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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for TNXB |
 Gene summary |
| Gene information | Gene symbol | TNXB | Gene ID | 7148 |
| Gene name | tenascin XB | |
| Synonyms | EDS3|EDSCLL|EDSCLL1|HXBL|TENX|TN-X|TNX|TNXB1|TNXB2|TNXBS|VUR8|XB|XBS | |
| Cytomap | 6p21.33-p21.32 | |
| Type of gene | protein-coding | |
| Description | tenascin-Xgrowth-inhibiting protein 45hexabrachion-like proteintenascin XB1tenascin XB2 | |
| Modification date | 20200313 | |
| UniProtAcc | A0A087WWA5, A0A087X0I0, A0A140T8Y3, A0A140T8Z8, A0A140T902, A0A140T923, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for TNXB |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000168477
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| PCC | UP | ENST00000442721.1 | TNXB-202:protein_coding:TNXB | 1.877501e+00 | 9.459531e-01 | 1.436473e-03 | 3.180434e-02 |
| IFG | UP | ENST00000375244.7 | TNXB-201:protein_coding:TNXB | 3.220745e+01 | 2.312565e+01 | 3.781029e-19 | 9.095795e-15 |
| CB | DOWN | ENST00000490077.5 | TNXB-206:retained_intron:TNXB | 3.999281e+02 | -1.010338e+00 | 1.173354e-03 | 5.910801e-03 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for TNXB |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_100595 | chr6 | 32062157:32062483:32064821:32065117:32067661:32067984 | 32064821:32065117 |
| exon_skip_135500 | chr6 | 32084413:32084709:32085750:32086118:32088785:32089048 | 32085750:32086118 |
| exon_skip_161757 | chr6 | 32069553:32069861:32070127:32070414:32071990:32072298 | 32070127:32070414 |
| exon_skip_170581 | chr6 | 32055851:32056174:32056586:32056903:32058058:32058390 | 32056586:32056903 |
| exon_skip_222938 | chr6 | 32047734:32048012:32048363:32048650:32049270:32049587 | 32048363:32048650 |
| exon_skip_26058 | chr6 | 32049998:32050321:32052670:32052993:32053388:32053705 | 32052670:32052993 |
| exon_skip_295697 | chr6 | 32085750:32086118:32087251:32087991:32088785:32089048 | 32087251:32087991 |
| exon_skip_63042 | chr6 | 32043175:32043318:32043437:32043556:32043749:32043881 | 32043437:32043556 |
| exon_skip_8097 | chr6 | 32070127:32070414:32071990:32072298:32073647:32073952 | 32071990:32072298 |
| exon_skip_88553 | chr6 | 32085750:32086118:32087251:32087991:32088785:32088909 | 32087251:32087991 |
| exon_skip_96111 | chr6 | 32088785:32089048:32089223:32089379:32095076:32095191 | 32089223:32089379 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for TNXB |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
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Infer the effects of exon skipping event on protein functional features for TNXB |
p-ENSG00000168477_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in TNXB |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for TNXB |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for TNXB |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TNXB |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
| CB | exon_skip_63042 | rs2072633 | chr6:31951801 | 1.180599e-04 | 1.961497e-02 |
| HCC | exon_skip_100595 | rs13199524 | chr6:32098988 | 1.162669e-04 | 1.040996e-02 |
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Correlation with RNA binding proteins (RBPs) for TNXB |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | CNOT4 | exon_skip_8097 | -4.143969e-01 | 8.302763e-08 |
| CB | HNRNPA2B1 | exon_skip_8097 | -4.147120e-01 | 8.099022e-08 |
| CB | RBM4B | exon_skip_8097 | -4.998641e-01 | 3.549720e-11 |
| HCC | RBM3 | exon_skip_8097 | 4.285864e-01 | 1.476132e-11 |
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RelatedDrugs for TNXB |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TNXB |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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