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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for WNT10B |
 Gene summary |
| Gene information | Gene symbol | WNT10B | Gene ID | 7480 |
| Gene name | Wnt family member 10B | |
| Synonyms | SHFM6|STHAG8|WNT-12 | |
| Cytomap | 12q13.12 | |
| Type of gene | protein-coding | |
| Description | protein Wnt-10bWNT-10B proteinwingless-type MMTV integration site family, member 10B | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| WNT10B | GO:0045599 | negative regulation of fat cell differentiation | 10937998 |
| WNT10B | GO:0050821 | protein stabilization | 10937998 |
| WNT10B | GO:0060070 | canonical Wnt signaling pathway | 17761539 |
| WNT10B | GO:0071425 | hematopoietic stem cell proliferation | 9787155 |
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Gene structures and expression levels for WNT10B |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000169884
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for WNT10B |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_1344 | chr12 | 48966313:48966553:48967946:48968006:48968149:48968319 | 48967946:48968006 |
| exon_skip_22423 | chr12 | 48965556:48966553:48967946:48968006:48968149:48968319 | 48967946:48968006 |
| exon_skip_260539 | chr12 | 48968296:48968319:48969110:48969144:48970089:48970342 | 48969110:48969144 |
| exon_skip_266634 | chr12 | 48967946:48968006:48968203:48968319:48970089:48970351 | 48968203:48968319 |
| exon_skip_276879 | chr12 | 48966313:48966553:48967946:48968319:48970089:48970351 | 48967946:48968319 |
| exon_skip_43512 | chr12 | 48965556:48966553:48967946:48968319:48970089:48970351 | 48967946:48968319 |
| exon_skip_53112 | chr12 | 48968296:48968319:48969110:48969144:48970089:48970351 | 48969110:48969144 |
| exon_skip_83736 | chr12 | 48967946:48968006:48968149:48968319:48970089:48970351 | 48968149:48968319 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for WNT10B |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000301061 | 48967946 | 48968319 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000301061 | 48967946 | 48968319 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000301061 | 48967946 | 48968319 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for WNT10B |
p-ENSG00000169884_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in WNT10B |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for WNT10B |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for WNT10B |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for WNT10B |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for WNT10B |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| DLPFC | RBM25 | exon_skip_43512 | 4.692918e-01 | 2.922882e-15 |
| DLPFC | RBM5 | exon_skip_43512 | 4.115040e-01 | 9.271781e-12 |
| DLPFC | SRSF5 | exon_skip_43512 | 4.242171e-01 | 1.790059e-12 |
| DLPFC | NOVA1 | exon_skip_43512 | 4.600047e-01 | 1.186121e-14 |
| IFG | SRSF2 | exon_skip_43512 | -4.650358e-01 | 3.882447e-02 |
| IFG | RBM25 | exon_skip_43512 | -4.869644e-01 | 2.943902e-02 |
| IFG | MBNL1 | exon_skip_43512 | -5.724100e-01 | 8.351352e-03 |
| IFG | ILF2 | exon_skip_43512 | -5.777031e-01 | 7.639570e-03 |
| IFG | HNRNPK | exon_skip_43512 | -5.383829e-01 | 1.432745e-02 |
| IFG | PUM1 | exon_skip_43512 | -4.778905e-01 | 3.307815e-02 |
| IFG | HNRNPA2B1 | exon_skip_43512 | -4.809151e-01 | 3.182808e-02 |
| IFG | RALYL | exon_skip_43512 | -6.518063e-01 | 1.846353e-03 |
| IFG | SRSF9 | exon_skip_43512 | -5.885105e-01 | 6.339790e-03 |
| IFG | SRSF5 | exon_skip_43512 | -4.506689e-01 | 4.613193e-02 |
| IFG | HNRNPH2 | exon_skip_43512 | -5.421637e-01 | 1.352957e-02 |
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RelatedDrugs for WNT10B |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for WNT10B |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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