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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for SLC35E2B |
Gene summary |
Gene information | Gene symbol | SLC35E2B | Gene ID | 728661 |
Gene name | solute carrier family 35 member E2B | |
Synonyms | SLC35E2 | |
Cytomap | 1p36.33 | |
Type of gene | protein-coding | |
Description | solute carrier family 35 member E2B | |
Modification date | 20200313 | |
UniProtAcc | ||
Context |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for SLC35E2B |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
STG | UP | ENST00000480991.1 | SLC35E2B-201:retained_intron:SLC35E2B | 5.816355e+01 | 9.293192e-01 | 1.092766e-06 | 5.530272e-04 |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for SLC35E2B |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_134377 | chr1 | 1670098:1670151:1671509:1671629:1675463:1675560 | 1671509:1671629 |
exon_skip_142321 | chr1 | 1676729:1676846:1690976:1691393:1692449:1692709 | 1690976:1691393 |
exon_skip_15953 | chr1 | 1668327:1668472:1675463:1675590:1676064:1676128 | 1675463:1675590 |
exon_skip_197872 | chr1 | 1670098:1670151:1671509:1671629:1675463:1675590 | 1671509:1671629 |
exon_skip_198883 | chr1 | 1668327:1668472:1675463:1675590:1676064:1676199 | 1675463:1675590 |
exon_skip_210386 | chr1 | 1671509:1671629:1675463:1675590:1676064:1676199 | 1675463:1675590 |
exon_skip_291807 | chr1 | 1676378:1676846:1690976:1691393:1692449:1692709 | 1690976:1691393 |
exon_skip_63804 | chr1 | 1676495:1676846:1690976:1691393:1692449:1692709 | 1690976:1691393 |
exon_skip_82220 | chr1 | 1676640:1676846:1690976:1691393:1692449:1692709 | 1690976:1691393 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for SLC35E2B |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000617444 | 1690976 | 1691393 | 3UTR-3UTR |
ENST00000611123 | 1671509 | 1671629 | Frame-shift |
ENST00000617444 | 1671509 | 1671629 | Frame-shift |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000617444 | 1690976 | 1691393 | 3UTR-3UTR |
ENST00000611123 | 1671509 | 1671629 | Frame-shift |
ENST00000617444 | 1671509 | 1671629 | Frame-shift |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000617444 | 1690976 | 1691393 | 3UTR-3UTR |
ENST00000611123 | 1671509 | 1671629 | Frame-shift |
ENST00000617444 | 1671509 | 1671629 | Frame-shift |
ENST00000611123 | 1675463 | 1675590 | Frame-shift |
ENST00000617444 | 1675463 | 1675590 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for SLC35E2B |
p-ENSG00000189339_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in SLC35E2B |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
Mayo | ENST00000617444 | 1690976 | 1691393 | hsa-miR-1287-5p | chr1:1691263-1691270 | 8mer-1a | chr1:1691249-1691270 | 153.00 | -20.71 |
Mayo | ENST00000617444 | 1690976 | 1691393 | hsa-miR-6748-3p | chr1:1691301-1691308 | 8mer-1a | chr1:1691282-1691308 | 157.00 | -30.70 |
Mayo | ENST00000617444 | 1690976 | 1691393 | hsa-miR-6762-3p | chr1:1691293-1691300 | 8mer-1a | chr1:1691282-1691302 | 163.00 | -29.36 |
Mayo | ENST00000617444 | 1690976 | 1691393 | hsa-miR-134-5p | chr1:1691077-1691084 | 8mer-1a | chr1:1691077-1691105 | 148.00 | -24.25 |
Mayo | ENST00000617444 | 1690976 | 1691393 | hsa-miR-3118 | chr1:1691077-1691084 | 8mer-1a | chr1:1691077-1691105 | 148.00 | -24.25 |
Mayo | ENST00000617444 | 1690976 | 1691393 | hsa-miR-4516 | chr1:1691224-1691231 | 8mer-1a | chr1:1691217-1691246 | 163.00 | -36.61 |
Mayo | ENST00000617444 | 1690976 | 1691393 | hsa-miR-3670 | chr1:1691142-1691149 | 8mer-1a | chr1:1691126-1691149 | 164.00 | -17.10 |
Mayo | ENST00000617444 | 1690976 | 1691393 | hsa-miR-6088 | chr1:1691328-1691335 | 8mer-1a | chr1:1691314-1691335 | 153.00 | -22.08 |
Mayo | ENST00000617444 | 1690976 | 1691393 | hsa-miR-4434 | chr1:1691224-1691231 | 8mer-1a | chr1:1691217-1691246 | 163.00 | -36.61 |
Mayo | ENST00000617444 | 1690976 | 1691393 | hsa-miR-5703 | chr1:1691224-1691231 | 8mer-1a | chr1:1691217-1691246 | 163.00 | -36.61 |
Mayo | ENST00000617444 | 1690976 | 1691393 | hsa-miR-4758-3p | chr1:1691013-1691020 | 8mer-1a | chr1:1690996-1691020 | 143.00 | -21.45 |
Mayo | ENST00000617444 | 1690976 | 1691393 | hsa-miR-143-3p | chr1:1691328-1691335 | 8mer-1a | chr1:1691314-1691335 | 153.00 | -22.08 |
Mayo | ENST00000617444 | 1690976 | 1691393 | hsa-miR-3151-5p | chr1:1691238-1691245 | 8mer-1a | chr1:1691217-1691246 | 163.00 | -36.61 |
Mayo | ENST00000617444 | 1690976 | 1691393 | hsa-miR-31-5p | chr1:1691215-1691222 | 8mer-1a | chr1:1691214-1691231 | 160.00 | -19.99 |
Mayo | ENST00000617444 | 1690976 | 1691393 | hsa-miR-4770 | chr1:1691328-1691335 | 8mer-1a | chr1:1691314-1691335 | 153.00 | -22.08 |
Mayo | ENST00000617444 | 1690976 | 1691393 | hsa-miR-532-3p | chr1:1691284-1691291 | 8mer-1a | chr1:1691275-1691295 | 181.00 | -36.56 |
Mayo | ENST00000617444 | 1690976 | 1691393 | hsa-miR-92a-2-5p | chr1:1691204-1691211 | 8mer-1a | chr1:1691190-1691211 | 156.00 | -22.29 |
MSBB | ENST00000617444 | 1690976 | 1691393 | hsa-miR-1287-5p | chr1:1691263-1691270 | 8mer-1a | chr1:1691249-1691270 | 153.00 | -20.71 |
MSBB | ENST00000617444 | 1690976 | 1691393 | hsa-miR-6748-3p | chr1:1691301-1691308 | 8mer-1a | chr1:1691282-1691308 | 157.00 | -30.70 |
MSBB | ENST00000617444 | 1690976 | 1691393 | hsa-miR-6762-3p | chr1:1691293-1691300 | 8mer-1a | chr1:1691282-1691302 | 163.00 | -29.36 |
MSBB | ENST00000617444 | 1690976 | 1691393 | hsa-miR-134-5p | chr1:1691077-1691084 | 8mer-1a | chr1:1691077-1691105 | 148.00 | -24.25 |
MSBB | ENST00000617444 | 1690976 | 1691393 | hsa-miR-3118 | chr1:1691077-1691084 | 8mer-1a | chr1:1691077-1691105 | 148.00 | -24.25 |
MSBB | ENST00000617444 | 1690976 | 1691393 | hsa-miR-4516 | chr1:1691224-1691231 | 8mer-1a | chr1:1691217-1691246 | 163.00 | -36.61 |
MSBB | ENST00000617444 | 1690976 | 1691393 | hsa-miR-3670 | chr1:1691142-1691149 | 8mer-1a | chr1:1691126-1691149 | 164.00 | -17.10 |
MSBB | ENST00000617444 | 1690976 | 1691393 | hsa-miR-6088 | chr1:1691328-1691335 | 8mer-1a | chr1:1691314-1691335 | 153.00 | -22.08 |
MSBB | ENST00000617444 | 1690976 | 1691393 | hsa-miR-4434 | chr1:1691224-1691231 | 8mer-1a | chr1:1691217-1691246 | 163.00 | -36.61 |
MSBB | ENST00000617444 | 1690976 | 1691393 | hsa-miR-5703 | chr1:1691224-1691231 | 8mer-1a | chr1:1691217-1691246 | 163.00 | -36.61 |
MSBB | ENST00000617444 | 1690976 | 1691393 | hsa-miR-4758-3p | chr1:1691013-1691020 | 8mer-1a | chr1:1690996-1691020 | 143.00 | -21.45 |
MSBB | ENST00000617444 | 1690976 | 1691393 | hsa-miR-143-3p | chr1:1691328-1691335 | 8mer-1a | chr1:1691314-1691335 | 153.00 | -22.08 |
MSBB | ENST00000617444 | 1690976 | 1691393 | hsa-miR-3151-5p | chr1:1691238-1691245 | 8mer-1a | chr1:1691217-1691246 | 163.00 | -36.61 |
MSBB | ENST00000617444 | 1690976 | 1691393 | hsa-miR-31-5p | chr1:1691215-1691222 | 8mer-1a | chr1:1691214-1691231 | 160.00 | -19.99 |
MSBB | ENST00000617444 | 1690976 | 1691393 | hsa-miR-4770 | chr1:1691328-1691335 | 8mer-1a | chr1:1691314-1691335 | 153.00 | -22.08 |
MSBB | ENST00000617444 | 1690976 | 1691393 | hsa-miR-532-3p | chr1:1691284-1691291 | 8mer-1a | chr1:1691275-1691295 | 181.00 | -36.56 |
MSBB | ENST00000617444 | 1690976 | 1691393 | hsa-miR-92a-2-5p | chr1:1691204-1691211 | 8mer-1a | chr1:1691190-1691211 | 156.00 | -22.29 |
ROSMAP | ENST00000617444 | 1690976 | 1691393 | hsa-miR-1287-5p | chr1:1691263-1691270 | 8mer-1a | chr1:1691249-1691270 | 153.00 | -20.71 |
ROSMAP | ENST00000617444 | 1690976 | 1691393 | hsa-miR-6748-3p | chr1:1691301-1691308 | 8mer-1a | chr1:1691282-1691308 | 157.00 | -30.70 |
ROSMAP | ENST00000617444 | 1690976 | 1691393 | hsa-miR-6762-3p | chr1:1691293-1691300 | 8mer-1a | chr1:1691282-1691302 | 163.00 | -29.36 |
ROSMAP | ENST00000617444 | 1690976 | 1691393 | hsa-miR-134-5p | chr1:1691077-1691084 | 8mer-1a | chr1:1691077-1691105 | 148.00 | -24.25 |
ROSMAP | ENST00000617444 | 1690976 | 1691393 | hsa-miR-3118 | chr1:1691077-1691084 | 8mer-1a | chr1:1691077-1691105 | 148.00 | -24.25 |
ROSMAP | ENST00000617444 | 1690976 | 1691393 | hsa-miR-4516 | chr1:1691224-1691231 | 8mer-1a | chr1:1691217-1691246 | 163.00 | -36.61 |
ROSMAP | ENST00000617444 | 1690976 | 1691393 | hsa-miR-3670 | chr1:1691142-1691149 | 8mer-1a | chr1:1691126-1691149 | 164.00 | -17.10 |
ROSMAP | ENST00000617444 | 1690976 | 1691393 | hsa-miR-6088 | chr1:1691328-1691335 | 8mer-1a | chr1:1691314-1691335 | 153.00 | -22.08 |
ROSMAP | ENST00000617444 | 1690976 | 1691393 | hsa-miR-4434 | chr1:1691224-1691231 | 8mer-1a | chr1:1691217-1691246 | 163.00 | -36.61 |
ROSMAP | ENST00000617444 | 1690976 | 1691393 | hsa-miR-5703 | chr1:1691224-1691231 | 8mer-1a | chr1:1691217-1691246 | 163.00 | -36.61 |
ROSMAP | ENST00000617444 | 1690976 | 1691393 | hsa-miR-4758-3p | chr1:1691013-1691020 | 8mer-1a | chr1:1690996-1691020 | 143.00 | -21.45 |
ROSMAP | ENST00000617444 | 1690976 | 1691393 | hsa-miR-143-3p | chr1:1691328-1691335 | 8mer-1a | chr1:1691314-1691335 | 153.00 | -22.08 |
ROSMAP | ENST00000617444 | 1690976 | 1691393 | hsa-miR-3151-5p | chr1:1691238-1691245 | 8mer-1a | chr1:1691217-1691246 | 163.00 | -36.61 |
ROSMAP | ENST00000617444 | 1690976 | 1691393 | hsa-miR-31-5p | chr1:1691215-1691222 | 8mer-1a | chr1:1691214-1691231 | 160.00 | -19.99 |
ROSMAP | ENST00000617444 | 1690976 | 1691393 | hsa-miR-4770 | chr1:1691328-1691335 | 8mer-1a | chr1:1691314-1691335 | 153.00 | -22.08 |
ROSMAP | ENST00000617444 | 1690976 | 1691393 | hsa-miR-532-3p | chr1:1691284-1691291 | 8mer-1a | chr1:1691275-1691295 | 181.00 | -36.56 |
ROSMAP | ENST00000617444 | 1690976 | 1691393 | hsa-miR-92a-2-5p | chr1:1691204-1691211 | 8mer-1a | chr1:1691190-1691211 | 156.00 | -22.29 |
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SNVs in the skipped exons for SLC35E2B |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for SLC35E2B |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for SLC35E2B |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for SLC35E2B |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
CB | TARDBP | exon_skip_215800 | 4.522192e-01 | 3.918839e-09 |
CB | PCBP1 | exon_skip_215800 | 4.130032e-01 | 1.020384e-07 |
CB | FUBP1 | exon_skip_215800 | 4.466641e-01 | 6.378999e-09 |
CB | HNRNPA2B1 | exon_skip_215800 | 5.114287e-01 | 1.218644e-11 |
CB | HNRNPC | exon_skip_215800 | 4.624354e-01 | 1.563130e-09 |
CB | HNRNPF | exon_skip_215800 | 4.516583e-01 | 4.118075e-09 |
CB | RBM4 | exon_skip_215800 | 4.432246e-01 | 8.587714e-09 |
CB | RBM6 | exon_skip_134377 | -4.611785e-01 | 1.371687e-09 |
CB | SAMD4A | exon_skip_134377 | -4.304514e-01 | 2.038734e-08 |
CB | CNOT4 | exon_skip_134377 | -4.294716e-01 | 2.212366e-08 |
CB | PCBP4 | exon_skip_134377 | 4.309345e-01 | 1.958027e-08 |
CB | RBM4 | exon_skip_134377 | -5.538234e-01 | 6.426463e-14 |
CB | TARDBP | exon_skip_28107 | -4.387482e-01 | 1.423391e-07 |
CB | SAMD4A | exon_skip_28107 | -4.242903e-01 | 3.978490e-07 |
CB | CNOT4 | exon_skip_28107 | -4.338502e-01 | 2.027123e-07 |
CB | FUBP1 | exon_skip_28107 | -4.684346e-01 | 1.476409e-08 |
CB | HNRNPA2B1 | exon_skip_28107 | -4.462591e-01 | 8.186706e-08 |
CB | RBM4 | exon_skip_28107 | -4.143257e-01 | 7.861462e-07 |
IFG | FUBP1 | exon_skip_91053 | 4.409377e-01 | 2.736472e-02 |
IFG | RBM4 | exon_skip_91053 | 4.196511e-01 | 3.676605e-02 |
TC | PTBP1 | exon_skip_91053 | 4.358627e-01 | 1.605041e-08 |
TC | ESRP1 | exon_skip_91053 | -4.059088e-01 | 1.762661e-07 |
TC | RBM6 | exon_skip_197872 | -4.374334e-01 | 1.013192e-08 |
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RelatedDrugs for SLC35E2B |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SLC35E2B |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |