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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for DEK |
 Gene summary |
| Gene information | Gene symbol | DEK | Gene ID | 7913 |
| Gene name | DEK proto-oncogene | |
| Synonyms | D6S231E | |
| Cytomap | 6p22.3 | |
| Type of gene | protein-coding | |
| Description | protein DEKDEK oncogene (DNA binding) | |
| Modification date | 20200313 | |
| UniProtAcc | A0A494C028, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for DEK |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000124795
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | UP | ENST00000512145.1 | DEK-205:retained_intron:DEK | 6.639350e+00 | 8.354104e-01 | 5.708722e-07 | 9.308379e-06 |
| CB | UP | ENST00000505224.5 | DEK-203:nonsense_mediated_decay:DEK | 6.427404e+01 | 9.279317e-01 | 6.718397e-06 | 7.526819e-05 |
| CB | UP | ENST00000652576.1 | DEK-211:protein_coding:DEK | 3.218843e+01 | 1.173839e+00 | 8.786154e-06 | 9.466435e-05 |
| CB | UP | ENST00000244776.11 | DEK-201:protein_coding:DEK | 3.434106e+01 | 1.720898e+00 | 1.627643e-05 | 1.593721e-04 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for DEK |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_114543 | chr6 | 18237381:18237516:18244508:18244603:18249651:18249687 | 18244508:18244603 |
| exon_skip_115822 | chr6 | 18256361:18256455:18257953:18258062:18258304:18258405 | 18257953:18258062 |
| exon_skip_142630 | chr6 | 18258304:18258405:18263843:18263996:18264385:18264541 | 18263843:18263996 |
| exon_skip_161499 | chr6 | 18226174:18226242:18236452:18236596:18237381:18237516 | 18236452:18236596 |
| exon_skip_169156 | chr6 | 18257953:18258062:18258304:18258405:18263843:18263884 | 18258304:18258405 |
| exon_skip_172620 | chr6 | 18237381:18237516:18249651:18249839:18255731:18255851 | 18249651:18249839 |
| exon_skip_181282 | chr6 | 18225666:18225730:18226174:18226242:18236452:18236596 | 18226174:18226242 |
| exon_skip_207516 | chr6 | 18237381:18237516:18244508:18244603:18249651:18249839 | 18244508:18244603 |
| exon_skip_235468 | chr6 | 18255736:18255851:18256361:18256455:18257953:18258031 | 18256361:18256455 |
| exon_skip_269137 | chr6 | 18249727:18249839:18255731:18255851:18256361:18256374 | 18255731:18255851 |
| exon_skip_37549 | chr6 | 18258304:18258405:18263843:18263996:18264385:18264400 | 18263843:18263996 |
| exon_skip_39550 | chr6 | 18226174:18226242:18236452:18236600:18237381:18237516 | 18236452:18236600 |
| exon_skip_45387 | chr6 | 18249651:18249839:18255731:18255851:18256361:18256374 | 18255731:18255851 |
| exon_skip_47297 | chr6 | 18237381:18237516:18244508:18244603:18249651:18249679 | 18244508:18244603 |
| exon_skip_47663 | chr6 | 18257953:18258062:18258304:18258405:18263843:18263996 | 18258304:18258405 |
| exon_skip_88664 | chr6 | 18249651:18249839:18257953:18258062:18258304:18258405 | 18257953:18258062 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for DEK |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
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Infer the effects of exon skipping event on protein functional features for DEK |
p-ENSG00000124795_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in DEK |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for DEK |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for DEK |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for DEK |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for DEK |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for DEK |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DEK |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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