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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for ZFAND5 |
 Gene summary |
| Gene information | Gene symbol | ZFAND5 | Gene ID | 7763 |
| Gene name | zinc finger AN1-type containing 5 | |
| Synonyms | ZA20D2|ZFAND5A|ZNF216 | |
| Cytomap | 9q21.13 | |
| Type of gene | protein-coding | |
| Description | AN1-type zinc finger protein 5zinc finger A20 domain-containing protein 2zinc finger protein 216zinc finger, A20 domain containing 2zinc finger, AN1-type domain 5 | |
| Modification date | 20200313 | |
| UniProtAcc | O76080, Q5QPB1, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for ZFAND5 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000107372
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| PCC | UP | ENST00000237937.7 | ZFAND5-201:protein_coding:ZFAND5 | 5.951282e+00 | 5.094918e+00 | 2.225766e-04 | 9.853940e-03 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for ZFAND5 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_133802 | chr9 | 72356946:72357056:72359418:72359521:72360110:72360215 | 72359418:72359521 |
| exon_skip_233792 | chr9 | 72356946:72357056:72359418:72359521:72360110:72360221 | 72359418:72359521 |
| exon_skip_239012 | chr9 | 72355955:72356101:72356931:72357056:72359418:72359521 | 72356931:72357056 |
| exon_skip_250913 | chr9 | 72359418:72359521:72360110:72360221:72360628:72360784 | 72360110:72360221 |
| exon_skip_60840 | chr9 | 72356946:72357056:72359418:72359521:72360110:72360211 | 72359418:72359521 |
| exon_skip_85794 | chr9 | 72360628:72360787:72363470:72363606:72364462:72364592 | 72363470:72363606 |
| exon_skip_8900 | chr9 | 72359418:72359521:72360110:72360221:72360628:72360704 | 72360110:72360221 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for ZFAND5 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000343431 | 72363470 | 72363606 | 3UTR-3UTR |
| ENST00000237937 | 72359418 | 72359521 | Frame-shift |
| ENST00000343431 | 72359418 | 72359521 | Frame-shift |
| ENST00000376960 | 72359418 | 72359521 | Frame-shift |
| ENST00000376962 | 72359418 | 72359521 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000343431 | 72363470 | 72363606 | 3UTR-3UTR |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000343431 | 72363470 | 72363606 | 3UTR-3UTR |
| ENST00000237937 | 72359418 | 72359521 | Frame-shift |
| ENST00000343431 | 72359418 | 72359521 | Frame-shift |
| ENST00000376960 | 72359418 | 72359521 | Frame-shift |
| ENST00000376962 | 72359418 | 72359521 | Frame-shift |
| ENST00000237937 | 72360110 | 72360221 | Frame-shift |
| ENST00000343431 | 72360110 | 72360221 | Frame-shift |
| ENST00000376960 | 72360110 | 72360221 | Frame-shift |
| ENST00000376962 | 72360110 | 72360221 | Frame-shift |
| ENST00000237937 | 72356931 | 72357056 | In-frame |
| ENST00000343431 | 72356931 | 72357056 | In-frame |
| ENST00000376960 | 72356931 | 72357056 | In-frame |
| ENST00000376962 | 72356931 | 72357056 | In-frame |
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Infer the effects of exon skipping event on protein functional features for ZFAND5 |
p-ENSG00000107372_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000237937 | 5327 | 213 | 72356931 | 72357056 | 508 | 632 | 122 | 164 |
| ENST00000343431 | 1090 | 213 | 72356931 | 72357056 | 679 | 803 | 122 | 164 |
| ENST00000376960 | 2703 | 213 | 72356931 | 72357056 | 917 | 1041 | 122 | 164 |
| ENST00000376962 | 2802 | 213 | 72356931 | 72357056 | 1016 | 1140 | 122 | 164 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| O76080 | 122 | 164 | 1 | 213 | Chain | ID=PRO_0000066557;Note=AN1-type zinc finger protein 5 |
| O76080 | 122 | 164 | 1 | 213 | Chain | ID=PRO_0000066557;Note=AN1-type zinc finger protein 5 |
| O76080 | 122 | 164 | 1 | 213 | Chain | ID=PRO_0000066557;Note=AN1-type zinc finger protein 5 |
| O76080 | 122 | 164 | 1 | 213 | Chain | ID=PRO_0000066557;Note=AN1-type zinc finger protein 5 |
| O76080 | 122 | 164 | 151 | 194 | Zinc finger | Note=AN1-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00449 |
| O76080 | 122 | 164 | 151 | 194 | Zinc finger | Note=AN1-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00449 |
| O76080 | 122 | 164 | 151 | 194 | Zinc finger | Note=AN1-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00449 |
| O76080 | 122 | 164 | 151 | 194 | Zinc finger | Note=AN1-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00449 |
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3'-UTR located exon skipping events that lost miRNA binding sites in ZFAND5 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
| Mayo | ENST00000343431 | 72363470 | 72363606 | hsa-miR-182-5p | chr9:72363561-72363568 | 8mer-1a | chr9:72363545-72363568 | 166.00 | -17.42 |
| Mayo | ENST00000343431 | 72363470 | 72363606 | hsa-miR-875-3p | chr9:72363539-72363546 | 8mer-1a | chr9:72363536-72363558 | 163.00 | -20.59 |
| MSBB | ENST00000343431 | 72363470 | 72363606 | hsa-miR-182-5p | chr9:72363561-72363568 | 8mer-1a | chr9:72363545-72363568 | 166.00 | -17.42 |
| MSBB | ENST00000343431 | 72363470 | 72363606 | hsa-miR-875-3p | chr9:72363539-72363546 | 8mer-1a | chr9:72363536-72363558 | 163.00 | -20.59 |
| ROSMAP | ENST00000343431 | 72363470 | 72363606 | hsa-miR-182-5p | chr9:72363561-72363568 | 8mer-1a | chr9:72363545-72363568 | 166.00 | -17.42 |
| ROSMAP | ENST00000343431 | 72363470 | 72363606 | hsa-miR-875-3p | chr9:72363539-72363546 | 8mer-1a | chr9:72363536-72363558 | 163.00 | -20.59 |
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SNVs in the skipped exons for ZFAND5 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for ZFAND5 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ZFAND5 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for ZFAND5 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | PCBP4 | exon_skip_62475 | 4.415808e-01 | 5.661166e-09 |
| CB | NUP42 | exon_skip_62475 | 5.689805e-01 | 5.089251e-15 |
| TC | KHDRBS3 | exon_skip_62475 | 5.416436e-01 | 1.676636e-13 |
| TC | NUP42 | exon_skip_62475 | 6.117995e-01 | 1.064270e-17 |
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RelatedDrugs for ZFAND5 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZFAND5 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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