|
||||||
|
 | |
| |
| |
| Open reading frame (ORF) annotation in the exon skipping event |
| |
| 3'-UTR located exon skipping events lost miRNA binding sites |
| |
| |
| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| |
| |
|
Gene summary for DAP3 |
 Gene summary |
| Gene information | Gene symbol | DAP3 | Gene ID | 7818 |
| Gene name | death associated protein 3 | |
| Synonyms | DAP-3|MRP-S29|MRPS29|S29mt|bMRP-10 | |
| Cytomap | 1q22 | |
| Type of gene | protein-coding | |
| Description | 28S ribosomal protein S29, mitochondrialionizing radiation resistance conferring proteinmitochondrial 28S ribosomal protein S29mitochondrial small ribosomal subunit protein mS29 | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
Top |
Gene structures and expression levels for DAP3 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
ENSG00000132676
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
 |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | DOWN | ENST00000535183.5 | DAP3-225:protein_coding:DAP3 | 1.266066e+02 | -9.778857e-01 | 1.479582e-06 | 2.091998e-05 |
| TC | DOWN | ENST00000491777.2 | DAP3-221:protein_coding:DAP3 | 1.322334e+00 | -2.817735e+00 | 1.195624e-04 | 1.864474e-03 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
 |
Top |
Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for DAP3 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
 |
| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_127858 | chr1 | 155725992:155726019:155727608:155727738:155729042:155729064 | 155727608:155727738 |
| exon_skip_138453 | chr1 | 155732022:155732033:155736608:155736694:155736946:155737063 | 155736608:155736694 |
| exon_skip_139844 | chr1 | 155727683:155727738:155729042:155729122:155729208:155729261 | 155729042:155729122 |
| exon_skip_145302 | chr1 | 155689102:155689174:155709773:155709824:155717006:155717128 | 155709773:155709824 |
| exon_skip_157464 | chr1 | 155731356:155731415:155731944:155732033:155738157:155738258 | 155731944:155732033 |
| exon_skip_157883 | chr1 | 155727608:155727738:155729042:155729122:155729208:155729242 | 155729042:155729122 |
| exon_skip_182188 | chr1 | 155689102:155689174:155709773:155709824:155721517:155721618 | 155709773:155709824 |
| exon_skip_21924 | chr1 | 155709801:155709824:155721517:155721618:155725382:155725411 | 155721517:155721618 |
| exon_skip_220928 | chr1 | 155709801:155709824:155717006:155717128:155721517:155721614 | 155717006:155717128 |
| exon_skip_238215 | chr1 | 155731944:155732033:155736946:155737063:155738157:155738258 | 155736946:155737063 |
| exon_skip_239848 | chr1 | 155725382:155725411:155725992:155726019:155727608:155727738 | 155725992:155726019 |
| exon_skip_242236 | chr1 | 155687991:155688192:155689095:155689174:155709773:155709824 | 155689095:155689174 |
| exon_skip_24904 | chr1 | 155709801:155709824:155717006:155717128:155721517:155721618 | 155717006:155717128 |
| exon_skip_249687 | chr1 | 155689102:155689174:155709033:155709125:155709773:155709824 | 155709033:155709125 |
| exon_skip_271398 | chr1 | 155721517:155721618:155725992:155726019:155727608:155727738 | 155725992:155726019 |
| exon_skip_274324 | chr1 | 155689091:155689243:155709773:155709824:155717006:155717128 | 155709773:155709824 |
| exon_skip_276909 | chr1 | 155731944:155732033:155736608:155736694:155736946:155737063 | 155736608:155736694 |
| exon_skip_293727 | chr1 | 155717006:155717128:155721517:155721618:155725382:155725411 | 155721517:155721618 |
| exon_skip_34704 | chr1 | 155731982:155732033:155736946:155737063:155738157:155738258 | 155736946:155737063 |
| exon_skip_38720 | chr1 | 155731944:155732033:155737006:155737063:155738157:155738258 | 155737006:155737063 |
| exon_skip_41376 | chr1 | 155709801:155709824:155717006:155717128:155725382:155725411 | 155717006:155717128 |
| exon_skip_46116 | chr1 | 155725992:155726019:155727608:155727738:155729208:155729261 | 155727608:155727738 |
| exon_skip_49254 | chr1 | 155729341:155729366:155731356:155731415:155736946:155737063 | 155731356:155731415 |
| exon_skip_58182 | chr1 | 155731356:155731415:155736946:155737063:155738157:155738258 | 155736946:155737063 |
| exon_skip_67471 | chr1 | 155721517:155721618:155725382:155725411:155725992:155726019 | 155725382:155725411 |
| exon_skip_69586 | chr1 | 155731356:155731415:155731944:155732033:155736946:155737063 | 155731944:155732033 |
| exon_skip_77351 | chr1 | 155727608:155727738:155729042:155729122:155729208:155729261 | 155729042:155729122 |
| exon_skip_81260 | chr1 | 155731982:155732033:155737006:155737063:155738157:155738258 | 155737006:155737063 |
| exon_skip_95446 | chr1 | 155727608:155727738:155729208:155729366:155731356:155731411 | 155729208:155729366 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
 |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
| exon_skip_157883 | Mayo_CB | 6.797561e-01 | 7.980519e-01 | -1.182959e-01 | 4.457834e-07 |
Top |
Open reading frame (ORF) annotation in the exon skipping event for DAP3 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000368336 | 155709773 | 155709824 | 5CDS-5UTR |
| ENST00000343043 | 155727608 | 155727738 | Frame-shift |
| ENST00000368336 | 155727608 | 155727738 | Frame-shift |
| ENST00000343043 | 155736946 | 155737063 | Frame-shift |
| ENST00000368336 | 155736946 | 155737063 | Frame-shift |
| ENST00000343043 | 155717006 | 155717128 | In-frame |
| ENST00000368336 | 155717006 | 155717128 | In-frame |
| ENST00000343043 | 155721517 | 155721618 | In-frame |
| ENST00000368336 | 155721517 | 155721618 | In-frame |
| ENST00000343043 | 155729042 | 155729122 | In-frame |
| ENST00000368336 | 155729042 | 155729122 | In-frame |
| ENST00000343043 | 155731944 | 155732033 | In-frame |
| ENST00000368336 | 155731944 | 155732033 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000343043 | 155709773 | 155709824 | 5CDS-5UTR |
| ENST00000368336 | 155709773 | 155709824 | 5CDS-5UTR |
| ENST00000343043 | 155727608 | 155727738 | Frame-shift |
| ENST00000368336 | 155727608 | 155727738 | Frame-shift |
| ENST00000343043 | 155717006 | 155717128 | In-frame |
| ENST00000368336 | 155717006 | 155717128 | In-frame |
| ENST00000343043 | 155721517 | 155721618 | In-frame |
| ENST00000368336 | 155721517 | 155721618 | In-frame |
| ENST00000343043 | 155729042 | 155729122 | In-frame |
| ENST00000368336 | 155729042 | 155729122 | In-frame |
| ENST00000343043 | 155731944 | 155732033 | In-frame |
| ENST00000368336 | 155731944 | 155732033 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000343043 | 155709773 | 155709824 | 5CDS-5UTR |
| ENST00000368336 | 155709773 | 155709824 | 5CDS-5UTR |
| ENST00000343043 | 155727608 | 155727738 | Frame-shift |
| ENST00000368336 | 155727608 | 155727738 | Frame-shift |
| ENST00000343043 | 155736946 | 155737063 | Frame-shift |
| ENST00000368336 | 155736946 | 155737063 | Frame-shift |
| ENST00000343043 | 155717006 | 155717128 | In-frame |
| ENST00000368336 | 155717006 | 155717128 | In-frame |
| ENST00000343043 | 155721517 | 155721618 | In-frame |
| ENST00000368336 | 155721517 | 155721618 | In-frame |
| ENST00000343043 | 155729042 | 155729122 | In-frame |
| ENST00000368336 | 155729042 | 155729122 | In-frame |
| ENST00000343043 | 155731944 | 155732033 | In-frame |
| ENST00000368336 | 155731944 | 155732033 | In-frame |
Top |
Infer the effects of exon skipping event on protein functional features for DAP3 |
p-ENSG00000132676_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000343043 | 1666 | 398 | 155717006 | 155717128 | 215 | 336 | 15 | 56 |
| ENST00000368336 | 2106 | 398 | 155717006 | 155717128 | 171 | 292 | 15 | 56 |
| ENST00000343043 | 1666 | 398 | 155721517 | 155721618 | 338 | 438 | 56 | 90 |
| ENST00000368336 | 2106 | 398 | 155721517 | 155721618 | 294 | 394 | 56 | 90 |
| ENST00000343043 | 1666 | 398 | 155729042 | 155729122 | 773 | 852 | 201 | 228 |
| ENST00000368336 | 2106 | 398 | 155729042 | 155729122 | 729 | 808 | 201 | 228 |
| ENST00000343043 | 1666 | 398 | 155731944 | 155732033 | 1073 | 1161 | 301 | 331 |
| ENST00000368336 | 2106 | 398 | 155731944 | 155732033 | 1029 | 1117 | 301 | 331 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000343043 | 1666 | 398 | 155717006 | 155717128 | 215 | 336 | 15 | 56 |
| ENST00000368336 | 2106 | 398 | 155717006 | 155717128 | 171 | 292 | 15 | 56 |
| ENST00000343043 | 1666 | 398 | 155721517 | 155721618 | 338 | 438 | 56 | 90 |
| ENST00000368336 | 2106 | 398 | 155721517 | 155721618 | 294 | 394 | 56 | 90 |
| ENST00000343043 | 1666 | 398 | 155729042 | 155729122 | 773 | 852 | 201 | 228 |
| ENST00000368336 | 2106 | 398 | 155729042 | 155729122 | 729 | 808 | 201 | 228 |
| ENST00000343043 | 1666 | 398 | 155731944 | 155732033 | 1073 | 1161 | 301 | 331 |
| ENST00000368336 | 2106 | 398 | 155731944 | 155732033 | 1029 | 1117 | 301 | 331 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000343043 | 1666 | 398 | 155717006 | 155717128 | 215 | 336 | 15 | 56 |
| ENST00000368336 | 2106 | 398 | 155717006 | 155717128 | 171 | 292 | 15 | 56 |
| ENST00000343043 | 1666 | 398 | 155721517 | 155721618 | 338 | 438 | 56 | 90 |
| ENST00000368336 | 2106 | 398 | 155721517 | 155721618 | 294 | 394 | 56 | 90 |
| ENST00000343043 | 1666 | 398 | 155729042 | 155729122 | 773 | 852 | 201 | 228 |
| ENST00000368336 | 2106 | 398 | 155729042 | 155729122 | 729 | 808 | 201 | 228 |
| ENST00000343043 | 1666 | 398 | 155731944 | 155732033 | 1073 | 1161 | 301 | 331 |
| ENST00000368336 | 2106 | 398 | 155731944 | 155732033 | 1029 | 1117 | 301 | 331 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P51398 | 15 | 56 | 16 | 56 | Alternative sequence | ID=VSP_042790;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| P51398 | 15 | 56 | 16 | 56 | Alternative sequence | ID=VSP_042790;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| P51398 | 15 | 56 | 22 | 398 | Chain | ID=PRO_0000087717;Note=28S ribosomal protein S29%2C mitochondrial |
| P51398 | 15 | 56 | 22 | 398 | Chain | ID=PRO_0000087717;Note=28S ribosomal protein S29%2C mitochondrial |
| P51398 | 15 | 56 | 1 | 21 | Transit peptide | Note=Mitochondrion;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P51398 | 15 | 56 | 1 | 21 | Transit peptide | Note=Mitochondrion;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P51398 | 56 | 90 | 16 | 56 | Alternative sequence | ID=VSP_042790;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| P51398 | 56 | 90 | 16 | 56 | Alternative sequence | ID=VSP_042790;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| P51398 | 56 | 90 | 57 | 90 | Alternative sequence | ID=VSP_044639;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| P51398 | 56 | 90 | 57 | 90 | Alternative sequence | ID=VSP_044639;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| P51398 | 56 | 90 | 22 | 398 | Chain | ID=PRO_0000087717;Note=28S ribosomal protein S29%2C mitochondrial |
| P51398 | 56 | 90 | 22 | 398 | Chain | ID=PRO_0000087717;Note=28S ribosomal protein S29%2C mitochondrial |
| P51398 | 201 | 228 | 22 | 398 | Chain | ID=PRO_0000087717;Note=28S ribosomal protein S29%2C mitochondrial |
| P51398 | 201 | 228 | 22 | 398 | Chain | ID=PRO_0000087717;Note=28S ribosomal protein S29%2C mitochondrial |
| P51398 | 201 | 228 | 207 | 207 | Modified residue | Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861 |
| P51398 | 201 | 228 | 207 | 207 | Modified residue | Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861 |
| P51398 | 301 | 331 | 22 | 398 | Chain | ID=PRO_0000087717;Note=28S ribosomal protein S29%2C mitochondrial |
| P51398 | 301 | 331 | 22 | 398 | Chain | ID=PRO_0000087717;Note=28S ribosomal protein S29%2C mitochondrial |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P51398 | 15 | 56 | 16 | 56 | Alternative sequence | ID=VSP_042790;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| P51398 | 15 | 56 | 16 | 56 | Alternative sequence | ID=VSP_042790;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| P51398 | 15 | 56 | 22 | 398 | Chain | ID=PRO_0000087717;Note=28S ribosomal protein S29%2C mitochondrial |
| P51398 | 15 | 56 | 22 | 398 | Chain | ID=PRO_0000087717;Note=28S ribosomal protein S29%2C mitochondrial |
| P51398 | 15 | 56 | 1 | 21 | Transit peptide | Note=Mitochondrion;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P51398 | 15 | 56 | 1 | 21 | Transit peptide | Note=Mitochondrion;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P51398 | 56 | 90 | 16 | 56 | Alternative sequence | ID=VSP_042790;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| P51398 | 56 | 90 | 16 | 56 | Alternative sequence | ID=VSP_042790;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| P51398 | 56 | 90 | 57 | 90 | Alternative sequence | ID=VSP_044639;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| P51398 | 56 | 90 | 57 | 90 | Alternative sequence | ID=VSP_044639;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| P51398 | 56 | 90 | 22 | 398 | Chain | ID=PRO_0000087717;Note=28S ribosomal protein S29%2C mitochondrial |
| P51398 | 56 | 90 | 22 | 398 | Chain | ID=PRO_0000087717;Note=28S ribosomal protein S29%2C mitochondrial |
| P51398 | 201 | 228 | 22 | 398 | Chain | ID=PRO_0000087717;Note=28S ribosomal protein S29%2C mitochondrial |
| P51398 | 201 | 228 | 22 | 398 | Chain | ID=PRO_0000087717;Note=28S ribosomal protein S29%2C mitochondrial |
| P51398 | 201 | 228 | 207 | 207 | Modified residue | Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861 |
| P51398 | 201 | 228 | 207 | 207 | Modified residue | Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861 |
| P51398 | 301 | 331 | 22 | 398 | Chain | ID=PRO_0000087717;Note=28S ribosomal protein S29%2C mitochondrial |
| P51398 | 301 | 331 | 22 | 398 | Chain | ID=PRO_0000087717;Note=28S ribosomal protein S29%2C mitochondrial |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P51398 | 15 | 56 | 16 | 56 | Alternative sequence | ID=VSP_042790;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| P51398 | 15 | 56 | 16 | 56 | Alternative sequence | ID=VSP_042790;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| P51398 | 15 | 56 | 22 | 398 | Chain | ID=PRO_0000087717;Note=28S ribosomal protein S29%2C mitochondrial |
| P51398 | 15 | 56 | 22 | 398 | Chain | ID=PRO_0000087717;Note=28S ribosomal protein S29%2C mitochondrial |
| P51398 | 15 | 56 | 1 | 21 | Transit peptide | Note=Mitochondrion;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P51398 | 15 | 56 | 1 | 21 | Transit peptide | Note=Mitochondrion;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P51398 | 56 | 90 | 16 | 56 | Alternative sequence | ID=VSP_042790;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| P51398 | 56 | 90 | 16 | 56 | Alternative sequence | ID=VSP_042790;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| P51398 | 56 | 90 | 57 | 90 | Alternative sequence | ID=VSP_044639;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| P51398 | 56 | 90 | 57 | 90 | Alternative sequence | ID=VSP_044639;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| P51398 | 56 | 90 | 22 | 398 | Chain | ID=PRO_0000087717;Note=28S ribosomal protein S29%2C mitochondrial |
| P51398 | 56 | 90 | 22 | 398 | Chain | ID=PRO_0000087717;Note=28S ribosomal protein S29%2C mitochondrial |
| P51398 | 201 | 228 | 22 | 398 | Chain | ID=PRO_0000087717;Note=28S ribosomal protein S29%2C mitochondrial |
| P51398 | 201 | 228 | 22 | 398 | Chain | ID=PRO_0000087717;Note=28S ribosomal protein S29%2C mitochondrial |
| P51398 | 201 | 228 | 207 | 207 | Modified residue | Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861 |
| P51398 | 201 | 228 | 207 | 207 | Modified residue | Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861 |
| P51398 | 301 | 331 | 22 | 398 | Chain | ID=PRO_0000087717;Note=28S ribosomal protein S29%2C mitochondrial |
| P51398 | 301 | 331 | 22 | 398 | Chain | ID=PRO_0000087717;Note=28S ribosomal protein S29%2C mitochondrial |
Top |
3'-UTR located exon skipping events that lost miRNA binding sites in DAP3 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
Top |
SNVs in the skipped exons for DAP3 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
Top |
AD stage-associated exon skippint events for DAP3 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
Top |
Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for DAP3 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
Top |
Correlation with RNA binding proteins (RBPs) for DAP3 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | PCBP4 | exon_skip_293727 | 4.927361e-01 | 4.817260e-11 |
| CB | SNRPA | exon_skip_293727 | -4.034727e-01 | 1.468226e-07 |
| CB | FUBP1 | exon_skip_293727 | -5.081086e-01 | 9.434050e-12 |
| CB | TARDBP | exon_skip_157883 | -4.059807e-01 | 1.100589e-07 |
| CB | RBM3 | exon_skip_157883 | 5.008383e-01 | 1.778035e-11 |
| CB | NUP42 | exon_skip_157883 | 4.150885e-01 | 5.320920e-08 |
| CB | TARDBP | exon_skip_206151 | -4.093698e-01 | 8.419156e-08 |
| CB | FUBP1 | exon_skip_206151 | -4.109276e-01 | 7.436198e-08 |
| DLPFC | RBM3 | exon_skip_139844 | 5.148497e-01 | 6.439473e-18 |
| FL | RBM3 | exon_skip_77351 | 5.712532e-01 | 3.057481e-17 |
| HCC | RBM3 | exon_skip_77351 | 5.478192e-01 | 8.803769e-23 |
| IFG | ELAVL4 | exon_skip_24904 | 4.229467e-01 | 2.493497e-02 |
| IFG | TARDBP | exon_skip_77351 | -4.186436e-01 | 2.660775e-02 |
| IFG | RBM3 | exon_skip_77351 | 6.426330e-01 | 2.264248e-04 |
| IFG | SNRNP70 | exon_skip_77351 | -4.652509e-01 | 1.260362e-02 |
| PCC | RBM3 | exon_skip_77351 | 5.471639e-01 | 4.947467e-18 |
| PG | RBM3 | exon_skip_77351 | 4.805396e-01 | 3.790758e-11 |
| TC | RBM3 | exon_skip_139844 | 4.398850e-01 | 5.884611e-09 |
Top |
RelatedDrugs for DAP3 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for DAP3 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|