|
Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for ZNF142 |
Gene summary |
Gene information | Gene symbol | ZNF142 | Gene ID | 7701 |
Gene name | zinc finger protein 142 | |
Synonyms | HA4654|NEDISHM|pHZ-49 | |
Cytomap | 2q35 | |
Type of gene | protein-coding | |
Description | zinc finger protein 142zinc finger protein 142 (clone pHZ-49) | |
Modification date | 20200313 | |
UniProtAcc | ||
Context |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
Top |
Gene structures and expression levels for ZNF142 |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
STG | UP | ENST00000450765.5 | ZNF142-207:nonsense_mediated_decay:ZNF142 | 1.022746e+02 | 9.202550e-01 | 8.541827e-04 | 3.537591e-02 |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
Top |
Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for ZNF142 |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_133875 | chr2 | 218650501:218650526:218651701:218651822:218656150:218656403 | 218651701:218651822 |
exon_skip_165152 | chr2 | 218656350:218656463:218658701:218658801:218658980:218659122 | 218658701:218658801 |
exon_skip_174517 | chr2 | 218658701:218658801:218658980:218659130:218659369:218659476 | 218658980:218659130 |
exon_skip_192204 | chr2 | 218656350:218656463:218658701:218658876:218658980:218659122 | 218658701:218658876 |
exon_skip_20396 | chr2 | 218650501:218650526:218651701:218652300:218656150:218656403 | 218651701:218652300 |
exon_skip_2316 | chr2 | 218658701:218658876:218658980:218659130:218659369:218659476 | 218658980:218659130 |
exon_skip_253844 | chr2 | 218656387:218656463:218658701:218658801:218658980:218659035 | 218658701:218658801 |
exon_skip_277142 | chr2 | 218656387:218656463:218658701:218658801:218658980:218659122 | 218658701:218658801 |
exon_skip_296204 | chr2 | 218642028:218645064:218646171:218646348:218648635:218649459 | 218646171:218646348 |
exon_skip_56135 | chr2 | 218650501:218650526:218656150:218656463:218658701:218658801 | 218656150:218656463 |
exon_skip_94678 | chr2 | 218656387:218656463:218658701:218658876:218658980:218659035 | 218658701:218658876 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
exon_skip_20396 | Mayo_CB | 5.225316e-01 | 6.509091e-01 | -1.283774e-01 | 3.020492e-07 |
Top |
Open reading frame (ORF) annotation in the exon skipping event for ZNF142 |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000411696 | 218656150 | 218656463 | 3UTR-3CDS |
ENST00000449707 | 218656150 | 218656463 | 3UTR-3CDS |
ENST00000449707 | 218658701 | 218658876 | 3UTR-3UTR |
ENST00000411696 | 218646171 | 218646348 | Frame-shift |
ENST00000449707 | 218646171 | 218646348 | Frame-shift |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000411696 | 218656150 | 218656463 | 3UTR-3CDS |
ENST00000449707 | 218656150 | 218656463 | 3UTR-3CDS |
ENST00000449707 | 218658701 | 218658876 | 3UTR-3UTR |
ENST00000411696 | 218646171 | 218646348 | Frame-shift |
ENST00000449707 | 218646171 | 218646348 | Frame-shift |
Top |
Infer the effects of exon skipping event on protein functional features for ZNF142 |
p-ENSG00000115568_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Top |
3'-UTR located exon skipping events that lost miRNA binding sites in ZNF142 |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
Mayo | ENST00000449707 | 218658701 | 218658876 | hsa-miR-942-5p | chr2:218658842-218658849 | 8mer-1a | chr2:218658830-218658849 | 152.00 | -23.73 |
Mayo | ENST00000449707 | 218658701 | 218658876 | hsa-miR-3620-3p | chr2:218658813-218658820 | 8mer-1a | chr2:218658799-218658822 | 171.00 | -32.89 |
Mayo | ENST00000449707 | 218658701 | 218658876 | hsa-miR-548q | chr2:218658837-218658844 | 8mer-1a | chr2:218658826-218658847 | 161.00 | -24.97 |
Mayo | ENST00000449707 | 218658701 | 218658876 | hsa-miR-4699-5p | chr2:218658724-218658731 | 8mer-1a | chr2:218658709-218658734 | 146.00 | -19.41 |
Mayo | ENST00000449707 | 218658701 | 218658876 | hsa-miR-6764-3p | chr2:218658839-218658846 | 8mer-1a | chr2:218658826-218658847 | 161.00 | -24.97 |
Mayo | ENST00000449707 | 218658701 | 218658876 | hsa-miR-212-5p | chr2:218658761-218658768 | 8mer-1a | chr2:218658746-218658768 | 151.00 | -22.70 |
Mayo | ENST00000449707 | 218658701 | 218658876 | hsa-miR-3191-5p | chr2:218658840-218658847 | 8mer-1a | chr2:218658826-218658847 | 161.00 | -24.97 |
Mayo | ENST00000449707 | 218658701 | 218658876 | hsa-miR-2355-5p | chr2:218658718-218658725 | 8mer-1a | chr2:218658706-218658725 | 155.00 | -21.05 |
Mayo | ENST00000449707 | 218658701 | 218658876 | hsa-miR-6824-3p | chr2:218658839-218658846 | 8mer-1a | chr2:218658826-218658847 | 161.00 | -24.97 |
Mayo | ENST00000449707 | 218658701 | 218658876 | hsa-miR-10398-5p | chr2:218658757-218658764 | 8mer-1a | chr2:218658746-218658768 | 151.00 | -22.70 |
Mayo | ENST00000449707 | 218658701 | 218658876 | hsa-miR-4659a-3p | chr2:218658844-218658851 | 8mer-1a | chr2:218658830-218658851 | 143.00 | -12.50 |
Mayo | ENST00000449707 | 218658701 | 218658876 | hsa-miR-4659b-3p | chr2:218658844-218658851 | 8mer-1a | chr2:218658830-218658851 | 143.00 | -12.50 |
Mayo | ENST00000449707 | 218658701 | 218658876 | hsa-miR-4290 | chr2:218658807-218658814 | 8mer-1a | chr2:218658799-218658822 | 171.00 | -32.89 |
ROSMAP | ENST00000449707 | 218658701 | 218658876 | hsa-miR-942-5p | chr2:218658842-218658849 | 8mer-1a | chr2:218658830-218658849 | 152.00 | -23.73 |
ROSMAP | ENST00000449707 | 218658701 | 218658876 | hsa-miR-3620-3p | chr2:218658813-218658820 | 8mer-1a | chr2:218658799-218658822 | 171.00 | -32.89 |
ROSMAP | ENST00000449707 | 218658701 | 218658876 | hsa-miR-548q | chr2:218658837-218658844 | 8mer-1a | chr2:218658826-218658847 | 161.00 | -24.97 |
ROSMAP | ENST00000449707 | 218658701 | 218658876 | hsa-miR-4699-5p | chr2:218658724-218658731 | 8mer-1a | chr2:218658709-218658734 | 146.00 | -19.41 |
ROSMAP | ENST00000449707 | 218658701 | 218658876 | hsa-miR-6764-3p | chr2:218658839-218658846 | 8mer-1a | chr2:218658826-218658847 | 161.00 | -24.97 |
ROSMAP | ENST00000449707 | 218658701 | 218658876 | hsa-miR-212-5p | chr2:218658761-218658768 | 8mer-1a | chr2:218658746-218658768 | 151.00 | -22.70 |
ROSMAP | ENST00000449707 | 218658701 | 218658876 | hsa-miR-3191-5p | chr2:218658840-218658847 | 8mer-1a | chr2:218658826-218658847 | 161.00 | -24.97 |
ROSMAP | ENST00000449707 | 218658701 | 218658876 | hsa-miR-2355-5p | chr2:218658718-218658725 | 8mer-1a | chr2:218658706-218658725 | 155.00 | -21.05 |
ROSMAP | ENST00000449707 | 218658701 | 218658876 | hsa-miR-6824-3p | chr2:218658839-218658846 | 8mer-1a | chr2:218658826-218658847 | 161.00 | -24.97 |
ROSMAP | ENST00000449707 | 218658701 | 218658876 | hsa-miR-10398-5p | chr2:218658757-218658764 | 8mer-1a | chr2:218658746-218658768 | 151.00 | -22.70 |
ROSMAP | ENST00000449707 | 218658701 | 218658876 | hsa-miR-4659a-3p | chr2:218658844-218658851 | 8mer-1a | chr2:218658830-218658851 | 143.00 | -12.50 |
ROSMAP | ENST00000449707 | 218658701 | 218658876 | hsa-miR-4659b-3p | chr2:218658844-218658851 | 8mer-1a | chr2:218658830-218658851 | 143.00 | -12.50 |
ROSMAP | ENST00000449707 | 218658701 | 218658876 | hsa-miR-4290 | chr2:218658807-218658814 | 8mer-1a | chr2:218658799-218658822 | 171.00 | -32.89 |
Top |
SNVs in the skipped exons for ZNF142 |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
Top |
AD stage-associated exon skippint events for ZNF142 |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
Top |
Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ZNF142 |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
Top |
Correlation with RNA binding proteins (RBPs) for ZNF142 |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
CB | CNOT4 | exon_skip_133875 | -5.308596e-01 | 3.764693e-10 |
CB | PCBP4 | exon_skip_133875 | 4.852760e-01 | 1.688502e-08 |
CB | TARDBP | exon_skip_20396 | -4.803770e-01 | 4.256422e-09 |
CB | ZNF638 | exon_skip_20396 | -5.631694e-01 | 1.407760e-12 |
CB | SAMD4A | exon_skip_20396 | -5.773981e-01 | 2.809945e-13 |
CB | CNOT4 | exon_skip_20396 | -5.601492e-01 | 1.962554e-12 |
CB | PCBP4 | exon_skip_20396 | 5.033375e-01 | 5.697298e-10 |
CB | TRA2A | exon_skip_20396 | -5.607014e-01 | 1.847347e-12 |
CB | EIF4G2 | exon_skip_20396 | -4.625704e-01 | 1.833971e-08 |
CB | RBM23 | exon_skip_20396 | -4.372103e-01 | 1.278038e-07 |
HCC | SAMD4A | exon_skip_20396 | -4.752785e-01 | 3.276542e-15 |
HCC | PTBP1 | exon_skip_20396 | -4.220135e-01 | 5.325168e-12 |
Top |
RelatedDrugs for ZNF142 |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for ZNF142 |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |