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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for TPR |
 Gene summary |
| Gene information | Gene symbol | TPR | Gene ID | 7175 |
| Gene name | translocated promoter region, nuclear basket protein | |
| Synonyms | - | |
| Cytomap | 1q31.1 | |
| Type of gene | protein-coding | |
| Description | nucleoprotein TPRNPC-associated intranuclear proteinmegatornuclear pore complex-associated protein TPRtranslocated promoter region (to activated MET oncogene)translocated promoter region proteintumor potentiating region | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| TPR | GO:0006404 | RNA import into nucleus | 9864356 |
| TPR | GO:0006606 | protein import into nucleus | 9864356 |
| TPR | GO:0031990 | mRNA export from nucleus in response to heat stress | 17897941 |
| TPR | GO:0034605 | cellular response to heat | 17897941 |
| TPR | GO:0046832 | negative regulation of RNA export from nucleus | 22253824 |
| TPR | GO:0070849 | response to epidermal growth factor | 18794356 |
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Gene structures and expression levels for TPR |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000047410
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | UP | ENST00000613151.1 | TPR-209:protein_coding:TPR | 1.067169e+01 | 1.493604e+00 | 9.593391e-08 | 2.050673e-06 |
| CB | UP | ENST00000469463.1 | TPR-204:retained_intron:TPR | 1.139326e+00 | 1.153804e+00 | 3.418146e-04 | 2.091329e-03 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for TPR |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_10619 | chr1 | 186352015:186352110:186353688:186353850:186355410:186355552 | 186353688:186353850 |
| exon_skip_121828 | chr1 | 186352015:186352110:186353688:186353880:186355410:186355552 | 186353688:186353880 |
| exon_skip_121953 | chr1 | 186318505:186318603:186318733:186318828:186320312:186320418 | 186318733:186318828 |
| exon_skip_127380 | chr1 | 186311652:186314026:186314629:186314724:186317482:186317600 | 186314629:186314724 |
| exon_skip_159214 | chr1 | 186338187:186338243:186339642:186339772:186341028:186341159 | 186339642:186339772 |
| exon_skip_166801 | chr1 | 186352015:186352110:186353688:186353880:186355410:186355558 | 186353688:186353880 |
| exon_skip_171207 | chr1 | 186352015:186352110:186353688:186353850:186355410:186355558 | 186353688:186353850 |
| exon_skip_171828 | chr1 | 186361622:186361709:186361789:186361869:186362288:186362380 | 186361789:186361869 |
| exon_skip_21437 | chr1 | 186341028:186341159:186341252:186341389:186343326:186343473 | 186341252:186341389 |
| exon_skip_242829 | chr1 | 186363342:186363445:186367886:186367982:186370970:186371043 | 186367886:186367982 |
| exon_skip_36898 | chr1 | 186325764:186325854:186326104:186326235:186327460:186327660 | 186326104:186326235 |
| exon_skip_50138 | chr1 | 186323686:186323870:186325764:186325854:186326104:186326220 | 186325764:186325854 |
| exon_skip_50624 | chr1 | 186314670:186314724:186317482:186317600:186318447:186318603 | 186317482:186317600 |
| exon_skip_54068 | chr1 | 186314629:186314724:186317482:186317600:186318447:186318603 | 186317482:186317600 |
| exon_skip_58197 | chr1 | 186325797:186325854:186326104:186326235:186327460:186327660 | 186326104:186326235 |
| exon_skip_59368 | chr1 | 186334325:186334533:186335068:186335129:186335338:186335543 | 186335068:186335129 |
| exon_skip_97428 | chr1 | 186355635:186355768:186356286:186356449:186357397:186357623 | 186356286:186356449 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for TPR |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000367478 | 186317482 | 186317600 | Frame-shift |
| ENST00000367478 | 186325764 | 186325854 | Frame-shift |
| ENST00000367478 | 186335068 | 186335129 | Frame-shift |
| ENST00000367478 | 186339642 | 186339772 | Frame-shift |
| ENST00000367478 | 186353688 | 186353850 | Frame-shift |
| ENST00000367478 | 186367886 | 186367982 | Frame-shift |
| ENST00000367478 | 186314629 | 186314724 | In-frame |
| ENST00000367478 | 186318733 | 186318828 | In-frame |
| ENST00000367478 | 186326104 | 186326235 | In-frame |
| ENST00000367478 | 186341252 | 186341389 | In-frame |
| ENST00000367478 | 186361789 | 186361869 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000367478 | 186325764 | 186325854 | Frame-shift |
| ENST00000367478 | 186339642 | 186339772 | Frame-shift |
| ENST00000367478 | 186353688 | 186353850 | Frame-shift |
| ENST00000367478 | 186318733 | 186318828 | In-frame |
| ENST00000367478 | 186341252 | 186341389 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000367478 | 186317482 | 186317600 | Frame-shift |
| ENST00000367478 | 186325764 | 186325854 | Frame-shift |
| ENST00000367478 | 186335068 | 186335129 | Frame-shift |
| ENST00000367478 | 186339642 | 186339772 | Frame-shift |
| ENST00000367478 | 186353688 | 186353850 | Frame-shift |
| ENST00000367478 | 186356286 | 186356449 | Frame-shift |
| ENST00000367478 | 186367886 | 186367982 | Frame-shift |
| ENST00000367478 | 186314629 | 186314724 | In-frame |
| ENST00000367478 | 186318733 | 186318828 | In-frame |
| ENST00000367478 | 186326104 | 186326235 | In-frame |
| ENST00000367478 | 186341252 | 186341389 | In-frame |
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Infer the effects of exon skipping event on protein functional features for TPR |
p-ENSG00000047410_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000367478 | 9725 | 2363 | 186361789 | 186361869 | 1087 | 1166 | 263 | 289 |
| ENST00000367478 | 9725 | 2363 | 186341252 | 186341389 | 4048 | 4184 | 1250 | 1295 |
| ENST00000367478 | 9725 | 2363 | 186326104 | 186326235 | 6187 | 6317 | 1963 | 2006 |
| ENST00000367478 | 9725 | 2363 | 186318733 | 186318828 | 6866 | 6960 | 2189 | 2221 |
| ENST00000367478 | 9725 | 2363 | 186314629 | 186314724 | 7238 | 7332 | 2313 | 2345 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000367478 | 9725 | 2363 | 186341252 | 186341389 | 4048 | 4184 | 1250 | 1295 |
| ENST00000367478 | 9725 | 2363 | 186318733 | 186318828 | 6866 | 6960 | 2189 | 2221 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000367478 | 9725 | 2363 | 186341252 | 186341389 | 4048 | 4184 | 1250 | 1295 |
| ENST00000367478 | 9725 | 2363 | 186326104 | 186326235 | 6187 | 6317 | 1963 | 2006 |
| ENST00000367478 | 9725 | 2363 | 186318733 | 186318828 | 6866 | 6960 | 2189 | 2221 |
| ENST00000367478 | 9725 | 2363 | 186314629 | 186314724 | 7238 | 7332 | 2313 | 2345 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P12270 | 263 | 289 | 2 | 2363 | Chain | ID=PRO_0000204920;Note=Nucleoprotein TPR |
| P12270 | 263 | 289 | 29 | 370 | Coiled coil | Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P12270 | 1250 | 1295 | 727 | 2363 | Alternative sequence | ID=VSP_057407;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1549355;Dbxref=PMID:1549355 |
| P12270 | 1250 | 1295 | 2 | 2363 | Chain | ID=PRO_0000204920;Note=Nucleoprotein TPR |
| P12270 | 1250 | 1295 | 1215 | 1630 | Coiled coil | Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P12270 | 1250 | 1295 | 1218 | 1320 | Region | Note=Necessary for interaction with HSF1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17897941;Dbxref=PMID:17897941 |
| P12270 | 1963 | 2006 | 727 | 2363 | Alternative sequence | ID=VSP_057407;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1549355;Dbxref=PMID:1549355 |
| P12270 | 1963 | 2006 | 2 | 2363 | Chain | ID=PRO_0000204920;Note=Nucleoprotein TPR |
| P12270 | 1963 | 2006 | 1971 | 1978 | Compositional bias | Note=Poly-Asp |
| P12270 | 1963 | 2006 | 1952 | 1965 | Sequence conflict | Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| P12270 | 2189 | 2221 | 727 | 2363 | Alternative sequence | ID=VSP_057407;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1549355;Dbxref=PMID:1549355 |
| P12270 | 2189 | 2221 | 2 | 2363 | Chain | ID=PRO_0000204920;Note=Nucleoprotein TPR |
| P12270 | 2313 | 2345 | 727 | 2363 | Alternative sequence | ID=VSP_057407;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1549355;Dbxref=PMID:1549355 |
| P12270 | 2313 | 2345 | 2 | 2363 | Chain | ID=PRO_0000204920;Note=Nucleoprotein TPR |
| P12270 | 2313 | 2345 | 2343 | 2343 | Modified residue | Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:F6ZDS4 |
| P12270 | 2313 | 2345 | 2345 | 2345 | Modified residue | Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:F6ZDS4 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P12270 | 1250 | 1295 | 727 | 2363 | Alternative sequence | ID=VSP_057407;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1549355;Dbxref=PMID:1549355 |
| P12270 | 1250 | 1295 | 2 | 2363 | Chain | ID=PRO_0000204920;Note=Nucleoprotein TPR |
| P12270 | 1250 | 1295 | 1215 | 1630 | Coiled coil | Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P12270 | 1250 | 1295 | 1218 | 1320 | Region | Note=Necessary for interaction with HSF1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17897941;Dbxref=PMID:17897941 |
| P12270 | 2189 | 2221 | 727 | 2363 | Alternative sequence | ID=VSP_057407;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1549355;Dbxref=PMID:1549355 |
| P12270 | 2189 | 2221 | 2 | 2363 | Chain | ID=PRO_0000204920;Note=Nucleoprotein TPR |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P12270 | 1250 | 1295 | 727 | 2363 | Alternative sequence | ID=VSP_057407;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1549355;Dbxref=PMID:1549355 |
| P12270 | 1250 | 1295 | 2 | 2363 | Chain | ID=PRO_0000204920;Note=Nucleoprotein TPR |
| P12270 | 1250 | 1295 | 1215 | 1630 | Coiled coil | Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P12270 | 1250 | 1295 | 1218 | 1320 | Region | Note=Necessary for interaction with HSF1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17897941;Dbxref=PMID:17897941 |
| P12270 | 1963 | 2006 | 727 | 2363 | Alternative sequence | ID=VSP_057407;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1549355;Dbxref=PMID:1549355 |
| P12270 | 1963 | 2006 | 2 | 2363 | Chain | ID=PRO_0000204920;Note=Nucleoprotein TPR |
| P12270 | 1963 | 2006 | 1971 | 1978 | Compositional bias | Note=Poly-Asp |
| P12270 | 1963 | 2006 | 1952 | 1965 | Sequence conflict | Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| P12270 | 2189 | 2221 | 727 | 2363 | Alternative sequence | ID=VSP_057407;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1549355;Dbxref=PMID:1549355 |
| P12270 | 2189 | 2221 | 2 | 2363 | Chain | ID=PRO_0000204920;Note=Nucleoprotein TPR |
| P12270 | 2313 | 2345 | 727 | 2363 | Alternative sequence | ID=VSP_057407;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1549355;Dbxref=PMID:1549355 |
| P12270 | 2313 | 2345 | 2 | 2363 | Chain | ID=PRO_0000204920;Note=Nucleoprotein TPR |
| P12270 | 2313 | 2345 | 2343 | 2343 | Modified residue | Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:F6ZDS4 |
| P12270 | 2313 | 2345 | 2345 | 2345 | Modified residue | Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:F6ZDS4 |
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3'-UTR located exon skipping events that lost miRNA binding sites in TPR |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for TPR |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for TPR |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TPR |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for TPR |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | TRA2A | exon_skip_10619 | -5.624944e-01 | 8.304099e-14 |
| CB | RBM45 | exon_skip_10619 | 6.050196e-01 | 3.033674e-16 |
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RelatedDrugs for TPR |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TPR |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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