639029:31639226:31639500:31639646:31640199:31640234 | 31639500:31639646 |
| exon_skip_18467 | chr6 | 31640222:31640306:31640385:31640528:31640645:31640704 | 31640385:31640528 |
| exon_skip_196738 | chr6 | 31644082:31644194:31644307:31644414:31644525:31644602 | 31644307:31644414 |
| exon_skip_207261 | chr6 | 31639029:31639226:31639500:31639646:31640199:31640306 | 31639500:31639646 |
| exon_skip_208713 | chr6 | 31644082:31644194:31644525:31644602:31644946:31645041 | 31644525:31644602 |
| exon_skip_217976 | chr6 | 31643113:31643115:31643890:31643974:31644082:31644194 | 31643890:31643974 |
| exon_skip_248677 | chr6 | 31640292:31640306:31640385:31640528:31640645:31640704 | 31640385:31640528 |
| exon_skip_258779 | chr6 | 31643113:31643115:31643890:31643977:31644946:31645069 | 31643890:31643977 |
| exon_skip_263346 | chr6 | 31640792:31640938:31641104:31641228:31641320:31641422 | 31641104:31641228 |
| exon_skip_273905 | chr6 | 31649199:31649395:31649510:31649627:31651656:31651776 | 31649510:31649627 |
| exon_skip_27483 | chr6 | 31644082:31644194:31644525:31644629:31644946:31645069 | 31644525:31644629 |
| exon_skip_3162 | chr6 | 31644317:31644414:31644525:31644602:31644946:31645069 | 31644525:31644602 |
| exon_skip_3525 | chr6 | 31648677:31648751:31648911:31648964:31649199:31649395 | 31648911:31648964 |
| exon_skip_54568 | chr6 | 31646394:31646523:31647591:31647844:31648677:31648751 | 31647591:31647844 |
| exon_skip_67519 | chr6 | 31640199:31640306:31640385:31640528:31640645:31640689 | 31640385:31640528 |
| exon_skip_69700 | chr6 | 31643890:31643977:31644082:31644194:31644946:31645069 | 31644082:31644194 |
| exon_skip_87968 | chr6 | 31639029:31639226:31639500:31639646:31640199:31640285 | 31639500:31639646 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for BAG6 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
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Infer the effects of exon skipping event on protein functional features for BAG6 |
p-ENSG00000204463_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in BAG6 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for BAG6 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for BAG6 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for BAG6 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for BAG6 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | SRSF2 | exon_skip_18467 | 4.525867e-01 | 2.106079e-09 |
| CB | PCBP4 | exon_skip_18467 | 4.262171e-01 | 2.125113e-08 |
| CB | TRA2A | exon_skip_18467 | -4.106200e-01 | 7.621127e-08 |
| CB | RBM4B | exon_skip_18467 | -4.142603e-01 | 5.689511e-08 |
| IFG | TARDBP | exon_skip_3525 | -4.889472e-01 | 8.282381e-03 |
| IFG | ZNF326 | exon_skip_3525 | -4.688859e-01 | 1.183935e-02 |
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RelatedDrugs for BAG6 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for BAG6 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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