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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for ZFYVE21 |
 Gene summary |
| Gene information | Gene symbol | ZFYVE21 | Gene ID | 79038 |
| Gene name | zinc finger FYVE-type containing 21 | |
| Synonyms | HCVP7TP1|ZF21 | |
| Cytomap | 14q32.33 | |
| Type of gene | protein-coding | |
| Description | zinc finger FYVE domain-containing protein 21FYVE domain containing 21HCV p7-transactivated protein 1zinc finger, FYVE domain containing 21 | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for ZFYVE21 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000100711
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for ZFYVE21 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_129317 | chr14 | 103727454:103727914:103728908:103728983:103729091:103729367 | 103728908:103728983 |
| exon_skip_13409 | chr14 | 103727454:103727914:103728908:103728983:103729091:103730274 | 103728908:103728983 |
| exon_skip_134904 | chr14 | 103728908:103728983:103729091:103729182:103729793:103729846 | 103729091:103729182 |
| exon_skip_18780 | chr14 | 103728911:103728983:103729091:103729182:103732620:103732762 | 103729091:103729182 |
| exon_skip_190587 | chr14 | 103729091:103729182:103729793:103729846:103732620:103732762 | 103729793:103729846 |
| exon_skip_208787 | chr14 | 103729155:103729182:103729793:103729846:103732620:103732762 | 103729793:103729846 |
| exon_skip_237669 | chr14 | 103726792:103726842:103727746:103727914:103728908:103728983 | 103727746:103727914 |
| exon_skip_261705 | chr14 | 103727454:103727914:103728908:103728983:103729091:103731445 | 103728908:103728983 |
| exon_skip_277789 | chr14 | 103729091:103729182:103732620:103732762:103732983:103733662 | 103732620:103732762 |
| exon_skip_28290 | chr14 | 103729793:103729846:103732620:103732762:103732983:103733662 | 103732620:103732762 |
| exon_skip_294648 | chr14 | 103729155:103729182:103732620:103732762:103732983:103733662 | 103732620:103732762 |
| exon_skip_71805 | chr14 | 103728908:103728983:103729091:103729182:103732620:103732762 | 103729091:103729182 |
| exon_skip_85615 | chr14 | 103726792:103726842:103727559:103727914:103728908:103728983 | 103727559:103727914 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
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| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
| exon_skip_208787 | MSBB_PG | 4.970543e-01 | 6.220370e-01 | -1.249828e-01 | 2.669521e-03 |
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Open reading frame (ORF) annotation in the exon skipping event for ZFYVE21 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000311141 | 103727746 | 103727914 | Frame-shift |
| ENST00000311141 | 103728908 | 103728983 | Frame-shift |
| ENST00000311141 | 103729091 | 103729182 | Frame-shift |
| ENST00000311141 | 103732620 | 103732762 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000311141 | 103729091 | 103729182 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000311141 | 103727746 | 103727914 | Frame-shift |
| ENST00000311141 | 103728908 | 103728983 | Frame-shift |
| ENST00000311141 | 103729091 | 103729182 | Frame-shift |
| ENST00000311141 | 103732620 | 103732762 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for ZFYVE21 |
p-ENSG00000100711_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in ZFYVE21 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for ZFYVE21 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for ZFYVE21 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
| ADstage | ROSMAP | PCC | exon_skip_208787 | -3.313935e-01 | 6.620000e-07 | chr14 | + | 103729155 | 103729182 | 103729793 | 103729846 | 103732620 | 103732762 |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ZFYVE21 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for ZFYVE21 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | NUP42 | exon_skip_208787 | 5.366910e-01 | 3.054639e-13 |
| DLPFC | HNRNPL | exon_skip_208787 | 4.255481e-01 | 1.612167e-16 |
| DLPFC | SART3 | exon_skip_208787 | 4.172904e-01 | 6.955363e-16 |
| DLPFC | NOVA1 | exon_skip_208787 | 4.115177e-01 | 1.887615e-15 |
| FL | ILF2 | exon_skip_208787 | 5.319613e-01 | 1.029247e-15 |
| FL | NUP42 | exon_skip_208787 | 4.618801e-01 | 9.480600e-12 |
| FL | HNRNPL | exon_skip_208787 | 5.242640e-01 | 3.116065e-15 |
| FL | SRSF1 | exon_skip_208787 | 4.539134e-01 | 2.360239e-11 |
| FL | SRSF9 | exon_skip_208787 | 5.228812e-01 | 3.790969e-15 |
| FL | HNRNPH2 | exon_skip_208787 | 4.688793e-01 | 4.171339e-12 |
| FL | NOVA1 | exon_skip_208787 | 4.615955e-01 | 9.798658e-12 |
| HCC | PABPN1 | exon_skip_208787 | -4.623142e-01 | 7.312822e-16 |
| HCC | RBM5 | exon_skip_208787 | -4.842427e-01 | 1.863004e-17 |
| PG | ILF2 | exon_skip_208787 | 5.775274e-01 | 1.142835e-17 |
| PG | NUP42 | exon_skip_208787 | 5.853175e-01 | 3.269365e-18 |
| PG | HNRNPL | exon_skip_208787 | 6.042496e-01 | 1.352059e-19 |
| PG | PABPC4 | exon_skip_208787 | 4.133748e-01 | 6.029029e-09 |
| PG | SRSF1 | exon_skip_208787 | 4.756037e-01 | 1.019618e-11 |
| PG | SRSF9 | exon_skip_208787 | 4.809961e-01 | 5.506454e-12 |
| PG | HNRNPH2 | exon_skip_208787 | 6.094154e-01 | 5.461898e-20 |
| PG | SART3 | exon_skip_208787 | 5.392794e-01 | 3.376111e-15 |
| PG | NOVA1 | exon_skip_208787 | 6.240129e-01 | 3.847365e-21 |
| STG | IGF2BP2 | exon_skip_208787 | -4.465367e-01 | 9.137833e-06 |
| STG | ILF2 | exon_skip_208787 | 4.673882e-01 | 3.000534e-06 |
| STG | NUP42 | exon_skip_208787 | 4.747038e-01 | 1.994540e-06 |
| STG | HNRNPL | exon_skip_208787 | 4.816807e-01 | 1.339177e-06 |
| STG | SRSF1 | exon_skip_208787 | 4.275130e-01 | 2.372584e-05 |
| STG | SRSF9 | exon_skip_208787 | 4.508634e-01 | 7.295945e-06 |
| STG | HNRNPH2 | exon_skip_208787 | 4.978212e-01 | 5.148238e-07 |
| STG | SART3 | exon_skip_208787 | 4.005585e-01 | 8.343073e-05 |
| STG | NOVA1 | exon_skip_208787 | 4.622659e-01 | 3.971631e-06 |
| TC | ILF2 | exon_skip_208787 | 4.127632e-01 | 5.829150e-08 |
| TC | NUP42 | exon_skip_208787 | 6.508166e-01 | 1.214190e-20 |
| TC | HNRNPH2 | exon_skip_208787 | 6.211001e-01 | 1.918449e-18 |
| TC | ESRP1 | exon_skip_208787 | 5.537096e-01 | 3.095323e-14 |
| TC | NOVA1 | exon_skip_208787 | 6.907002e-01 | 5.211506e-24 |
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RelatedDrugs for ZFYVE21 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZFYVE21 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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