ExonSkipAD: functional annotation of exon skipping event in human

Gene summary for ZMYM2

Gene summary

Gene information	Gene symbol	ZMYM2
	Gene ID	7750
	Gene name	zinc finger MYM-type containing 2
	Synonyms	FIM\|MYM\|RAMP\|SCLL\|ZNF198
	Cytomap	13q12.11
	Type of gene	protein-coding
	Description	zinc finger MYM-type protein 2fused in myeloproliferative disorders proteinrearranged in an atypical myeloproliferative disorderzinc finger protein 198zinc finger, MYM-type 2
	Modification date	20200313
	UniProtAcc	A0A087X151, Q9UBW7,
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene

GO ID

GO term

PubMed ID

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Gene structures and expression levels for ZMYM2

Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

ENSG00000121741

Differentially expressed gene analysis across multiple brain tissues between AD and control.

Tissue type

DEG direction

Base mean exp.

log2FC(AD/control)

P-value

Adj. p-value

Differentially expressed isoform analysis across multiple brain tissues between AD and control.

Tissue type	DEG direction	ENST	Transcript info.	Base mean exp.	log2FC(AD/control)	P-value	Adjc. p-value
CB	UP	ENST00000620447.1	ZMYM2-211:protein_coding:ZMYM2	1.295036e+01	1.570036e+00	1.495608e-08	4.243289e-07
TC	UP	ENST00000620447.1	ZMYM2-211:protein_coding:ZMYM2	1.487126e+01	1.062411e+00	1.749484e-05	4.033190e-04
TC	DOWN	ENST00000382874.6	ZMYM2-203:protein_coding:ZMYM2	1.953065e+02	-2.037697e+00	3.479850e-03	2.553338e-02

Landscape of isoform expressions across multiple brain tissues between AD and control.

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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for ZMYM2

Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap).

All exon skipping events in AD cohorts.

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon
exon_skip_107806	chr13	19959958:19960026:19970025:19970071:19993063:19993548	19970025:19970071
exon_skip_116350	chr13	19959958:19960026:19970025:19970071:19993063:19993559	19970025:19970071
exon_skip_16371	chr13	20019547:20019618:20026612:20026762:20027203:20027318	20026612:20026762
exon_skip_167699	chr13	20006374:20006586:20019547:20019618:20026612:20026762	20019547:20019618
exon_skip_168533	chr13	20067284:20067390:20082016:20082130:20082781:20083032	20082016:20082130
exon_skip_172331	chr13	20064451:20064545:20066851:20067019:20067239:20067390	20066851:20067019
exon_skip_188483	chr13	19959958:19960026:19993063:19993919:20002850:20003092	19993063:19993919
exon_skip_190854	chr13	20027203:20027318:20027985:20028064:20031319:20031379	20027985:20028064
exon_skip_213707	chr13	19959958:19960026:19965220:19965281:19993063:19993564	19965220:19965281
exon_skip_217303	chr13	20031319:20031435:20034254:20034404:20036737:20036909	20034254:20034404
exon_skip_233858	chr13	19959958:19960026:19970025:19970071:19993063:19993564	19970025:19970071
exon_skip_237011	chr13	20005074:20005239:20006374:20006586:20019547:20019618	20006374:20006586
exon_skip_248836	chr13	19959958:19960026:19965220:19965281:19993063:19993559	19965220:19965281
exon_skip_26819	chr13	19959958:19960026:19965220:19965281:19993063:19993548	19965220:19965281
exon_skip_274655	chr13	20067239:20067390:20082016:20082130:20082781:20082848	20082016:20082130
exon_skip_281905	chr13	20051441:20051598:20052277:20052311:20058575:20058704	20052277:20052311
exon_skip_287172	chr13	19959859:19960026:19965220:19965281:19993063:19993559	19965220:19965281
exon_skip_3974	chr13	20059447:20059562:20061053:20061224:20062846:20062971	20061053:20061224
exon_skip_42836	chr13	19993063:19993564:19993826:19993919:20002850:20003092	19993826:19993919
exon_skip_52716	chr13	20019551:20019618:20026612:20026762:20027203:20027318	20026612:20026762
exon_skip_54279	chr13	20067239:20067390:20082016:20082130:20082781:20083032	20082016:20082130
exon_skip_82925	chr13	19993826:19993919:20002850:20003135:20005074:20005239	20002850:20003135
exon_skip_96946	chr13	20061053:20061224:20062846:20062971:20064451:20064545	20062846:20062971

Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control.

Exon skipping information

Tissue type

Avg(PSIs) in AD

Avg(PSIs) in control

Difference (PSI)

Adj. p-value

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Open reading frame (ORF) annotation in the exon skipping event for ZMYM2

Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000382871	19970025	19970071	5UTR-5UTR
ENST00000382874	19970025	19970071	5UTR-5UTR
ENST00000382871	20026612	20026762	Frame-shift
ENST00000382874	20026612	20026762	Frame-shift
ENST00000610343	20026612	20026762	Frame-shift
ENST00000382871	20034254	20034404	Frame-shift
ENST00000382874	20034254	20034404	Frame-shift
ENST00000610343	20034254	20034404	Frame-shift
ENST00000382871	20066851	20067019	Frame-shift
ENST00000382874	20066851	20067019	Frame-shift
ENST00000610343	20066851	20067019	Frame-shift
ENST00000382871	20082016	20082130	Frame-shift
ENST00000382874	20082016	20082130	Frame-shift
ENST00000610343	20082016	20082130	Frame-shift
ENST00000382871	20006374	20006586	In-frame
ENST00000382874	20006374	20006586	In-frame
ENST00000610343	20006374	20006586	In-frame
ENST00000382871	20062846	20062971	In-frame
ENST00000382874	20062846	20062971	In-frame
ENST00000610343	20062846	20062971	In-frame

Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000382871	19970025	19970071	5UTR-5UTR
ENST00000382874	19970025	19970071	5UTR-5UTR
ENST00000382871	20034254	20034404	Frame-shift
ENST00000382874	20034254	20034404	Frame-shift
ENST00000610343	20034254	20034404	Frame-shift
ENST00000382871	20082016	20082130	Frame-shift
ENST00000382874	20082016	20082130	Frame-shift
ENST00000610343	20082016	20082130	Frame-shift
ENST00000382871	20006374	20006586	In-frame
ENST00000382874	20006374	20006586	In-frame
ENST00000610343	20006374	20006586	In-frame
ENST00000382871	20019547	20019618	In-frame
ENST00000382874	20019547	20019618	In-frame
ENST00000610343	20019547	20019618	In-frame
ENST00000382871	20062846	20062971	In-frame
ENST00000382874	20062846	20062971	In-frame
ENST00000610343	20062846	20062971	In-frame

Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000610343	19993063	19993919	5CDS-5UTR
ENST00000382871	19970025	19970071	5UTR-5UTR
ENST00000382874	19970025	19970071	5UTR-5UTR
ENST00000382871	20002850	20003135	Frame-shift
ENST00000382874	20002850	20003135	Frame-shift
ENST00000610343	20002850	20003135	Frame-shift
ENST00000382871	20026612	20026762	Frame-shift
ENST00000382874	20026612	20026762	Frame-shift
ENST00000610343	20026612	20026762	Frame-shift
ENST00000382871	20034254	20034404	Frame-shift
ENST00000382874	20034254	20034404	Frame-shift
ENST00000610343	20034254	20034404	Frame-shift
ENST00000382871	20052277	20052311	Frame-shift
ENST00000382874	20052277	20052311	Frame-shift
ENST00000610343	20052277	20052311	Frame-shift
ENST00000382871	20061053	20061224	Frame-shift
ENST00000382874	20061053	20061224	Frame-shift
ENST00000610343	20061053	20061224	Frame-shift
ENST00000382871	20066851	20067019	Frame-shift
ENST00000382874	20066851	20067019	Frame-shift
ENST00000610343	20066851	20067019	Frame-shift
ENST00000382871	20082016	20082130	Frame-shift
ENST00000382874	20082016	20082130	Frame-shift
ENST00000610343	20082016	20082130	Frame-shift
ENST00000382871	20006374	20006586	In-frame
ENST00000382874	20006374	20006586	In-frame
ENST00000610343	20006374	20006586	In-frame
ENST00000382871	20019547	20019618	In-frame
ENST00000382874	20019547	20019618	In-frame
ENST00000610343	20019547	20019618	In-frame
ENST00000382871	20062846	20062971	In-frame
ENST00000382874	20062846	20062971	In-frame
ENST00000610343	20062846	20062971	In-frame

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Infer the effects of exon skipping event on protein functional features for ZMYM2

p-ENSG00000121741_img4.png
boxplot

Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000382871	5068	1377	20006374	20006586	1486	1697	433	504
ENST00000382874	10156	1377	20006374	20006586	1491	1702	433	504
ENST00000610343	10217	1377	20006374	20006586	1552	1763	433	504
ENST00000382871	5068	1377	20062846	20062971	3098	3222	971	1012
ENST00000382874	10156	1377	20062846	20062971	3103	3227	971	1012
ENST00000610343	10217	1377	20062846	20062971	3164	3288	971	1012

Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000382871	5068	1377	20006374	20006586	1486	1697	433	504
ENST00000382874	10156	1377	20006374	20006586	1491	1702	433	504
ENST00000610343	10217	1377	20006374	20006586	1552	1763	433	504
ENST00000382871	5068	1377	20019547	20019618	1699	1769	504	528
ENST00000382874	10156	1377	20019547	20019618	1704	1774	504	528
ENST00000610343	10217	1377	20019547	20019618	1765	1835	504	528
ENST00000382871	5068	1377	20062846	20062971	3098	3222	971	1012
ENST00000382874	10156	1377	20062846	20062971	3103	3227	971	1012
ENST00000610343	10217	1377	20062846	20062971	3164	3288	971	1012

Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000382871	5068	1377	20006374	20006586	1486	1697	433	504
ENST00000382874	10156	1377	20006374	20006586	1491	1702	433	504
ENST00000610343	10217	1377	20006374	20006586	1552	1763	433	504
ENST00000382871	5068	1377	20019547	20019618	1699	1769	504	528
ENST00000382874	10156	1377	20019547	20019618	1704	1774	504	528
ENST00000610343	10217	1377	20019547	20019618	1765	1835	504	528
ENST00000382871	5068	1377	20062846	20062971	3098	3222	971	1012
ENST00000382874	10156	1377	20062846	20062971	3103	3227	971	1012
ENST00000610343	10217	1377	20062846	20062971	3164	3288	971	1012

Lost protein functional features of individual exon skipping events in ROSMAP.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
Q9UBW7	433	504	1	1377	Chain	ID=PRO_0000191382;Note=Zinc finger MYM-type protein 2
Q9UBW7	433	504	1	1377	Chain	ID=PRO_0000191382;Note=Zinc finger MYM-type protein 2
Q9UBW7	433	504	1	1377	Chain	ID=PRO_0000191382;Note=Zinc finger MYM-type protein 2
Q9UBW7	433	504	441	441	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:25218447,ECO:0000244\|PubMed:25755297,ECO:0000244\|PubMed:28112733;Dbxref=PMID:25218447,PMID:25755297,PMI
Q9UBW7	433	504	441	441	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:25218447,ECO:0000244\|PubMed:25755297,ECO:0000244\|PubMed:28112733;Dbxref=PMID:25218447,PMID:25755297,PMI
Q9UBW7	433	504	441	441	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:25218447,ECO:0000244\|PubMed:25755297,ECO:0000244\|PubMed:28112733;Dbxref=PMID:25218447,PMID:25755297,PMI
Q9UBW7	433	504	491	491	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:28112733;Dbxref=PMID:28112733
Q9UBW7	433	504	491	491	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:28112733;Dbxref=PMID:28112733
Q9UBW7	433	504	491	491	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:28112733;Dbxref=PMID:28112733
Q9UBW7	433	504	503	503	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:28112733;Dbxref=PMID:28112733
Q9UBW7	433	504	503	503	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:28112733;Dbxref=PMID:28112733
Q9UBW7	433	504	503	503	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:28112733;Dbxref=PMID:28112733
Q9UBW7	433	504	398	436	Zinc finger	Note=MYM-type 2
Q9UBW7	433	504	398	436	Zinc finger	Note=MYM-type 2
Q9UBW7	433	504	398	436	Zinc finger	Note=MYM-type 2
Q9UBW7	433	504	445	480	Zinc finger	Note=MYM-type 3
Q9UBW7	433	504	445	480	Zinc finger	Note=MYM-type 3
Q9UBW7	433	504	445	480	Zinc finger	Note=MYM-type 3
Q9UBW7	433	504	491	549	Zinc finger	Note=MYM-type 4
Q9UBW7	433	504	491	549	Zinc finger	Note=MYM-type 4
Q9UBW7	433	504	491	549	Zinc finger	Note=MYM-type 4
Q9UBW7	971	1012	550	1377	Alternative sequence	ID=VSP_039067;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11230166;Dbxref=PMID:11230166
Q9UBW7	971	1012	550	1377	Alternative sequence	ID=VSP_039067;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11230166;Dbxref=PMID:11230166
Q9UBW7	971	1012	550	1377	Alternative sequence	ID=VSP_039067;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11230166;Dbxref=PMID:11230166
Q9UBW7	971	1012	1	1377	Chain	ID=PRO_0000191382;Note=Zinc finger MYM-type protein 2
Q9UBW7	971	1012	1	1377	Chain	ID=PRO_0000191382;Note=Zinc finger MYM-type protein 2
Q9UBW7	971	1012	1	1377	Chain	ID=PRO_0000191382;Note=Zinc finger MYM-type protein 2
Q9UBW7	971	1012	1009	1010	Sequence conflict	Note=DF->IS;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q9UBW7	971	1012	1009	1010	Sequence conflict	Note=DF->IS;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q9UBW7	971	1012	1009	1010	Sequence conflict	Note=DF->IS;Ontology_term=ECO:0000305;evidence=ECO:0000305

Lost protein functional features of individual exon skipping events in MSBB.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
Q9UBW7	433	504	1	1377	Chain	ID=PRO_0000191382;Note=Zinc finger MYM-type protein 2
Q9UBW7	433	504	1	1377	Chain	ID=PRO_0000191382;Note=Zinc finger MYM-type protein 2
Q9UBW7	433	504	1	1377	Chain	ID=PRO_0000191382;Note=Zinc finger MYM-type protein 2
Q9UBW7	433	504	441	441	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:25218447,ECO:0000244\|PubMed:25755297,ECO:0000244\|PubMed:28112733;Dbxref=PMID:25218447,PMID:25755297,PMI
Q9UBW7	433	504	441	441	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:25218447,ECO:0000244\|PubMed:25755297,ECO:0000244\|PubMed:28112733;Dbxref=PMID:25218447,PMID:25755297,PMI
Q9UBW7	433	504	441	441	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:25218447,ECO:0000244\|PubMed:25755297,ECO:0000244\|PubMed:28112733;Dbxref=PMID:25218447,PMID:25755297,PMI
Q9UBW7	433	504	491	491	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:28112733;Dbxref=PMID:28112733
Q9UBW7	433	504	491	491	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:28112733;Dbxref=PMID:28112733
Q9UBW7	433	504	491	491	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:28112733;Dbxref=PMID:28112733
Q9UBW7	433	504	503	503	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:28112733;Dbxref=PMID:28112733
Q9UBW7	433	504	503	503	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:28112733;Dbxref=PMID:28112733
Q9UBW7	433	504	503	503	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:28112733;Dbxref=PMID:28112733
Q9UBW7	433	504	398	436	Zinc finger	Note=MYM-type 2
Q9UBW7	433	504	398	436	Zinc finger	Note=MYM-type 2
Q9UBW7	433	504	398	436	Zinc finger	Note=MYM-type 2
Q9UBW7	433	504	445	480	Zinc finger	Note=MYM-type 3
Q9UBW7	433	504	445	480	Zinc finger	Note=MYM-type 3
Q9UBW7	433	504	445	480	Zinc finger	Note=MYM-type 3
Q9UBW7	433	504	491	549	Zinc finger	Note=MYM-type 4
Q9UBW7	433	504	491	549	Zinc finger	Note=MYM-type 4
Q9UBW7	433	504	491	549	Zinc finger	Note=MYM-type 4
Q9UBW7	504	528	1	1377	Chain	ID=PRO_0000191382;Note=Zinc finger MYM-type protein 2
Q9UBW7	504	528	1	1377	Chain	ID=PRO_0000191382;Note=Zinc finger MYM-type protein 2
Q9UBW7	504	528	1	1377	Chain	ID=PRO_0000191382;Note=Zinc finger MYM-type protein 2
Q9UBW7	504	528	513	513	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:25755297,ECO:0000244\|PubMed:28112733;Dbxref=PMID:25755297,PMID:28112733
Q9UBW7	504	528	513	513	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:25755297,ECO:0000244\|PubMed:28112733;Dbxref=PMID:25755297,PMID:28112733
Q9UBW7	504	528	513	513	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:25755297,ECO:0000244\|PubMed:28112733;Dbxref=PMID:25755297,PMID:28112733
Q9UBW7	504	528	491	549	Zinc finger	Note=MYM-type 4
Q9UBW7	504	528	491	549	Zinc finger	Note=MYM-type 4
Q9UBW7	504	528	491	549	Zinc finger	Note=MYM-type 4
Q9UBW7	971	1012	550	1377	Alternative sequence	ID=VSP_039067;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11230166;Dbxref=PMID:11230166
Q9UBW7	971	1012	550	1377	Alternative sequence	ID=VSP_039067;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11230166;Dbxref=PMID:11230166
Q9UBW7	971	1012	550	1377	Alternative sequence	ID=VSP_039067;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11230166;Dbxref=PMID:11230166
Q9UBW7	971	1012	1	1377	Chain	ID=PRO_0000191382;Note=Zinc finger MYM-type protein 2
Q9UBW7	971	1012	1	1377	Chain	ID=PRO_0000191382;Note=Zinc finger MYM-type protein 2
Q9UBW7	971	1012	1	1377	Chain	ID=PRO_0000191382;Note=Zinc finger MYM-type protein 2
Q9UBW7	971	1012	1009	1010	Sequence conflict	Note=DF->IS;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q9UBW7	971	1012	1009	1010	Sequence conflict	Note=DF->IS;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q9UBW7	971	1012	1009	1010	Sequence conflict	Note=DF->IS;Ontology_term=ECO:0000305;evidence=ECO:0000305

Lost protein functional features of individual exon skipping events in Mayo.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
Q9UBW7	433	504	1	1377	Chain	ID=PRO_0000191382;Note=Zinc finger MYM-type protein 2
Q9UBW7	433	504	1	1377	Chain	ID=PRO_0000191382;Note=Zinc finger MYM-type protein 2
Q9UBW7	433	504	1	1377	Chain	ID=PRO_0000191382;Note=Zinc finger MYM-type protein 2
Q9UBW7	433	504	441	441	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:25218447,ECO:0000244\|PubMed:25755297,ECO:0000244\|PubMed:28112733;Dbxref=PMID:25218447,PMID:25755297,PMI
Q9UBW7	433	504	441	441	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:25218447,ECO:0000244\|PubMed:25755297,ECO:0000244\|PubMed:28112733;Dbxref=PMID:25218447,PMID:25755297,PMI
Q9UBW7	433	504	441	441	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:25218447,ECO:0000244\|PubMed:25755297,ECO:0000244\|PubMed:28112733;Dbxref=PMID:25218447,PMID:25755297,PMI
Q9UBW7	433	504	491	491	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:28112733;Dbxref=PMID:28112733
Q9UBW7	433	504	491	491	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:28112733;Dbxref=PMID:28112733
Q9UBW7	433	504	491	491	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:28112733;Dbxref=PMID:28112733
Q9UBW7	433	504	503	503	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:28112733;Dbxref=PMID:28112733
Q9UBW7	433	504	503	503	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:28112733;Dbxref=PMID:28112733
Q9UBW7	433	504	503	503	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:28112733;Dbxref=PMID:28112733
Q9UBW7	433	504	398	436	Zinc finger	Note=MYM-type 2
Q9UBW7	433	504	398	436	Zinc finger	Note=MYM-type 2
Q9UBW7	433	504	398	436	Zinc finger	Note=MYM-type 2
Q9UBW7	433	504	445	480	Zinc finger	Note=MYM-type 3
Q9UBW7	433	504	445	480	Zinc finger	Note=MYM-type 3
Q9UBW7	433	504	445	480	Zinc finger	Note=MYM-type 3
Q9UBW7	433	504	491	549	Zinc finger	Note=MYM-type 4
Q9UBW7	433	504	491	549	Zinc finger	Note=MYM-type 4
Q9UBW7	433	504	491	549	Zinc finger	Note=MYM-type 4
Q9UBW7	504	528	1	1377	Chain	ID=PRO_0000191382;Note=Zinc finger MYM-type protein 2
Q9UBW7	504	528	1	1377	Chain	ID=PRO_0000191382;Note=Zinc finger MYM-type protein 2
Q9UBW7	504	528	1	1377	Chain	ID=PRO_0000191382;Note=Zinc finger MYM-type protein 2
Q9UBW7	504	528	513	513	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:25755297,ECO:0000244\|PubMed:28112733;Dbxref=PMID:25755297,PMID:28112733
Q9UBW7	504	528	513	513	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:25755297,ECO:0000244\|PubMed:28112733;Dbxref=PMID:25755297,PMID:28112733
Q9UBW7	504	528	513	513	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:25755297,ECO:0000244\|PubMed:28112733;Dbxref=PMID:25755297,PMID:28112733
Q9UBW7	504	528	491	549	Zinc finger	Note=MYM-type 4
Q9UBW7	504	528	491	549	Zinc finger	Note=MYM-type 4
Q9UBW7	504	528	491	549	Zinc finger	Note=MYM-type 4
Q9UBW7	971	1012	550	1377	Alternative sequence	ID=VSP_039067;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11230166;Dbxref=PMID:11230166
Q9UBW7	971	1012	550	1377	Alternative sequence	ID=VSP_039067;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11230166;Dbxref=PMID:11230166
Q9UBW7	971	1012	550	1377	Alternative sequence	ID=VSP_039067;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11230166;Dbxref=PMID:11230166
Q9UBW7	971	1012	1	1377	Chain	ID=PRO_0000191382;Note=Zinc finger MYM-type protein 2
Q9UBW7	971	1012	1	1377	Chain	ID=PRO_0000191382;Note=Zinc finger MYM-type protein 2
Q9UBW7	971	1012	1	1377	Chain	ID=PRO_0000191382;Note=Zinc finger MYM-type protein 2
Q9UBW7	971	1012	1009	1010	Sequence conflict	Note=DF->IS;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q9UBW7	971	1012	1009	1010	Sequence conflict	Note=DF->IS;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q9UBW7	971	1012	1009	1010	Sequence conflict	Note=DF->IS;Ontology_term=ECO:0000305;evidence=ECO:0000305

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3'-UTR located exon skipping events that lost miRNA binding sites in ZMYM2

3'-UTR exon skipping evnets lost miRNA binding.

