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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for DHX58 |
 Gene summary |
| Gene information | Gene symbol | DHX58 | Gene ID | 79132 |
| Gene name | DExH-box helicase 58 | |
| Synonyms | D11LGP2|D11lgp2e|LGP2|RLR-3 | |
| Cytomap | 17q21.2 | |
| Type of gene | protein-coding | |
| Description | probable ATP-dependent RNA helicase DHX58DEXH (Asp-Glu-X-His) box polypeptide 58RIG-I-like receptor 3RIG-I-like receptor LGP2RLRRNA helicase LGP2ortholog of mouse D11lgp2probable ATP-dependent helicase LGP2protein D11Lgp2 homolog | |
| Modification date | 20200322 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| DHX58 | GO:0032480 | negative regulation of type I interferon production | 21525357 |
| DHX58 | GO:0039536 | negative regulation of RIG-I signaling pathway | 18411269 |
| DHX58 | GO:0045088 | regulation of innate immune response | 18411269 |
| DHX58 | GO:0045824 | negative regulation of innate immune response | 21525357 |
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Gene structures and expression levels for DHX58 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000108771
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for DHX58 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_133810 | chr17 | 42111746:42111893:42112113:42112205:42112605:42112713 | 42112113:42112205 |
| exon_skip_135403 | chr17 | 42111296:42111497:42111746:42111893:42112113:42112205 | 42111746:42111893 |
| exon_skip_142884 | chr17 | 42102216:42102312:42103608:42103798:42104766:42104907 | 42103608:42103798 |
| exon_skip_188081 | chr17 | 42102216:42102312:42103608:42103798:42104766:42104881 | 42103608:42103798 |
| exon_skip_202700 | chr17 | 42104766:42104927:42105018:42105167:42107604:42107795 | 42105018:42105167 |
| exon_skip_21990 | chr17 | 42111296:42111497:42111725:42111893:42112113:42112205 | 42111725:42111893 |
| exon_skip_258243 | chr17 | 42111296:42111497:42111746:42111893:42112113:42112199 | 42111746:42111893 |
| exon_skip_280126 | chr17 | 42105018:42105167:42105736:42105989:42107604:42107689 | 42105736:42105989 |
| exon_skip_35752 | chr17 | 42105018:42105167:42105736:42105989:42107604:42107795 | 42105736:42105989 |
| exon_skip_84461 | chr17 | 42111296:42111497:42111725:42111893:42112113:42112199 | 42111725:42111893 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for DHX58 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000251642 | 42111725 | 42111893 | 3UTR-3CDS |
| ENST00000251642 | 42112113 | 42112205 | 3UTR-3UTR |
| ENST00000251642 | 42103608 | 42103798 | Frame-shift |
| ENST00000251642 | 42105736 | 42105989 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000251642 | 42111725 | 42111893 | 3UTR-3CDS |
| ENST00000251642 | 42103608 | 42103798 | Frame-shift |
| ENST00000251642 | 42105736 | 42105989 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000251642 | 42111725 | 42111893 | 3UTR-3CDS |
| ENST00000251642 | 42112113 | 42112205 | 3UTR-3UTR |
| ENST00000251642 | 42103608 | 42103798 | Frame-shift |
| ENST00000251642 | 42105736 | 42105989 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for DHX58 |
p-ENSG00000108771_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in DHX58 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
| Mayo | ENST00000251642 | 42112113 | 42112205 | hsa-miR-4424 | chr17:42112150-42112157 | 8mer-1a | chr17:42112140-42112160 | 154.00 | -25.28 |
| Mayo | ENST00000251642 | 42112113 | 42112205 | hsa-miR-9851-3p | chr17:42112161-42112168 | 8mer-1a | chr17:42112147-42112170 | 150.00 | -21.63 |
| Mayo | ENST00000251642 | 42112113 | 42112205 | hsa-miR-3160-3p | chr17:42112175-42112182 | 8mer-1a | chr17:42112169-42112185 | 162.00 | -24.62 |
| Mayo | ENST00000251642 | 42112113 | 42112205 | hsa-miR-8052 | chr17:42112141-42112148 | 8mer-1a | chr17:42112125-42112148 | 169.00 | -27.34 |
| Mayo | ENST00000251642 | 42112113 | 42112205 | hsa-miR-3199 | chr17:42112141-42112148 | 8mer-1a | chr17:42112125-42112148 | 169.00 | -27.34 |
| Mayo | ENST00000251642 | 42112113 | 42112205 | hsa-miR-3921 | chr17:42112179-42112186 | 8mer-1a | chr17:42112165-42112186 | 150.00 | -18.11 |
| Mayo | ENST00000251642 | 42112113 | 42112205 | hsa-miR-4653-5p | chr17:42112179-42112186 | 8mer-1a | chr17:42112165-42112186 | 150.00 | -18.11 |
| Mayo | ENST00000251642 | 42112113 | 42112205 | hsa-miR-593-5p | chr17:42112161-42112168 | 8mer-1a | chr17:42112147-42112170 | 150.00 | -21.63 |
| Mayo | ENST00000251642 | 42112113 | 42112205 | hsa-miR-4468 | chr17:42112170-42112177 | 8mer-1a | chr17:42112169-42112185 | 162.00 | -24.62 |
| ROSMAP | ENST00000251642 | 42112113 | 42112205 | hsa-miR-4424 | chr17:42112150-42112157 | 8mer-1a | chr17:42112140-42112160 | 154.00 | -25.28 |
| ROSMAP | ENST00000251642 | 42112113 | 42112205 | hsa-miR-9851-3p | chr17:42112161-42112168 | 8mer-1a | chr17:42112147-42112170 | 150.00 | -21.63 |
| ROSMAP | ENST00000251642 | 42112113 | 42112205 | hsa-miR-3160-3p | chr17:42112175-42112182 | 8mer-1a | chr17:42112169-42112185 | 162.00 | -24.62 |
| ROSMAP | ENST00000251642 | 42112113 | 42112205 | hsa-miR-8052 | chr17:42112141-42112148 | 8mer-1a | chr17:42112125-42112148 | 169.00 | -27.34 |
| ROSMAP | ENST00000251642 | 42112113 | 42112205 | hsa-miR-3199 | chr17:42112141-42112148 | 8mer-1a | chr17:42112125-42112148 | 169.00 | -27.34 |
| ROSMAP | ENST00000251642 | 42112113 | 42112205 | hsa-miR-3921 | chr17:42112179-42112186 | 8mer-1a | chr17:42112165-42112186 | 150.00 | -18.11 |
| ROSMAP | ENST00000251642 | 42112113 | 42112205 | hsa-miR-4653-5p | chr17:42112179-42112186 | 8mer-1a | chr17:42112165-42112186 | 150.00 | -18.11 |
| ROSMAP | ENST00000251642 | 42112113 | 42112205 | hsa-miR-593-5p | chr17:42112161-42112168 | 8mer-1a | chr17:42112147-42112170 | 150.00 | -21.63 |
| ROSMAP | ENST00000251642 | 42112113 | 42112205 | hsa-miR-4468 | chr17:42112170-42112177 | 8mer-1a | chr17:42112169-42112185 | 162.00 | -24.62 |
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SNVs in the skipped exons for DHX58 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for DHX58 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for DHX58 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for DHX58 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | RBM6 | exon_skip_142884 | -4.453876e-01 | 7.792861e-08 |
| CB | RBM45 | exon_skip_142884 | 5.176181e-01 | 1.770965e-10 |
| CB | RBM4B | exon_skip_142884 | -4.085989e-01 | 1.047180e-06 |
| CB | HNRNPK | exon_skip_35752 | -4.588390e-01 | 2.832133e-07 |
| CB | PCBP2 | exon_skip_35752 | -5.008378e-01 | 1.387283e-08 |
| CB | EIF4B | exon_skip_35752 | -4.058647e-01 | 7.461692e-06 |
| TC | RBM6 | exon_skip_188081 | -4.007589e-01 | 2.375378e-07 |
| TC | ILF2 | exon_skip_35752 | -4.058497e-01 | 6.530568e-07 |
| TC | NUP42 | exon_skip_35752 | -5.600010e-01 | 6.313367e-13 |
| TC | ESRP1 | exon_skip_35752 | -4.699612e-01 | 4.678958e-09 |
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RelatedDrugs for DHX58 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DHX58 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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