ExonSkipAD: functional annotation of exon skipping event in human

Gene summary for XPO1

Gene summary

Gene information	Gene symbol	XPO1
	Gene ID	7514
	Gene name	exportin 1
	Synonyms	CRM-1\|CRM1\|emb\|exp1
	Cytomap	2p15
	Type of gene	protein-coding
	Description	exportin-1chromosome region maintenance 1 homologchromosome region maintenance 1 protein homologexportin 1 (CRM1 homolog, yeast)exportin-1 (required for chromosome region maintenance)
	Modification date	20200327
	UniProtAcc	C9IYM2, C9IZS4, C9J673, C9JF49, C9JKM9, C9JQ02, C9JV99, F8WF71, H7BZC5, O14980,
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
XPO1	GO:0006611	protein export from nucleus	22250199

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Gene structures and expression levels for XPO1

Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

ENSG00000082898

Differentially expressed gene analysis across multiple brain tissues between AD and control.

Tissue type

DEG direction

Base mean exp.

log2FC(AD/control)

P-value

Adj. p-value

Differentially expressed isoform analysis across multiple brain tissues between AD and control.

Tissue type	DEG direction	ENST	Transcript info.	Base mean exp.	log2FC(AD/control)	P-value	Adjc. p-value
PCC	UP	ENST00000481073.5	XPO1-219:retained_intron:XPO1	2.930329e+02	9.481098e-01	5.178981e-04	1.688124e-02
HCC	UP	ENST00000451765.5	XPO1-211:protein_coding:XPO1	3.397538e+00	1.034032e+00	6.828558e-06	1.069360e-03
CB	UP	ENST00000404992.6	XPO1-202:protein_coding:XPO1	6.466839e+02	9.315114e-01	1.626374e-07	3.201820e-06
CB	UP	ENST00000475744.1	XPO1-217:retained_intron:XPO1	5.873450e+00	1.159881e+00	7.463632e-07	1.168365e-05
CB	UP	ENST00000422552.5	XPO1-205:protein_coding:XPO1	1.741146e+01	9.774194e-01	1.094838e-06	1.620400e-05
CB	UP	ENST00000437159.5	XPO1-208:nonsense_mediated_decay:XPO1	9.134137e+00	1.104207e+00	9.705000e-06	1.027699e-04
CB	UP	ENST00000476585.5	XPO1-218:lncRNA:XPO1	2.542444e+00	9.360369e-01	2.721284e-04	1.727058e-03
CB	UP	ENST00000492182.5	XPO1-222:retained_intron:XPO1	5.236946e+01	8.754394e-01	2.970126e-04	1.857454e-03
CB	UP	ENST00000460037.1	XPO1-213:retained_intron:XPO1	3.927424e+00	8.045973e-01	5.928354e-03	2.264948e-02
CB	UP	ENST00000451765.5	XPO1-211:protein_coding:XPO1	1.356525e+00	1.173916e+00	1.360097e-02	4.455606e-02
TC	UP	ENST00000451765.5	XPO1-211:protein_coding:XPO1	1.775622e+00	1.118706e+00	2.373098e-03	1.909305e-02
TC	UP	ENST00000475744.1	XPO1-217:retained_intron:XPO1	1.816786e+00	9.211148e-01	3.798931e-03	2.723399e-02
TC	UP	ENST00000460037.1	XPO1-213:retained_intron:XPO1	1.888030e+00	1.110073e+00	4.022893e-03	2.844375e-02

Landscape of isoform expressions across multiple brain tissues between AD and control.

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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for XPO1

Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap).

All exon skipping events in AD cohorts.

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon
exon_skip_112201	chr2	61495455:61495613:61496879:61497007:61498673:61498792	61496879:61497007
exon_skip_123172	chr2	61522630:61522683:61525270:61525333:61525492:61525559	61525270:61525333
exon_skip_13025	chr2	61498865:61498913:61499713:61499894:61522611:61522683	61499713:61499894
exon_skip_149658	chr2	61533772:61533903:61537562:61537587:61538492:61538626	61537562:61537587
exon_skip_160860	chr2	61522630:61522683:61526420:61526521:61533772:61533903	61526420:61526521
exon_skip_16456	chr2	61496994:61497007:61498673:61498792:61498865:61498913	61498673:61498792
exon_skip_242796	chr2	61483937:61484105:61485768:61485962:61488165:61488271	61485768:61485962
exon_skip_243411	chr2	61478924:61478966:61481185:61481281:61482380:61482539	61481185:61481281
exon_skip_249686	chr2	61533772:61533903:61534558:61534678:61537562:61537587	61534558:61534678
exon_skip_265440	chr2	61526471:61526521:61533772:61533903:61537562:61537587	61533772:61533903
exon_skip_271157	chr2	61481185:61481281:61482380:61482539:61482957:61483091	61482380:61482539
exon_skip_276410	chr2	61488588:61488771:61490642:61490776:61492035:61492196	61490642:61490776
exon_skip_281338	chr2	61478938:61478966:61481185:61481281:61482380:61482539	61481185:61481281
exon_skip_284959	chr2	61492915:61493053:61493894:61494091:61495455:61495573	61493894:61494091
exon_skip_30037	chr2	61502006:61502040:61502249:61502310:61522611:61522683	61502249:61502310
exon_skip_30314	chr2	61488588:61488771:61490642:61490776:61492035:61492198	61490642:61490776
exon_skip_38866	chr2	61488165:61488271:61488588:61488771:61490642:61490776	61488588:61488771
exon_skip_42902	chr2	61478700:61478966:61481185:61481281:61482380:61482539	61481185:61481281
exon_skip_43210	chr2	61499765:61499894:61501996:61502040:61502249:61502310	61501996:61502040
exon_skip_4543	chr2	61522630:61522683:61525270:61525333:61525492:61526521	61525270:61525333
exon_skip_94499	chr2	61495455:61495613:61496879:61497007:61498673:61498739	61496879:61497007

Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control.

Exon skipping information

Tissue type

Avg(PSIs) in AD

Avg(PSIs) in control

Difference (PSI)

Adj. p-value

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Open reading frame (ORF) annotation in the exon skipping event for XPO1

Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000406957	61533772	61533903	3UTR-3CDS
ENST00000401558	61481185	61481281	Frame-shift
ENST00000404992	61481185	61481281	Frame-shift
ENST00000406957	61481185	61481281	Frame-shift
ENST00000401558	61482380	61482539	Frame-shift
ENST00000404992	61482380	61482539	Frame-shift
ENST00000406957	61482380	61482539	Frame-shift
ENST00000401558	61488588	61488771	Frame-shift
ENST00000404992	61488588	61488771	Frame-shift
ENST00000406957	61488588	61488771	Frame-shift
ENST00000401558	61485768	61485962	In-frame
ENST00000404992	61485768	61485962	In-frame
ENST00000406957	61485768	61485962	In-frame
ENST00000401558	61490642	61490776	In-frame
ENST00000404992	61490642	61490776	In-frame
ENST00000406957	61490642	61490776	In-frame
ENST00000401558	61493894	61494091	In-frame
ENST00000404992	61493894	61494091	In-frame
ENST00000406957	61493894	61494091	In-frame
ENST00000401558	61496879	61497007	In-frame
ENST00000404992	61496879	61497007	In-frame
ENST00000406957	61496879	61497007	In-frame
ENST00000401558	61501996	61502040	In-frame
ENST00000404992	61501996	61502040	In-frame
ENST00000406957	61501996	61502040	In-frame

Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000401558	61481185	61481281	Frame-shift
ENST00000404992	61481185	61481281	Frame-shift
ENST00000406957	61481185	61481281	Frame-shift
ENST00000401558	61482380	61482539	Frame-shift
ENST00000404992	61482380	61482539	Frame-shift
ENST00000406957	61482380	61482539	Frame-shift
ENST00000401558	61485768	61485962	In-frame
ENST00000404992	61485768	61485962	In-frame
ENST00000406957	61485768	61485962	In-frame
ENST00000401558	61490642	61490776	In-frame
ENST00000404992	61490642	61490776	In-frame
ENST00000406957	61490642	61490776	In-frame
ENST00000401558	61493894	61494091	In-frame
ENST00000404992	61493894	61494091	In-frame
ENST00000406957	61493894	61494091	In-frame
ENST00000401558	61496879	61497007	In-frame
ENST00000404992	61496879	61497007	In-frame
ENST00000406957	61496879	61497007	In-frame
ENST00000401558	61501996	61502040	In-frame
ENST00000404992	61501996	61502040	In-frame
ENST00000406957	61501996	61502040	In-frame

Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000406957	61533772	61533903	3UTR-3CDS
ENST00000401558	61481185	61481281	Frame-shift
ENST00000404992	61481185	61481281	Frame-shift
ENST00000406957	61481185	61481281	Frame-shift
ENST00000401558	61482380	61482539	Frame-shift
ENST00000404992	61482380	61482539	Frame-shift
ENST00000406957	61482380	61482539	Frame-shift
ENST00000401558	61488588	61488771	Frame-shift
ENST00000404992	61488588	61488771	Frame-shift
ENST00000406957	61488588	61488771	Frame-shift
ENST00000401558	61502249	61502310	Frame-shift
ENST00000404992	61502249	61502310	Frame-shift
ENST00000406957	61502249	61502310	Frame-shift
ENST00000401558	61485768	61485962	In-frame
ENST00000404992	61485768	61485962	In-frame
ENST00000406957	61485768	61485962	In-frame
ENST00000401558	61490642	61490776	In-frame
ENST00000404992	61490642	61490776	In-frame
ENST00000406957	61490642	61490776	In-frame
ENST00000401558	61493894	61494091	In-frame
ENST00000404992	61493894	61494091	In-frame
ENST00000406957	61493894	61494091	In-frame
ENST00000401558	61496879	61497007	In-frame
ENST00000404992	61496879	61497007	In-frame
ENST00000406957	61496879	61497007	In-frame
ENST00000401558	61498673	61498792	In-frame
ENST00000404992	61498673	61498792	In-frame
ENST00000406957	61498673	61498792	In-frame
ENST00000401558	61501996	61502040	In-frame
ENST00000404992	61501996	61502040	In-frame
ENST00000406957	61501996	61502040	In-frame
ENST00000401558	61526420	61526521	In-frame
ENST00000404992	61526420	61526521	In-frame
ENST00000406957	61526420	61526521	In-frame

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Infer the effects of exon skipping event on protein functional features for XPO1

p-ENSG00000082898_img4.png
boxplot

Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000401558	4932	1071	61501996	61502040	1092	1135	121	135
ENST00000404992	4122	1071	61501996	61502040	771	814	121	135
ENST00000406957	3496	1071	61501996	61502040	507	550	121	135
ENST00000401558	4932	1071	61496879	61497007	1488	1615	253	295
ENST00000404992	4122	1071	61496879	61497007	1167	1294	253	295
ENST00000406957	3496	1071	61496879	61497007	903	1030	253	295
ENST00000401558	4932	1071	61493894	61494091	1776	1972	349	414
ENST00000404992	4122	1071	61493894	61494091	1455	1651	349	414
ENST00000406957	3496	1071	61493894	61494091	1191	1387	349	414
ENST00000401558	4932	1071	61490642	61490776	2616	2749	629	673
ENST00000404992	4122	1071	61490642	61490776	2295	2428	629	673
ENST00000406957	3496	1071	61490642	61490776	2031	2164	629	673
ENST00000401558	4932	1071	61485768	61485962	3042	3235	771	835
ENST00000404992	4122	1071	61485768	61485962	2721	2914	771	835
ENST00000406957	3496	1071	61485768	61485962	2457	2650	771	835

Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000401558	4932	1071	61501996	61502040	1092	1135	121	135
ENST00000404992	4122	1071	61501996	61502040	771	814	121	135
ENST00000406957	3496	1071	61501996	61502040	507	550	121	135
ENST00000401558	4932	1071	61496879	61497007	1488	1615	253	295
ENST00000404992	4122	1071	61496879	61497007	1167	1294	253	295
ENST00000406957	3496	1071	61496879	61497007	903	1030	253	295
ENST00000401558	4932	1071	61493894	61494091	1776	1972	349	414
ENST00000404992	4122	1071	61493894	61494091	1455	1651	349	414
ENST00000406957	3496	1071	61493894	61494091	1191	1387	349	414
ENST00000401558	4932	1071	61490642	61490776	2616	2749	629	673
ENST00000404992	4122	1071	61490642	61490776	2295	2428	629	673
ENST00000406957	3496	1071	61490642	61490776	2031	2164	629	673
ENST00000401558	4932	1071	61485768	61485962	3042	3235	771	835
ENST00000404992	4122	1071	61485768	61485962	2721	2914	771	835
ENST00000406957	3496	1071	61485768	61485962	2457	2650	771	835

Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000401558	4932	1071	61526420	61526521	855	955	42	75
ENST00000404992	4122	1071	61526420	61526521	534	634	42	75
ENST00000406957	3496	1071	61526420	61526521	270	370	42	75
ENST00000401558	4932	1071	61501996	61502040	1092	1135	121	135
ENST00000404992	4122	1071	61501996	61502040	771	814	121	135
ENST00000406957	3496	1071	61501996	61502040	507	550	121	135
ENST00000401558	4932	1071	61498673	61498792	1368	1486	213	252
ENST00000404992	4122	1071	61498673	61498792	1047	1165	213	252
ENST00000406957	3496	1071	61498673	61498792	783	901	213	252
ENST00000401558	4932	1071	61496879	61497007	1488	1615	253	295
ENST00000404992	4122	1071	61496879	61497007	1167	1294	253	295
ENST00000406957	3496	1071	61496879	61497007	903	1030	253	295
ENST00000401558	4932	1071	61493894	61494091	1776	1972	349	414
ENST00000404992	4122	1071	61493894	61494091	1455	1651	349	414
ENST00000406957	3496	1071	61493894	61494091	1191	1387	349	414
ENST00000401558	4932	1071	61490642	61490776	2616	2749	629	673
ENST00000404992	4122	1071	61490642	61490776	2295	2428	629	673
ENST00000406957	3496	1071	61490642	61490776	2031	2164	629	673
ENST00000401558	4932	1071	61485768	61485962	3042	3235	771	835
ENST00000404992	4122	1071	61485768	61485962	2721	2914	771	835
ENST00000406957	3496	1071	61485768	61485962	2457	2650	771	835

