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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for ZNF202 |
Gene summary |
Gene information | Gene symbol | ZNF202 | Gene ID | 7753 |
Gene name | zinc finger protein 202 | |
Synonyms | ZKSCAN10|ZSCAN42 | |
Cytomap | 11q24.1 | |
Type of gene | protein-coding | |
Description | zinc finger protein 202zinc finger protein with KRAB and SCAN domains 10 | |
Modification date | 20200313 | |
UniProtAcc | ||
Context |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
ZNF202 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 10748193 |
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Gene structures and expression levels for ZNF202 |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
CB | UP | ENST00000533463.5 | ZNF202-209:protein_coding:ZNF202 | 3.191944e+00 | 1.673621e+00 | 1.879976e-05 | 1.796128e-04 |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for ZNF202 |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_109980 | chr11 | 123730858:123730985:123740393:123740536:123741549:123741614 | 123740393:123740536 |
exon_skip_120116 | chr11 | 123730858:123730985:123740117:123740232:123740417:123740536 | 123740117:123740232 |
exon_skip_215234 | chr11 | 123730858:123730985:123740117:123740189:123740417:123740536 | 123740117:123740189 |
exon_skip_226421 | chr11 | 123724780:123726991:123727476:123727595:123728133:123728262 | 123727476:123727595 |
exon_skip_232788 | chr11 | 123730858:123730985:123739434:123739543:123740117:123740232 | 123739434:123739543 |
exon_skip_237792 | chr11 | 123730858:123730985:123739434:123739543:123740117:123740189 | 123739434:123739543 |
exon_skip_284485 | chr11 | 123730491:123730985:123740117:123740232:123740393:123740536 | 123740117:123740232 |
exon_skip_289871 | chr11 | 123730491:123730985:123740393:123740536:123741549:123741614 | 123740393:123740536 |
exon_skip_295255 | chr11 | 123730858:123730985:123740393:123740536:123741549:123741560 | 123740393:123740536 |
exon_skip_29841 | chr11 | 123730858:123730985:123740117:123740232:123740393:123740536 | 123740117:123740232 |
exon_skip_90503 | chr11 | 123730858:123730985:123740117:123740192:123740417:123740536 | 123740117:123740192 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for ZNF202 |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000530393 | 123740117 | 123740192 | 3UTR-3UTR |
ENST00000336139 | 123740393 | 123740536 | 3UTR-3UTR |
ENST00000336139 | 123727476 | 123727595 | In-frame |
ENST00000529691 | 123727476 | 123727595 | In-frame |
ENST00000530393 | 123727476 | 123727595 | In-frame |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000336139 | 123727476 | 123727595 | In-frame |
ENST00000529691 | 123727476 | 123727595 | In-frame |
ENST00000530393 | 123727476 | 123727595 | In-frame |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000336139 | 123740393 | 123740536 | 3UTR-3UTR |
ENST00000336139 | 123727476 | 123727595 | In-frame |
ENST00000529691 | 123727476 | 123727595 | In-frame |
ENST00000530393 | 123727476 | 123727595 | In-frame |
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Infer the effects of exon skipping event on protein functional features for ZNF202 |
p-ENSG00000166261_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000336139 | 4147 | 648 | 123727476 | 123727595 | 1196 | 1314 | 277 | 317 |
ENST00000529691 | 3401 | 648 | 123727476 | 123727595 | 1053 | 1171 | 277 | 317 |
ENST00000530393 | 3581 | 648 | 123727476 | 123727595 | 1233 | 1351 | 277 | 317 |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000336139 | 4147 | 648 | 123727476 | 123727595 | 1196 | 1314 | 277 | 317 |
ENST00000529691 | 3401 | 648 | 123727476 | 123727595 | 1053 | 1171 | 277 | 317 |
ENST00000530393 | 3581 | 648 | 123727476 | 123727595 | 1233 | 1351 | 277 | 317 |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000336139 | 4147 | 648 | 123727476 | 123727595 | 1196 | 1314 | 277 | 317 |
ENST00000529691 | 3401 | 648 | 123727476 | 123727595 | 1053 | 1171 | 277 | 317 |
ENST00000530393 | 3581 | 648 | 123727476 | 123727595 | 1233 | 1351 | 277 | 317 |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
O95125 | 277 | 317 | 1 | 648 | Chain | ID=PRO_0000047450;Note=Zinc finger protein 202 |
O95125 | 277 | 317 | 1 | 648 | Chain | ID=PRO_0000047450;Note=Zinc finger protein 202 |
O95125 | 277 | 317 | 1 | 648 | Chain | ID=PRO_0000047450;Note=Zinc finger protein 202 |
O95125 | 277 | 317 | 237 | 308 | Domain | Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119 |