Tissue type

ENST

Exon skip start

Exon skip end

microRNA

Binding site by TargetScan

Binding type by TargetScan

Bdinding site by miRanda

Score of miRanda

Energy by miRanda

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SNVs in the skipped exons for ZMYM2

- Differential PSIs between mutated versus non-mutated samples.

- Depth of Coverage in the skipped exon of the mutated samples.

- Sashimi plot in the skipped exon of the mutated samples.

- Non-synonymous mutations located in the skipped exons.

Cancer type

Sample

ESID

Skipped exon start

Skipped exon end

Mutation start

Mutation end

Mutation type

Reference seq

Mutation seq

AAchange

- Non-synonymous mutations located in the skipped exons in CCLE.

Sample

Skipped exon start

Skipped exon end

Mutation start

Mutation end

Mutation type

Reference seq

Mutation seq

AAchange

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AD stage-associated exon skippint events for ZMYM2

Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR).

AD stage info

Cohort

Tissue

SE id

Coefficient

P-value

Chromosome

Strand

E1 start

E1 end

Skipped start

Skipped end

E2 start

E2 end

ADstage

MSBB

IFG

exon_skip_96946

-4.386924e-01

1.952789e-02

chr13

20061053

20061224

20062846

20062971

20064451

20064545

CDR

MSBB

IFG

exon_skip_190854

4.521281e-01

1.571284e-02

chr13

20027203

20027318

20027985

20028064

20031319

20031379

CDR

MSBB

IFG

exon_skip_237011

-4.253428e-01

2.404130e-02

chr13

20005074

20005239

20006374

20006586

20019547

20019618

CDR

MSBB

IFG

exon_skip_96946

-4.037619e-01

3.310854e-02

chr13

20061053

20061224

20062846

20062971

20064451

20064545

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ZMYM2

sQTL information located at the skipped exons.

Tissue type

Exon skip ID

SNP id

Location

P-value

FDR

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Correlation with RNA binding proteins (RBPs) for ZMYM2

Correlated RBP and related information.

Tissue type

RBP name

Exon skip ID

Correlation coeifficient

P-value

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RelatedDrugs for ZMYM2

Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for ZMYM2

Diseases associated with this gene.
(DisGeNet 4.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	Gene structures and expression levels
	Exon skipping events with PSIs in RPSMAP, MSBB, and Mayo
	Open reading frame (ORF) annotation in the exon skipping event
	Exon skipping events in the canonical protein sequence
	3'-UTR located exon skipping events lost miRNA binding sites
	SNVs in the skipped exons with depth of coverage
	AD stage-associated exon skipping events
	Splicing Quantitative Trait Loci (sQTLs) in the skipped exons
	Correlation with RNA binding proteins (RBPs)
	Related drugs with this gene
	Related diseases with this gene

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Gene summary for ZMYM2

Gene structures and expression levels for ZMYM2

Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for ZMYM2

Open reading frame (ORF) annotation in the exon skipping event for ZMYM2

Infer the effects of exon skipping event on protein functional features for ZMYM2

3'-UTR located exon skipping events that lost miRNA binding sites in ZMYM2

SNVs in the skipped exons for ZMYM2

AD stage-associated exon skippint events for ZMYM2

Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ZMYM2

Correlation with RNA binding proteins (RBPs) for ZMYM2

RelatedDrugs for ZMYM2

RelatedDiseases for ZMYM2