Lost protein functional features of individual exon skipping events in ROSMAP.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
O14980	121	135	1	1071	Chain	ID=PRO_0000204705;Note=Exportin-1
O14980	121	135	1	1071	Chain	ID=PRO_0000204705;Note=Exportin-1
O14980	121	135	1	1071	Chain	ID=PRO_0000204705;Note=Exportin-1
O14980	121	135	124	141	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	121	135	124	141	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	121	135	124	141	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	121	135	1	679	Region	Note=Necessary for HTLV-1 Rex-mediated mRNA export
O14980	121	135	1	679	Region	Note=Necessary for HTLV-1 Rex-mediated mRNA export
O14980	121	135	1	679	Region	Note=Necessary for HTLV-1 Rex-mediated mRNA export
O14980	121	135	120	123	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	121	135	120	123	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	121	135	120	123	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	253	295	255	257	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	253	295	255	257	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	253	295	255	257	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	253	295	1	1071	Chain	ID=PRO_0000204705;Note=Exportin-1
O14980	253	295	1	1071	Chain	ID=PRO_0000204705;Note=Exportin-1
O14980	253	295	1	1071	Chain	ID=PRO_0000204705;Note=Exportin-1
O14980	253	295	246	253	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	253	295	246	253	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	253	295	246	253	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	253	295	258	273	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	253	295	258	273	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	253	295	258	273	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	253	295	277	279	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	253	295	277	279	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	253	295	277	279	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	253	295	280	297	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	253	295	280	297	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	253	295	280	297	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	253	295	284	284	Mutagenesis	Note=Does not abolish Rex-mediated mRNA export. V->E;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:14612415;Dbxref=PMID:14612415
O14980	253	295	284	284	Mutagenesis	Note=Does not abolish Rex-mediated mRNA export. V->E;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:14612415;Dbxref=PMID:14612415
O14980	253	295	284	284	Mutagenesis	Note=Does not abolish Rex-mediated mRNA export. V->E;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:14612415;Dbxref=PMID:14612415
O14980	253	295	1	679	Region	Note=Necessary for HTLV-1 Rex-mediated mRNA export
O14980	253	295	1	679	Region	Note=Necessary for HTLV-1 Rex-mediated mRNA export
O14980	253	295	1	679	Region	Note=Necessary for HTLV-1 Rex-mediated mRNA export
O14980	253	295	241	277	Repeat	Note=HEAT 2
O14980	253	295	241	277	Repeat	Note=HEAT 2
O14980	253	295	241	277	Repeat	Note=HEAT 2
O14980	349	414	1	1071	Chain	ID=PRO_0000204705;Note=Exportin-1
O14980	349	414	1	1071	Chain	ID=PRO_0000204705;Note=Exportin-1
O14980	349	414	1	1071	Chain	ID=PRO_0000204705;Note=Exportin-1
O14980	349	414	344	358	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	349	414	344	358	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	349	414	344	358	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	349	414	363	383	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	349	414	363	383	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	349	414	363	383	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	349	414	404	423	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	349	414	404	423	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	349	414	404	423	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	349	414	391	391	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:20068231,ECO:0000244\|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163
O14980	349	414	391	391	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:20068231,ECO:0000244\|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163
O14980	349	414	391	391	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:20068231,ECO:0000244\|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163
O14980	349	414	402	402	Mutagenesis	Note=Does not abolish Rex-mediated mRNA export. V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:14612415;Dbxref=PMID:14612415
O14980	349	414	402	402	Mutagenesis	Note=Does not abolish Rex-mediated mRNA export. V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:14612415;Dbxref=PMID:14612415
O14980	349	414	402	402	Mutagenesis	Note=Does not abolish Rex-mediated mRNA export. V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:14612415;Dbxref=PMID:14612415
O14980	349	414	411	411	Mutagenesis	Note=Strongly abolishes interaction with Rex and RANBP3%2C abolishes Rex-mediated mRNA export. Does not abolish interaction with RANBP3%3B when associated with S-414. Abolishes Rex multimerization%3B when associated with S-414. P->T;Ontology_term=ECO:0000
O14980	349	414	411	411	Mutagenesis	Note=Strongly abolishes interaction with Rex and RANBP3%2C abolishes Rex-mediated mRNA export. Does not abolish interaction with RANBP3%3B when associated with S-414. Abolishes Rex multimerization%3B when associated with S-414. P->T;Ontology_term=ECO:0000
O14980	349	414	411	411	Mutagenesis	Note=Strongly abolishes interaction with Rex and RANBP3%2C abolishes Rex-mediated mRNA export. Does not abolish interaction with RANBP3%3B when associated with S-414. Abolishes Rex multimerization%3B when associated with S-414. P->T;Ontology_term=ECO:0000
O14980	349	414	412	412	Mutagenesis	Note=Does not abolish interaction with Rex and RANBP3%2C and Rex-mediated mRNA export. M->V;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:14612415;Dbxref=PMID:14612415
O14980	349	414	412	412	Mutagenesis	Note=Does not abolish interaction with Rex and RANBP3%2C and Rex-mediated mRNA export. M->V;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:14612415;Dbxref=PMID:14612415
O14980	349	414	412	412	Mutagenesis	Note=Does not abolish interaction with Rex and RANBP3%2C and Rex-mediated mRNA export. M->V;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:14612415;Dbxref=PMID:14612415
O14980	349	414	414	414	Mutagenesis	Note=Strongly abolishes interaction with Rex and RANBP3%2C abolishes Rex-mediated mRNA export. Does not abolish interaction with RANBP3%3B when associated with T-411. Abolishes Rex multimerization%3B when associated with T-411. F->S;Ontology_term=ECO:0000
O14980	349	414	414	414	Mutagenesis	Note=Strongly abolishes interaction with Rex and RANBP3%2C abolishes Rex-mediated mRNA export. Does not abolish interaction with RANBP3%3B when associated with T-411. Abolishes Rex multimerization%3B when associated with T-411. F->S;Ontology_term=ECO:0000
O14980	349	414	414	414	Mutagenesis	Note=Strongly abolishes interaction with Rex and RANBP3%2C abolishes Rex-mediated mRNA export. Does not abolish interaction with RANBP3%3B when associated with T-411. Abolishes Rex multimerization%3B when associated with T-411. F->S;Ontology_term=ECO:0000
O14980	349	414	1	679	Region	Note=Necessary for HTLV-1 Rex-mediated mRNA export
O14980	349	414	1	679	Region	Note=Necessary for HTLV-1 Rex-mediated mRNA export
O14980	349	414	1	679	Region	Note=Necessary for HTLV-1 Rex-mediated mRNA export
O14980	349	414	327	450	Region	Note=Interaction with Ran and nuclear export complex formation
O14980	349	414	327	450	Region	Note=Interaction with Ran and nuclear export complex formation
O14980	349	414	327	450	Region	Note=Interaction with Ran and nuclear export complex formation
O14980	349	414	411	481	Region	Note=Interaction with RANBP3
O14980	349	414	411	481	Region	Note=Interaction with RANBP3
O14980	349	414	411	481	Region	Note=Interaction with RANBP3
O14980	349	414	411	414	Region	Note=Necessary for HTLV-1 Rex multimerization
O14980	349	414	411	414	Region	Note=Necessary for HTLV-1 Rex multimerization
O14980	349	414	411	414	Region	Note=Necessary for HTLV-1 Rex multimerization
O14980	349	414	354	472	Repeat	Note=HEAT 3
O14980	349	414	354	472	Repeat	Note=HEAT 3
O14980	349	414	354	472	Repeat	Note=HEAT 3
O14980	349	414	406	406	Sequence conflict	Note=R->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
O14980	349	414	406	406	Sequence conflict	Note=R->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
O14980	349	414	406	406	Sequence conflict	Note=R->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
O14980	629	673	1	1071	Chain	ID=PRO_0000204705;Note=Exportin-1
O14980	629	673	1	1071	Chain	ID=PRO_0000204705;Note=Exportin-1
O14980	629	673	1	1071	Chain	ID=PRO_0000204705;Note=Exportin-1
O14980	629	673	627	642	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	629	673	627	642	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	629	673	627	642	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	629	673	647	657	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	629	673	647	657	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	629	673	647	657	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	629	673	659	674	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	629	673	659	674	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	629	673	659	674	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	629	673	1	679	Region	Note=Necessary for HTLV-1 Rex-mediated mRNA export
O14980	629	673	1	679	Region	Note=Necessary for HTLV-1 Rex-mediated mRNA export
O14980	629	673	1	679	Region	Note=Necessary for HTLV-1 Rex-mediated mRNA export
O14980	629	673	602	639	Repeat	Note=HEAT 6
O14980	629	673	602	639	Repeat	Note=HEAT 6
O14980	629	673	602	639	Repeat	Note=HEAT 6
O14980	771	835	1	1071	Chain	ID=PRO_0000204705;Note=Exportin-1
O14980	771	835	1	1071	Chain	ID=PRO_0000204705;Note=Exportin-1
O14980	771	835	1	1071	Chain	ID=PRO_0000204705;Note=Exportin-1
O14980	771	835	769	775	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1W9C
O14980	771	835	769	775	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1W9C
O14980	771	835	769	775	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1W9C
O14980	771	835	777	789	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1W9C
O14980	771	835	777	789	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1W9C
O14980	771	835	777	789	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1W9C
O14980	771	835	793	795	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1W9C
O14980	771	835	793	795	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1W9C
O14980	771	835	793	795	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1W9C
O14980	771	835	799	811	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1W9C
O14980	771	835	799	811	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1W9C
O14980	771	835	799	811	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1W9C
O14980	771	835	812	818	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1W9C
O14980	771	835	812	818	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1W9C
O14980	771	835	812	818	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1W9C
O14980	771	835	819	834	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1W9C
O14980	771	835	819	834	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1W9C
O14980	771	835	819	834	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1W9C
O14980	771	835	800	820	Region	Note=Interaction with HIV-1 Rev
O14980	771	835	800	820	Region	Note=Interaction with HIV-1 Rev
O14980	771	835	800	820	Region	Note=Interaction with HIV-1 Rev
O14980	771	835	775	813	Repeat	Note=HEAT 7
O14980	771	835	775	813	Repeat	Note=HEAT 7
O14980	771	835	775	813	Repeat	Note=HEAT 7

Lost protein functional features of individual exon skipping events in MSBB.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
O14980	121	135	1	1071	Chain	ID=PRO_0000204705;Note=Exportin-1
O14980	121	135	1	1071	Chain	ID=PRO_0000204705;Note=Exportin-1
O14980	121	135	1	1071	Chain	ID=PRO_0000204705;Note=Exportin-1
O14980	121	135	124	141	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	121	135	124	141	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	121	135	124	141	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	121	135	1	679	Region	Note=Necessary for HTLV-1 Rex-mediated mRNA export
O14980	121	135	1	679	Region	Note=Necessary for HTLV-1 Rex-mediated mRNA export
O14980	121	135	1	679	Region	Note=Necessary for HTLV-1 Rex-mediated mRNA export
O14980	121	135	120	123	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	121	135	120	123	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	121	135	120	123	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	253	295	255	257	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	253	295	255	257	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	253	295	255	257	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	253	295	1	1071	Chain	ID=PRO_0000204705;Note=Exportin-1
O14980	253	295	1	1071	Chain	ID=PRO_0000204705;Note=Exportin-1
O14980	253	295	1	1071	Chain	ID=PRO_0000204705;Note=Exportin-1
O14980	253	295	246	253	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	253	295	246	253	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	253	295	246	253	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	253	295	258	273	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	253	295	258	273	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	253	295	258	273	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	253	295	277	279	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	253	295	277	279	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	253	295	277	279	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	253	295	280	297	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	253	295	280	297	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	253	295	280	297	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	253	295	284	284	Mutagenesis	Note=Does not abolish Rex-mediated mRNA export. V->E;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:14612415;Dbxref=PMID:14612415
O14980	253	295	284	284	Mutagenesis	Note=Does not abolish Rex-mediated mRNA export. V->E;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:14612415;Dbxref=PMID:14612415
O14980	253	295	284	284	Mutagenesis	Note=Does not abolish Rex-mediated mRNA export. V->E;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:14612415;Dbxref=PMID:14612415
O14980	253	295	1	679	Region	Note=Necessary for HTLV-1 Rex-mediated mRNA export
O14980	253	295	1	679	Region	Note=Necessary for HTLV-1 Rex-mediated mRNA export
O14980	253	295	1	679	Region	Note=Necessary for HTLV-1 Rex-mediated mRNA export
O14980	253	295	241	277	Repeat	Note=HEAT 2
O14980	253	295	241	277	Repeat	Note=HEAT 2
O14980	253	295	241	277	Repeat	Note=HEAT 2
O14980	349	414	1	1071	Chain	ID=PRO_0000204705;Note=Exportin-1
O14980	349	414	1	1071	Chain	ID=PRO_0000204705;Note=Exportin-1
O14980	349	414	1	1071	Chain	ID=PRO_0000204705;Note=Exportin-1
O14980	349	414	344	358	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	349	414	344	358	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	349	414	344	358	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	349	414	363	383	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	349	414	363	383	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	349	414	363	383	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	349	414	404	423	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	349	414	404	423	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	349	414	404	423	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	349	414	391	391	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:20068231,ECO:0000244\|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163
O14980	349	414	391	391	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:20068231,ECO:0000244\|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163
O14980	349	414	391	391	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:20068231,ECO:0000244\|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163
O14980	349	414	402	402	Mutagenesis	Note=Does not abolish Rex-mediated mRNA export. V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:14612415;Dbxref=PMID:14612415
O14980	349	414	402	402	Mutagenesis	Note=Does not abolish Rex-mediated mRNA export. V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:14612415;Dbxref=PMID:14612415
O14980	349	414	402	402	Mutagenesis	Note=Does not abolish Rex-mediated mRNA export. V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:14612415;Dbxref=PMID:14612415
O14980	349	414	411	411	Mutagenesis	Note=Strongly abolishes interaction with Rex and RANBP3%2C abolishes Rex-mediated mRNA export. Does not abolish interaction with RANBP3%3B when associated with S-414. Abolishes Rex multimerization%3B when associated with S-414. P->T;Ontology_term=ECO:0000
O14980	349	414	411	411	Mutagenesis	Note=Strongly abolishes interaction with Rex and RANBP3%2C abolishes Rex-mediated mRNA export. Does not abolish interaction with RANBP3%3B when associated with S-414. Abolishes Rex multimerization%3B when associated with S-414. P->T;Ontology_term=ECO:0000
O14980	349	414	411	411	Mutagenesis	Note=Strongly abolishes interaction with Rex and RANBP3%2C abolishes Rex-mediated mRNA export. Does not abolish interaction with RANBP3%3B when associated with S-414. Abolishes Rex multimerization%3B when associated with S-414. P->T;Ontology_term=ECO:0000
O14980	349	414	412	412	Mutagenesis	Note=Does not abolish interaction with Rex and RANBP3%2C and Rex-mediated mRNA export. M->V;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:14612415;Dbxref=PMID:14612415
O14980	349	414	412	412	Mutagenesis	Note=Does not abolish interaction with Rex and RANBP3%2C and Rex-mediated mRNA export. M->V;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:14612415;Dbxref=PMID:14612415
O14980	349	414	412	412	Mutagenesis	Note=Does not abolish interaction with Rex and RANBP3%2C and Rex-mediated mRNA export. M->V;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:14612415;Dbxref=PMID:14612415
O14980	349	414	414	414	Mutagenesis	Note=Strongly abolishes interaction with Rex and RANBP3%2C abolishes Rex-mediated mRNA export. Does not abolish interaction with RANBP3%3B when associated with T-411. Abolishes Rex multimerization%3B when associated with T-411. F->S;Ontology_term=ECO:0000
O14980	349	414	414	414	Mutagenesis	Note=Strongly abolishes interaction with Rex and RANBP3%2C abolishes Rex-mediated mRNA export. Does not abolish interaction with RANBP3%3B when associated with T-411. Abolishes Rex multimerization%3B when associated with T-411. F->S;Ontology_term=ECO:0000
O14980	349	414	414	414	Mutagenesis	Note=Strongly abolishes interaction with Rex and RANBP3%2C abolishes Rex-mediated mRNA export. Does not abolish interaction with RANBP3%3B when associated with T-411. Abolishes Rex multimerization%3B when associated with T-411. F->S;Ontology_term=ECO:0000
O14980	349	414	1	679	Region	Note=Necessary for HTLV-1 Rex-mediated mRNA export
O14980	349	414	1	679	Region	Note=Necessary for HTLV-1 Rex-mediated mRNA export
O14980	349	414	1	679	Region	Note=Necessary for HTLV-1 Rex-mediated mRNA export
O14980	349	414	327	450	Region	Note=Interaction with Ran and nuclear export complex formation
O14980	349	414	327	450	Region	Note=Interaction with Ran and nuclear export complex formation
O14980	349	414	327	450	Region	Note=Interaction with Ran and nuclear export complex formation
O14980	349	414	411	481	Region	Note=Interaction with RANBP3
O14980	349	414	411	481	Region	Note=Interaction with RANBP3
O14980	349	414	411	481	Region	Note=Interaction with RANBP3
O14980	349	414	411	414	Region	Note=Necessary for HTLV-1 Rex multimerization
O14980	349	414	411	414	Region	Note=Necessary for HTLV-1 Rex multimerization
O14980	349	414	411	414	Region	Note=Necessary for HTLV-1 Rex multimerization
O14980	349	414	354	472	Repeat	Note=HEAT 3
O14980	349	414	354	472	Repeat	Note=HEAT 3
O14980	349	414	354	472	Repeat	Note=HEAT 3
O14980	349	414	406	406	Sequence conflict	Note=R->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
O14980	349	414	406	406	Sequence conflict	Note=R->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
O14980	349	414	406	406	Sequence conflict	Note=R->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
O14980	629	673	1	1071	Chain	ID=PRO_0000204705;Note=Exportin-1
O14980	629	673	1	1071	Chain	ID=PRO_0000204705;Note=Exportin-1
O14980	629	673	1	1071	Chain	ID=PRO_0000204705;Note=Exportin-1
O14980	629	673	627	642	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	629	673	627	642	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	629	673	627	642	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	629	673	647	657	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	629	673	647	657	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	629	673	647	657	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	629	673	659	674	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	629	673	659	674	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	629	673	659	674	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	629	673	1	679	Region	Note=Necessary for HTLV-1 Rex-mediated mRNA export
O14980	629	673	1	679	Region	Note=Necessary for HTLV-1 Rex-mediated mRNA export
O14980	629	673	1	679	Region	Note=Necessary for HTLV-1 Rex-mediated mRNA export
O14980	629	673	602	639	Repeat	Note=HEAT 6
O14980	629	673	602	639	Repeat	Note=HEAT 6
O14980	629	673	602	639	Repeat	Note=HEAT 6
O14980	771	835	1	1071	Chain	ID=PRO_0000204705;Note=Exportin-1
O14980	771	835	1	1071	Chain	ID=PRO_0000204705;Note=Exportin-1
O14980	771	835	1	1071	Chain	ID=PRO_0000204705;Note=Exportin-1
O14980	771	835	769	775	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1W9C
O14980	771	835	769	775	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1W9C
O14980	771	835	769	775	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1W9C
O14980	771	835	777	789	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1W9C
O14980	771	835	777	789	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1W9C
O14980	771	835	777	789	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1W9C
O14980	771	835	793	795	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1W9C
O14980	771	835	793	795	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1W9C
O14980	771	835	793	795	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1W9C
O14980	771	835	799	811	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1W9C
O14980	771	835	799	811	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1W9C
O14980	771	835	799	811	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1W9C
O14980	771	835	812	818	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1W9C
O14980	771	835	812	818	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1W9C
O14980	771	835	812	818	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1W9C
O14980	771	835	819	834	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1W9C
O14980	771	835	819	834	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1W9C
O14980	771	835	819	834	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1W9C
O14980	771	835	800	820	Region	Note=Interaction with HIV-1 Rev
O14980	771	835	800	820	Region	Note=Interaction with HIV-1 Rev
O14980	771	835	800	820	Region	Note=Interaction with HIV-1 Rev
O14980	771	835	775	813	Repeat	Note=HEAT 7
O14980	771	835	775	813	Repeat	Note=HEAT 7
O14980	771	835	775	813	Repeat	Note=HEAT 7

Lost protein functional features of individual exon skipping events in Mayo.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
O14980	42	75	1	1071	Chain	ID=PRO_0000204705;Note=Exportin-1
O14980	42	75	1	1071	Chain	ID=PRO_0000204705;Note=Exportin-1
O14980	42	75	1	1071	Chain	ID=PRO_0000204705;Note=Exportin-1
O14980	42	75	46	112	Domain	Note=Importin N-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00115
O14980	42	75	46	112	Domain	Note=Importin N-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00115
O14980	42	75	46	112	Domain	Note=Importin N-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00115
O14980	42	75	40	55	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	42	75	40	55	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	42	75	40	55	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	42	75	60	69	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	42	75	60	69	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	42	75	60	69	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	42	75	73	90	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	42	75	73	90	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	42	75	73	90	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	42	75	1	679	Region	Note=Necessary for HTLV-1 Rex-mediated mRNA export
O14980	42	75	1	679	Region	Note=Necessary for HTLV-1 Rex-mediated mRNA export
O14980	42	75	1	679	Region	Note=Necessary for HTLV-1 Rex-mediated mRNA export
O14980	42	75	57	59	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	42	75	57	59	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	42	75	57	59	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	121	135	1	1071	Chain	ID=PRO_0000204705;Note=Exportin-1
O14980	121	135	1	1071	Chain	ID=PRO_0000204705;Note=Exportin-1
O14980	121	135	1	1071	Chain	ID=PRO_0000204705;Note=Exportin-1
O14980	121	135	124	141	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	121	135	124	141	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	121	135	124	141	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	121	135	1	679	Region	Note=Necessary for HTLV-1 Rex-mediated mRNA export
O14980	121	135	1	679	Region	Note=Necessary for HTLV-1 Rex-mediated mRNA export
O14980	121	135	1	679	Region	Note=Necessary for HTLV-1 Rex-mediated mRNA export
O14980	121	135	120	123	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	121	135	120	123	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	121	135	120	123	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	213	252	243	245	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	213	252	243	245	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	213	252	243	245	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	213	252	1	1071	Chain	ID=PRO_0000204705;Note=Exportin-1
O14980	213	252	1	1071	Chain	ID=PRO_0000204705;Note=Exportin-1
O14980	213	252	1	1071	Chain	ID=PRO_0000204705;Note=Exportin-1
O14980	213	252	202	215	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	213	252	202	215	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	213	252	202	215	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	213	252	219	235	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	213	252	219	235	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	213	252	219	235	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	213	252	239	242	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	213	252	239	242	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	213	252	239	242	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	213	252	246	253	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	213	252	246	253	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	213	252	246	253	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	213	252	1	679	Region	Note=Necessary for HTLV-1 Rex-mediated mRNA export
O14980	213	252	1	679	Region	Note=Necessary for HTLV-1 Rex-mediated mRNA export
O14980	213	252	1	679	Region	Note=Necessary for HTLV-1 Rex-mediated mRNA export
O14980	213	252	217	240	Repeat	Note=HEAT 1
O14980	213	252	217	240	Repeat	Note=HEAT 1
O14980	213	252	217	240	Repeat	Note=HEAT 1
O14980	213	252	241	277	Repeat	Note=HEAT 2
O14980	213	252	241	277	Repeat	Note=HEAT 2
O14980	213	252	241	277	Repeat	Note=HEAT 2
O14980	253	295	255	257	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	253	295	255	257	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	253	295	255	257	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	253	295	1	1071	Chain	ID=PRO_0000204705;Note=Exportin-1
O14980	253	295	1	1071	Chain	ID=PRO_0000204705;Note=Exportin-1
O14980	253	295	1	1071	Chain	ID=PRO_0000204705;Note=Exportin-1
O14980	253	295	246	253	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	253	295	246	253	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	253	295	246	253	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	253	295	258	273	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	253	295	258	273	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	253	295	258	273	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	253	295	277	279	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	253	295	277	279	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	253	295	277	279	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	253	295	280	297	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	253	295	280	297	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	253	295	280	297	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	253	295	284	284	Mutagenesis	Note=Does not abolish Rex-mediated mRNA export. V->E;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:14612415;Dbxref=PMID:14612415
O14980	253	295	284	284	Mutagenesis	Note=Does not abolish Rex-mediated mRNA export. V->E;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:14612415;Dbxref=PMID:14612415
O14980	253	295	284	284	Mutagenesis	Note=Does not abolish Rex-mediated mRNA export. V->E;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:14612415;Dbxref=PMID:14612415
O14980	253	295	1	679	Region	Note=Necessary for HTLV-1 Rex-mediated mRNA export
O14980	253	295	1	679	Region	Note=Necessary for HTLV-1 Rex-mediated mRNA export
O14980	253	295	1	679	Region	Note=Necessary for HTLV-1 Rex-mediated mRNA export
O14980	253	295	241	277	Repeat	Note=HEAT 2
O14980	253	295	241	277	Repeat	Note=HEAT 2
O14980	253	295	241	277	Repeat	Note=HEAT 2
O14980	349	414	1	1071	Chain	ID=PRO_0000204705;Note=Exportin-1
O14980	349	414	1	1071	Chain	ID=PRO_0000204705;Note=Exportin-1
O14980	349	414	1	1071	Chain	ID=PRO_0000204705;Note=Exportin-1
O14980	349	414	344	358	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	349	414	344	358	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	349	414	344	358	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	349	414	363	383	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	349	414	363	383	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	349	414	363	383	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	349	414	404	423	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	349	414	404	423	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	349	414	404	423	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	349	414	391	391	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:20068231,ECO:0000244\|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163
O14980	349	414	391	391	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:20068231,ECO:0000244\|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163
O14980	349	414	391	391	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:20068231,ECO:0000244\|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163
O14980	349	414	402	402	Mutagenesis	Note=Does not abolish Rex-mediated mRNA export. V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:14612415;Dbxref=PMID:14612415
O14980	349	414	402	402	Mutagenesis	Note=Does not abolish Rex-mediated mRNA export. V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:14612415;Dbxref=PMID:14612415
O14980	349	414	402	402	Mutagenesis	Note=Does not abolish Rex-mediated mRNA export. V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:14612415;Dbxref=PMID:14612415
O14980	349	414	411	411	Mutagenesis	Note=Strongly abolishes interaction with Rex and RANBP3%2C abolishes Rex-mediated mRNA export. Does not abolish interaction with RANBP3%3B when associated with S-414. Abolishes Rex multimerization%3B when associated with S-414. P->T;Ontology_term=ECO:0000
O14980	349	414	411	411	Mutagenesis	Note=Strongly abolishes interaction with Rex and RANBP3%2C abolishes Rex-mediated mRNA export. Does not abolish interaction with RANBP3%3B when associated with S-414. Abolishes Rex multimerization%3B when associated with S-414. P->T;Ontology_term=ECO:0000
O14980	349	414	411	411	Mutagenesis	Note=Strongly abolishes interaction with Rex and RANBP3%2C abolishes Rex-mediated mRNA export. Does not abolish interaction with RANBP3%3B when associated with S-414. Abolishes Rex multimerization%3B when associated with S-414. P->T;Ontology_term=ECO:0000
O14980	349	414	412	412	Mutagenesis	Note=Does not abolish interaction with Rex and RANBP3%2C and Rex-mediated mRNA export. M->V;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:14612415;Dbxref=PMID:14612415
O14980	349	414	412	412	Mutagenesis	Note=Does not abolish interaction with Rex and RANBP3%2C and Rex-mediated mRNA export. M->V;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:14612415;Dbxref=PMID:14612415
O14980	349	414	412	412	Mutagenesis	Note=Does not abolish interaction with Rex and RANBP3%2C and Rex-mediated mRNA export. M->V;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:14612415;Dbxref=PMID:14612415
O14980	349	414	414	414	Mutagenesis	Note=Strongly abolishes interaction with Rex and RANBP3%2C abolishes Rex-mediated mRNA export. Does not abolish interaction with RANBP3%3B when associated with T-411. Abolishes Rex multimerization%3B when associated with T-411. F->S;Ontology_term=ECO:0000
O14980	349	414	414	414	Mutagenesis	Note=Strongly abolishes interaction with Rex and RANBP3%2C abolishes Rex-mediated mRNA export. Does not abolish interaction with RANBP3%3B when associated with T-411. Abolishes Rex multimerization%3B when associated with T-411. F->S;Ontology_term=ECO:0000
O14980	349	414	414	414	Mutagenesis	Note=Strongly abolishes interaction with Rex and RANBP3%2C abolishes Rex-mediated mRNA export. Does not abolish interaction with RANBP3%3B when associated with T-411. Abolishes Rex multimerization%3B when associated with T-411. F->S;Ontology_term=ECO:0000
O14980	349	414	1	679	Region	Note=Necessary for HTLV-1 Rex-mediated mRNA export
O14980	349	414	1	679	Region	Note=Necessary for HTLV-1 Rex-mediated mRNA export
O14980	349	414	1	679	Region	Note=Necessary for HTLV-1 Rex-mediated mRNA export
O14980	349	414	327	450	Region	Note=Interaction with Ran and nuclear export complex formation
O14980	349	414	327	450	Region	Note=Interaction with Ran and nuclear export complex formation
O14980	349	414	327	450	Region	Note=Interaction with Ran and nuclear export complex formation
O14980	349	414	411	481	Region	Note=Interaction with RANBP3
O14980	349	414	411	481	Region	Note=Interaction with RANBP3
O14980	349	414	411	481	Region	Note=Interaction with RANBP3
O14980	349	414	411	414	Region	Note=Necessary for HTLV-1 Rex multimerization
O14980	349	414	411	414	Region	Note=Necessary for HTLV-1 Rex multimerization
O14980	349	414	411	414	Region	Note=Necessary for HTLV-1 Rex multimerization
O14980	349	414	354	472	Repeat	Note=HEAT 3
O14980	349	414	354	472	Repeat	Note=HEAT 3
O14980	349	414	354	472	Repeat	Note=HEAT 3
O14980	349	414	406	406	Sequence conflict	Note=R->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
O14980	349	414	406	406	Sequence conflict	Note=R->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
O14980	349	414	406	406	Sequence conflict	Note=R->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
O14980	629	673	1	1071	Chain	ID=PRO_0000204705;Note=Exportin-1
O14980	629	673	1	1071	Chain	ID=PRO_0000204705;Note=Exportin-1
O14980	629	673	1	1071	Chain	ID=PRO_0000204705;Note=Exportin-1
O14980	629	673	627	642	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	629	673	627	642	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	629	673	627	642	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	629	673	647	657	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	629	673	647	657	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	629	673	647	657	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	629	673	659	674	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	629	673	659	674	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	629	673	659	674	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5DIS
O14980	629	673	1	679	Region	Note=Necessary for HTLV-1 Rex-mediated mRNA export
O14980	629	673	1	679	Region	Note=Necessary for HTLV-1 Rex-mediated mRNA export
O14980	629	673	1	679	Region	Note=Necessary for HTLV-1 Rex-mediated mRNA export
O14980	629	673	602	639	Repeat	Note=HEAT 6
O14980	629	673	602	639	Repeat	Note=HEAT 6
O14980	629	673	602	639	Repeat	Note=HEAT 6
O14980	771	835	1	1071	Chain	ID=PRO_0000204705;Note=Exportin-1
O14980	771	835	1	1071	Chain	ID=PRO_0000204705;Note=Exportin-1
O14980	771	835	1	1071	Chain	ID=PRO_0000204705;Note=Exportin-1
O14980	771	835	769	775	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1W9C
O14980	771	835	769	775	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1W9C
O14980	771	835	769	775	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1W9C
O14980	771	835	777	789	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1W9C
O14980	771	835	777	789	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1W9C
O14980	771	835	777	789	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1W9C
O14980	771	835	793	795	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1W9C
O14980	771	835	793	795	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1W9C
O14980	771	835	793	795	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1W9C
O14980	771	835	799	811	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1W9C
O14980	771	835	799	811	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1W9C
O14980	771	835	799	811	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1W9C
O14980	771	835	812	818	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1W9C
O14980	771	835	812	818	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1W9C
O14980	771	835	812	818	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1W9C
O14980	771	835	819	834	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1W9C
O14980	771	835	819	834	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1W9C
O14980	771	835	819	834	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1W9C
O14980	771	835	800	820	Region	Note=Interaction with HIV-1 Rev
O14980	771	835	800	820	Region	Note=Interaction with HIV-1 Rev
O14980	771	835	800	820	Region	Note=Interaction with HIV-1 Rev
O14980	771	835	775	813	Repeat	Note=HEAT 7
O14980	771	835	775	813	Repeat	Note=HEAT 7
O14980	771	835	775	813	Repeat	Note=HEAT 7

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3'-UTR located exon skipping events that lost miRNA binding sites in XPO1

3'-UTR exon skipping evnets lost miRNA binding.

Tissue type

ENST

Exon skip start

Exon skip end

microRNA

Binding site by TargetScan

Binding type by TargetScan

Bdinding site by miRanda

Score of miRanda

Energy by miRanda

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SNVs in the skipped exons for XPO1

- Differential PSIs between mutated versus non-mutated samples.

- Depth of Coverage in the skipped exon of the mutated samples.

- Sashimi plot in the skipped exon of the mutated samples.

- Non-synonymous mutations located in the skipped exons.

Cancer type

Sample

ESID

Skipped exon start

Skipped exon end

Mutation start

Mutation end

Mutation type

Reference seq

Mutation seq

AAchange

- Non-synonymous mutations located in the skipped exons in CCLE.

Sample

Skipped exon start

Skipped exon end

Mutation start

Mutation end

Mutation type

Reference seq

Mutation seq

AAchange

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AD stage-associated exon skippint events for XPO1

Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR).

AD stage info

Cohort

Tissue

SE id

Coefficient

P-value

Chromosome

Strand

E1 start

E1 end

Skipped start

Skipped end

E2 start

E2 end

CDR

MSBB

IFG

exon_skip_50859

-3.756440e-01

4.884771e-02

chr2

61522630

61522683

61525270

61525333

61526420

61526518

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for XPO1

sQTL information located at the skipped exons.

Tissue type

Exon skip ID

SNP id

Location

P-value

FDR

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Correlation with RNA binding proteins (RBPs) for XPO1

Correlated RBP and related information.

Tissue type	RBP name	Exon skip ID	Correlation coeifficient	P-value
DLPFC	ILF2	exon_skip_50859	-4.566717e-01	2.356032e-18
DLPFC	TRA2A	exon_skip_50859	-4.106102e-01	8.193963e-15
DLPFC	RBM23	exon_skip_50859	-4.019776e-01	3.303724e-14
DLPFC	SRSF9	exon_skip_50859	-4.427345e-01	3.170109e-17
DLPFC	HNRNPF	exon_skip_50859	-5.450588e-01	7.464694e-27
IFG	HNRNPH2	exon_skip_50859	4.629305e-01	1.311265e-02
IFG	TARDBP	exon_skip_249686	4.228261e-01	2.498065e-02
STG	TRA2A	exon_skip_50859	-4.045671e-01	6.966801e-05
STG	SRSF9	exon_skip_50859	-4.199001e-01	3.421439e-05
TC	RBM45	exon_skip_50859	4.004457e-01	1.547590e-07

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RelatedDrugs for XPO1

Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for XPO1

Diseases associated with this gene.
(DisGeNet 4.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	Gene structures and expression levels
	Exon skipping events with PSIs in RPSMAP, MSBB, and Mayo
	Open reading frame (ORF) annotation in the exon skipping event
	Exon skipping events in the canonical protein sequence
	3'-UTR located exon skipping events lost miRNA binding sites
	SNVs in the skipped exons with depth of coverage
	AD stage-associated exon skipping events
	Splicing Quantitative Trait Loci (sQTLs) in the skipped exons
	Correlation with RNA binding proteins (RBPs)
	Related drugs with this gene
	Related diseases with this gene

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Gene summary for XPO1

Gene structures and expression levels for XPO1

Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for XPO1

Open reading frame (ORF) annotation in the exon skipping event for XPO1

Infer the effects of exon skipping event on protein functional features for XPO1

3'-UTR located exon skipping events that lost miRNA binding sites in XPO1

SNVs in the skipped exons for XPO1

AD stage-associated exon skippint events for XPO1

Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for XPO1

Correlation with RNA binding proteins (RBPs) for XPO1

RelatedDrugs for XPO1

RelatedDiseases for XPO1