O95125 | 277 | 317 | 237 | 308 | Domain | Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119 |
O95125 | 277 | 317 | 237 | 308 | Domain | Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119 |
O95125 | 277 | 317 | 278 | 278 | Sequence conflict | Note=S->AA;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
O95125 | 277 | 317 | 278 | 278 | Sequence conflict | Note=S->AA;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
O95125 | 277 | 317 | 278 | 278 | Sequence conflict | Note=S->AA;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
O95125 | 277 | 317 | 1 | 648 | Chain | ID=PRO_0000047450;Note=Zinc finger protein 202 |
O95125 | 277 | 317 | 1 | 648 | Chain | ID=PRO_0000047450;Note=Zinc finger protein 202 |
O95125 | 277 | 317 | 1 | 648 | Chain | ID=PRO_0000047450;Note=Zinc finger protein 202 |
O95125 | 277 | 317 | 237 | 308 | Domain | Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119 |
O95125 | 277 | 317 | 237 | 308 | Domain | Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119 |
O95125 | 277 | 317 | 237 | 308 | Domain | Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119 |
O95125 | 277 | 317 | 278 | 278 | Sequence conflict | Note=S->AA;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
O95125 | 277 | 317 | 278 | 278 | Sequence conflict | Note=S->AA;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
O95125 | 277 | 317 | 278 | 278 | Sequence conflict | Note=S->AA;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
O95125 | 277 | 317 | 1 | 648 | Chain | ID=PRO_0000047450;Note=Zinc finger protein 202 |
O95125 | 277 | 317 | 1 | 648 | Chain | ID=PRO_0000047450;Note=Zinc finger protein 202 |
O95125 | 277 | 317 | 1 | 648 | Chain | ID=PRO_0000047450;Note=Zinc finger protein 202 |
O95125 | 277 | 317 | 237 | 308 | Domain | Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119 |
O95125 | 277 | 317 | 237 | 308 | Domain | Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119 |
O95125 | 277 | 317 | 237 | 308 | Domain | Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119 |
O95125 | 277 | 317 | 278 | 278 | Sequence conflict | Note=S->AA;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
O95125 | 277 | 317 | 278 | 278 | Sequence conflict | Note=S->AA;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
O95125 | 277 | 317 | 278 | 278 | Sequence conflict | Note=S->AA;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
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3'-UTR located exon skipping events that lost miRNA binding sites in ZNF202 |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
Mayo | ENST00000336139 | 123740393 | 123740536 | hsa-miR-640 | chr11:123740435-123740442 | 8mer-1a | chr11:123740422-123740442 | 175.00 | -24.68 |
Mayo | ENST00000336139 | 123740393 | 123740536 | hsa-miR-12115 | chr11:123740487-123740494 | 8mer-1a | chr11:123740475-123740498 | 164.00 | -21.81 |
Mayo | ENST00000336139 | 123740393 | 123740536 | hsa-miR-1236-3p | chr11:123740460-123740467 | 8mer-1a | chr11:123740449-123740471 | 157.00 | -29.28 |
ROSMAP | ENST00000530393 | 123740117 | 123740192 | hsa-miR-3529-3p | chr11:123740166-123740173 | 8mer-1a | chr11:123740164-123740187 | 160.00 | -17.23 |
ROSMAP | ENST00000336139 | 123740393 | 123740536 | hsa-miR-640 | chr11:123740435-123740442 | 8mer-1a | chr11:123740422-123740442 | 175.00 | -24.68 |
ROSMAP | ENST00000530393 | 123740117 | 123740192 | hsa-miR-3126-5p | chr11:123740144-123740151 | 8mer-1a | chr11:123740131-123740152 | 158.00 | -25.94 |
ROSMAP | ENST00000336139 | 123740393 | 123740536 | hsa-miR-12115 | chr11:123740487-123740494 | 8mer-1a | chr11:123740475-123740498 | 164.00 | -21.81 |
ROSMAP | ENST00000336139 | 123740393 | 123740536 | hsa-miR-1236-3p | chr11:123740460-123740467 | 8mer-1a | chr11:123740449-123740471 | 157.00 | -29.28 |
ROSMAP | ENST00000530393 | 123740117 | 123740192 | hsa-miR-6875-5p | chr11:123740144-123740151 | 8mer-1a | chr11:123740131-123740152 | 158.00 | -25.94 |
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SNVs in the skipped exons for ZNF202 |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for ZNF202 |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ZNF202 |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for ZNF202 |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for ZNF202 |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZNF202 |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |