ExonSkipAD: functional annotation of exon skipping event in human

Gene summary for CSDE1

Gene summary

Gene information	Gene symbol	CSDE1
	Gene ID	7812
	Gene name	cold shock domain containing E1
	Synonyms	D1S155E\|UNR
	Cytomap	1p13.2
	Type of gene	protein-coding
	Description	cold shock domain-containing protein E1N-ras upstream gene proteinNRAS-relatedcold shock domain containing E1, RNA bindingupstream of NRAS
	Modification date	20200313
	UniProtAcc	A0A024R0E2, A0A024R0K2, A0A1Y8EMC9, E9PJK7, E9PKN4, E9PLD4, E9PLT0, E9PNG3, O75534, Q8WU01,
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene

GO ID

GO term

PubMed ID

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Gene structures and expression levels for CSDE1

Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

ENSG00000009307

Differentially expressed gene analysis across multiple brain tissues between AD and control.

Tissue type

DEG direction

Base mean exp.

log2FC(AD/control)

P-value

Adj. p-value

Differentially expressed isoform analysis across multiple brain tissues between AD and control.

Tissue type	DEG direction	ENST	Transcript info.	Base mean exp.	log2FC(AD/control)	P-value	Adjc. p-value
STG	UP	ENST00000261443.9	CSDE1-201:protein_coding:CSDE1	1.104170e+02	7.710630e+00	9.201610e-06	2.598503e-03
CB	UP	ENST00000525970.5	CSDE1-211:protein_coding:CSDE1	5.805718e+00	1.661311e+00	1.533474e-04	1.064933e-03
CB	UP	ENST00000530886.5	CSDE1-214:protein_coding:CSDE1	1.240239e+02	9.840758e-01	9.025017e-04	4.736965e-03
CB	UP	ENST00000529046.5	CSDE1-212:protein_coding:CSDE1	7.409388e-01	1.862551e+00	4.545556e-03	1.819709e-02

Landscape of isoform expressions across multiple brain tissues between AD and control.

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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for CSDE1

Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap).

All exon skipping events in AD cohorts.

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon
exon_skip_100830	chr1	114730508:114730648:114732604:114732816:114733732:114733857	114732604:114732816
exon_skip_107092	chr1	114726211:114726386:114726983:114727090:114730258:114730422	114726983:114727090
exon_skip_1311	chr1	114737988:114738072:114739692:114739890:114749821:114749904	114739692:114739890
exon_skip_141406	chr1	114739753:114739890:114741527:114741673:114749821:114749904	114741527:114741673
exon_skip_156337	chr1	114739858:114739890:114749821:114750207:114757925:114757969	114749821:114750207
exon_skip_161230	chr1	114739753:114739890:114741527:114741673:114749821:114750190	114741527:114741673
exon_skip_16572	chr1	114750149:114750207:114756777:114756888:114757925:114757969	114756777:114756888
exon_skip_175498	chr1	114736758:114736855:114737471:114737563:114737963:114738072	114737471:114737563
exon_skip_18209	chr1	114718735:114718745:114719579:114719742:114720539:114720717	114719579:114719742
exon_skip_188700	chr1	114737988:114738072:114739692:114739890:114757925:114757969	114739692:114739890
exon_skip_190311	chr1	114730258:114730422:114730508:114730648:114732604:114732816	114730508:114730648
exon_skip_19165	chr1	114733769:114733857:114733989:114734117:114734442:114734523	114733989:114734117
exon_skip_193198	chr1	114749821:114750207:114756777:114756888:114757925:114757987	114756777:114756888
exon_skip_196590	chr1	114730258:114730422:114730508:114730648:114732604:114732636	114730508:114730648
exon_skip_205515	chr1	114725221:114725333:114726211:114726386:114726983:114727090	114726211:114726386
exon_skip_206742	chr1	114730529:114730648:114732604:114732816:114733732:114733857	114732604:114732816
exon_skip_217395	chr1	114737963:114738072:114739692:114739890:114749821:114749904	114739692:114739890
exon_skip_23801	chr1	114736758:114736855:114737471:114737563:114737963:114738004	114737471:114737563
exon_skip_258279	chr1	114733989:114734117:114734442:114734523:114736758:114736855	114734442:114734523
exon_skip_273461	chr1	114718613:114718745:114719579:114719742:114720539:114720717	114719579:114719742
exon_skip_280074	chr1	114737963:114738072:114739692:114739890:114757925:114757987	114739692:114739890
exon_skip_281348	chr1	114737988:114738072:114749821:114750207:114757925:114757969	114749821:114750207
exon_skip_292428	chr1	114739753:114739890:114749821:114750207:114757925:114757969	114749821:114750207
exon_skip_294836	chr1	114726983:114727090:114730258:114730422:114730508:114730648	114730258:114730422
exon_skip_46315	chr1	114717957:114718216:114718613:114718745:114719579:114719742	114718613:114718745
exon_skip_51847	chr1	114720578:114720717:114723883:114724002:114725221:114725333	114723883:114724002
exon_skip_65274	chr1	114749821:114750207:114756777:114756888:114757925:114757969	114756777:114756888
exon_skip_68285	chr1	114730514:114730648:114732604:114732816:114733732:114733857	114732604:114732816
exon_skip_80448	chr1	114736758:114736855:114737471:114737563:114737963:114738054	114737471:114737563
exon_skip_81636	chr1	114737963:114738072:114749821:114750207:114757925:114757987	114749821:114750207
exon_skip_86456	chr1	114737988:114738072:114739692:114739890:114749821:114750190	114739692:114739890

Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control.

Exon skipping information

Tissue type

Avg(PSIs) in AD

Avg(PSIs) in control

Difference (PSI)

Adj. p-value

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Open reading frame (ORF) annotation in the exon skipping event for CSDE1

Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000358528	114749821	114750207	3UTR-3UTR
ENST00000358528	114719579	114719742	Frame-shift
ENST00000534699	114719579	114719742	Frame-shift
ENST00000358528	114723883	114724002	In-frame
ENST00000534699	114723883	114724002	In-frame
ENST00000358528	114726983	114727090	In-frame
ENST00000534699	114726983	114727090	In-frame
ENST00000358528	114730258	114730422	In-frame
ENST00000534699	114730258	114730422	In-frame
ENST00000358528	114730508	114730648	In-frame
ENST00000534699	114730508	114730648	In-frame
ENST00000358528	114732604	114732816	In-frame
ENST00000534699	114732604	114732816	In-frame
ENST00000358528	114737471	114737563	In-frame
ENST00000534699	114737471	114737563	In-frame
ENST00000358528	114739692	114739890	In-frame
ENST00000534699	114739692	114739890	In-frame

Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000358528	114749821	114750207	3UTR-3UTR
ENST00000358528	114719579	114719742	Frame-shift
ENST00000534699	114719579	114719742	Frame-shift
ENST00000358528	114730508	114730648	In-frame
ENST00000534699	114730508	114730648	In-frame
ENST00000358528	114732604	114732816	In-frame
ENST00000534699	114732604	114732816	In-frame
ENST00000358528	114737471	114737563	In-frame
ENST00000534699	114737471	114737563	In-frame
ENST00000358528	114739692	114739890	In-frame
ENST00000534699	114739692	114739890	In-frame

Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000358528	114749821	114750207	3UTR-3UTR
ENST00000358528	114718613	114718745	Frame-shift
ENST00000534699	114718613	114718745	Frame-shift
ENST00000358528	114719579	114719742	Frame-shift
ENST00000534699	114719579	114719742	Frame-shift
ENST00000358528	114726211	114726386	Frame-shift
ENST00000534699	114726211	114726386	Frame-shift
ENST00000358528	114734442	114734523	Frame-shift
ENST00000534699	114734442	114734523	Frame-shift
ENST00000358528	114723883	114724002	In-frame
ENST00000534699	114723883	114724002	In-frame
ENST00000358528	114730258	114730422	In-frame
ENST00000534699	114730258	114730422	In-frame
ENST00000358528	114730508	114730648	In-frame
ENST00000534699	114730508	114730648	In-frame
ENST00000358528	114732604	114732816	In-frame
ENST00000534699	114732604	114732816	In-frame
ENST00000358528	114733989	114734117	In-frame
ENST00000534699	114733989	114734117	In-frame
ENST00000358528	114737471	114737563	In-frame
ENST00000534699	114737471	114737563	In-frame
ENST00000358528	114739692	114739890	In-frame
ENST00000534699	114739692	114739890	In-frame

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Infer the effects of exon skipping event on protein functional features for CSDE1

p-ENSG00000009307_img4.png
boxplot

Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000358528	4093	798	114739692	114739890	428	625	0	66
ENST00000534699	2684	798	114739692	114739890	59	256	0	66
ENST00000358528	4093	798	114737471	114737563	737	828	103	133
ENST00000534699	2684	798	114737471	114737563	368	459	103	133
ENST00000358528	4093	798	114732604	114732816	1265	1476	279	349
ENST00000534699	2684	798	114732604	114732816	896	1107	279	349
ENST00000358528	4093	798	114730508	114730648	1478	1617	350	396
ENST00000534699	2684	798	114730508	114730648	1109	1248	350	396
ENST00000358528	4093	798	114730258	114730422	1619	1782	397	451
ENST00000534699	2684	798	114730258	114730422	1250	1413	397	451
ENST00000358528	4093	798	114726983	114727090	1784	1890	452	487
ENST00000534699	2684	798	114726983	114727090	1415	1521	452	487
ENST00000358528	4093	798	114723883	114724002	2181	2299	584	624
ENST00000534699	2684	798	114723883	114724002	1812	1930	584	624

Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000358528	4093	798	114739692	114739890	428	625	0	66
ENST00000534699	2684	798	114739692	114739890	59	256	0	66
ENST00000358528	4093	798	114737471	114737563	737	828	103	133
ENST00000534699	2684	798	114737471	114737563	368	459	103	133
ENST00000358528	4093	798	114732604	114732816	1265	1476	279	349
ENST00000534699	2684	798	114732604	114732816	896	1107	279	349
ENST00000358528	4093	798	114730508	114730648	1478	1617	350	396
ENST00000534699	2684	798	114730508	114730648	1109	1248	350	396

Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000358528	4093	798	114739692	114739890	428	625	0	66
ENST00000534699	2684	798	114739692	114739890	59	256	0	66
ENST00000358528	4093	798	114737471	114737563	737	828	103	133
ENST00000534699	2684	798	114737471	114737563	368	459	103	133
ENST00000358528	4093	798	114733989	114734117	1010	1137	194	236
ENST00000534699	2684	798	114733989	114734117	641	768	194	236
ENST00000358528	4093	798	114732604	114732816	1265	1476	279	349
ENST00000534699	2684	798	114732604	114732816	896	1107	279	349
ENST00000358528	4093	798	114730508	114730648	1478	1617	350	396
ENST00000534699	2684	798	114730508	114730648	1109	1248	350	396
ENST00000358528	4093	798	114730258	114730422	1619	1782	397	451
ENST00000534699	2684	798	114730258	114730422	1250	1413	397	451
ENST00000358528	4093	798	114723883	114724002	2181	2299	584	624
ENST00000534699	2684	798	114723883	114724002	1812	1930	584	624

Lost protein functional features of individual exon skipping events in ROSMAP.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
O75534	0	66	1	1	Alternative sequence	ID=VSP_045615;Note=In isoform 3 and isoform 4. M->MENVFTVSSDPHPSPAAPPSLSLPLSSSSTSSGTKKQKRTPTYQRSM;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
O75534	0	66	1	1	Alternative sequence	ID=VSP_045615;Note=In isoform 3 and isoform 4. M->MENVFTVSSDPHPSPAAPPSLSLPLSSSSTSSGTKKQKRTPTYQRSM;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
O75534	0	66	19	21	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1WFQ
O75534	0	66	19	21	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1WFQ
O75534	0	66	25	33	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1WFQ
O75534	0	66	25	33	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1WFQ
O75534	0	66	35	42	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1WFQ
O75534	0	66	35	42	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1WFQ
O75534	0	66	47	52	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1WFQ
O75534	0	66	47	52	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1WFQ
O75534	0	66	1	798	Chain	ID=PRO_0000100348;Note=Cold shock domain-containing protein E1
O75534	0	66	1	798	Chain	ID=PRO_0000100348;Note=Cold shock domain-containing protein E1
O75534	0	66	26	87	Domain	Note=CSD 1
O75534	0	66	26	87	Domain	Note=CSD 1
O75534	0	66	31	31	Sequence conflict	Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
O75534	0	66	31	31	Sequence conflict	Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
O75534	0	66	43	46	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1WFQ
O75534	0	66	43	46	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1WFQ
O75534	0	66	53	55	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1WFQ
O75534	0	66	53	55	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1WFQ
O75534	0	66	60	62	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1WFQ
O75534	0	66	60	62	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1WFQ
O75534	103	133	104	134	Alternative sequence	ID=VSP_001138;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:10931946,ECO:0000303\|PubMed:15489334,ECO:0000303\|PubMed:17974005,ECO:0000303\|PubMed:2052355,ECO:00
O75534	103	133	104	134	Alternative sequence	ID=VSP_001138;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:10931946,ECO:0000303\|PubMed:15489334,ECO:0000303\|PubMed:17974005,ECO:0000303\|PubMed:2052355,ECO:00
O75534	103	133	1	798	Chain	ID=PRO_0000100348;Note=Cold shock domain-containing protein E1
O75534	103	133	1	798	Chain	ID=PRO_0000100348;Note=Cold shock domain-containing protein E1
O75534	103	133	123	123	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:18669648,ECO:0000244\|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
O75534	103	133	123	123	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:18669648,ECO:0000244\|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
O75534	279	349	349	355	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1X65
O75534	279	349	349	355	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1X65
O75534	279	349	1	798	Chain	ID=PRO_0000100348;Note=Cold shock domain-containing protein E1
O75534	279	349	1	798	Chain	ID=PRO_0000100348;Note=Cold shock domain-containing protein E1
O75534	279	349	297	337	Domain	Note=CSD 4%3B truncated
O75534	279	349	297	337	Domain	Note=CSD 4%3B truncated
O75534	279	349	349	410	Domain	Note=CSD 5
O75534	279	349	349	410	Domain	Note=CSD 5
O75534	279	349	299	299	Sequence conflict	Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
O75534	279	349	299	299	Sequence conflict	Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
O75534	350	396	349	355	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1X65
O75534	350	396	349	355	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1X65
O75534	350	396	362	370	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1X65
O75534	350	396	362	370	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1X65
O75534	350	396	391	393	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1X65
O75534	350	396	391	393	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1X65
O75534	350	396	1	798	Chain	ID=PRO_0000100348;Note=Cold shock domain-containing protein E1
O75534	350	396	1	798	Chain	ID=PRO_0000100348;Note=Cold shock domain-containing protein E1
O75534	350	396	349	410	Domain	Note=CSD 5
O75534	350	396	349	410	Domain	Note=CSD 5
O75534	350	396	378	381	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1X65
O75534	350	396	378	381	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1X65
O75534	350	396	363	385	Sequence conflict	Note=IKCVDRDVRMFFHFSEILDGNQL->HPSVWIRECSVCSFPLPVKFWMGTSS;Ontology_term=ECO:0000305;evidence=ECO:0000305
O75534	350	396	363	385	Sequence conflict	Note=IKCVDRDVRMFFHFSEILDGNQL->HPSVWIRECSVCSFPLPVKFWMGTSS;Ontology_term=ECO:0000305;evidence=ECO:0000305
O75534	397	451	399	401	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1X65
O75534	397	451	399	401	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1X65
O75534	397	451	1	798	Chain	ID=PRO_0000100348;Note=Cold shock domain-containing protein E1
O75534	397	451	1	798	Chain	ID=PRO_0000100348;Note=Cold shock domain-containing protein E1
O75534	397	451	349	410	Domain	Note=CSD 5
O75534	397	451	349	410	Domain	Note=CSD 5
O75534	397	451	447	507	Domain	Note=CSD 6
O75534	397	451	447	507	Domain	Note=CSD 6
O75534	452	487	1	798	Chain	ID=PRO_0000100348;Note=Cold shock domain-containing protein E1
O75534	452	487	1	798	Chain	ID=PRO_0000100348;Note=Cold shock domain-containing protein E1
O75534	452	487	447	507	Domain	Note=CSD 6
O75534	452	487	447	507	Domain	Note=CSD 6
O75534	584	624	1	798	Chain	ID=PRO_0000100348;Note=Cold shock domain-containing protein E1
O75534	584	624	1	798	Chain	ID=PRO_0000100348;Note=Cold shock domain-containing protein E1
O75534	584	624	610	670	Domain	Note=CSD 8
O75534	584	624	610	670	Domain	Note=CSD 8
O75534	584	624	584	584	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:23186163;Dbxref=PMID:23186163
O75534	584	624	584	584	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:23186163;Dbxref=PMID:23186163
O75534	584	624	608	608	Sequence conflict	Note=V->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
O75534	584	624	608	608	Sequence conflict	Note=V->I;Ontology_term=ECO:0000305;evidence=ECO:0000305

Lost protein functional features of individual exon skipping events in MSBB.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
O75534	0	66	1	1	Alternative sequence	ID=VSP_045615;Note=In isoform 3 and isoform 4. M->MENVFTVSSDPHPSPAAPPSLSLPLSSSSTSSGTKKQKRTPTYQRSM;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
O75534	0	66	1	1	Alternative sequence	ID=VSP_045615;Note=In isoform 3 and isoform 4. M->MENVFTVSSDPHPSPAAPPSLSLPLSSSSTSSGTKKQKRTPTYQRSM;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
O75534	0	66	19	21	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1WFQ
O75534	0	66	19	21	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1WFQ
O75534	0	66	25	33	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1WFQ
O75534	0	66	25	33	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1WFQ
O75534	0	66	35	42	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1WFQ
O75534	0	66	35	42	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1WFQ
O75534	0	66	47	52	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1WFQ
O75534	0	66	47	52	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1WFQ
O75534	0	66	1	798	Chain	ID=PRO_0000100348;Note=Cold shock domain-containing protein E1
O75534	0	66	1	798	Chain	ID=PRO_0000100348;Note=Cold shock domain-containing protein E1
O75534	0	66	26	87	Domain	Note=CSD 1
O75534	0	66	26	87	Domain	Note=CSD 1
O75534	0	66	31	31	Sequence conflict	Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
O75534	0	66	31	31	Sequence conflict	Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
O75534	0	66	43	46	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1WFQ
O75534	0	66	43	46	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1WFQ
O75534	0	66	53	55	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1WFQ
O75534	0	66	53	55	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1WFQ
O75534	0	66	60	62	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1WFQ
O75534	0	66	60	62	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1WFQ
O75534	103	133	104	134	Alternative sequence	ID=VSP_001138;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:10931946,ECO:0000303\|PubMed:15489334,ECO:0000303\|PubMed:17974005,ECO:0000303\|PubMed:2052355,ECO:00
O75534	103	133	104	134	Alternative sequence	ID=VSP_001138;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:10931946,ECO:0000303\|PubMed:15489334,ECO:0000303\|PubMed:17974005,ECO:0000303\|PubMed:2052355,ECO:00
O75534	103	133	1	798	Chain	ID=PRO_0000100348;Note=Cold shock domain-containing protein E1
O75534	103	133	1	798	Chain	ID=PRO_0000100348;Note=Cold shock domain-containing protein E1
O75534	103	133	123	123	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:18669648,ECO:0000244\|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
O75534	103	133	123	123	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:18669648,ECO:0000244\|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
O75534	279	349	349	355	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1X65
O75534	279	349	349	355	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1X65
O75534	279	349	1	798	Chain	ID=PRO_0000100348;Note=Cold shock domain-containing protein E1
O75534	279	349	1	798	Chain	ID=PRO_0000100348;Note=Cold shock domain-containing protein E1
O75534	279	349	297	337	Domain	Note=CSD 4%3B truncated
O75534	279	349	297	337	Domain	Note=CSD 4%3B truncated
O75534	279	349	349	410	Domain	Note=CSD 5
O75534	279	349	349	410	Domain	Note=CSD 5
O75534	279	349	299	299	Sequence conflict	Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
O75534	279	349	299	299	Sequence conflict	Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
O75534	350	396	349	355	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1X65
O75534	350	396	349	355	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1X65
O75534	350	396	362	370	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1X65
O75534	350	396	362	370	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1X65
O75534	350	396	391	393	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1X65
O75534	350	396	391	393	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1X65
O75534	350	396	1	798	Chain	ID=PRO_0000100348;Note=Cold shock domain-containing protein E1
O75534	350	396	1	798	Chain	ID=PRO_0000100348;Note=Cold shock domain-containing protein E1
O75534	350	396	349	410	Domain	Note=CSD 5
O75534	350	396	349	410	Domain	Note=CSD 5
O75534	350	396	378	381	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1X65
O75534	350	396	378	381	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1X65
O75534	350	396	363	385	Sequence conflict	Note=IKCVDRDVRMFFHFSEILDGNQL->HPSVWIRECSVCSFPLPVKFWMGTSS;Ontology_term=ECO:0000305;evidence=ECO:0000305
O75534	350	396	363	385	Sequence conflict	Note=IKCVDRDVRMFFHFSEILDGNQL->HPSVWIRECSVCSFPLPVKFWMGTSS;Ontology_term=ECO:0000305;evidence=ECO:0000305

Lost protein functional features of individual exon skipping events in Mayo.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
O75534	0	66	1	1	Alternative sequence	ID=VSP_045615;Note=In isoform 3 and isoform 4. M->MENVFTVSSDPHPSPAAPPSLSLPLSSSSTSSGTKKQKRTPTYQRSM;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
O75534	0	66	1	1	Alternative sequence	ID=VSP_045615;Note=In isoform 3 and isoform 4. M->MENVFTVSSDPHPSPAAPPSLSLPLSSSSTSSGTKKQKRTPTYQRSM;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
O75534	0	66	19	21	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1WFQ
O75534	0	66	19	21	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1WFQ
O75534	0	66	25	33	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1WFQ
O75534	0	66	25	33	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1WFQ
O75534	0	66	35	42	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1WFQ
O75534	0	66	35	42	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1WFQ
O75534	0	66	47	52	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1WFQ
O75534	0	66	47	52	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1WFQ
O75534	0	66	1	798	Chain	ID=PRO_0000100348;Note=Cold shock domain-containing protein E1
O75534	0	66	1	798	Chain	ID=PRO_0000100348;Note=Cold shock domain-containing protein E1
O75534	0	66	26	87	Domain	Note=CSD 1
O75534	0	66	26	87	Domain	Note=CSD 1
O75534	0	66	31	31	Sequence conflict	Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
O75534	0	66	31	31	Sequence conflict	Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
O75534	0	66	43	46	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1WFQ
O75534	0	66	43	46	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1WFQ
O75534	0	66	53	55	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1WFQ
O75534	0	66	53	55	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1WFQ
O75534	0	66	60	62	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1WFQ
O75534	0	66	60	62	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1WFQ
O75534	103	133	104	134	Alternative sequence	ID=VSP_001138;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:10931946,ECO:0000303\|PubMed:15489334,ECO:0000303\|PubMed:17974005,ECO:0000303\|PubMed:2052355,ECO:00
O75534	103	133	104	134	Alternative sequence	ID=VSP_001138;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:10931946,ECO:0000303\|PubMed:15489334,ECO:0000303\|PubMed:17974005,ECO:0000303\|PubMed:2052355,ECO:00
O75534	103	133	1	798	Chain	ID=PRO_0000100348;Note=Cold shock domain-containing protein E1
O75534	103	133	1	798	Chain	ID=PRO_0000100348;Note=Cold shock domain-containing protein E1
O75534	103	133	123	123	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:18669648,ECO:0000244\|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
O75534	103	133	123	123	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:18669648,ECO:0000244\|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
O75534	194	236	195	201	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2YTX
O75534	194	236	195	201	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2YTX
O75534	194	236	203	205	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2YTX
O75534	194	236	203	205	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2YTX
O75534	194	236	209	212	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2YTX
O75534	194	236	209	212	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2YTX
O75534	194	236	228	233	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2YTX
O75534	194	236	228	233	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2YTX
O75534	194	236	1	798	Chain	ID=PRO_0000100348;Note=Cold shock domain-containing protein E1
O75534	194	236	1	798	Chain	ID=PRO_0000100348;Note=Cold shock domain-containing protein E1
O75534	194	236	186	245	Domain	Note=CSD 3
O75534	194	236	186	245	Domain	Note=CSD 3
O75534	194	236	213	215	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2YTX
O75534	194	236	213	215	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2YTX
O75534	279	349	349	355	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1X65
O75534	279	349	349	355	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1X65
O75534	279	349	1	798	Chain	ID=PRO_0000100348;Note=Cold shock domain-containing protein E1
O75534	279	349	1	798	Chain	ID=PRO_0000100348;Note=Cold shock domain-containing protein E1
O75534	279	349	297	337	Domain	Note=CSD 4%3B truncated
O75534	279	349	297	337	Domain	Note=CSD 4%3B truncated
O75534	279	349	349	410	Domain	Note=CSD 5
O75534	279	349	349	410	Domain	Note=CSD 5
O75534	279	349	299	299	Sequence conflict	Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
O75534	279	349	299	299	Sequence conflict	Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
O75534	350	396	349	355	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1X65
O75534	350	396	349	355	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1X65
O75534	350	396	362	370	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1X65
O75534	350	396	362	370	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1X65
O75534	350	396	391	393	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1X65
O75534	350	396	391	393	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1X65
O75534	350	396	1	798	Chain	ID=PRO_0000100348;Note=Cold shock domain-containing protein E1
O75534	350	396	1	798	Chain	ID=PRO_0000100348;Note=Cold shock domain-containing protein E1
O75534	350	396	349	410	Domain	Note=CSD 5
O75534	350	396	349	410	Domain	Note=CSD 5
O75534	350	396	378	381	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1X65
O75534	350	396	378	381	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1X65
O75534	350	396	363	385	Sequence conflict	Note=IKCVDRDVRMFFHFSEILDGNQL->HPSVWIRECSVCSFPLPVKFWMGTSS;Ontology_term=ECO:0000305;evidence=ECO:0000305
O75534	350	396	363	385	Sequence conflict	Note=IKCVDRDVRMFFHFSEILDGNQL->HPSVWIRECSVCSFPLPVKFWMGTSS;Ontology_term=ECO:0000305;evidence=ECO:0000305
O75534	397	451	399	401	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1X65
O75534	397	451	399	401	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1X65
O75534	397	451	1	798	Chain	ID=PRO_0000100348;Note=Cold shock domain-containing protein E1
O75534	397	451	1	798	Chain	ID=PRO_0000100348;Note=Cold shock domain-containing protein E1
O75534	397	451	349	410	Domain	Note=CSD 5
O75534	397	451	349	410	Domain	Note=CSD 5
O75534	397	451	447	507	Domain	Note=CSD 6
O75534	397	451	447	507	Domain	Note=CSD 6
O75534	584	624	1	798	Chain	ID=PRO_0000100348;Note=Cold shock domain-containing protein E1
O75534	584	624	1	798	Chain	ID=PRO_0000100348;Note=Cold shock domain-containing protein E1
O75534	584	624	610	670	Domain	Note=CSD 8
O75534	584	624	610	670	Domain	Note=CSD 8
O75534	584	624	584	584	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:23186163;Dbxref=PMID:23186163
O75534	584	624	584	584	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:23186163;Dbxref=PMID:23186163
O75534	584	624	608	608	Sequence conflict	Note=V->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
O75534	584	624	608	608	Sequence conflict	Note=V->I;Ontology_term=ECO:0000305;evidence=ECO:0000305

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3'-UTR located exon skipping events that lost miRNA binding sites in CSDE1

3'-UTR exon skipping evnets lost miRNA binding.

Tissue type	ENST	Exon skip start	Exon skip end	microRNA	Binding site by TargetScan	Binding type by TargetScan	Bdinding site by miRanda	Score of miRanda	Energy by miRanda
Mayo	ENST00000358528	114749821	114750207	hsa-miR-194-5p	chr1:114750193-114750200	8mer-1a	chr1:114750183-114750206	157.00	-18.42
Mayo	ENST00000358528	114749821	114750207	hsa-miR-4742-5p	chr1:114750145-114750152	8mer-1a	chr1:114750135-114750157	158.00	-23.26
Mayo	ENST00000358528	114749821	114750207	hsa-miR-5100	chr1:114750151-114750158	8mer-1a	chr1:114750140-114750161	145.00	-11.53
Mayo	ENST00000358528	114749821	114750207	hsa-miR-4538	chr1:114749941-114749948	8mer-1a	chr1:114749940-114749967	150.00	-17.99
Mayo	ENST00000358528	114749821	114750207	hsa-miR-630	chr1:114749953-114749960	8mer-1a	chr1:114749948-114749970	159.00	-16.18
Mayo	ENST00000358528	114749821	114750207	hsa-miR-4718	chr1:114749988-114749995	8mer-1a	chr1:114749975-114749995	155.00	-21.46
Mayo	ENST00000358528	114749821	114750207	hsa-miR-1288-5p	chr1:114750150-114750157	8mer-1a	chr1:114750135-114750157	158.00	-23.26
Mayo	ENST00000358528	114749821	114750207	hsa-miR-4738-3p	chr1:114750169-114750176	8mer-1a	chr1:114750160-114750181	147.00	-17.54
Mayo	ENST00000358528	114749821	114750207	hsa-miR-1250-3p	chr1:114749929-114749936	8mer-1a	chr1:114749927-114749948	146.00	-12.75
Mayo	ENST00000358528	114749821	114750207	hsa-miR-10395-3p	chr1:114749954-114749961	8mer-1a	chr1:114749948-114749970	159.00	-16.18
Mayo	ENST00000358528	114749821	114750207	hsa-miR-24-2-5p	chr1:114750051-114750058	8mer-1a	chr1:114750037-114750058	156.00	-18.61
Mayo	ENST00000358528	114749821	114750207	hsa-miR-6812-3p	chr1:114749919-114749926	8mer-1a	chr1:114749913-114749932	145.00	-11.59
Mayo	ENST00000358528	114749821	114750207	hsa-miR-5186	chr1:114749978-114749985	8mer-1a	chr1:114749967-114749991	163.00	-15.37
Mayo	ENST00000358528	114749821	114750207	hsa-miR-4453	chr1:114749941-114749948	8mer-1a	chr1:114749940-114749967	150.00	-17.99
Mayo	ENST00000358528	114749821	114750207	hsa-miR-6833-3p	chr1:114749925-114749932	8mer-1a	chr1:114749913-114749932	145.00	-11.59
Mayo	ENST00000358528	114749821	114750207	hsa-miR-550b-2-5p	chr1:114750054-114750061	8mer-1a	chr1:114750044-114750063	153.00	-15.04
Mayo	ENST00000358528	114749821	114750207	hsa-miR-8084	chr1:114749906-114749913	8mer-1a	chr1:114749904-114749924	146.00	-13.37
Mayo	ENST00000358528	114749821	114750207	hsa-miR-24-1-5p	chr1:114750051-114750058	8mer-1a	chr1:114750037-114750058	156.00	-18.61
Mayo	ENST00000358528	114749821	114750207	hsa-miR-4768-5p	chr1:114749925-114749932	8mer-1a	chr1:114749913-114749932	145.00	-11.59
Mayo	ENST00000358528	114749821	114750207	hsa-miR-545-3p	chr1:114749858-114749865	8mer-1a	chr1:114749846-114749868	177.00	-21.65
Mayo	ENST00000358528	114749821	114750207	hsa-miR-510-3p	chr1:114749885-114749892	8mer-1a	chr1:114749874-114749897	150.00	-16.03
MSBB	ENST00000358528	114749821	114750207	hsa-miR-194-5p	chr1:114750193-114750200	8mer-1a	chr1:114750183-114750206	157.00	-18.42
MSBB	ENST00000358528	114749821	114750207	hsa-miR-4742-5p	chr1:114750145-114750152	8mer-1a	chr1:114750135-114750157	158.00	-23.26
MSBB	ENST00000358528	114749821	114750207	hsa-miR-5100	chr1:114750151-114750158	8mer-1a	chr1:114750140-114750161	145.00	-11.53
MSBB	ENST00000358528	114749821	114750207	hsa-miR-4538	chr1:114749941-114749948	8mer-1a	chr1:114749940-114749967	150.00	-17.99
MSBB	ENST00000358528	114749821	114750207	hsa-miR-630	chr1:114749953-114749960	8mer-1a	chr1:114749948-114749970	159.00	-16.18
MSBB	ENST00000358528	114749821	114750207	hsa-miR-4718	chr1:114749988-114749995	8mer-1a	chr1:114749975-114749995	155.00	-21.46
MSBB	ENST00000358528	114749821	114750207	hsa-miR-1288-5p	chr1:114750150-114750157	8mer-1a	chr1:114750135-114750157	158.00	-23.26
MSBB	ENST00000358528	114749821	114750207	hsa-miR-4738-3p	chr1:114750169-114750176	8mer-1a	chr1:114750160-114750181	147.00	-17.54
MSBB	ENST00000358528	114749821	114750207	hsa-miR-1250-3p	chr1:114749929-114749936	8mer-1a	chr1:114749927-114749948	146.00	-12.75
MSBB	ENST00000358528	114749821	114750207	hsa-miR-10395-3p	chr1:114749954-114749961	8mer-1a	chr1:114749948-114749970	159.00	-16.18
MSBB	ENST00000358528	114749821	114750207	hsa-miR-24-2-5p	chr1:114750051-114750058	8mer-1a	chr1:114750037-114750058	156.00	-18.61
MSBB	ENST00000358528	114749821	114750207	hsa-miR-6812-3p	chr1:114749919-114749926	8mer-1a	chr1:114749913-114749932	145.00	-11.59
MSBB	ENST00000358528	114749821	114750207	hsa-miR-5186	chr1:114749978-114749985	8mer-1a	chr1:114749967-114749991	163.00	-15.37
MSBB	ENST00000358528	114749821	114750207	hsa-miR-4453	chr1:114749941-114749948	8mer-1a	chr1:114749940-114749967	150.00	-17.99
MSBB	ENST00000358528	114749821	114750207	hsa-miR-6833-3p	chr1:114749925-114749932	8mer-1a	chr1:114749913-114749932	145.00	-11.59
MSBB	ENST00000358528	114749821	114750207	hsa-miR-550b-2-5p	chr1:114750054-114750061	8mer-1a	chr1:114750044-114750063	153.00	-15.04
MSBB	ENST00000358528	114749821	114750207	hsa-miR-8084	chr1:114749906-114749913	8mer-1a	chr1:114749904-114749924	146.00	-13.37
MSBB	ENST00000358528	114749821	114750207	hsa-miR-24-1-5p	chr1:114750051-114750058	8mer-1a	chr1:114750037-114750058	156.00	-18.61
MSBB	ENST00000358528	114749821	114750207	hsa-miR-4768-5p	chr1:114749925-114749932	8mer-1a	chr1:114749913-114749932	145.00	-11.59
MSBB	ENST00000358528	114749821	114750207	hsa-miR-545-3p	chr1:114749858-114749865	8mer-1a	chr1:114749846-114749868	177.00	-21.65
MSBB	ENST00000358528	114749821	114750207	hsa-miR-510-3p	chr1:114749885-114749892	8mer-1a	chr1:114749874-114749897	150.00	-16.03
ROSMAP	ENST00000358528	114749821	114750207	hsa-miR-194-5p	chr1:114750193-114750200	8mer-1a	chr1:114750183-114750206	157.00	-18.42
ROSMAP	ENST00000358528	114749821	114750207	hsa-miR-4742-5p	chr1:114750145-114750152	8mer-1a	chr1:114750135-114750157	158.00	-23.26
ROSMAP	ENST00000358528	114749821	114750207	hsa-miR-5100	chr1:114750151-114750158	8mer-1a	chr1:114750140-114750161	145.00	-11.53
ROSMAP	ENST00000358528	114749821	114750207	hsa-miR-4538	chr1:114749941-114749948	8mer-1a	chr1:114749940-114749967	150.00	-17.99
ROSMAP	ENST00000358528	114749821	114750207	hsa-miR-630	chr1:114749953-114749960	8mer-1a	chr1:114749948-114749970	159.00	-16.18
ROSMAP	ENST00000358528	114749821	114750207	hsa-miR-4718	chr1:114749988-114749995	8mer-1a	chr1:114749975-114749995	155.00	-21.46
ROSMAP	ENST00000358528	114749821	114750207	hsa-miR-1288-5p	chr1:114750150-114750157	8mer-1a	chr1:114750135-114750157	158.00	-23.26
ROSMAP	ENST00000358528	114749821	114750207	hsa-miR-4738-3p	chr1:114750169-114750176	8mer-1a	chr1:114750160-114750181	147.00	-17.54
ROSMAP	ENST00000358528	114749821	114750207	hsa-miR-1250-3p	chr1:114749929-114749936	8mer-1a	chr1:114749927-114749948	146.00	-12.75
ROSMAP	ENST00000358528	114749821	114750207	hsa-miR-10395-3p	chr1:114749954-114749961	8mer-1a	chr1:114749948-114749970	159.00	-16.18
ROSMAP	ENST00000358528	114749821	114750207	hsa-miR-24-2-5p	chr1:114750051-114750058	8mer-1a	chr1:114750037-114750058	156.00	-18.61
ROSMAP	ENST00000358528	114749821	114750207	hsa-miR-6812-3p	chr1:114749919-114749926	8mer-1a	chr1:114749913-114749932	145.00	-11.59
ROSMAP	ENST00000358528	114749821	114750207	hsa-miR-5186	chr1:114749978-114749985	8mer-1a	chr1:114749967-114749991	163.00	-15.37
ROSMAP	ENST00000358528	114749821	114750207	hsa-miR-4453	chr1:114749941-114749948	8mer-1a	chr1:114749940-114749967	150.00	-17.99
ROSMAP	ENST00000358528	114749821	114750207	hsa-miR-6833-3p	chr1:114749925-114749932	8mer-1a	chr1:114749913-114749932	145.00	-11.59
ROSMAP	ENST00000358528	114749821	114750207	hsa-miR-550b-2-5p	chr1:114750054-114750061	8mer-1a	chr1:114750044-114750063	153.00	-15.04
ROSMAP	ENST00000358528	114749821	114750207	hsa-miR-8084	chr1:114749906-114749913	8mer-1a	chr1:114749904-114749924	146.00	-13.37
ROSMAP	ENST00000358528	114749821	114750207	hsa-miR-24-1-5p	chr1:114750051-114750058	8mer-1a	chr1:114750037-114750058	156.00	-18.61
ROSMAP	ENST00000358528	114749821	114750207	hsa-miR-4768-5p	chr1:114749925-114749932	8mer-1a	chr1:114749913-114749932	145.00	-11.59
ROSMAP	ENST00000358528	114749821	114750207	hsa-miR-545-3p	chr1:114749858-114749865	8mer-1a	chr1:114749846-114749868	177.00	-21.65
ROSMAP	ENST00000358528	114749821	114750207	hsa-miR-510-3p	chr1:114749885-114749892	8mer-1a	chr1:114749874-114749897	150.00	-16.03

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SNVs in the skipped exons for CSDE1

- Differential PSIs between mutated versus non-mutated samples.

- Depth of Coverage in the skipped exon of the mutated samples.

- Sashimi plot in the skipped exon of the mutated samples.

- Non-synonymous mutations located in the skipped exons.

Cancer type

Sample

ESID

Skipped exon start

Skipped exon end

Mutation start

Mutation end

Mutation type

Reference seq

Mutation seq

AAchange

- Non-synonymous mutations located in the skipped exons in CCLE.

Sample

Skipped exon start

Skipped exon end

Mutation start

Mutation end

Mutation type

Reference seq

Mutation seq

AAchange

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AD stage-associated exon skippint events for CSDE1

Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR).

AD stage info	Cohort	Tissue	SE id	Coefficient	P-value	Chromosome	Strand	E1 start	E1 end	Skipped start	Skipped end	E2 start	E2 end
ADstage	MSBB	IFG	exon_skip_86456	4.753338e-01	1.057867e-02	chr1	-	114737988	114738072	114739692	114739890	114749821	114750190
ADstage	ROSMAP	PCC	exon_skip_175498	-4.153419e-01	2.250000e-10	chr1	-	114736758	114736855	114737471	114737563	114737963	114738072
CDR	MSBB	STG	exon_skip_292428	-3.484361e-01	6.200900e-04	chr1	-	114739753	114739890	114749821	114750207	114757925	114757969
CDR	MSBB	STG	exon_skip_141406	-3.070770e-01	2.753603e-03	chr1	-	114739753	114739890	114741527	114741673	114749821	114749904

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for CSDE1

sQTL information located at the skipped exons.

Tissue type

Exon skip ID

SNP id

Location

P-value

FDR

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Correlation with RNA binding proteins (RBPs) for CSDE1

Correlated RBP and related information.

Tissue type	RBP name	Exon skip ID	Correlation coeifficient	P-value
CB	RBM6	exon_skip_213430	4.095559e-01	1.611588e-07
CB	U2AF2	exon_skip_213430	4.910006e-01	1.343211e-10
CB	TRA2A	exon_skip_213430	5.689300e-01	2.059127e-14
CB	TARDBP	exon_skip_190311	-4.202311e-01	3.496073e-08
CB	ELAVL1	exon_skip_190311	-4.098503e-01	8.103404e-08
CB	ZNF638	exon_skip_190311	-6.257178e-01	1.163991e-18
HCC	HNRNPF	exon_skip_175498	-4.890527e-01	8.036248e-18
PCC	G3BP2	exon_skip_213430	-5.512897e-01	6.116129e-16
PCC	HNRNPF	exon_skip_175498	-4.631915e-01	7.847180e-13
TC	SRSF2	exon_skip_266992	-4.292726e-01	3.422737e-08
TC	HNRNPA0	exon_skip_266992	-4.348737e-01	2.163966e-08
TC	ESRP1	exon_skip_23801	4.672886e-01	4.684936e-10

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RelatedDrugs for CSDE1

Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for CSDE1

Diseases associated with this gene.
(DisGeNet 4.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	Gene structures and expression levels
	Exon skipping events with PSIs in RPSMAP, MSBB, and Mayo
	Open reading frame (ORF) annotation in the exon skipping event
	Exon skipping events in the canonical protein sequence
	3'-UTR located exon skipping events lost miRNA binding sites
	SNVs in the skipped exons with depth of coverage
	AD stage-associated exon skipping events
	Splicing Quantitative Trait Loci (sQTLs) in the skipped exons
	Correlation with RNA binding proteins (RBPs)
	Related drugs with this gene
	Related diseases with this gene

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Gene summary for CSDE1

Gene structures and expression levels for CSDE1

Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for CSDE1

Open reading frame (ORF) annotation in the exon skipping event for CSDE1

Infer the effects of exon skipping event on protein functional features for CSDE1

3'-UTR located exon skipping events that lost miRNA binding sites in CSDE1

SNVs in the skipped exons for CSDE1

AD stage-associated exon skippint events for CSDE1

Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for CSDE1

Correlation with RNA binding proteins (RBPs) for CSDE1

RelatedDrugs for CSDE1

RelatedDiseases for CSDE1