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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for ZBTB16 |
 Gene summary |
| Gene information | Gene symbol | ZBTB16 | Gene ID | 7704 |
| Gene name | zinc finger and BTB domain containing 16 | |
| Synonyms | PLZF|ZNF145 | |
| Cytomap | 11q23.2 | |
| Type of gene | protein-coding | |
| Description | zinc finger and BTB domain-containing protein 16promyelocytic leukaemia zinc fingerzinc finger protein 145 (Kruppel-like, expressed in promyelocytic leukemia)zinc finger protein PLZF | |
| Modification date | 20200329 | |
| UniProtAcc | ||
| Context | - 32296772(mGluR5 Contribution to Neuropathology in Alzheimer Mice Is Disease Stage-Dependent) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| ZBTB16 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 12802276 |
| ZBTB16 | GO:0030097 | hemopoiesis | 8541544 |
| ZBTB16 | GO:0045778 | positive regulation of ossification | 21547890 |
| ZBTB16 | GO:0045892 | negative regulation of transcription, DNA-templated | 12802276|24359566 |
| ZBTB16 | GO:0045893 | positive regulation of transcription, DNA-templated | 21547890 |
| ZBTB16 | GO:0051216 | cartilage development | 21547890 |
| ZBTB16 | GO:0061036 | positive regulation of cartilage development | 21547890 |
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Gene structures and expression levels for ZBTB16 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000109906
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | UP | ENST00000535509.1 | ZBTB16-204:retained_intron:ZBTB16 | 8.773231e+01 | 1.318644e+00 | 1.251314e-17 | 1.832795e-14 |
| CB | UP | ENST00000392996.2 | ZBTB16-202:protein_coding:ZBTB16 | 1.148806e+01 | 1.580362e+00 | 5.406469e-03 | 2.100015e-02 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for ZBTB16 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_104672 | chr11 | 114156337:114156434:114186952:114187038:114242167:114242337 | 114186952:114187038 |
| exon_skip_17834 | chr11 | 114064412:114064568:114156337:114156434:114186952:114187038 | 114156337:114156434 |
| exon_skip_189919 | chr11 | 114059737:114059882:114063211:114064568:114156337:114156434 | 114063211:114064568 |
| exon_skip_38697 | chr11 | 114059737:114059882:114061371:114061561:114063211:114063646 | 114061371:114061561 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for ZBTB16 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000335953 | 114156337 | 114156434 | Frame-shift |
| ENST00000392996 | 114156337 | 114156434 | Frame-shift |
| ENST00000335953 | 114186952 | 114187038 | In-frame |
| ENST00000392996 | 114186952 | 114187038 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000335953 | 114186952 | 114187038 | In-frame |
| ENST00000392996 | 114186952 | 114187038 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000335953 | 114156337 | 114156434 | Frame-shift |
| ENST00000392996 | 114156337 | 114156434 | Frame-shift |
| ENST00000335953 | 114186952 | 114187038 | In-frame |
| ENST00000392996 | 114186952 | 114187038 | In-frame |
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Infer the effects of exon skipping event on protein functional features for ZBTB16 |
p-ENSG00000109906_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000335953 | 2540 | 673 | 114186952 | 114187038 | 1748 | 1833 | 456 | 484 |
| ENST00000392996 | 2304 | 673 | 114186952 | 114187038 | 1536 | 1621 | 456 | 484 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000335953 | 2540 | 673 | 114186952 | 114187038 | 1748 | 1833 | 456 | 484 |
| ENST00000392996 | 2304 | 673 | 114186952 | 114187038 | 1536 | 1621 | 456 | 484 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000335953 | 2540 | 673 | 114186952 | 114187038 | 1748 | 1833 | 456 | 484 |
| ENST00000392996 | 2304 | 673 | 114186952 | 114187038 | 1536 | 1621 | 456 | 484 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q05516 | 456 | 484 | 1 | 673 | Chain | ID=PRO_0000047729;Note=Zinc finger and BTB domain-containing protein 16 |
| Q05516 | 456 | 484 | 1 | 673 | Chain | ID=PRO_0000047729;Note=Zinc finger and BTB domain-containing protein 16 |
| Q05516 | 456 | 484 | 461 | 483 | Zinc finger | Note=C2H2-type 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042 |
| Q05516 | 456 | 484 | 461 | 483 | Zinc finger | Note=C2H2-type 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q05516 | 456 | 484 | 1 | 673 | Chain | ID=PRO_0000047729;Note=Zinc finger and BTB domain-containing protein 16 |
| Q05516 | 456 | 484 | 1 | 673 | Chain | ID=PRO_0000047729;Note=Zinc finger and BTB domain-containing protein 16 |
| Q05516 | 456 | 484 | 461 | 483 | Zinc finger | Note=C2H2-type 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042 |
| Q05516 | 456 | 484 | 461 | 483 | Zinc finger | Note=C2H2-type 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042 |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q05516 | 456 | 484 | 1 | 673 | Chain | ID=PRO_0000047729;Note=Zinc finger and BTB domain-containing protein 16 |
| Q05516 | 456 | 484 | 1 | 673 | Chain | ID=PRO_0000047729;Note=Zinc finger and BTB domain-containing protein 16 |
| Q05516 | 456 | 484 | 461 | 483 | Zinc finger | Note=C2H2-type 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042 |
| Q05516 | 456 | 484 | 461 | 483 | Zinc finger | Note=C2H2-type 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042 |
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3'-UTR located exon skipping events that lost miRNA binding sites in ZBTB16 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for ZBTB16 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for ZBTB16 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
| ADstage | MSBB | IFG | exon_skip_104672 | 3.935323e-01 | 3.827670e-02 | chr11 | + | 114156337 | 114156434 | 114186952 | 114187038 | 114242167 | 114242337 |
| CDR | MSBB | IFG | exon_skip_104672 | 4.415670e-01 | 1.865349e-02 | chr11 | + | 114156337 | 114156434 | 114186952 | 114187038 | 114242167 | 114242337 |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ZBTB16 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for ZBTB16 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for ZBTB16 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZBTB16 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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