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![]() | Open reading frame (ORF) annotation in the exon skipping event |
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![]() | 3'-UTR located exon skipping events lost miRNA binding sites |
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![]() | Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for VDAC3 |
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Gene information | Gene symbol | VDAC3 | Gene ID | 7419 |
Gene name | voltage dependent anion channel 3 | |
Synonyms | HD-VDAC3|VDAC-3 | |
Cytomap | 8p11.21 | |
Type of gene | protein-coding | |
Description | voltage-dependent anion-selective channel protein 3outer mitochondrial membrane protein porin 3 | |
Modification date | 20200313 | |
UniProtAcc | ||
Context |
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Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for VDAC3 |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
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Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for VDAC3 |
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Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_114475 | chr8 | 42395084:42395133:42396678:42396680:42398712:42398768 | 42396678:42396680 |
exon_skip_117237 | chr8 | 42394210:42394278:42395084:42395133:42398712:42398768 | 42395084:42395133 |
exon_skip_13005 | chr8 | 42398712:42398864:42399651:42399703:42401788:42401836 | 42399651:42399703 |
exon_skip_168578 | chr8 | 42395084:42395133:42396656:42396680:42398712:42398864 | 42396656:42396680 |
exon_skip_169142 | chr8 | 42395084:42395133:42398712:42398864:42401788:42402015 | 42398712:42398864 |
exon_skip_215830 | chr8 | 42395084:42395133:42398712:42398864:42401788:42401836 | 42398712:42398864 |
exon_skip_217396 | chr8 | 42398712:42398864:42399651:42399703:42401788:42402015 | 42399651:42399703 |
exon_skip_250973 | chr8 | 42398712:42398864:42399651:42399703:42401788:42401947 | 42399651:42399703 |
exon_skip_260659 | chr8 | 42403311:42403461:42404867:42404924:42405371:42405415 | 42404867:42404924 |
exon_skip_34300 | chr8 | 42394210:42394278:42395084:42395133:42398712:42398864 | 42395084:42395133 |
exon_skip_53621 | chr8 | 42391903:42391928:42393845:42393884:42394210:42394278 | 42393845:42393884 |
exon_skip_76560 | chr8 | 42398797:42398864:42399651:42399703:42401788:42402015 | 42399651:42399703 |
exon_skip_93718 | chr8 | 42395084:42395133:42396678:42396680:42398712:42398864 | 42396678:42396680 |
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Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
exon_skip_93718 | MSBB_PG | 5.066423e-01 | 6.841818e-01 | -1.775395e-01 | 3.025029e-04 |
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Open reading frame (ORF) annotation in the exon skipping event for VDAC3 |
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ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000022615 | 42393845 | 42393884 | 5UTR-5UTR |
ENST00000022615 | 42395084 | 42395133 | Frame-shift |
ENST00000022615 | 42399651 | 42399703 | Frame-shift |
ENST00000022615 | 42404867 | 42404924 | Frame-shift |
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ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000022615 | 42393845 | 42393884 | 5UTR-5UTR |
ENST00000022615 | 42395084 | 42395133 | Frame-shift |
ENST00000022615 | 42404867 | 42404924 | Frame-shift |
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ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000022615 | 42393845 | 42393884 | 5UTR-5UTR |
ENST00000022615 | 42395084 | 42395133 | Frame-shift |
ENST00000022615 | 42399651 | 42399703 | Frame-shift |
ENST00000022615 | 42404867 | 42404924 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for VDAC3 |
p-ENSG00000078668_img4.png![]() |
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ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
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ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
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ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
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UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in VDAC3 |
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Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for VDAC3 |
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Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for VDAC3 |
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AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for VDAC3 |
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Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for VDAC3 |
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Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
CB | SRSF9 | exon_skip_93718 | 5.165812e-01 | 3.164500e-12 |
TC | SRSF9 | exon_skip_114475 | 4.783020e-01 | 1.588219e-10 |
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RelatedDrugs for VDAC3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for VDAC3 |
![]() (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |