ExonSkipAD: functional annotation of exon skipping event in human

Gene summary for TP53

Gene summary

Gene information	Gene symbol	TP53
	Gene ID	7157
	Gene name	tumor protein p53
	Synonyms	BCC7\|BMFS5\|LFS1\|P53\|TRP53
	Cytomap	17p13.1
	Type of gene	protein-coding
	Description	cellular tumor antigen p53antigen NY-CO-13mutant tumor protein 53p53 tumor suppressorphosphoprotein p53transformation-related protein 53tumor protein 53tumor supressor p53
	Modification date	20200329
	UniProtAcc	A0A087WT22, A0A087WXZ1, A0A087WZU8, A0A087X1Q1, A0A0A0U7X4, A0A0M4B4Y9, A0A0R9RRX7, A0A0U1RQC9, A0A1B1PFC7, A0A1B1PFD4, A0A1D8V7A7, A0A218MJB0, A0A218MJC8, A0A218MJD5, A0A218MJD9, A0A218MJE1, A0A218MJE5, A0A218MJF3, A0A346XLN8, A0A346XLN9, A0A346XLP0, A0A346XLP1, A0A346XLP2, A0A346XLP3, A0A346XLP5, A0A346XLP6, A0A346XLP7, A0A346XLP8, A0A346XLP9, A0A346XLQ1, A0A346XLR1, A0A346XLR9, A0A346XLS5, A0A346XLS6, A0A346XLS7, A0A346XLS8, A0A346XLS9, A0A346XLT0, A0A346XLT1, A0A346XLT2, A0A346XLT3, A0A346XLT4, A0A346XLU1, A0A346XLW0, A0A346XLW4, A0A346XLW8, A0A346XLX0, A0A346XLX2, A0A346XLX3, A0A346XLX5, A0A346XLY3, A0A346XLY6, A0A346XM05, A0A346XM06, A0A346XM22, A0A346XM28, A0A346XM34, A0A346XM38, A0A346XM39, A0A346XM40, A0A346XM43, A0A346XM49, A0A346XM50, A0A346XM51, A0A346XM56, A0A386NBZ1, A0A386NC20, A0A386NC22, A0A386NC25, A0A386NC55, A0A386NC62, A0A386NCA6, A0A386NCB1, A0A386NCU2, A0A386NCW8, A0A386NCX4, A0A386NDA8, A0A386NDB3, A0A386NFX3, A0A386NFY2, A0A386NG45, A0A386YR42, A0A3Q8QC73, A0A514TSZ1, A0A514TSZ6, A0A514TSZ9, A0A514TT08, A0A514TT13, A0A514TT20, A0A514TT23, A0A514TT34, A0A514TT40, A0A514TT49, A0A514TT50, A0A514TT61, A2I9Y7, A2I9Z0, A2I9Z1, A2I9Z2, A4GW67, A4GW74, A4GW75, A4GW76, A4GW97, A4GWB4, A4GWB5, A4GWB8, A4GWD0, B1PZ15, B4XAK8, B4XAL0, B5AKF5, B5AKF6, B5AKF7, D5KL86, D5KL87, D5KL88, D5KL89, D5KL90, E2G6R5, E5RMA8, E7EMR6, E7EQX7, E7ESS1, E9PCY9, E9PFT5, G4Y083, H2EHT1, I3L0W9, J3KP33, K7PPA8, K7PPU4, L0ENF7, L0ENG6, L0ENG9, L0EP82, L0EP99, L0EPV7, L0EPW3, L0EPX4, L0EPY0, L0EPZ1, L0EQ03, L0EQ05, L0EQ52, L0EQ89, L0EQ92, L0EQE2, L0EQJ1, L0EQP1, L0EQP9, L0EQQ9, L0EQS1, L0EQT1, L0EQU5, L0EQV3, L0EQX3, L0EQX9, L0EQY4, L0ERB4, L0ERI9, L0ERJ3, L0ERK8, L0ERL2, L0ERS6, L0ES54, L0ES73, L0ES92, L0ESB7, L0ESQ5, P04637, Q0ZAJ9, Q0ZAK0, Q0ZAK1, Q19RW5, Q19RW6, Q1HGV0, Q1HGV1, Q1HGV2, Q1HGV3, Q1MSW8, Q1MSW9, Q1MSX0, Q2XSC7, Q761V2, S4R334, S5LJ04, S5LJ49, S5LJ61, S5LMC6, S5LME3, S5LMG1, S5LMI5, S5LQQ1, S5LQU3, S5LQU8, S5LQX7, S5M207, S5M224, S5M706, S5M713, U6BGT3, U6BHT9, U6BHU6, U6BI14, U6BKV7,
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
TP53	GO:0000733	DNA strand renaturation	8183576
TP53	GO:0006355	regulation of transcription, DNA-templated	7587074
TP53	GO:0006974	cellular response to DNA damage stimulus	14744935\|15710329\|17938203
TP53	GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	16213212
TP53	GO:0006983	ER overload response	14744935
TP53	GO:0007050	cell cycle arrest	15149599
TP53	GO:0008104	protein localization	16507995
TP53	GO:0008285	negative regulation of cell proliferation	22783376
TP53	GO:0010628	positive regulation of gene expression	15314173\|20332243
TP53	GO:0030330	DNA damage response, signal transduction by p53 class mediator	15149599
TP53	GO:0031497	chromatin assembly	16322561
TP53	GO:0034644	cellular response to UV	16213212\|23629966
TP53	GO:0036003	positive regulation of transcription from RNA polymerase II promoter in response to stress	30089260
TP53	GO:0042149	cellular response to glucose starvation	14744935\|21471221
TP53	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	14654789\|14744935\|17403783
TP53	GO:0042981	regulation of apoptotic process	14744935
TP53	GO:0043065	positive regulation of apoptotic process	12667443\|15565177\|20959462
TP53	GO:0045892	negative regulation of transcription, DNA-templated	24051492
TP53	GO:0045893	positive regulation of transcription, DNA-templated	16322561\|17403783\|18549481\|20378837
TP53	GO:0045899	positive regulation of RNA polymerase II transcriptional preinitiation complex assembly	24289924
TP53	GO:0045944	positive regulation of transcription by RNA polymerase II	11672523\|17145718\|17310983\|17599062\|18549481\|20959462\|24652652
TP53	GO:0051123	RNA polymerase II preinitiation complex assembly	24289924
TP53	GO:0051974	negative regulation of telomerase activity	10597287
TP53	GO:0065003	protein-containing complex assembly	12915590
TP53	GO:0071158	positive regulation of cell cycle arrest	15314173
TP53	GO:0071480	cellular response to gamma radiation	16213212
TP53	GO:0072331	signal transduction by p53 class mediator	15314173
TP53	GO:0072717	cellular response to actinomycin D	15314173
TP53	GO:0090200	positive regulation of release of cytochrome c from mitochondria	14963330
TP53	GO:0097252	oligodendrocyte apoptotic process	7720704
TP53	GO:1902895	positive regulation of pri-miRNA transcription by RNA polymerase II	20546595
TP53	GO:1903800	positive regulation of production of miRNAs involved in gene silencing by miRNA	26100857
TP53	GO:1990248	regulation of transcription from RNA polymerase II promoter in response to DNA damage	30089260

Top

Gene structures and expression levels for TP53

Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

ENSG00000141510

Differentially expressed gene analysis across multiple brain tissues between AD and control.

Tissue type

DEG direction

Base mean exp.

log2FC(AD/control)

P-value

Adj. p-value

Differentially expressed isoform analysis across multiple brain tissues between AD and control.

Tissue type	DEG direction	ENST	Transcript info.	Base mean exp.	log2FC(AD/control)	P-value	Adjc. p-value
CB	DOWN	ENST00000504937.5	TP53-209:protein_coding:TP53	1.077285e+01	-2.229788e+00	2.013697e-04	1.338855e-03
CB	DOWN	ENST00000619186.4	TP53-225:protein_coding:TP53	1.077285e+01	-2.229788e+00	2.013697e-04	1.338855e-03
TC	DOWN	ENST00000504937.5	TP53-209:protein_coding:TP53	1.428425e+01	-1.889473e+00	1.684332e-03	1.470300e-02
TC	DOWN	ENST00000619186.4	TP53-225:protein_coding:TP53	1.428425e+01	-1.889473e+00	1.684332e-03	1.470300e-02

Landscape of isoform expressions across multiple brain tissues between AD and control.

Top

Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for TP53

Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap).

All exon skipping events in AD cohorts.

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon
exon_skip_100713	chr17	7669609:7669690:7670609:7670715:7673535:7673587	7670609:7670715
exon_skip_112179	chr17	7674254:7674290:7674859:7674971:7675053:7675119	7674859:7674971
exon_skip_118272	chr17	7675053:7675236:7675994:7676272:7676382:7676403	7675994:7676272
exon_skip_73	chr17	7675229:7675236:7675994:7676272:7676382:7676403	7675994:7676272

Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control.

Exon skipping information

Tissue type

Avg(PSIs) in AD

Avg(PSIs) in control

Difference (PSI)

Adj. p-value

Top

Open reading frame (ORF) annotation in the exon skipping event for TP53

Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000269305	7670609	7670715	Frame-shift
ENST00000445888	7670609	7670715	Frame-shift
ENST00000269305	7674859	7674971	Frame-shift
ENST00000445888	7674859	7674971	Frame-shift
ENST00000269305	7675994	7676272	In-frame
ENST00000445888	7675994	7676272	In-frame

Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms.

ENST

Start of skipped exon

End of skipped exon

ORF

Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms.

ENST

Start of skipped exon

End of skipped exon

ORF

Top

Infer the effects of exon skipping event on protein functional features for TP53

Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000269305	2596	393	7675994	7676272	287	564	32	124
ENST00000445888	2523	393	7675994	7676272	233	510	32	124

Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases.

ENST

Length of mRNA

Length of AA seq.

Genomic start

Genomic end

mRNA start

mRNA end

AA start

AA end

Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases.

ENST

Length of mRNA

Length of AA seq.

Genomic start

Genomic end

mRNA start

mRNA end

AA start

AA end

Lost protein functional features of individual exon skipping events in ROSMAP.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
P04637	32	124	1	132	Alternative sequence	ID=VSP_040833;Note=In isoform 7%2C isoform 8 and isoform 9. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:16131611;Dbxref=PMID:16131611
P04637	32	124	1	132	Alternative sequence	ID=VSP_040833;Note=In isoform 7%2C isoform 8 and isoform 9. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:16131611;Dbxref=PMID:16131611
P04637	32	124	1	39	Alternative sequence	ID=VSP_040832;Note=In isoform 4%2C isoform 5 and isoform 6. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
P04637	32	124	1	39	Alternative sequence	ID=VSP_040832;Note=In isoform 4%2C isoform 5 and isoform 6. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
P04637	32	124	33	35	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2L14
P04637	32	124	33	35	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2L14
P04637	32	124	110	112	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3D06
P04637	32	124	110	112	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3D06
P04637	32	124	118	120	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3Q05
P04637	32	124	118	120	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3Q05
P04637	32	124	124	127	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3D06
P04637	32	124	124	127	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3D06
P04637	32	124	1	393	Chain	ID=PRO_0000185703;Note=Cellular tumor antigen p53
P04637	32	124	1	393	Chain	ID=PRO_0000185703;Note=Cellular tumor antigen p53
P04637	32	124	102	292	DNA binding	.
P04637	32	124	102	292	DNA binding	.
P04637	32	124	30	32	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5HPD
P04637	32	124	30	32	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5HPD
P04637	32	124	36	38	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2B3G
P04637	32	124	36	38	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2B3G
P04637	32	124	41	44	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2B3G
P04637	32	124	41	44	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2B3G
P04637	32	124	47	55	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2B3G
P04637	32	124	47	55	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2B3G
P04637	32	124	33	33	Modified residue	Note=Phosphoserine%3B by CDK5 and CDK7;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:17591690,ECO:0000269\|PubMed:9372954;Dbxref=PMID:17591690,PMID:9372954
P04637	32	124	33	33	Modified residue	Note=Phosphoserine%3B by CDK5 and CDK7;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:17591690,ECO:0000269\|PubMed:9372954;Dbxref=PMID:17591690,PMID:9372954
P04637	32	124	37	37	Modified residue	Note=Phosphoserine%3B by MAPKAPK5;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17254968;Dbxref=PMID:17254968
P04637	32	124	37	37	Modified residue	Note=Phosphoserine%3B by MAPKAPK5;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17254968;Dbxref=PMID:17254968
P04637	32	124	46	46	Modified residue	Note=Phosphoserine%3B by CDK5%2C DYRK2%2C HIPK2 and PKC/PRKCG;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11740489,ECO:0000269\|PubMed:11780126,ECO:0000269\|PubMed:16377624,ECO:0000269\|PubMed:1734995
P04637	32	124	46	46	Modified residue	Note=Phosphoserine%3B by CDK5%2C DYRK2%2C HIPK2 and PKC/PRKCG;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11740489,ECO:0000269\|PubMed:11780126,ECO:0000269\|PubMed:16377624,ECO:0000269\|PubMed:1734995
P04637	32	124	55	55	Modified residue	Note=Phosphothreonine%3B by TAF1 and GRK5;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:15053879,ECO:0000269\|PubMed:20124405;Dbxref=PMID:15053879,PMID:20124405
P04637	32	124	55	55	Modified residue	Note=Phosphothreonine%3B by TAF1 and GRK5;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:15053879,ECO:0000269\|PubMed:20124405;Dbxref=PMID:15053879,PMID:20124405
P04637	32	124	120	120	Modified residue	Note=N6-acetyllysine%3B by KAT6A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:23431171;Dbxref=PMID:23431171
P04637	32	124	120	120	Modified residue	Note=N6-acetyllysine%3B by KAT6A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:23431171;Dbxref=PMID:23431171
P04637	32	124	48	56	Motif	Note=TADII
P04637	32	124	48	56	Motif	Note=TADII
P04637	32	124	37	37	Mutagenesis	Note=Abolihes phosphorylation by MAPKAPK5. S->D;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17254968;Dbxref=PMID:17254968
P04637	32	124	37	37	Mutagenesis	Note=Abolihes phosphorylation by MAPKAPK5. S->D;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17254968;Dbxref=PMID:17254968
P04637	32	124	46	46	Mutagenesis	Note=Abolishes phosphorylation by DYRK2 and HIPK2 and acetylation of K-382 by CREBBP. S->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11740489,ECO:0000269\|PubMed:16219768,ECO:0000269\|PubMed:17349958;Dbxref=PMID:11740489,
P04637	32	124	46	46	Mutagenesis	Note=Abolishes phosphorylation by DYRK2 and HIPK2 and acetylation of K-382 by CREBBP. S->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11740489,ECO:0000269\|PubMed:16219768,ECO:0000269\|PubMed:17349958;Dbxref=PMID:11740489,
P04637	32	124	46	46	Mutagenesis	Note=Alters interaction with WWOX. Missing;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11740489,ECO:0000269\|PubMed:16219768,ECO:0000269\|PubMed:17349958;Dbxref=PMID:11740489,PMID:16219768,PMID:17349958
P04637	32	124	46	46	Mutagenesis	Note=Alters interaction with WWOX. Missing;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11740489,ECO:0000269\|PubMed:16219768,ECO:0000269\|PubMed:17349958;Dbxref=PMID:11740489,PMID:16219768,PMID:17349958
P04637	32	124	55	55	Mutagenesis	Note=Blocks phosphorylation by TAF1. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:15053879;Dbxref=PMID:15053879
P04637	32	124	55	55	Mutagenesis	Note=Blocks phosphorylation by TAF1. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:15053879;Dbxref=PMID:15053879
P04637	32	124	33	33	Natural variant	ID=VAR_044555;Note=In a sporadic cancer%3B somatic mutation. S->T
P04637	32	124	33	33	Natural variant	ID=VAR_044555;Note=In a sporadic cancer%3B somatic mutation. S->T
P04637	32	124	34	34	Natural variant	ID=VAR_044556;Note=In a sporadic cancer%3B somatic mutation. P->L
P04637	32	124	34	34	Natural variant	ID=VAR_044556;Note=In a sporadic cancer%3B somatic mutation. P->L
P04637	32	124	35	35	Natural variant	ID=VAR_005852;Note=In sporadic cancers%3B somatic mutation. L->F;Dbxref=dbSNP:rs121912661
P04637	32	124	35	35	Natural variant	ID=VAR_005852;Note=In sporadic cancers%3B somatic mutation. L->F;Dbxref=dbSNP:rs121912661
P04637	32	124	36	36	Natural variant	ID=VAR_044557;Note=In a sporadic cancer%3B somatic mutation. P->L;Dbxref=dbSNP:rs587781866
P04637	32	124	36	36	Natural variant	ID=VAR_044557;Note=In a sporadic cancer%3B somatic mutation. P->L;Dbxref=dbSNP:rs587781866
P04637	32	124	37	37	Natural variant	ID=VAR_044558;Note=In a sporadic cancer%3B somatic mutation. S->P
P04637	32	124	37	37	Natural variant	ID=VAR_044558;Note=In a sporadic cancer%3B somatic mutation. S->P
P04637	32	124	37	37	Natural variant	ID=VAR_044559;Note=In a sporadic cancer%3B somatic mutation. S->T
P04637	32	124	37	37	Natural variant	ID=VAR_044559;Note=In a sporadic cancer%3B somatic mutation. S->T
P04637	32	124	39	39	Natural variant	ID=VAR_044560;Note=In a sporadic cancer%3B somatic mutation. A->P
P04637	32	124	39	39	Natural variant	ID=VAR_044560;Note=In a sporadic cancer%3B somatic mutation. A->P
P04637	32	124	39	39	Natural variant	ID=VAR_044561;Note=In a sporadic cancer%3B somatic mutation. A->V;Dbxref=dbSNP:rs1353016807
P04637	32	124	39	39	Natural variant	ID=VAR_044561;Note=In a sporadic cancer%3B somatic mutation. A->V;Dbxref=dbSNP:rs1353016807
P04637	32	124	42	42	Natural variant	ID=VAR_044562;Note=In a sporadic cancer%3B somatic mutation. D->Y
P04637	32	124	42	42	Natural variant	ID=VAR_044562;Note=In a sporadic cancer%3B somatic mutation. D->Y
P04637	32	124	43	43	Natural variant	ID=VAR_005853;Note=In a sporadic cancer%3B somatic mutation. L->S
P04637	32	124	43	43	Natural variant	ID=VAR_005853;Note=In a sporadic cancer%3B somatic mutation. L->S
P04637	32	124	44	44	Natural variant	ID=VAR_044563;Note=In a sporadic cancer%3B somatic mutation. M->I;Dbxref=dbSNP:rs1060501190
P04637	32	124	44	44	Natural variant	ID=VAR_044563;Note=In a sporadic cancer%3B somatic mutation. M->I;Dbxref=dbSNP:rs1060501190
P04637	32	124	44	44	Natural variant	ID=VAR_044564;Note=In a sporadic cancer%3B somatic mutation. M->T
P04637	32	124	44	44	Natural variant	ID=VAR_044564;Note=In a sporadic cancer%3B somatic mutation. M->T
P04637	32	124	44	44	Natural variant	ID=VAR_044565;Note=In a sporadic cancer%3B somatic mutation. M->V
P04637	32	124	44	44	Natural variant	ID=VAR_044565;Note=In a sporadic cancer%3B somatic mutation. M->V
P04637	32	124	45	45	Natural variant	ID=VAR_044566;Note=In a sporadic cancer%3B somatic mutation. L->M
P04637	32	124	45	45	Natural variant	ID=VAR_044566;Note=In a sporadic cancer%3B somatic mutation. L->M
P04637	32	124	46	46	Natural variant	ID=VAR_044567;Note=In sporadic cancers%3B somatic mutation. S->F
P04637	32	124	46	46	Natural variant	ID=VAR_044567;Note=In sporadic cancers%3B somatic mutation. S->F
P04637	32	124	46	46	Natural variant	ID=VAR_044568;Note=In sporadic cancers%3B somatic mutation. S->P;Dbxref=dbSNP:rs876659630
P04637	32	124	46	46	Natural variant	ID=VAR_044568;Note=In sporadic cancers%3B somatic mutation. S->P;Dbxref=dbSNP:rs876659630
P04637	32	124	47	47	Natural variant	ID=VAR_044569;Note=In sporadic cancers%3B somatic mutation. P->L
P04637	32	124	47	47	Natural variant	ID=VAR_044569;Note=In sporadic cancers%3B somatic mutation. P->L
P04637	32	124	47	47	Natural variant	ID=VAR_014632;Note=P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269\|Ref.12;Dbxref=dbSNP:rs1800371
P04637	32	124	47	47	Natural variant	ID=VAR_014632;Note=P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269\|Ref.12;Dbxref=dbSNP:rs1800371
P04637	32	124	48	48	Natural variant	ID=VAR_044570;Note=In a sporadic cancer%3B somatic mutation. D->G
P04637	32	124	48	48	Natural variant	ID=VAR_044570;Note=In a sporadic cancer%3B somatic mutation. D->G
P04637	32	124	49	49	Natural variant	ID=VAR_044571;Note=In sporadic cancers%3B somatic mutation. D->H;Dbxref=dbSNP:rs587780728
P04637	32	124	49	49	Natural variant	ID=VAR_044571;Note=In sporadic cancers%3B somatic mutation. D->H;Dbxref=dbSNP:rs587780728
P04637	32	124	49	49	Natural variant	ID=VAR_044572;Note=In a sporadic cancer%3B somatic mutation. D->N;Dbxref=dbSNP:rs587780728
P04637	32	124	49	49	Natural variant	ID=VAR_044572;Note=In a sporadic cancer%3B somatic mutation. D->N;Dbxref=dbSNP:rs587780728
P04637	32	124	49	49	Natural variant	ID=VAR_044573;Note=In sporadic cancers%3B somatic mutation. D->Y
P04637	32	124	49	49	Natural variant	ID=VAR_044573;Note=In sporadic cancers%3B somatic mutation. D->Y
P04637	32	124	52	52	Natural variant	ID=VAR_044574;Note=In a sporadic cancer%3B somatic mutation. Q->H
P04637	32	124	52	52	Natural variant	ID=VAR_044574;Note=In a sporadic cancer%3B somatic mutation. Q->H
P04637	32	124	53	53	Natural variant	ID=VAR_005854;Note=In sporadic cancers%3B somatic mutation. W->C
P04637	32	124	53	53	Natural variant	ID=VAR_005854;Note=In sporadic cancers%3B somatic mutation. W->C
P04637	32	124	53	53	Natural variant	ID=VAR_044575;Note=In a sporadic cancer%3B somatic mutation. W->G
P04637	32	124	53	53	Natural variant	ID=VAR_044575;Note=In a sporadic cancer%3B somatic mutation. W->G
P04637	32	124	54	54	Natural variant	ID=VAR_044576;Note=In a sporadic cancer%3B somatic mutation. F->L
P04637	32	124	54	54	Natural variant	ID=VAR_044576;Note=In a sporadic cancer%3B somatic mutation. F->L
P04637	32	124	54	54	Natural variant	ID=VAR_044577;Note=In a sporadic cancer%3B somatic mutation. F->Y
P04637	32	124	54	54	Natural variant	ID=VAR_044577;Note=In a sporadic cancer%3B somatic mutation. F->Y
P04637	32	124	56	56	Natural variant	ID=VAR_044578;Note=In sporadic cancers%3B somatic mutation. E->K
P04637	32	124	56	56	Natural variant	ID=VAR_044578;Note=In sporadic cancers%3B somatic mutation. E->K
P04637	32	124	56	56	Natural variant	ID=VAR_044579;Note=In a sporadic cancer%3B somatic mutation. E->V
P04637	32	124	56	56	Natural variant	ID=VAR_044579;Note=In a sporadic cancer%3B somatic mutation. E->V
P04637	32	124	58	58	Natural variant	ID=VAR_044580;Note=In a sporadic cancer%3B somatic mutation. P->Q
P04637	32	124	58	58	Natural variant	ID=VAR_044580;Note=In a sporadic cancer%3B somatic mutation. P->Q
P04637	32	124	58	58	Natural variant	ID=VAR_044581;Note=In a sporadic cancer%3B somatic mutation. P->T
P04637	32	124	58	58	Natural variant	ID=VAR_044581;Note=In a sporadic cancer%3B somatic mutation. P->T
P04637	32	124	59	59	Natural variant	ID=VAR_044582;Note=In sporadic cancers%3B somatic mutation. G->C;Dbxref=dbSNP:rs1237722021
P04637	32	124	59	59	Natural variant	ID=VAR_044582;Note=In sporadic cancers%3B somatic mutation. G->C;Dbxref=dbSNP:rs1237722021
P04637	32	124	59	59	Natural variant	ID=VAR_044583;Note=In sporadic cancers%3B somatic mutation. G->D
P04637	32	124	59	59	Natural variant	ID=VAR_044583;Note=In sporadic cancers%3B somatic mutation. G->D
P04637	32	124	59	59	Natural variant	ID=VAR_045783;Note=In a sporadic cancer%3B somatic mutation%3B requires 2 nucleotide substitutions. G->N
P04637	32	124	59	59	Natural variant	ID=VAR_045783;Note=In a sporadic cancer%3B somatic mutation%3B requires 2 nucleotide substitutions. G->N
P04637	32	124	60	60	Natural variant	ID=VAR_044584;Note=In sporadic cancers%3B somatic mutation. P->L
P04637	32	124	60	60	Natural variant	ID=VAR_044584;Note=In sporadic cancers%3B somatic mutation. P->L
P04637	32	124	60	60	Natural variant	ID=VAR_044585;Note=In a sporadic cancer%3B somatic mutation. P->Q
P04637	32	124	60	60	Natural variant	ID=VAR_044585;Note=In a sporadic cancer%3B somatic mutation. P->Q
P04637	32	124	60	60	Natural variant	ID=VAR_005855;Note=In a sporadic cancer%3B somatic mutation. P->S
P04637	32	124	60	60	Natural variant	ID=VAR_005855;Note=In a sporadic cancer%3B somatic mutation. P->S
P04637	32	124	61	61	Natural variant	ID=VAR_044586;Note=In sporadic cancers%3B somatic mutation. D->G;Dbxref=dbSNP:rs1460793472
P04637	32	124	61	61	Natural variant	ID=VAR_044586;Note=In sporadic cancers%3B somatic mutation. D->G;Dbxref=dbSNP:rs1460793472
P04637	32	124	61	61	Natural variant	ID=VAR_044587;Note=In sporadic cancers%3B somatic mutation. D->N
P04637	32	124	61	61	Natural variant	ID=VAR_044587;Note=In sporadic cancers%3B somatic mutation. D->N
P04637	32	124	62	62	Natural variant	ID=VAR_044588;Note=In a sporadic cancer%3B somatic mutation. E->D
P04637	32	124	62	62	Natural variant	ID=VAR_044588;Note=In a sporadic cancer%3B somatic mutation. E->D
P04637	32	124	63	63	Natural variant	ID=VAR_044589;Note=In a sporadic cancer%3B somatic mutation. A->T;Dbxref=dbSNP:rs876658902
P04637	32	124	63	63	Natural variant	ID=VAR_044589;Note=In a sporadic cancer%3B somatic mutation. A->T;Dbxref=dbSNP:rs876658902
P04637	32	124	63	63	Natural variant	ID=VAR_044590;Note=In a sporadic cancer%3B somatic mutation. A->V;Dbxref=dbSNP:rs372201428
P04637	32	124	63	63	Natural variant	ID=VAR_044590;Note=In a sporadic cancer%3B somatic mutation. A->V;Dbxref=dbSNP:rs372201428
P04637	32	124	65	65	Natural variant	ID=VAR_044591;Note=In a sporadic cancer%3B somatic mutation. R->T;Dbxref=dbSNP:rs1060501210
P04637	32	124	65	65	Natural variant	ID=VAR_044591;Note=In a sporadic cancer%3B somatic mutation. R->T;Dbxref=dbSNP:rs1060501210
P04637	32	124	66	66	Natural variant	ID=VAR_044592;Note=In a sporadic cancer%3B somatic mutation. M->I
P04637	32	124	66	66	Natural variant	ID=VAR_044592;Note=In a sporadic cancer%3B somatic mutation. M->I
P04637	32	124	66	66	Natural variant	ID=VAR_044593;Note=In a sporadic cancer%3B somatic mutation. M->R
P04637	32	124	66	66	Natural variant	ID=VAR_044593;Note=In a sporadic cancer%3B somatic mutation. M->R
P04637	32	124	67	67	Natural variant	ID=VAR_044594;Note=In sporadic cancers%3B somatic mutation. P->L
P04637	32	124	67	67	Natural variant	ID=VAR_044594;Note=In sporadic cancers%3B somatic mutation. P->L
P04637	32	124	67	67	Natural variant	ID=VAR_044595;Note=In a sporadic cancer%3B somatic mutation. P->R
P04637	32	124	67	67	Natural variant	ID=VAR_044595;Note=In a sporadic cancer%3B somatic mutation. P->R
P04637	32	124	67	67	Natural variant	ID=VAR_044596;Note=In sporadic cancers%3B somatic mutation. P->S
P04637	32	124	67	67	Natural variant	ID=VAR_044596;Note=In sporadic cancers%3B somatic mutation. P->S
P04637	32	124	68	68	Natural variant	ID=VAR_044597;Note=In sporadic cancers%3B somatic mutation. E->G
P04637	32	124	68	68	Natural variant	ID=VAR_044597;Note=In sporadic cancers%3B somatic mutation. E->G
P04637	32	124	68	68	Natural variant	ID=VAR_044598;Note=In a sporadic cancer%3B somatic mutation. E->Q
P04637	32	124	68	68	Natural variant	ID=VAR_044598;Note=In a sporadic cancer%3B somatic mutation. E->Q
P04637	32	124	69	69	Natural variant	ID=VAR_044599;Note=In a sporadic cancer%3B somatic mutation. A->D
P04637	32	124	69	69	Natural variant	ID=VAR_044599;Note=In a sporadic cancer%3B somatic mutation. A->D
P04637	32	124	69	69	Natural variant	ID=VAR_044600;Note=In sporadic cancers%3B somatic mutation. A->G;Dbxref=dbSNP:rs756233241
P04637	32	124	69	69	Natural variant	ID=VAR_044600;Note=In sporadic cancers%3B somatic mutation. A->G;Dbxref=dbSNP:rs756233241
P04637	32	124	69	69	Natural variant	ID=VAR_044601;Note=In a sporadic cancer%3B somatic mutation. A->T
P04637	32	124	69	69	Natural variant	ID=VAR_044601;Note=In a sporadic cancer%3B somatic mutation. A->T
P04637	32	124	69	69	Natural variant	ID=VAR_044602;Note=In a sporadic cancer%3B somatic mutation. A->V;Dbxref=dbSNP:rs756233241
P04637	32	124	69	69	Natural variant	ID=VAR_044602;Note=In a sporadic cancer%3B somatic mutation. A->V;Dbxref=dbSNP:rs756233241
P04637	32	124	70	70	Natural variant	ID=VAR_044603;Note=In a sporadic cancer%3B somatic mutation. A->T
P04637	32	124	70	70	Natural variant	ID=VAR_044603;Note=In a sporadic cancer%3B somatic mutation. A->T
P04637	32	124	71	71	Natural variant	ID=VAR_044604;Note=In a sporadic cancer%3B somatic mutation. P->T
P04637	32	124	71	71	Natural variant	ID=VAR_044604;Note=In a sporadic cancer%3B somatic mutation. P->T
P04637	32	124	72	72	Natural variant	ID=VAR_045784;Note=In sporadic cancers%3B somatic mutation%3B requires 2 nucleotide substitutions. P->C;Dbxref=dbSNP:rs730882014
P04637	32	124	72	72	Natural variant	ID=VAR_045784;Note=In sporadic cancers%3B somatic mutation%3B requires 2 nucleotide substitutions. P->C;Dbxref=dbSNP:rs730882014
P04637	32	124	72	72	Natural variant	ID=VAR_045785;Note=In sporadic cancers%3B somatic mutation%3B requires 2 nucleotide substitutions. P->G
P04637	32	124	72	72	Natural variant	ID=VAR_045785;Note=In sporadic cancers%3B somatic mutation%3B requires 2 nucleotide substitutions. P->G
P04637	32	124	72	72	Natural variant	ID=VAR_045786;Note=In sporadic cancers%3B somatic mutation. P->H;Dbxref=dbSNP:rs1042522
P04637	32	124	72	72	Natural variant	ID=VAR_045786;Note=In sporadic cancers%3B somatic mutation. P->H;Dbxref=dbSNP:rs1042522
P04637	32	124	72	72	Natural variant	ID=VAR_045787;Note=In a sporadic cancer%3B somatic mutation. P->L
P04637	32	124	72	72	Natural variant	ID=VAR_045787;Note=In a sporadic cancer%3B somatic mutation. P->L
P04637	32	124	72	72	Natural variant	ID=VAR_005856;Note=P->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:14702039,ECO:0000269\|PubMed:16131611,ECO:0000269\|PubMed:1999338,ECO:0000269\|Ref.17;Dbxref=dbSNP:rs1042522,PMID:14702039,PMID:16131611,PMID:19
P04637	32	124	72	72	Natural variant	ID=VAR_005856;Note=P->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:14702039,ECO:0000269\|PubMed:16131611,ECO:0000269\|PubMed:1999338,ECO:0000269\|Ref.17;Dbxref=dbSNP:rs1042522,PMID:14702039,PMID:16131611,PMID:19
P04637	32	124	73	73	Natural variant	ID=VAR_044605;Note=In a sporadic cancer%3B somatic mutation. V->E
P04637	32	124	73	73	Natural variant	ID=VAR_044605;Note=In a sporadic cancer%3B somatic mutation. V->E
P04637	32	124	73	73	Natural variant	ID=VAR_044606;Note=In sporadic cancers%3B somatic mutation. V->L
P04637	32	124	73	73	Natural variant	ID=VAR_044606;Note=In sporadic cancers%3B somatic mutation. V->L
P04637	32	124	73	73	Natural variant	ID=VAR_044607;Note=In sporadic cancers%3B somatic mutation. V->M;Dbxref=dbSNP:rs587782423
P04637	32	124	73	73	Natural variant	ID=VAR_044607;Note=In sporadic cancers%3B somatic mutation. V->M;Dbxref=dbSNP:rs587782423
P04637	32	124	74	74	Natural variant	ID=VAR_044608;Note=In a sporadic cancer%3B somatic mutation. A->T
P04637	32	124	74	74	Natural variant	ID=VAR_044608;Note=In a sporadic cancer%3B somatic mutation. A->T
P04637	32	124	75	75	Natural variant	ID=VAR_044609;Note=In sporadic cancers%3B somatic mutation. P->L
P04637	32	124	75	75	Natural variant	ID=VAR_044609;Note=In sporadic cancers%3B somatic mutation. P->L
P04637	32	124	75	75	Natural variant	ID=VAR_044610;Note=In sporadic cancers%3B somatic mutation. P->R
P04637	32	124	75	75	Natural variant	ID=VAR_044610;Note=In sporadic cancers%3B somatic mutation. P->R
P04637	32	124	75	75	Natural variant	ID=VAR_044611;Note=In a sporadic cancer%3B somatic mutation. P->S
P04637	32	124	75	75	Natural variant	ID=VAR_044611;Note=In a sporadic cancer%3B somatic mutation. P->S
P04637	32	124	76	76	Natural variant	ID=VAR_044612;Note=In a sporadic cancer%3B somatic mutation. A->G;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:2946935;Dbxref=PMID:2946935
P04637	32	124	76	76	Natural variant	ID=VAR_044612;Note=In a sporadic cancer%3B somatic mutation. A->G;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:2946935;Dbxref=PMID:2946935
P04637	32	124	76	76	Natural variant	ID=VAR_044613;Note=In a sporadic cancer%3B somatic mutation. A->T
P04637	32	124	76	76	Natural variant	ID=VAR_044613;Note=In a sporadic cancer%3B somatic mutation. A->T
P04637	32	124	77	77	Natural variant	ID=VAR_044614;Note=In sporadic cancers%3B somatic mutation. P->A
P04637	32	124	77	77	Natural variant	ID=VAR_044614;Note=In sporadic cancers%3B somatic mutation. P->A
P04637	32	124	78	78	Natural variant	ID=VAR_044615;Note=In sporadic cancers%3B somatic mutation. A->V
P04637	32	124	78	78	Natural variant	ID=VAR_044615;Note=In sporadic cancers%3B somatic mutation. A->V
P04637	32	124	79	79	Natural variant	ID=VAR_044616;Note=In a sporadic cancer%3B somatic mutation. A->G
P04637	32	124	79	79	Natural variant	ID=VAR_044616;Note=In a sporadic cancer%3B somatic mutation. A->G
P04637	32	124	79	79	Natural variant	ID=VAR_005857;Note=In a sporadic cancer%3B somatic mutation. A->T
P04637	32	124	79	79	Natural variant	ID=VAR_005857;Note=In a sporadic cancer%3B somatic mutation. A->T
P04637	32	124	79	79	Natural variant	ID=VAR_044617;Note=In sporadic cancers%3B somatic mutation. A->V
P04637	32	124	79	79	Natural variant	ID=VAR_044617;Note=In sporadic cancers%3B somatic mutation. A->V
P04637	32	124	80	80	Natural variant	ID=VAR_044618;Note=In a sporadic cancer%3B somatic mutation. P->L
P04637	32	124	80	80	Natural variant	ID=VAR_044618;Note=In a sporadic cancer%3B somatic mutation. P->L
P04637	32	124	80	80	Natural variant	ID=VAR_044619;Note=In a sporadic cancer%3B somatic mutation. P->S;Dbxref=dbSNP:rs1060501204
P04637	32	124	80	80	Natural variant	ID=VAR_044619;Note=In a sporadic cancer%3B somatic mutation. P->S;Dbxref=dbSNP:rs1060501204
P04637	32	124	81	81	Natural variant	ID=VAR_044620;Note=In sporadic cancers%3B somatic mutation. T->I
P04637	32	124	81	81	Natural variant	ID=VAR_044620;Note=In sporadic cancers%3B somatic mutation. T->I
P04637	32	124	82	82	Natural variant	ID=VAR_044621;Note=In LFS%3B germline mutation and in sporadic cancers%3B somatic mutation. P->L;Dbxref=dbSNP:rs534447939
P04637	32	124	82	82	Natural variant	ID=VAR_044621;Note=In LFS%3B germline mutation and in sporadic cancers%3B somatic mutation. P->L;Dbxref=dbSNP:rs534447939
P04637	32	124	82	82	Natural variant	ID=VAR_044622;Note=In sporadic cancers%3B somatic mutation. P->S
P04637	32	124	82	82	Natural variant	ID=VAR_044622;Note=In sporadic cancers%3B somatic mutation. P->S
P04637	32	124	83	83	Natural variant	ID=VAR_044623;Note=In a sporadic cancer%3B somatic mutation. A->E;Dbxref=dbSNP:rs201717599
P04637	32	124	83	83	Natural variant	ID=VAR_044623;Note=In a sporadic cancer%3B somatic mutation. A->E;Dbxref=dbSNP:rs201717599
P04637	32	124	83	83	Natural variant	ID=VAR_044624;Note=In sporadic cancers%3B somatic mutation. A->V;Dbxref=dbSNP:rs201717599
P04637	32	124	83	83	Natural variant	ID=VAR_044624;Note=In sporadic cancers%3B somatic mutation. A->V;Dbxref=dbSNP:rs201717599
P04637	32	124	84	84	Natural variant	ID=VAR_044625;Note=In sporadic cancers%3B somatic mutation. A->G
P04637	32	124	84	84	Natural variant	ID=VAR_044625;Note=In sporadic cancers%3B somatic mutation. A->G
P04637	32	124	84	84	Natural variant	ID=VAR_044626;Note=In sporadic cancers%3B somatic mutation. A->V
P04637	32	124	84	84	Natural variant	ID=VAR_044626;Note=In sporadic cancers%3B somatic mutation. A->V
P04637	32	124	85	85	Natural variant	ID=VAR_044627;Note=In sporadic cancers%3B somatic mutation. P->L
P04637	32	124	85	85	Natural variant	ID=VAR_044627;Note=In sporadic cancers%3B somatic mutation. P->L
P04637	32	124	85	85	Natural variant	ID=VAR_044628;Note=In sporadic cancers%3B somatic mutation. P->S
P04637	32	124	85	85	Natural variant	ID=VAR_044628;Note=In sporadic cancers%3B somatic mutation. P->S
P04637	32	124	86	86	Natural variant	ID=VAR_044629;Note=In a sporadic cancer%3B somatic mutation. A->V
P04637	32	124	86	86	Natural variant	ID=VAR_044629;Note=In a sporadic cancer%3B somatic mutation. A->V
P04637	32	124	87	87	Natural variant	ID=VAR_005858;Note=In sporadic cancers%3B somatic mutation. P->Q
P04637	32	124	87	87	Natural variant	ID=VAR_005858;Note=In sporadic cancers%3B somatic mutation. P->Q
P04637	32	124	88	88	Natural variant	ID=VAR_044630;Note=In a sporadic cancer%3B somatic mutation. A->T
P04637	32	124	88	88	Natural variant	ID=VAR_044630;Note=In a sporadic cancer%3B somatic mutation. A->T
P04637	32	124	88	88	Natural variant	ID=VAR_044631;Note=In sporadic cancers%3B somatic mutation. A->V
P04637	32	124	88	88	Natural variant	ID=VAR_044631;Note=In sporadic cancers%3B somatic mutation. A->V
P04637	32	124	89	89	Natural variant	ID=VAR_044632;Note=In sporadic cancers%3B somatic mutation. P->L;Dbxref=dbSNP:rs730881994
P04637	32	124	89	89	Natural variant	ID=VAR_044632;Note=In sporadic cancers%3B somatic mutation. P->L;Dbxref=dbSNP:rs730881994
P04637	32	124	89	89	Natural variant	ID=VAR_044633;Note=In sporadic cancers%3B somatic mutation. P->S
P04637	32	124	89	89	Natural variant	ID=VAR_044633;Note=In sporadic cancers%3B somatic mutation. P->S
P04637	32	124	90	90	Natural variant	ID=VAR_044634;Note=In sporadic cancers%3B somatic mutation. S->F
P04637	32	124	90	90	Natural variant	ID=VAR_044634;Note=In sporadic cancers%3B somatic mutation. S->F
P04637	32	124	90	90	Natural variant	ID=VAR_044635;Note=In a sporadic cancer%3B somatic mutation. S->Y
P04637	32	124	90	90	Natural variant	ID=VAR_044635;Note=In a sporadic cancer%3B somatic mutation. S->Y
P04637	32	124	91	91	Natural variant	ID=VAR_044636;Note=In a sporadic cancer%3B somatic mutation. W->C
P04637	32	124	91	91	Natural variant	ID=VAR_044636;Note=In a sporadic cancer%3B somatic mutation. W->C
P04637	32	124	92	92	Natural variant	ID=VAR_044637;Note=In a sporadic cancer%3B somatic mutation. P->A
P04637	32	124	92	92	Natural variant	ID=VAR_044637;Note=In a sporadic cancer%3B somatic mutation. P->A
P04637	32	124	92	92	Natural variant	ID=VAR_044638;Note=In a sporadic cancer%3B somatic mutation. P->L;Dbxref=dbSNP:rs1210700121
P04637	32	124	92	92	Natural variant	ID=VAR_044638;Note=In a sporadic cancer%3B somatic mutation. P->L;Dbxref=dbSNP:rs1210700121
P04637	32	124	92	92	Natural variant	ID=VAR_044639;Note=In a sporadic cancer%3B somatic mutation. P->S
P04637	32	124	92	92	Natural variant	ID=VAR_044639;Note=In a sporadic cancer%3B somatic mutation. P->S
P04637	32	124	93	93	Natural variant	ID=VAR_044640;Note=In a sporadic cancer%3B somatic mutation. L->M
P04637	32	124	93	93	Natural variant	ID=VAR_044640;Note=In a sporadic cancer%3B somatic mutation. L->M
P04637	32	124	93	93	Natural variant	ID=VAR_044641;Note=In a sporadic cancer%3B somatic mutation. L->P
P04637	32	124	93	93	Natural variant	ID=VAR_044641;Note=In a sporadic cancer%3B somatic mutation. L->P
P04637	32	124	94	94	Natural variant	ID=VAR_044642;Note=In sporadic cancers%3B somatic mutation. S->L
P04637	32	124	94	94	Natural variant	ID=VAR_044642;Note=In sporadic cancers%3B somatic mutation. S->L
P04637	32	124	94	94	Natural variant	ID=VAR_005859;Note=In sporadic cancers%3B somatic mutation. S->T
P04637	32	124	94	94	Natural variant	ID=VAR_005859;Note=In sporadic cancers%3B somatic mutation. S->T
P04637	32	124	95	95	Natural variant	ID=VAR_044643;Note=In sporadic cancers%3B somatic mutation. S->F
P04637	32	124	95	95	Natural variant	ID=VAR_044643;Note=In sporadic cancers%3B somatic mutation. S->F
P04637	32	124	95	95	Natural variant	ID=VAR_044644;Note=In a sporadic cancer%3B somatic mutation. S->T
P04637	32	124	95	95	Natural variant	ID=VAR_044644;Note=In a sporadic cancer%3B somatic mutation. S->T
P04637	32	124	96	96	Natural variant	ID=VAR_044645;Note=In a sporadic cancer%3B somatic mutation. S->C
P04637	32	124	96	96	Natural variant	ID=VAR_044645;Note=In a sporadic cancer%3B somatic mutation. S->C
P04637	32	124	96	96	Natural variant	ID=VAR_044646;Note=In sporadic cancers%3B somatic mutation. S->F
P04637	32	124	96	96	Natural variant	ID=VAR_044646;Note=In sporadic cancers%3B somatic mutation. S->F
P04637	32	124	96	96	Natural variant	ID=VAR_044647;Note=In a sporadic cancer%3B somatic mutation. S->P
P04637	32	124	96	96	Natural variant	ID=VAR_044647;Note=In a sporadic cancer%3B somatic mutation. S->P
P04637	32	124	97	97	Natural variant	ID=VAR_044648;Note=In a sporadic cancer%3B somatic mutation. V->A
P04637	32	124	97	97	Natural variant	ID=VAR_044648;Note=In a sporadic cancer%3B somatic mutation. V->A
P04637	32	124	97	97	Natural variant	ID=VAR_044649;Note=In a sporadic cancer%3B somatic mutation. V->F
P04637	32	124	97	97	Natural variant	ID=VAR_044649;Note=In a sporadic cancer%3B somatic mutation. V->F
P04637	32	124	97	97	Natural variant	ID=VAR_044650;Note=In familial cancer not matching LFS%3B germline mutation and in a sporadic cancer%3B somatic mutation. V->I
P04637	32	124	97	97	Natural variant	ID=VAR_044650;Note=In familial cancer not matching LFS%3B germline mutation and in a sporadic cancer%3B somatic mutation. V->I
P04637	32	124	98	98	Natural variant	ID=VAR_044651;Note=In sporadic cancers%3B somatic mutation. P->L;Dbxref=dbSNP:rs1245723119
P04637	32	124	98	98	Natural variant	ID=VAR_044651;Note=In sporadic cancers%3B somatic mutation. P->L;Dbxref=dbSNP:rs1245723119
P04637	32	124	98	98	Natural variant	ID=VAR_044652;Note=In sporadic cancers%3B somatic mutation. P->S
P04637	32	124	98	98	Natural variant	ID=VAR_044652;Note=In sporadic cancers%3B somatic mutation. P->S
P04637	32	124	99	99	Natural variant	ID=VAR_044653;Note=In sporadic cancers%3B somatic mutation. S->F
P04637	32	124	99	99	Natural variant	ID=VAR_044653;Note=In sporadic cancers%3B somatic mutation. S->F
P04637	32	124	99	99	Natural variant	ID=VAR_044654;Note=In a sporadic cancer%3B somatic mutation. S->P
P04637	32	124	99	99	Natural variant	ID=VAR_044654;Note=In a sporadic cancer%3B somatic mutation. S->P
P04637	32	124	100	100	Natural variant	ID=VAR_044655;Note=In a sporadic cancer%3B somatic mutation. Q->R
P04637	32	124	100	100	Natural variant	ID=VAR_044655;Note=In a sporadic cancer%3B somatic mutation. Q->R
P04637	32	124	101	101	Natural variant	ID=VAR_044656;Note=In a sporadic cancer%3B somatic mutation. K->N;Dbxref=dbSNP:rs878854069
P04637	32	124	101	101	Natural variant	ID=VAR_044656;Note=In a sporadic cancer%3B somatic mutation. K->N;Dbxref=dbSNP:rs878854069
P04637	32	124	101	101	Natural variant	ID=VAR_044657;Note=In sporadic cancers%3B somatic mutation. K->R
P04637	32	124	101	101	Natural variant	ID=VAR_044657;Note=In sporadic cancers%3B somatic mutation. K->R
P04637	32	124	102	102	Natural variant	ID=VAR_044658;Note=In sporadic cancers%3B somatic mutation. T->I;Dbxref=dbSNP:rs786202717
P04637	32	124	102	102	Natural variant	ID=VAR_044658;Note=In sporadic cancers%3B somatic mutation. T->I;Dbxref=dbSNP:rs786202717
P04637	32	124	104	104	Natural variant	ID=VAR_044659;Note=In sporadic cancers%3B somatic mutation. Q->H
P04637	32	124	104	104	Natural variant	ID=VAR_044659;Note=In sporadic cancers%3B somatic mutation. Q->H
P04637	32	124	104	104	Natural variant	ID=VAR_044660;Note=In a sporadic cancer%3B somatic mutation. Q->L
P04637	32	124	104	104	Natural variant	ID=VAR_044660;Note=In a sporadic cancer%3B somatic mutation. Q->L
P04637	32	124	105	105	Natural variant	ID=VAR_044661;Note=In LFS%3B germline mutation and in sporadic cancers%3B somatic mutation. G->C
P04637	32	124	105	105	Natural variant	ID=VAR_044661;Note=In LFS%3B germline mutation and in sporadic cancers%3B somatic mutation. G->C
P04637	32	124	105	105	Natural variant	ID=VAR_044662;Note=In sporadic cancers%3B somatic mutation. G->D;Dbxref=dbSNP:rs587781504
P04637	32	124	105	105	Natural variant	ID=VAR_044662;Note=In sporadic cancers%3B somatic mutation. G->D;Dbxref=dbSNP:rs587781504
P04637	32	124	105	105	Natural variant	ID=VAR_044663;Note=In sporadic cancers%3B somatic mutation. G->R;Dbxref=dbSNP:rs1060501195
P04637	32	124	105	105	Natural variant	ID=VAR_044663;Note=In sporadic cancers%3B somatic mutation. G->R;Dbxref=dbSNP:rs1060501195
P04637	32	124	105	105	Natural variant	ID=VAR_044664;Note=In a sporadic cancer%3B somatic mutation. G->S
P04637	32	124	105	105	Natural variant	ID=VAR_044664;Note=In a sporadic cancer%3B somatic mutation. G->S
P04637	32	124	105	105	Natural variant	ID=VAR_044665;Note=In sporadic cancers%3B somatic mutation. G->V
P04637	32	124	105	105	Natural variant	ID=VAR_044665;Note=In sporadic cancers%3B somatic mutation. G->V
P04637	32	124	106	106	Natural variant	ID=VAR_044666;Note=In a sporadic cancer%3B somatic mutation. S->G
P04637	32	124	106	106	Natural variant	ID=VAR_044666;Note=In a sporadic cancer%3B somatic mutation. S->G
P04637	32	124	106	106	Natural variant	ID=VAR_044667;Note=In a familial cancer not matching LFS%3B germline mutation and in sporadic cancers%3B somatic mutation. S->R
P04637	32	124	106	106	Natural variant	ID=VAR_044667;Note=In a familial cancer not matching LFS%3B germline mutation and in sporadic cancers%3B somatic mutation. S->R
P04637	32	124	107	107	Natural variant	ID=VAR_044668;Note=In a sporadic cancer%3B somatic mutation. Y->C;Dbxref=dbSNP:rs587782447
P04637	32	124	107	107	Natural variant	ID=VAR_044668;Note=In a sporadic cancer%3B somatic mutation. Y->C;Dbxref=dbSNP:rs587782447
P04637	32	124	107	107	Natural variant	ID=VAR_044669;Note=In sporadic cancers%3B somatic mutation. Y->D
P04637	32	124	107	107	Natural variant	ID=VAR_044669;Note=In sporadic cancers%3B somatic mutation. Y->D
P04637	32	124	107	107	Natural variant	ID=VAR_044670;Note=In a sporadic cancer%3B somatic mutation. Y->H;Dbxref=dbSNP:rs368771578
P04637	32	124	107	107	Natural variant	ID=VAR_044670;Note=In a sporadic cancer%3B somatic mutation. Y->H;Dbxref=dbSNP:rs368771578
P04637	32	124	108	108	Natural variant	ID=VAR_044671;Note=In a sporadic cancer%3B somatic mutation. G->D
P04637	32	124	108	108	Natural variant	ID=VAR_044671;Note=In a sporadic cancer%3B somatic mutation. G->D
P04637	32	124	108	108	Natural variant	ID=VAR_044672;Note=In sporadic cancers%3B somatic mutation. G->S;Dbxref=dbSNP:rs587782461
P04637	32	124	108	108	Natural variant	ID=VAR_044672;Note=In sporadic cancers%3B somatic mutation. G->S;Dbxref=dbSNP:rs587782461
P04637	32	124	109	109	Natural variant	ID=VAR_044673;Note=In sporadic cancers%3B somatic mutation. F->C
P04637	32	124	109	109	Natural variant	ID=VAR_044673;Note=In sporadic cancers%3B somatic mutation. F->C
P04637	32	124	109	109	Natural variant	ID=VAR_044674;Note=In a sporadic cancer%3B somatic mutation. F->L
P04637	32	124	109	109	Natural variant	ID=VAR_044674;Note=In a sporadic cancer%3B somatic mutation. F->L
P04637	32	124	109	109	Natural variant	ID=VAR_044675;Note=In sporadic cancers%3B somatic mutation. F->S;Dbxref=dbSNP:rs1064796722
P04637	32	124	109	109	Natural variant	ID=VAR_044675;Note=In sporadic cancers%3B somatic mutation. F->S;Dbxref=dbSNP:rs1064796722
P04637	32	124	110	110	Natural variant	ID=VAR_005860;Note=In sporadic cancers%3B somatic mutation. R->C;Dbxref=dbSNP:rs587781371
P04637	32	124	110	110	Natural variant	ID=VAR_005860;Note=In sporadic cancers%3B somatic mutation. R->C;Dbxref=dbSNP:rs587781371
P04637	32	124	110	110	Natural variant	ID=VAR_044676;Note=In a sporadic cancer%3B somatic mutation. R->G
P04637	32	124	110	110	Natural variant	ID=VAR_044676;Note=In a sporadic cancer%3B somatic mutation. R->G
P04637	32	124	110	110	Natural variant	ID=VAR_044677;Note=In sporadic cancers%3B somatic mutation. R->H;Dbxref=dbSNP:rs11540654
P04637	32	124	110	110	Natural variant	ID=VAR_044677;Note=In sporadic cancers%3B somatic mutation. R->H;Dbxref=dbSNP:rs11540654
P04637	32	124	110	110	Natural variant	ID=VAR_005861;Note=In a familial cancer not matching LFS%3B germline mutation and in sporadic cancers%3B somatic mutation%3B does not induce SNAI1 degradation. R->L;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:20385133;Dbxref=dbSNP:rs11540654,PMI
P04637	32	124	110	110	Natural variant	ID=VAR_005861;Note=In a familial cancer not matching LFS%3B germline mutation and in sporadic cancers%3B somatic mutation%3B does not induce SNAI1 degradation. R->L;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:20385133;Dbxref=dbSNP:rs11540654,PMI
P04637	32	124	110	110	Natural variant	ID=VAR_005862;Note=In sporadic cancers%3B somatic mutation. R->P;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17224074;Dbxref=dbSNP:rs11540654,PMID:17224074
P04637	32	124	110	110	Natural variant	ID=VAR_005862;Note=In sporadic cancers%3B somatic mutation. R->P;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17224074;Dbxref=dbSNP:rs11540654,PMID:17224074
P04637	32	124	110	110	Natural variant	ID=VAR_044678;Note=In a sporadic cancer%3B somatic mutation. R->S;Dbxref=dbSNP:rs587781371
P04637	32	124	110	110	Natural variant	ID=VAR_044678;Note=In a sporadic cancer%3B somatic mutation. R->S;Dbxref=dbSNP:rs587781371
P04637	32	124	111	111	Natural variant	ID=VAR_044679;Note=In a sporadic cancer%3B somatic mutation. L->M
P04637	32	124	111	111	Natural variant	ID=VAR_044679;Note=In a sporadic cancer%3B somatic mutation. L->M
P04637	32	124	111	111	Natural variant	ID=VAR_044680;Note=In sporadic cancers%3B somatic mutation. L->P
P04637	32	124	111	111	Natural variant	ID=VAR_044680;Note=In sporadic cancers%3B somatic mutation. L->P
P04637	32	124	111	111	Natural variant	ID=VAR_044681;Note=In sporadic cancers%3B somatic mutation. L->Q
P04637	32	124	111	111	Natural variant	ID=VAR_044681;Note=In sporadic cancers%3B somatic mutation. L->Q
P04637	32	124	111	111	Natural variant	ID=VAR_044682;Note=In sporadic cancers%3B somatic mutation. L->R;Dbxref=dbSNP:rs1057519997
P04637	32	124	111	111	Natural variant	ID=VAR_044682;Note=In sporadic cancers%3B somatic mutation. L->R;Dbxref=dbSNP:rs1057519997
P04637	32	124	112	112	Natural variant	ID=VAR_044683;Note=In sporadic cancers%3B somatic mutation. G->D
P04637	32	124	112	112	Natural variant	ID=VAR_044683;Note=In sporadic cancers%3B somatic mutation. G->D
P04637	32	124	112	112	Natural variant	ID=VAR_044684;Note=In sporadic cancers%3B somatic mutation. G->S;Dbxref=dbSNP:rs1423803759
P04637	32	124	112	112	Natural variant	ID=VAR_044684;Note=In sporadic cancers%3B somatic mutation. G->S;Dbxref=dbSNP:rs1423803759
P04637	32	124	113	113	Natural variant	ID=VAR_005863;Note=In sporadic cancers%3B somatic mutation. F->C
P04637	32	124	113	113	Natural variant	ID=VAR_005863;Note=In sporadic cancers%3B somatic mutation. F->C
P04637	32	124	113	113	Natural variant	ID=VAR_045788;Note=In a sporadic cancer%3B somatic mutation%3B requires 2 nucleotide substitutions. F->G
P04637	32	124	113	113	Natural variant	ID=VAR_045788;Note=In a sporadic cancer%3B somatic mutation%3B requires 2 nucleotide substitutions. F->G
P04637	32	124	113	113	Natural variant	ID=VAR_044685;Note=In a sporadic cancer%3B somatic mutation. F->I
P04637	32	124	113	113	Natural variant	ID=VAR_044685;Note=In a sporadic cancer%3B somatic mutation. F->I
P04637	32	124	113	113	Natural variant	ID=VAR_044686;Note=In sporadic cancers%3B somatic mutation. F->L
P04637	32	124	113	113	Natural variant	ID=VAR_044686;Note=In sporadic cancers%3B somatic mutation. F->L
P04637	32	124	113	113	Natural variant	ID=VAR_044687;Note=In sporadic cancers%3B somatic mutation. F->S
P04637	32	124	113	113	Natural variant	ID=VAR_044687;Note=In sporadic cancers%3B somatic mutation. F->S
P04637	32	124	113	113	Natural variant	ID=VAR_033033;Note=In sporadic cancers%3B somatic mutation. F->V;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17224074;Dbxref=dbSNP:rs587781642,PMID:17224074
P04637	32	124	113	113	Natural variant	ID=VAR_033033;Note=In sporadic cancers%3B somatic mutation. F->V;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17224074;Dbxref=dbSNP:rs587781642,PMID:17224074
P04637	32	124	115	115	Natural variant	ID=VAR_044688;Note=In sporadic cancers%3B somatic mutation. H->Y
P04637	32	124	115	115	Natural variant	ID=VAR_044688;Note=In sporadic cancers%3B somatic mutation. H->Y
P04637	32	124	116	116	Natural variant	ID=VAR_044689;Note=In sporadic cancers%3B somatic mutation. S->C
P04637	32	124	116	116	Natural variant	ID=VAR_044689;Note=In sporadic cancers%3B somatic mutation. S->C
P04637	32	124	116	116	Natural variant	ID=VAR_044690;Note=In a sporadic cancer%3B somatic mutation. S->F
P04637	32	124	116	116	Natural variant	ID=VAR_044690;Note=In a sporadic cancer%3B somatic mutation. S->F
P04637	32	124	116	116	Natural variant	ID=VAR_044691;Note=In a sporadic cancer%3B somatic mutation. S->P
P04637	32	124	116	116	Natural variant	ID=VAR_044691;Note=In a sporadic cancer%3B somatic mutation. S->P
P04637	32	124	117	117	Natural variant	ID=VAR_044692;Note=In sporadic cancers%3B somatic mutation. G->E;Dbxref=dbSNP:rs755238756
P04637	32	124	117	117	Natural variant	ID=VAR_044692;Note=In sporadic cancers%3B somatic mutation. G->E;Dbxref=dbSNP:rs755238756
P04637	32	124	117	117	Natural variant	ID=VAR_044693;Note=In sporadic cancers%3B somatic mutation. G->R
P04637	32	124	117	117	Natural variant	ID=VAR_044693;Note=In sporadic cancers%3B somatic mutation. G->R
P04637	32	124	118	118	Natural variant	ID=VAR_044694;Note=In a sporadic cancer%3B somatic mutation. T->A
P04637	32	124	118	118	Natural variant	ID=VAR_044694;Note=In a sporadic cancer%3B somatic mutation. T->A
P04637	32	124	118	118	Natural variant	ID=VAR_044695;Note=In sporadic cancers%3B somatic mutation. T->I;Dbxref=dbSNP:rs1064794141
P04637	32	124	118	118	Natural variant	ID=VAR_044695;Note=In sporadic cancers%3B somatic mutation. T->I;Dbxref=dbSNP:rs1064794141
P04637	32	124	118	118	Natural variant	ID=VAR_044696;Note=In a sporadic cancer%3B somatic mutation. T->R
P04637	32	124	118	118	Natural variant	ID=VAR_044696;Note=In a sporadic cancer%3B somatic mutation. T->R
P04637	32	124	119	119	Natural variant	ID=VAR_044697;Note=In a sporadic cancer%3B somatic mutation. A->D
P04637	32	124	119	119	Natural variant	ID=VAR_044697;Note=In a sporadic cancer%3B somatic mutation. A->D
P04637	32	124	119	119	Natural variant	ID=VAR_044698;Note=In a sporadic cancer%3B somatic mutation. A->T
P04637	32	124	119	119	Natural variant	ID=VAR_044698;Note=In a sporadic cancer%3B somatic mutation. A->T
P04637	32	124	120	120	Natural variant	ID=VAR_044699;Note=In sporadic cancers%3B somatic mutation. K->E;Dbxref=dbSNP:rs121912658
P04637	32	124	120	120	Natural variant	ID=VAR_044699;Note=In sporadic cancers%3B somatic mutation. K->E;Dbxref=dbSNP:rs121912658
P04637	32	124	120	120	Natural variant	ID=VAR_044700;Note=In sporadic cancers%3B somatic mutation. K->M
P04637	32	124	120	120	Natural variant	ID=VAR_044700;Note=In sporadic cancers%3B somatic mutation. K->M
P04637	32	124	120	120	Natural variant	ID=VAR_044701;Note=In a sporadic cancer%3B somatic mutation. K->Q
P04637	32	124	120	120	Natural variant	ID=VAR_044701;Note=In a sporadic cancer%3B somatic mutation. K->Q
P04637	32	124	120	120	Natural variant	ID=VAR_044702;Note=In sporadic cancers%3B somatic mutation. K->R
P04637	32	124	120	120	Natural variant	ID=VAR_044702;Note=In sporadic cancers%3B somatic mutation. K->R
P04637	32	124	121	121	Natural variant	ID=VAR_044703;Note=In sporadic cancers%3B somatic mutation. S->F
P04637	32	124	121	121	Natural variant	ID=VAR_044703;Note=In sporadic cancers%3B somatic mutation. S->F
P04637	32	124	122	122	Natural variant	ID=VAR_044704;Note=In a sporadic cancer%3B somatic mutation. V->L
P04637	32	124	122	122	Natural variant	ID=VAR_044704;Note=In a sporadic cancer%3B somatic mutation. V->L
P04637	32	124	123	123	Natural variant	ID=VAR_044705;Note=In a sporadic cancer%3B somatic mutation. T->I
P04637	32	124	123	123	Natural variant	ID=VAR_044705;Note=In a sporadic cancer%3B somatic mutation. T->I
P04637	32	124	123	123	Natural variant	ID=VAR_044706;Note=In a sporadic cancer%3B somatic mutation. T->N
P04637	32	124	123	123	Natural variant	ID=VAR_044706;Note=In a sporadic cancer%3B somatic mutation. T->N
P04637	32	124	124	124	Natural variant	ID=VAR_044707;Note=In a sporadic cancer%3B somatic mutation. C->G;Dbxref=dbSNP:rs730881997
P04637	32	124	124	124	Natural variant	ID=VAR_044707;Note=In a sporadic cancer%3B somatic mutation. C->G;Dbxref=dbSNP:rs730881997
P04637	32	124	124	124	Natural variant	ID=VAR_044708;Note=In sporadic cancers%3B somatic mutation. C->R
P04637	32	124	124	124	Natural variant	ID=VAR_044708;Note=In sporadic cancers%3B somatic mutation. C->R
P04637	32	124	124	124	Natural variant	ID=VAR_044709;Note=In sporadic cancers%3B somatic mutation. C->S;Dbxref=dbSNP:rs730881997
P04637	32	124	124	124	Natural variant	ID=VAR_044709;Note=In sporadic cancers%3B somatic mutation. C->S;Dbxref=dbSNP:rs730881997
P04637	32	124	124	124	Natural variant	ID=VAR_044710;Note=In a sporadic cancer%3B somatic mutation. C->W
P04637	32	124	124	124	Natural variant	ID=VAR_044710;Note=In a sporadic cancer%3B somatic mutation. C->W
P04637	32	124	124	124	Natural variant	ID=VAR_044711;Note=In a sporadic cancer%3B somatic mutation. C->Y
P04637	32	124	124	124	Natural variant	ID=VAR_044711;Note=In a sporadic cancer%3B somatic mutation. C->Y
P04637	32	124	1	320	Region	Note=Interaction with CCAR2;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:25732823;Dbxref=PMID:25732823
P04637	32	124	1	320	Region	Note=Interaction with CCAR2;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:25732823;Dbxref=PMID:25732823
P04637	32	124	1	83	Region	Note=Interaction with HRMT1L2;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:15186775;Dbxref=PMID:15186775
P04637	32	124	1	83	Region	Note=Interaction with HRMT1L2;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:15186775;Dbxref=PMID:15186775
P04637	32	124	1	44	Region	Note=Transcription activation (acidic)
P04637	32	124	1	44	Region	Note=Transcription activation (acidic)
P04637	32	124	66	110	Region	Note=Interaction with WWOX
P04637	32	124	66	110	Region	Note=Interaction with WWOX
P04637	32	124	100	370	Region	Note=Interaction with HIPK1;Ontology_term=ECO:0000250;evidence=ECO:0000250
P04637	32	124	100	370	Region	Note=Interaction with HIPK1;Ontology_term=ECO:0000250;evidence=ECO:0000250
P04637	32	124	100	300	Region	Note=Required for interaction with ZNF385A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17719541;Dbxref=PMID:17719541
P04637	32	124	100	300	Region	Note=Required for interaction with ZNF385A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17719541;Dbxref=PMID:17719541
P04637	32	124	113	236	Region	Note=Required for interaction with FBXO42;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:19509332;Dbxref=PMID:19509332
P04637	32	124	113	236	Region	Note=Required for interaction with FBXO42;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:19509332;Dbxref=PMID:19509332
P04637	32	124	116	292	Region	Note=Interaction with AXIN1;Ontology_term=ECO:0000250;evidence=ECO:0000250
P04637	32	124	116	292	Region	Note=Interaction with AXIN1;Ontology_term=ECO:0000250;evidence=ECO:0000250
P04637	32	124	120	120	Site	Note=Interaction with DNA
P04637	32	124	120	120	Site	Note=Interaction with DNA
P04637	32	124	105	108	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3D06
P04637	32	124	105	108	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3D06
P04637	32	124	121	123	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3Q05
P04637	32	124	121	123	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3Q05

Lost protein functional features of individual exon skipping events in MSBB.

UniProt acc.

Start of exon skipping (AA)

End of exon skipping (AA)

Protein feature start (AA)

Protein feature end (AA)

Category of protein feature

Description of feature

Lost protein functional features of individual exon skipping events in Mayo.

UniProt acc.

Start of exon skipping (AA)

End of exon skipping (AA)

Protein feature start (AA)

Protein feature end (AA)

Category of protein feature

Description of feature

Top

3'-UTR located exon skipping events that lost miRNA binding sites in TP53

3'-UTR exon skipping evnets lost miRNA binding.

Tissue type

ENST

Exon skip start

Exon skip end

microRNA

Binding site by TargetScan

Binding type by TargetScan

Bdinding site by miRanda

Score of miRanda

Energy by miRanda

Top

SNVs in the skipped exons for TP53

- Differential PSIs between mutated versus non-mutated samples.

- Depth of Coverage in the skipped exon of the mutated samples.

- Sashimi plot in the skipped exon of the mutated samples.

- Non-synonymous mutations located in the skipped exons.

Cancer type

Sample

ESID

Skipped exon start

Skipped exon end

Mutation start

Mutation end

Mutation type

Reference seq

Mutation seq

AAchange

- Non-synonymous mutations located in the skipped exons in CCLE.

Sample

Skipped exon start

Skipped exon end

Mutation start

Mutation end

Mutation type

Reference seq

Mutation seq

AAchange

Top

AD stage-associated exon skippint events for TP53

Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR).

AD stage info

Cohort

Tissue

SE id

Coefficient

P-value

Chromosome

Strand

E1 start

E1 end

Skipped start

Skipped end

E2 start

E2 end

Top

Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TP53

sQTL information located at the skipped exons.

Tissue type

Exon skip ID

SNP id

Location

P-value

FDR

Top

Correlation with RNA binding proteins (RBPs) for TP53

Correlated RBP and related information.

Tissue type

RBP name

Exon skip ID

Correlation coeifficient

P-value

Top

RelatedDrugs for TP53

Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)

UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
P04637	approved\|vet_approved	DB00945	Acetylsalicylic acid	small molecule	P04637
P04637	approved\|investigational	DB01593	Zinc	small molecule	P04637
P04637	approved\|investigational	DB14487	Zinc acetate	small molecule	P04637
P04637	approved\|investigational	DB14533	Zinc chloride	small molecule	P04637

Top

RelatedDiseases for TP53

Diseases associated with this gene.
(DisGeNet 4.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	Gene structures and expression levels
	Exon skipping events with PSIs in RPSMAP, MSBB, and Mayo
	Open reading frame (ORF) annotation in the exon skipping event
	Exon skipping events in the canonical protein sequence
	3'-UTR located exon skipping events lost miRNA binding sites
	SNVs in the skipped exons with depth of coverage
	AD stage-associated exon skipping events
	Splicing Quantitative Trait Loci (sQTLs) in the skipped exons
	Correlation with RNA binding proteins (RBPs)
	Related drugs with this gene
	Related diseases with this gene

Home

Download

Statistics

Landscape

Help

Contact

Gene summary for TP53

Gene structures and expression levels for TP53

Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for TP53

Open reading frame (ORF) annotation in the exon skipping event for TP53

Infer the effects of exon skipping event on protein functional features for TP53

3'-UTR located exon skipping events that lost miRNA binding sites in TP53

SNVs in the skipped exons for TP53

AD stage-associated exon skippint events for TP53

Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TP53

Correlation with RNA binding proteins (RBPs) for TP53

RelatedDrugs for TP53

RelatedDiseases for TP53