![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | Open reading frame (ORF) annotation in the exon skipping event |
![]() | |
![]() | 3'-UTR located exon skipping events lost miRNA binding sites |
![]() | |
![]() | |
![]() | Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
![]() | |
![]() | |
![]() |
Gene summary for UBP1 |
![]() |
Gene information | Gene symbol | UBP1 | Gene ID | 7342 |
Gene name | upstream binding protein 1 | |
Synonyms | LBP-1B|LBP-1a|LBP1A|LBP1B | |
Cytomap | 3p22.3 | |
Type of gene | protein-coding | |
Description | upstream-binding protein 1transcription factor LBP-1 | |
Modification date | 20200313 | |
UniProtAcc | ||
Context |
![]() |
Gene | GO ID | GO term | PubMed ID |
Top |
Gene structures and expression levels for UBP1 |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
![]() |
![]() |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
![]() |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
CB | DOWN | ENST00000480673.5 | FUBP1-207:lncRNA:FUBP1 | 8.657958e+01 | -1.387613e+00 | 1.395127e-08 | 3.999817e-07 |
CB | UP | ENST00000370767.5 | FUBP1-202:protein_coding:FUBP1 | 5.672744e+02 | 8.563142e-01 | 7.172312e-08 | 1.603767e-06 |
CB | DOWN | ENST00000474632.5 | FUBP1-206:lncRNA:FUBP1 | 2.733853e+01 | -9.528486e-01 | 1.334230e-07 | 2.717005e-06 |
CB | UP | ENST00000487684.1 | FUBP1-209:lncRNA:FUBP1 | 9.667259e+01 | 8.012985e-01 | 1.552383e-07 | 3.078855e-06 |
CB | UP | ENST00000294623.8 | FUBP1-201:nonsense_mediated_decay:FUBP1 | 7.021032e+02 | 8.818328e-01 | 1.599873e-07 | 3.156418e-06 |
CB | UP | ENST00000470287.1 | FUBP1-205:lncRNA:FUBP1 | 6.863653e+00 | 8.339444e-01 | 2.785528e-06 | 3.582258e-05 |
CB | DOWN | ENST00000488814.5 | FUBP1-210:lncRNA:FUBP1 | 8.210926e+00 | -8.556382e-01 | 1.566188e-03 | 7.523030e-03 |
CB | DOWN | ENST00000573663.1 | NUBP1-205:lncRNA:NUBP1 | 4.040186e+00 | -1.418174e+00 | 1.289517e-02 | 4.273288e-02 |
TC | DOWN | ENST00000480673.5 | FUBP1-207:lncRNA:FUBP1 | 3.228486e+01 | -1.384732e+00 | 9.556762e-09 | 8.671438e-07 |
TC | DOWN | ENST00000488814.5 | FUBP1-210:lncRNA:FUBP1 | 5.868790e+00 | -1.156605e+00 | 1.766944e-03 | 1.526421e-02 |
![]() |
Top |
Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for UBP1 |
![]() |
![]() |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_160359 | chr3 | 33402801:33402904:33408690:33408797:33409236:33409346 | 33408690:33408797 |
exon_skip_1747 | chr3 | 33412722:33412827:33416006:33416100:33416758:33416820 | 33416006:33416100 |
exon_skip_203183 | chr3 | 33416793:33416834:33425590:33425741:33439736:33439856 | 33425590:33425741 |
exon_skip_223626 | chr3 | 33402801:33402904:33408690:33408797:33409236:33409339 | 33408690:33408797 |
exon_skip_233999 | chr3 | 33396243:33396280:33396745:33396878:33397045:33397135 | 33396745:33396878 |
exon_skip_236338 | chr3 | 33412726:33412827:33416006:33416100:33416758:33416820 | 33416006:33416100 |
exon_skip_271666 | chr3 | 33390266:33390368:33392563:33392614:33393312:33393454 | 33392563:33392614 |
exon_skip_42595 | chr3 | 33400962:33401016:33402801:33402904:33409236:33409346 | 33402801:33402904 |
![]() |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
exon_skip_160359 | ROSMAP_DLPFC | 5.110881e-01 | 6.240909e-01 | -1.130028e-01 | 1.118608e-04 |
exon_skip_223626 | Mayo_CB | 2.900000e-01 | 4.544156e-01 | -1.644156e-01 | 4.885421e-07 |
exon_skip_223626 | Mayo_TC | 4.921951e-01 | 6.112987e-01 | -1.191036e-01 | 1.875273e-05 |
Top |
Open reading frame (ORF) annotation in the exon skipping event for UBP1 |
![]() |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000283628 | 33425590 | 33425741 | Frame-shift |
ENST00000283628 | 33408690 | 33408797 | In-frame |
ENST00000283629 | 33408690 | 33408797 | In-frame |
![]() |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000283628 | 33408690 | 33408797 | In-frame |
ENST00000283629 | 33408690 | 33408797 | In-frame |
![]() |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000283628 | 33392563 | 33392614 | Frame-shift |
ENST00000283629 | 33392563 | 33392614 | Frame-shift |
ENST00000283628 | 33425590 | 33425741 | Frame-shift |
ENST00000283628 | 33408690 | 33408797 | In-frame |
ENST00000283629 | 33408690 | 33408797 | In-frame |
Top |
Infer the effects of exon skipping event on protein functional features for UBP1 |
p-ENSG00000153560_img4.png![]() |
![]() |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000283628 | 2091 | 540 | 33408690 | 33408797 | 1074 | 1180 | 273 | 308 |
ENST00000283629 | 4165 | 540 | 33408690 | 33408797 | 1350 | 1456 | 273 | 308 |
![]() |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000283628 | 2091 | 540 | 33408690 | 33408797 | 1074 | 1180 | 273 | 308 |
ENST00000283629 | 4165 | 540 | 33408690 | 33408797 | 1350 | 1456 | 273 | 308 |
![]() |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000283628 | 2091 | 540 | 33408690 | 33408797 | 1074 | 1180 | 273 | 308 |
ENST00000283629 | 4165 | 540 | 33408690 | 33408797 | 1350 | 1456 | 273 | 308 |
![]() |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Q9NZI7 | 273 | 308 | 274 | 309 | Alternative sequence | ID=VSP_017730;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:8114710;Dbxref=PMID:14702039,PMID:8114710 |
Q9NZI7 | 273 | 308 | 274 | 309 | Alternative sequence | ID=VSP_017730;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:8114710;Dbxref=PMID:14702039,PMID:8114710 |
Q9NZI7 | 273 | 308 | 1 | 540 | Chain | ID=PRO_0000229026;Note=Upstream-binding protein 1 |
Q9NZI7 | 273 | 308 | 1 | 540 | Chain | ID=PRO_0000229026;Note=Upstream-binding protein 1 |
Q9NZI7 | 273 | 308 | 273 | 273 | Sequence conflict | Note=E->EE;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
Q9NZI7 | 273 | 308 | 273 | 273 | Sequence conflict | Note=E->EE;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
Q9NZI7 | 273 | 308 | 291 | 297 | Sequence conflict | Note=SSKRTLP->VQQADFA;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
Q9NZI7 | 273 | 308 | 291 | 297 | Sequence conflict | Note=SSKRTLP->VQQADFA;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
![]() |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Q9NZI7 | 273 | 308 | 274 | 309 | Alternative sequence | ID=VSP_017730;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:8114710;Dbxref=PMID:14702039,PMID:8114710 |
Q9NZI7 | 273 | 308 | 274 | 309 | Alternative sequence | ID=VSP_017730;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:8114710;Dbxref=PMID:14702039,PMID:8114710 |
Q9NZI7 | 273 | 308 | 1 | 540 | Chain | ID=PRO_0000229026;Note=Upstream-binding protein 1 |
Q9NZI7 | 273 | 308 | 1 | 540 | Chain | ID=PRO_0000229026;Note=Upstream-binding protein 1 |
Q9NZI7 | 273 | 308 | 273 | 273 | Sequence conflict | Note=E->EE;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
Q9NZI7 | 273 | 308 | 273 | 273 | Sequence conflict | Note=E->EE;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
Q9NZI7 | 273 | 308 | 291 | 297 | Sequence conflict | Note=SSKRTLP->VQQADFA;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
Q9NZI7 | 273 | 308 | 291 | 297 | Sequence conflict | Note=SSKRTLP->VQQADFA;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
![]() |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Q9NZI7 | 273 | 308 | 274 | 309 | Alternative sequence | ID=VSP_017730;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:8114710;Dbxref=PMID:14702039,PMID:8114710 |
Q9NZI7 | 273 | 308 | 274 | 309 | Alternative sequence | ID=VSP_017730;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:8114710;Dbxref=PMID:14702039,PMID:8114710 |
Q9NZI7 | 273 | 308 | 1 | 540 | Chain | ID=PRO_0000229026;Note=Upstream-binding protein 1 |
Q9NZI7 | 273 | 308 | 1 | 540 | Chain | ID=PRO_0000229026;Note=Upstream-binding protein 1 |
Q9NZI7 | 273 | 308 | 273 | 273 | Sequence conflict | Note=E->EE;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
Q9NZI7 | 273 | 308 | 273 | 273 | Sequence conflict | Note=E->EE;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
Q9NZI7 | 273 | 308 | 291 | 297 | Sequence conflict | Note=SSKRTLP->VQQADFA;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
Q9NZI7 | 273 | 308 | 291 | 297 | Sequence conflict | Note=SSKRTLP->VQQADFA;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
Top |
3'-UTR located exon skipping events that lost miRNA binding sites in UBP1 |
![]() |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
Top |
SNVs in the skipped exons for UBP1 |
![]() |
![]() |
![]() |
![]() |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
![]() |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
Top |
AD stage-associated exon skippint events for UBP1 |
![]() |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
CDR | MSBB | IFG | exon_skip_160359 | -3.835731e-01 | 4.390889e-02 | chr3 | - | 33402801 | 33402904 | 33408690 | 33408797 | 33409236 | 33409346 |
CDR | MSBB | IFG | exon_skip_236338 | 3.765290e-01 | 4.827567e-02 | chr3 | - | 33412726 | 33412827 | 33416006 | 33416100 | 33416758 | 33416820 |
Top |
Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for UBP1 |
![]() |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
Top |
Correlation with RNA binding proteins (RBPs) for UBP1 |
![]() |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
CB | CNOT4 | exon_skip_223626 | -5.785942e-01 | 1.376819e-15 |
CB | TRA2A | exon_skip_223626 | -6.422646e-01 | 7.222210e-20 |
CB | EIF4G2 | exon_skip_223626 | -4.824863e-01 | 1.193624e-10 |
HCC | SRSF11 | exon_skip_160359 | -4.129822e-01 | 1.255601e-12 |
HCC | EIF4G2 | exon_skip_160359 | -5.076068e-01 | 3.212654e-19 |
TC | KHDRBS2 | exon_skip_223626 | 4.037887e-01 | 1.306770e-07 |
Top |
RelatedDrugs for UBP1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for UBP1 |
![]() (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |