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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for LUZP1 |
Gene summary |
Gene information | Gene symbol | LUZP1 | Gene ID | 7798 |
Gene name | leucine zipper protein 1 | |
Synonyms | LUZP | |
Cytomap | 1p36.12 | |
Type of gene | protein-coding | |
Description | leucine zipper protein 1 | |
Modification date | 20200313 | |
UniProtAcc | ||
Context |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for LUZP1 |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
CB | UP | ENST00000314174.5 | LUZP1-202:protein_coding:LUZP1 | 6.104527e+00 | 1.012153e+00 | 4.717378e-05 | 3.914861e-04 |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for LUZP1 |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_22345 | chr1 | 23109022:23109127:23168766:23169024:23177491:23177808 | 23168766:23169024 |
exon_skip_232036 | chr1 | 23094155:23094380:23109022:23109127:23168766:23168817 | 23109022:23109127 |
exon_skip_258706 | chr1 | 23109022:23109127:23109585:23109650:23168766:23168817 | 23109585:23109650 |
exon_skip_264214 | chr1 | 23091190:23094380:23109022:23109127:23168766:23168817 | 23109022:23109127 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for LUZP1 |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000302291 | 23109022 | 23109127 | 3UTR-3UTR |
ENST00000302291 | 23168766 | 23169024 | 3UTR-3UTR |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000302291 | 23109022 | 23109127 | 3UTR-3UTR |
ENST00000302291 | 23168766 | 23169024 | 3UTR-3UTR |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000302291 | 23168766 | 23169024 | 3UTR-3UTR |
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Infer the effects of exon skipping event on protein functional features for LUZP1 |
p-ENSG00000169641_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in LUZP1 |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
Mayo | ENST00000302291 | 23168766 | 23169024 | hsa-miR-4294 | chr1:23168973-23168980 | 8mer-1a | chr1:23168955-23168981 | 155.00 | -29.36 |
Mayo | ENST00000302291 | 23168766 | 23169024 | hsa-miR-6880-5p | chr1:23168976-23168983 | 8mer-1a | chr1:23168962-23168983 | 143.00 | -22.73 |
Mayo | ENST00000302291 | 23168766 | 23169024 | hsa-miR-548x-3p | chr1:23168984-23168991 | 8mer-1a | chr1:23168981-23169000 | 148.00 | -18.83 |
Mayo | ENST00000302291 | 23168766 | 23169024 | hsa-miR-4747-5p | chr1:23168959-23168966 | 8mer-1a | chr1:23168948-23168968 | 170.00 | -24.11 |
Mayo | ENST00000302291 | 23168766 | 23169024 | hsa-miR-5196-5p | chr1:23168959-23168966 | 8mer-1a | chr1:23168948-23168968 | 170.00 | -24.11 |
Mayo | ENST00000302291 | 23168766 | 23169024 | hsa-miR-548ae-3p | chr1:23168984-23168991 | 8mer-1a | chr1:23168981-23169000 | 148.00 | -18.83 |
Mayo | ENST00000302291 | 23168766 | 23169024 | hsa-miR-548j-3p | chr1:23168984-23168991 | 8mer-1a | chr1:23168981-23169000 | 148.00 | -18.83 |
Mayo | ENST00000302291 | 23168766 | 23169024 | hsa-miR-548aq-3p | chr1:23168984-23168991 | 8mer-1a | chr1:23168981-23169000 | 148.00 | -18.83 |
Mayo | ENST00000302291 | 23168766 | 23169024 | hsa-miR-548ah-3p | chr1:23168984-23168991 | 8mer-1a | chr1:23168981-23169000 | 148.00 | -18.83 |
Mayo | ENST00000302291 | 23168766 | 23169024 | hsa-miR-548aj-3p | chr1:23168984-23168991 | 8mer-1a | chr1:23168981-23169000 | 148.00 | -18.83 |
Mayo | ENST00000302291 | 23168766 | 23169024 | hsa-miR-548am-3p | chr1:23168984-23168991 | 8mer-1a | chr1:23168981-23169000 | 148.00 | -18.83 |
MSBB | ENST00000302291 | 23168766 | 23169024 | hsa-miR-4294 | chr1:23168973-23168980 | 8mer-1a | chr1:23168955-23168981 | 155.00 | -29.36 |
MSBB | ENST00000302291 | 23109022 | 23109127 | hsa-miR-6760-5p | chr1:23109063-23109070 | 8mer-1a | chr1:23109061-23109081 | 167.00 | -19.66 |
MSBB | ENST00000302291 | 23168766 | 23169024 | hsa-miR-6880-5p | chr1:23168976-23168983 | 8mer-1a | chr1:23168962-23168983 | 143.00 | -22.73 |
MSBB | ENST00000302291 | 23168766 | 23169024 | hsa-miR-548x-3p | chr1:23168984-23168991 | 8mer-1a | chr1:23168981-23169000 | 148.00 | -18.83 |
MSBB | ENST00000302291 | 23168766 | 23169024 | hsa-miR-4747-5p | chr1:23168959-23168966 | 8mer-1a | chr1:23168948-23168968 | 170.00 | -24.11 |
MSBB | ENST00000302291 | 23168766 | 23169024 | hsa-miR-5196-5p | chr1:23168959-23168966 | 8mer-1a | chr1:23168948-23168968 | 170.00 | -24.11 |
MSBB | ENST00000302291 | 23168766 | 23169024 | hsa-miR-548ae-3p | chr1:23168984-23168991 | 8mer-1a | chr1:23168981-23169000 | 148.00 | -18.83 |
MSBB | ENST00000302291 | 23168766 | 23169024 | hsa-miR-548j-3p | chr1:23168984-23168991 | 8mer-1a | chr1:23168981-23169000 | 148.00 | -18.83 |
MSBB | ENST00000302291 | 23168766 | 23169024 | hsa-miR-548aq-3p | chr1:23168984-23168991 | 8mer-1a | chr1:23168981-23169000 | 148.00 | -18.83 |
MSBB | ENST00000302291 | 23168766 | 23169024 | hsa-miR-548ah-3p | chr1:23168984-23168991 | 8mer-1a | chr1:23168981-23169000 | 148.00 | -18.83 |
MSBB | ENST00000302291 | 23168766 | 23169024 | hsa-miR-548aj-3p | chr1:23168984-23168991 | 8mer-1a | chr1:23168981-23169000 | 148.00 | -18.83 |
MSBB | ENST00000302291 | 23168766 | 23169024 | hsa-miR-548am-3p | chr1:23168984-23168991 | 8mer-1a | chr1:23168981-23169000 | 148.00 | -18.83 |
ROSMAP | ENST00000302291 | 23168766 | 23169024 | hsa-miR-4294 | chr1:23168973-23168980 | 8mer-1a | chr1:23168955-23168981 | 155.00 | -29.36 |
ROSMAP | ENST00000302291 | 23109022 | 23109127 | hsa-miR-6760-5p | chr1:23109063-23109070 | 8mer-1a | chr1:23109061-23109081 | 167.00 | -19.66 |
ROSMAP | ENST00000302291 | 23168766 | 23169024 | hsa-miR-6880-5p | chr1:23168976-23168983 | 8mer-1a | chr1:23168962-23168983 | 143.00 | -22.73 |
ROSMAP | ENST00000302291 | 23168766 | 23169024 | hsa-miR-548x-3p | chr1:23168984-23168991 | 8mer-1a | chr1:23168981-23169000 | 148.00 | -18.83 |
ROSMAP | ENST00000302291 | 23168766 | 23169024 | hsa-miR-4747-5p | chr1:23168959-23168966 | 8mer-1a | chr1:23168948-23168968 | 170.00 | -24.11 |
ROSMAP | ENST00000302291 | 23168766 | 23169024 | hsa-miR-5196-5p | chr1:23168959-23168966 | 8mer-1a | chr1:23168948-23168968 | 170.00 | -24.11 |
ROSMAP | ENST00000302291 | 23168766 | 23169024 | hsa-miR-548ae-3p | chr1:23168984-23168991 | 8mer-1a | chr1:23168981-23169000 | 148.00 | -18.83 |
ROSMAP | ENST00000302291 | 23168766 | 23169024 | hsa-miR-548j-3p | chr1:23168984-23168991 | 8mer-1a | chr1:23168981-23169000 | 148.00 | -18.83 |
ROSMAP | ENST00000302291 | 23168766 | 23169024 | hsa-miR-548aq-3p | chr1:23168984-23168991 | 8mer-1a | chr1:23168981-23169000 | 148.00 | -18.83 |
ROSMAP | ENST00000302291 | 23168766 | 23169024 | hsa-miR-548ah-3p | chr1:23168984-23168991 | 8mer-1a | chr1:23168981-23169000 | 148.00 | -18.83 |
ROSMAP | ENST00000302291 | 23168766 | 23169024 | hsa-miR-548aj-3p | chr1:23168984-23168991 | 8mer-1a | chr1:23168981-23169000 | 148.00 | -18.83 |
ROSMAP | ENST00000302291 | 23168766 | 23169024 | hsa-miR-548am-3p | chr1:23168984-23168991 | 8mer-1a | chr1:23168981-23169000 | 148.00 | -18.83 |
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SNVs in the skipped exons for LUZP1 |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for LUZP1 |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for LUZP1 |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for LUZP1 |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
IFG | TARDBP | exon_skip_258706 | -4.161054e-01 | 3.855524e-02 |
IFG | KHSRP | exon_skip_258706 | -4.107115e-01 | 4.140868e-02 |
STG | RBM24 | exon_skip_258706 | 4.096279e-01 | 4.737531e-04 |
STG | RALYL | exon_skip_258706 | 4.114363e-01 | 4.445382e-04 |
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RelatedDrugs for LUZP1 |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for LUZP1 |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |