ExonSkipAD: functional annotation of exon skipping event in human

Gene summary for YWHAZ

Gene summary

Gene information	Gene symbol	YWHAZ
	Gene ID	7534
	Gene name	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
	Synonyms	14-3-3-zeta\|HEL-S-3\|HEL-S-93\|HEL4\|KCIP-1\|POPCHAS\|YWHAD
	Cytomap	8q22.3
	Type of gene	protein-coding
	Description	14-3-3 protein zeta/delta14-3-3 delta14-3-3 protein/cytosolic phospholipase A214-3-3 zetaepididymis luminal protein 4epididymis secretory protein Li 3epididymis secretory protein Li 93phospholipase A2protein kinase C inhibitor protein-1tyrosine 3
	Modification date	20200329
	UniProtAcc	B0AZS6, B7Z2E6, D0PNI1, E5RGE1, E5RIR4, E7ESK7, E7EVZ2, E7EX29, E9PD24, H0YB80, P63104,
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
YWHAZ	GO:0070372	regulation of ERK1 and ERK2 cascade	31024343
YWHAZ	GO:0090128	regulation of synapse maturation	16959763

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Gene structures and expression levels for YWHAZ

Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

ENSG00000164924

Differentially expressed gene analysis across multiple brain tissues between AD and control.

Tissue type

DEG direction

Base mean exp.

log2FC(AD/control)

P-value

Adj. p-value

Differentially expressed isoform analysis across multiple brain tissues between AD and control.

Tissue type	DEG direction	ENST	Transcript info.	Base mean exp.	log2FC(AD/control)	P-value	Adjc. p-value
HCC	DOWN	ENST00000523131.1	YWHAZ-221:protein_coding:YWHAZ	2.470078e+00	-1.371007e+00	6.231226e-05	5.075940e-03

Landscape of isoform expressions across multiple brain tissues between AD and control.

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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for YWHAZ

Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap).

All exon skipping events in AD cohorts.

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon
exon_skip_117063	chr8	100948872:100948900:100951929:100952308:100952850:100952883	100951929:100952308
exon_skip_123733	chr8	100924916:100925039:100948596:100948900:100951929:100952019	100948596:100948900
exon_skip_167	chr8	100924922:100925039:100948596:100948900:100953269:100953341	100948596:100948900
exon_skip_184297	chr8	100924922:100925039:100948596:100948900:100950406:100950540	100948596:100948900
exon_skip_191571	chr8	100948735:100948900:100951929:100952308:100952850:100952883	100951929:100952308
exon_skip_214307	chr8	100948735:100948900:100951929:100952308:100952473:100952552	100951929:100952308
exon_skip_216103	chr8	100948735:100948900:100951929:100952125:100952473:100952552	100951929:100952125
exon_skip_219939	chr8	100924922:100925039:100948596:100948900:100951929:100951969	100948596:100948900
exon_skip_238292	chr8	100948768:100948900:100951929:100952125:100952850:100952883	100951929:100952125
exon_skip_243764	chr8	100951956:100952308:100952850:100953057:100953269:100953341	100952850:100953057
exon_skip_249486	chr8	100948872:100948900:100951929:100952125:100952850:100952883	100951929:100952125
exon_skip_274428	chr8	100920716:100920752:100923955:100924050:100924135:100924298	100923955:100924050
exon_skip_31542	chr8	100948735:100948900:100951929:100952125:100952473:100952604	100951929:100952125
exon_skip_44770	chr8	100948735:100948900:100951929:100952125:100952850:100952883	100951929:100952125
exon_skip_57778	chr8	100923955:100924050:100924135:100924322:100924916:100924988	100924135:100924322
exon_skip_67290	chr8	100924135:100924298:100924916:100925039:100951929:100951969	100924916:100925039
exon_skip_6941	chr8	100948768:100948900:100951929:100952308:100952850:100952883	100951929:100952308
exon_skip_86652	chr8	100923955:100924050:100924135:100924298:100924916:100924988	100924135:100924298
exon_skip_99923	chr8	100924916:100925039:100948596:100948900:100951929:100951948	100948596:100948900

Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control.

Exon skipping information

Tissue type

Avg(PSIs) in AD

Avg(PSIs) in control

Difference (PSI)

Adj. p-value

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Open reading frame (ORF) annotation in the exon skipping event for YWHAZ

Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000395951	100948596	100948900	3UTR-3CDS
ENST00000395957	100948596	100948900	3UTR-3CDS
ENST00000395957	100951929	100952125	3UTR-3UTR
ENST00000353245	100923955	100924050	In-frame
ENST00000395951	100923955	100924050	In-frame
ENST00000395953	100923955	100924050	In-frame
ENST00000395956	100923955	100924050	In-frame
ENST00000395957	100923955	100924050	In-frame
ENST00000395958	100923955	100924050	In-frame
ENST00000419477	100923955	100924050	In-frame
ENST00000457309	100923955	100924050	In-frame

Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000395957	100948596	100948900	3UTR-3CDS
ENST00000395957	100951929	100952125	3UTR-3UTR
ENST00000353245	100923955	100924050	In-frame
ENST00000395951	100923955	100924050	In-frame
ENST00000395953	100923955	100924050	In-frame
ENST00000395956	100923955	100924050	In-frame
ENST00000395957	100923955	100924050	In-frame
ENST00000395958	100923955	100924050	In-frame
ENST00000419477	100923955	100924050	In-frame
ENST00000457309	100923955	100924050	In-frame

Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000353245	100948596	100948900	3UTR-3CDS
ENST00000395957	100948596	100948900	3UTR-3CDS
ENST00000395957	100951929	100952125	3UTR-3UTR
ENST00000353245	100924135	100924298	Frame-shift
ENST00000395951	100924135	100924298	Frame-shift
ENST00000395953	100924135	100924298	Frame-shift
ENST00000395956	100924135	100924298	Frame-shift
ENST00000395957	100924135	100924298	Frame-shift
ENST00000395958	100924135	100924298	Frame-shift
ENST00000419477	100924135	100924298	Frame-shift
ENST00000457309	100924135	100924298	Frame-shift
ENST00000353245	100923955	100924050	In-frame
ENST00000395951	100923955	100924050	In-frame
ENST00000395953	100923955	100924050	In-frame
ENST00000395956	100923955	100924050	In-frame
ENST00000395957	100923955	100924050	In-frame
ENST00000395958	100923955	100924050	In-frame
ENST00000419477	100923955	100924050	In-frame
ENST00000457309	100923955	100924050	In-frame

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Infer the effects of exon skipping event on protein functional features for YWHAZ

p-ENSG00000164924_img4.png
boxplot

Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000353245	2846	245	100923955	100924050	667	761	194	225
ENST00000395951	981	245	100923955	100924050	746	840	194	225
ENST00000395953	1011	245	100923955	100924050	733	827	194	225
ENST00000395956	2991	245	100923955	100924050	809	903	194	225
ENST00000395957	5265	245	100923955	100924050	925	1019	194	225
ENST00000395958	3083	245	100923955	100924050	795	889	194	225
ENST00000419477	908	245	100923955	100924050	685	779	194	225
ENST00000457309	3024	245	100923955	100924050	738	832	194	225

Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000353245	2846	245	100923955	100924050	667	761	194	225
ENST00000395951	981	245	100923955	100924050	746	840	194	225
ENST00000395953	1011	245	100923955	100924050	733	827	194	225
ENST00000395956	2991	245	100923955	100924050	809	903	194	225
ENST00000395957	5265	245	100923955	100924050	925	1019	194	225
ENST00000395958	3083	245	100923955	100924050	795	889	194	225
ENST00000419477	908	245	100923955	100924050	685	779	194	225
ENST00000457309	3024	245	100923955	100924050	738	832	194	225

Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000353245	2846	245	100923955	100924050	667	761	194	225
ENST00000395951	981	245	100923955	100924050	746	840	194	225
ENST00000395953	1011	245	100923955	100924050	733	827	194	225
ENST00000395956	2991	245	100923955	100924050	809	903	194	225
ENST00000395957	5265	245	100923955	100924050	925	1019	194	225
ENST00000395958	3083	245	100923955	100924050	795	889	194	225
ENST00000419477	908	245	100923955	100924050	685	779	194	225
ENST00000457309	3024	245	100923955	100924050	738	832	194	225

Lost protein functional features of individual exon skipping events in ROSMAP.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
P63104	194	225	1	245	Chain	ID=PRO_0000058627;Note=14-3-3 protein zeta/delta
P63104	194	225	1	245	Chain	ID=PRO_0000058627;Note=14-3-3 protein zeta/delta
P63104	194	225	1	245	Chain	ID=PRO_0000058627;Note=14-3-3 protein zeta/delta
P63104	194	225	1	245	Chain	ID=PRO_0000058627;Note=14-3-3 protein zeta/delta
P63104	194	225	1	245	Chain	ID=PRO_0000058627;Note=14-3-3 protein zeta/delta
P63104	194	225	1	245	Chain	ID=PRO_0000058627;Note=14-3-3 protein zeta/delta
P63104	194	225	1	245	Chain	ID=PRO_0000058627;Note=14-3-3 protein zeta/delta
P63104	194	225	1	245	Chain	ID=PRO_0000058627;Note=14-3-3 protein zeta/delta
P63104	194	225	185	200	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02
P63104	194	225	185	200	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02
P63104	194	225	185	200	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02
P63104	194	225	185	200	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02
P63104	194	225	185	200	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02
P63104	194	225	185	200	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02
P63104	194	225	185	200	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02
P63104	194	225	185	200	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02
P63104	194	225	201	205	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02
P63104	194	225	201	205	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02
P63104	194	225	201	205	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02
P63104	194	225	201	205	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02
P63104	194	225	201	205	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02
P63104	194	225	201	205	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02
P63104	194	225	201	205	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02
P63104	194	225	201	205	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02
P63104	194	225	211	228	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02
P63104	194	225	211	228	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02
P63104	194	225	211	228	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02
P63104	194	225	211	228	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02
P63104	194	225	211	228	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02
P63104	194	225	211	228	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02
P63104	194	225	211	228	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02
P63104	194	225	211	228	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02
P63104	194	225	207	207	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:19690332,ECO:0000244\|PubMed:20068231;Dbxref=PMID:19690332,PMID:20068231
P63104	194	225	207	207	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:19690332,ECO:0000244\|PubMed:20068231;Dbxref=PMID:19690332,PMID:20068231
P63104	194	225	207	207	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:19690332,ECO:0000244\|PubMed:20068231;Dbxref=PMID:19690332,PMID:20068231
P63104	194	225	207	207	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:19690332,ECO:0000244\|PubMed:20068231;Dbxref=PMID:19690332,PMID:20068231
P63104	194	225	207	207	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:19690332,ECO:0000244\|PubMed:20068231;Dbxref=PMID:19690332,PMID:20068231
P63104	194	225	207	207	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:19690332,ECO:0000244\|PubMed:20068231;Dbxref=PMID:19690332,PMID:20068231
P63104	194	225	207	207	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:19690332,ECO:0000244\|PubMed:20068231;Dbxref=PMID:19690332,PMID:20068231
P63104	194	225	207	207	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:19690332,ECO:0000244\|PubMed:20068231;Dbxref=PMID:19690332,PMID:20068231
P63104	194	225	210	210	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P63102
P63104	194	225	210	210	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P63102
P63104	194	225	210	210	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P63102
P63104	194	225	210	210	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P63102
P63104	194	225	210	210	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P63102
P63104	194	225	210	210	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P63102
P63104	194	225	210	210	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P63102
P63104	194	225	210	210	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P63102
P63104	194	225	208	210	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02
P63104	194	225	208	210	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02
P63104	194	225	208	210	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02
P63104	194	225	208	210	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02
P63104	194	225	208	210	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02
P63104	194	225	208	210	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02
P63104	194	225	208	210	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02
P63104	194	225	208	210	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02

Lost protein functional features of individual exon skipping events in MSBB.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
P63104	194	225	1	245	Chain	ID=PRO_0000058627;Note=14-3-3 protein zeta/delta
P63104	194	225	1	245	Chain	ID=PRO_0000058627;Note=14-3-3 protein zeta/delta
P63104	194	225	1	245	Chain	ID=PRO_0000058627;Note=14-3-3 protein zeta/delta
P63104	194	225	1	245	Chain	ID=PRO_0000058627;Note=14-3-3 protein zeta/delta
P63104	194	225	1	245	Chain	ID=PRO_0000058627;Note=14-3-3 protein zeta/delta
P63104	194	225	1	245	Chain	ID=PRO_0000058627;Note=14-3-3 protein zeta/delta
P63104	194	225	1	245	Chain	ID=PRO_0000058627;Note=14-3-3 protein zeta/delta
P63104	194	225	1	245	Chain	ID=PRO_0000058627;Note=14-3-3 protein zeta/delta
P63104	194	225	185	200	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02
P63104	194	225	185	200	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02
P63104	194	225	185	200	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02
P63104	194	225	185	200	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02
P63104	194	225	185	200	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02
P63104	194	225	185	200	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02
P63104	194	225	185	200	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02
P63104	194	225	185	200	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02
P63104	194	225	201	205	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02
P63104	194	225	201	205	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02
P63104	194	225	201	205	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02
P63104	194	225	201	205	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02
P63104	194	225	201	205	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02
P63104	194	225	201	205	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02
P63104	194	225	201	205	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02
P63104	194	225	201	205	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02
P63104	194	225	211	228	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02
P63104	194	225	211	228	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02
P63104	194	225	211	228	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02
P63104	194	225	211	228	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02
P63104	194	225	211	228	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02
P63104	194	225	211	228	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02
P63104	194	225	211	228	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02
P63104	194	225	211	228	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02
P63104	194	225	207	207	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:19690332,ECO:0000244\|PubMed:20068231;Dbxref=PMID:19690332,PMID:20068231
P63104	194	225	207	207	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:19690332,ECO:0000244\|PubMed:20068231;Dbxref=PMID:19690332,PMID:20068231
P63104	194	225	207	207	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:19690332,ECO:0000244\|PubMed:20068231;Dbxref=PMID:19690332,PMID:20068231
P63104	194	225	207	207	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:19690332,ECO:0000244\|PubMed:20068231;Dbxref=PMID:19690332,PMID:20068231
P63104	194	225	207	207	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:19690332,ECO:0000244\|PubMed:20068231;Dbxref=PMID:19690332,PMID:20068231
P63104	194	225	207	207	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:19690332,ECO:0000244\|PubMed:20068231;Dbxref=PMID:19690332,PMID:20068231
P63104	194	225	207	207	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:19690332,ECO:0000244\|PubMed:20068231;Dbxref=PMID:19690332,PMID:20068231
P63104	194	225	207	207	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:19690332,ECO:0000244\|PubMed:20068231;Dbxref=PMID:19690332,PMID:20068231
P63104	194	225	210	210	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P63102
P63104	194	225	210	210	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P63102
P63104	194	225	210	210	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P63102
P63104	194	225	210	210	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P63102
P63104	194	225	210	210	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P63102
P63104	194	225	210	210	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P63102
P63104	194	225	210	210	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P63102
P63104	194	225	210	210	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P63102
P63104	194	225	208	210	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02
P63104	194	225	208	210	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02
P63104	194	225	208	210	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02
P63104	194	225	208	210	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02
P63104	194	225	208	210	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02
P63104	194	225	208	210	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02
P63104	194	225	208	210	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02
P63104	194	225	208	210	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02

Lost protein functional features of individual exon skipping events in Mayo.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
P63104	194	225	1	245	Chain	ID=PRO_0000058627;Note=14-3-3 protein zeta/delta
P63104	194	225	1	245	Chain	ID=PRO_0000058627;Note=14-3-3 protein zeta/delta
P63104	194	225	1	245	Chain	ID=PRO_0000058627;Note=14-3-3 protein zeta/delta
P63104	194	225	1	245	Chain	ID=PRO_0000058627;Note=14-3-3 protein zeta/delta
P63104	194	225	1	245	Chain	ID=PRO_0000058627;Note=14-3-3 protein zeta/delta
P63104	194	225	1	245	Chain	ID=PRO_0000058627;Note=14-3-3 protein zeta/delta
P63104	194	225	1	245	Chain	ID=PRO_0000058627;Note=14-3-3 protein zeta/delta
P63104	194	225	1	245	Chain	ID=PRO_0000058627;Note=14-3-3 protein zeta/delta
P63104	194	225	185	200	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02
P63104	194	225	185	200	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02
P63104	194	225	185	200	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02
P63104	194	225	185	200	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02
P63104	194	225	185	200	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02
P63104	194	225	185	200	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02
P63104	194	225	185	200	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02
P63104	194	225	185	200	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02
P63104	194	225	201	205	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02
P63104	194	225	201	205	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02
P63104	194	225	201	205	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02
P63104	194	225	201	205	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02
P63104	194	225	201	205	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02
P63104	194	225	201	205	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02
P63104	194	225	201	205	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02
P63104	194	225	201	205	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02
P63104	194	225	211	228	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02
P63104	194	225	211	228	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02
P63104	194	225	211	228	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02
P63104	194	225	211	228	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02
P63104	194	225	211	228	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02
P63104	194	225	211	228	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02
P63104	194	225	211	228	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02
P63104	194	225	211	228	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02
P63104	194	225	207	207	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:19690332,ECO:0000244\|PubMed:20068231;Dbxref=PMID:19690332,PMID:20068231
P63104	194	225	207	207	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:19690332,ECO:0000244\|PubMed:20068231;Dbxref=PMID:19690332,PMID:20068231
P63104	194	225	207	207	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:19690332,ECO:0000244\|PubMed:20068231;Dbxref=PMID:19690332,PMID:20068231
P63104	194	225	207	207	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:19690332,ECO:0000244\|PubMed:20068231;Dbxref=PMID:19690332,PMID:20068231
P63104	194	225	207	207	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:19690332,ECO:0000244\|PubMed:20068231;Dbxref=PMID:19690332,PMID:20068231
P63104	194	225	207	207	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:19690332,ECO:0000244\|PubMed:20068231;Dbxref=PMID:19690332,PMID:20068231
P63104	194	225	207	207	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:19690332,ECO:0000244\|PubMed:20068231;Dbxref=PMID:19690332,PMID:20068231
P63104	194	225	207	207	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:19690332,ECO:0000244\|PubMed:20068231;Dbxref=PMID:19690332,PMID:20068231
P63104	194	225	210	210	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P63102
P63104	194	225	210	210	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P63102
P63104	194	225	210	210	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P63102
P63104	194	225	210	210	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P63102
P63104	194	225	210	210	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P63102
P63104	194	225	210	210	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P63102
P63104	194	225	210	210	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P63102
P63104	194	225	210	210	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P63102
P63104	194	225	208	210	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02
P63104	194	225	208	210	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02
P63104	194	225	208	210	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02
P63104	194	225	208	210	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02
P63104	194	225	208	210	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02
P63104	194	225	208	210	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02
P63104	194	225	208	210	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02
P63104	194	225	208	210	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2O02

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3'-UTR located exon skipping events that lost miRNA binding sites in YWHAZ

3'-UTR exon skipping evnets lost miRNA binding.

Tissue type	ENST	Exon skip start	Exon skip end	microRNA	Binding site by TargetScan	Binding type by TargetScan	Bdinding site by miRanda	Score of miRanda	Energy by miRanda
Mayo	ENST00000395957	100951929	100952125	hsa-miR-210-5p	chr8:100952094-100952101	8mer-1a	chr8:100952080-100952101	145.00	-24.59
Mayo	ENST00000395957	100951929	100952125	hsa-miR-7113-5p	chr8:100952019-100952026	8mer-1a	chr8:100952006-100952026	156.00	-24.87
Mayo	ENST00000395957	100951929	100952125	hsa-miR-4663	chr8:100951965-100951972	8mer-1a	chr8:100951955-100951978	166.00	-28.04
Mayo	ENST00000395957	100951929	100952125	hsa-miR-766-5p	chr8:100952069-100952076	8mer-1a	chr8:100952066-100952088	147.00	-27.56
MSBB	ENST00000395957	100951929	100952125	hsa-miR-210-5p	chr8:100952094-100952101	8mer-1a	chr8:100952080-100952101	145.00	-24.59
MSBB	ENST00000395957	100951929	100952125	hsa-miR-7113-5p	chr8:100952019-100952026	8mer-1a	chr8:100952006-100952026	156.00	-24.87
MSBB	ENST00000395957	100951929	100952125	hsa-miR-4663	chr8:100951965-100951972	8mer-1a	chr8:100951955-100951978	166.00	-28.04
MSBB	ENST00000395957	100951929	100952125	hsa-miR-766-5p	chr8:100952069-100952076	8mer-1a	chr8:100952066-100952088	147.00	-27.56
ROSMAP	ENST00000395957	100951929	100952125	hsa-miR-210-5p	chr8:100952094-100952101	8mer-1a	chr8:100952080-100952101	145.00	-24.59
ROSMAP	ENST00000395957	100951929	100952125	hsa-miR-7113-5p	chr8:100952019-100952026	8mer-1a	chr8:100952006-100952026	156.00	-24.87
ROSMAP	ENST00000395957	100951929	100952125	hsa-miR-4663	chr8:100951965-100951972	8mer-1a	chr8:100951955-100951978	166.00	-28.04
ROSMAP	ENST00000395957	100951929	100952125	hsa-miR-766-5p	chr8:100952069-100952076	8mer-1a	chr8:100952066-100952088	147.00	-27.56

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SNVs in the skipped exons for YWHAZ

- Differential PSIs between mutated versus non-mutated samples.

- Depth of Coverage in the skipped exon of the mutated samples.

- Sashimi plot in the skipped exon of the mutated samples.

- Non-synonymous mutations located in the skipped exons.

Cancer type

Sample

ESID

Skipped exon start

Skipped exon end

Mutation start

Mutation end

Mutation type

Reference seq

Mutation seq

AAchange

- Non-synonymous mutations located in the skipped exons in CCLE.

Sample

Skipped exon start

Skipped exon end

Mutation start

Mutation end

Mutation type

Reference seq

Mutation seq

AAchange

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AD stage-associated exon skippint events for YWHAZ

Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR).

AD stage info

Cohort

Tissue

SE id

Coefficient

P-value

Chromosome

Strand

E1 start

E1 end

Skipped start

Skipped end

E2 start

E2 end

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for YWHAZ

sQTL information located at the skipped exons.

Tissue type

Exon skip ID

SNP id

Location

P-value

FDR

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Correlation with RNA binding proteins (RBPs) for YWHAZ

Correlated RBP and related information.

Tissue type	RBP name	Exon skip ID	Correlation coeifficient	P-value
CB	TARDBP	exon_skip_6941	4.149457e-01	2.111358e-07
CB	SAMD4A	exon_skip_6941	4.118341e-01	2.654318e-07
CB	CNOT4	exon_skip_6941	4.419635e-01	2.619134e-08
CB	HNRNPA2B1	exon_skip_6941	4.658498e-01	3.534942e-09
CB	RBM4	exon_skip_6941	5.163149e-01	2.988052e-11
DLPFC	SRSF11	exon_skip_44770	4.233067e-01	5.982388e-14
DLPFC	FXR2	exon_skip_44770	4.096675e-01	4.408357e-13
DLPFC	FXR2	exon_skip_50767	4.072273e-01	3.293896e-12
DLPFC	NOVA1	exon_skip_50767	4.153462e-01	1.100756e-12
FL	SRSF2	exon_skip_44770	-5.255066e-01	4.255603e-13
FL	SRSF11	exon_skip_44770	-5.050311e-01	4.597718e-12
FL	HNRNPK	exon_skip_44770	-4.979211e-01	1.013051e-11
FL	RBM24	exon_skip_44770	-4.555852e-01	7.815090e-10
FL	SRSF1	exon_skip_44770	-4.604883e-01	4.867835e-10
FL	SRSF9	exon_skip_44770	-5.659826e-01	2.338448e-15

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RelatedDrugs for YWHAZ

Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for YWHAZ

Diseases associated with this gene.
(DisGeNet 4.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	Gene structures and expression levels
	Exon skipping events with PSIs in RPSMAP, MSBB, and Mayo
	Open reading frame (ORF) annotation in the exon skipping event
	Exon skipping events in the canonical protein sequence
	3'-UTR located exon skipping events lost miRNA binding sites
	SNVs in the skipped exons with depth of coverage
	AD stage-associated exon skipping events
	Splicing Quantitative Trait Loci (sQTLs) in the skipped exons
	Correlation with RNA binding proteins (RBPs)
	Related drugs with this gene
	Related diseases with this gene

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Gene summary for YWHAZ

Gene structures and expression levels for YWHAZ

Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for YWHAZ

Open reading frame (ORF) annotation in the exon skipping event for YWHAZ

Infer the effects of exon skipping event on protein functional features for YWHAZ

3'-UTR located exon skipping events that lost miRNA binding sites in YWHAZ

SNVs in the skipped exons for YWHAZ

AD stage-associated exon skippint events for YWHAZ

Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for YWHAZ

Correlation with RNA binding proteins (RBPs) for YWHAZ

RelatedDrugs for YWHAZ

RelatedDiseases for YWHAZ