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![]() | Open reading frame (ORF) annotation in the exon skipping event |
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![]() | 3'-UTR located exon skipping events lost miRNA binding sites |
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![]() | Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for ZNF207 |
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Gene information | Gene symbol | ZNF207 | Gene ID | 7756 |
Gene name | zinc finger protein 207 | |
Synonyms | BuGZ|hBuGZ | |
Cytomap | 17q11.2 | |
Type of gene | protein-coding | |
Description | BUB3-interacting and GLEBS motif-containing protein ZNF207 | |
Modification date | 20200313 | |
UniProtAcc | H0Y3M2, | |
Context |
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Gene | GO ID | GO term | PubMed ID |
ZNF207 | GO:0090307 | mitotic spindle assembly | 26388440 |
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Gene structures and expression levels for ZNF207 |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
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Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
CB | UP | ENST00000394673.6 | ZNF207-204:protein_coding:ZNF207 | 1.311368e+02 | 9.541401e-01 | 3.088717e-04 | 1.918547e-03 |
CB | UP | ENST00000584416.1 | ZNF207-216:lncRNA:ZNF207 | 5.261865e+00 | 8.201385e-01 | 1.243411e-02 | 4.148583e-02 |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for ZNF207 |
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Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_169109 | chr17 | 32360892:32360967:32361468:32361515:32362914:32362984 | 32361468:32361515 |
exon_skip_191309 | chr17 | 32365478:32365487:32366665:32366757:32367772:32368014 | 32366665:32366757 |
exon_skip_221211 | chr17 | 32365330:32365487:32366665:32366757:32367772:32367943 | 32366665:32366757 |
exon_skip_256609 | chr17 | 32360948:32360967:32361468:32361515:32362914:32362984 | 32361468:32361515 |
exon_skip_261904 | chr17 | 32365330:32365487:32366665:32366757:32367772:32368014 | 32366665:32366757 |
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Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
exon_skip_169109 | MSBB_PG | 5.836719e-01 | 6.840741e-01 | -1.004022e-01 | 2.657477e-02 |
exon_skip_169109 | Mayo_CB | 3.175610e-01 | 4.537662e-01 | -1.362053e-01 | 5.352149e-06 |
exon_skip_236847 | Mayo_CB | 3.418519e-01 | 4.526230e-01 | -1.107711e-01 | 3.838589e-07 |
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Open reading frame (ORF) annotation in the exon skipping event for ZNF207 |
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ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000321233 | 32366665 | 32366757 | In-frame |
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ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000321233 | 32366665 | 32366757 | In-frame |
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ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000321233 | 32366665 | 32366757 | In-frame |
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Infer the effects of exon skipping event on protein functional features for ZNF207 |
p-ENSG00000010244_img4.png![]() |
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ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000321233 | 2300 | 478 | 32366665 | 32366757 | 936 | 1027 | 260 | 291 |
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ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000321233 | 2300 | 478 | 32366665 | 32366757 | 936 | 1027 | 260 | 291 |
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ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000321233 | 2300 | 478 | 32366665 | 32366757 | 936 | 1027 | 260 | 291 |
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UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
O43670 | 260 | 291 | 261 | 291 | Alternative sequence | ID=VSP_006905;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
O43670 | 260 | 291 | 1 | 478 | Chain | ID=PRO_0000047453;Note=BUB3-interacting and GLEBS motif-containing protein ZNF207 |
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UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
O43670 | 260 | 291 | 261 | 291 | Alternative sequence | ID=VSP_006905;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
O43670 | 260 | 291 | 1 | 478 | Chain | ID=PRO_0000047453;Note=BUB3-interacting and GLEBS motif-containing protein ZNF207 |
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UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
O43670 | 260 | 291 | 261 | 291 | Alternative sequence | ID=VSP_006905;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
O43670 | 260 | 291 | 1 | 478 | Chain | ID=PRO_0000047453;Note=BUB3-interacting and GLEBS motif-containing protein ZNF207 |
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3'-UTR located exon skipping events that lost miRNA binding sites in ZNF207 |
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Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for ZNF207 |
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Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for ZNF207 |
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AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ZNF207 |
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Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for ZNF207 |
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Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
CB | PCBP4 | exon_skip_169109 | 5.146300e-01 | 3.938345e-12 |
CB | RBM4B | exon_skip_169109 | -6.340304e-01 | 2.941486e-19 |
CB | RBM6 | exon_skip_221211 | -4.267058e-01 | 2.039614e-08 |
CB | PCBP4 | exon_skip_221211 | 5.169822e-01 | 3.024836e-12 |
CB | DAZAP1 | exon_skip_236847 | -4.057183e-01 | 5.468586e-07 |
CB | ZNF638 | exon_skip_236847 | -4.505082e-01 | 1.848459e-08 |
CB | SAMD4A | exon_skip_236847 | -4.661361e-01 | 5.029506e-09 |
CB | NUP42 | exon_skip_236847 | 4.879927e-01 | 7.274151e-10 |
CB | ZNF638 | exon_skip_229928 | -4.475092e-01 | 1.871149e-08 |
HCC | RBM4B | exon_skip_169109 | -4.550033e-01 | 2.347379e-15 |
IFG | RBMS3 | exon_skip_169109 | -4.754012e-01 | 1.056611e-02 |
IFG | IGF2BP3 | exon_skip_169109 | -4.233938e-01 | 2.476620e-02 |
IFG | RBM4B | exon_skip_169109 | -5.094575e-01 | 5.621495e-03 |
PCC | RBM6 | exon_skip_221211 | -4.249562e-01 | 9.476336e-11 |
PG | NUP42 | exon_skip_169109 | 4.392252e-01 | 5.547462e-10 |
PG | FXR2 | exon_skip_221211 | 4.220225e-01 | 7.240064e-10 |
PG | FUBP1 | exon_skip_221211 | 4.081076e-01 | 2.893803e-09 |
PG | ENOX1 | exon_skip_221211 | 4.706628e-01 | 3.373763e-12 |
PG | RALYL | exon_skip_221211 | 5.195490e-01 | 6.058207e-15 |
PG | NOVA1 | exon_skip_221211 | 5.259294e-01 | 2.457822e-15 |
TC | RBM4B | exon_skip_256609 | -4.056717e-01 | 1.027607e-07 |
TC | RALYL | exon_skip_221211 | 4.770376e-01 | 1.801752e-10 |
TC | NOVA1 | exon_skip_221211 | 6.561642e-01 | 4.595135e-21 |
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RelatedDrugs for ZNF207 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZNF207 |
![]() (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |