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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for TSPAN4 |
 Gene summary |
| Gene information | Gene symbol | TSPAN4 | Gene ID | 7106 |
| Gene name | tetraspanin 4 | |
| Synonyms | NAG-2|NAG2|TETRASPAN|TM4SF7|TSPAN-4 | |
| Cytomap | 11p15.5 | |
| Type of gene | protein-coding | |
| Description | tetraspanin-4novel antigen 2tetraspan TM4SFtransmembrane 4 superfamily member 7 | |
| Modification date | 20200313 | |
| UniProtAcc | A0A024RCE1, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| TSPAN4 | GO:0065003 | protein-containing complex assembly | 9360996 |
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Gene structures and expression levels for TSPAN4 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000214063
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for TSPAN4 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_11171 | chr11 | 864437:864511:865513:865614:865694:865825 | 865513:865614 |
| exon_skip_161935 | chr11 | 850296:850367:862550:862741:864437:864511 | 862550:862741 |
| exon_skip_190900 | chr11 | 850288:850367:862550:862741:864437:864511 | 862550:862741 |
| exon_skip_22131 | chr11 | 844153:844186:847201:847300:862550:862741 | 847201:847300 |
| exon_skip_253107 | chr11 | 844117:844186:847201:847300:850288:850367 | 847201:847300 |
| exon_skip_269774 | chr11 | 842852:842915:847201:847300:850288:850367 | 847201:847300 |
| exon_skip_273238 | chr11 | 844153:844186:850288:850367:862550:862741 | 850288:850367 |
| exon_skip_294991 | chr11 | 864437:864511:865513:865614:865694:865740 | 865513:865614 |
| exon_skip_8132 | chr11 | 844153:844186:847201:847300:850288:850367 | 847201:847300 |
| exon_skip_98123 | chr11 | 847201:847300:850288:850367:862550:862741 | 850288:850367 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for TSPAN4 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000397397 | 850288 | 850367 | 5CDS-5UTR |
| ENST00000397404 | 850288 | 850367 | 5CDS-5UTR |
| ENST00000397406 | 850288 | 850367 | 5CDS-5UTR |
| ENST00000397408 | 850288 | 850367 | 5CDS-5UTR |
| ENST00000409543 | 850288 | 850367 | 5CDS-5UTR |
| ENST00000397397 | 847201 | 847300 | 5UTR-5UTR |
| ENST00000397406 | 847201 | 847300 | 5UTR-5UTR |
| ENST00000397397 | 862550 | 862741 | In-frame |
| ENST00000397404 | 862550 | 862741 | In-frame |
| ENST00000397406 | 862550 | 862741 | In-frame |
| ENST00000397408 | 862550 | 862741 | In-frame |
| ENST00000397411 | 862550 | 862741 | In-frame |
| ENST00000409543 | 862550 | 862741 | In-frame |
| ENST00000397397 | 865513 | 865614 | In-frame |
| ENST00000397404 | 865513 | 865614 | In-frame |
| ENST00000397406 | 865513 | 865614 | In-frame |
| ENST00000397408 | 865513 | 865614 | In-frame |
| ENST00000397411 | 865513 | 865614 | In-frame |
| ENST00000409543 | 865513 | 865614 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000397397 | 850288 | 850367 | 5CDS-5UTR |
| ENST00000397404 | 850288 | 850367 | 5CDS-5UTR |
| ENST00000397406 | 850288 | 850367 | 5CDS-5UTR |
| ENST00000397408 | 850288 | 850367 | 5CDS-5UTR |
| ENST00000397397 | 847201 | 847300 | 5UTR-5UTR |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000397397 | 850288 | 850367 | 5CDS-5UTR |
| ENST00000397404 | 850288 | 850367 | 5CDS-5UTR |
| ENST00000397406 | 850288 | 850367 | 5CDS-5UTR |
| ENST00000397408 | 850288 | 850367 | 5CDS-5UTR |
| ENST00000409543 | 850288 | 850367 | 5CDS-5UTR |
| ENST00000397397 | 847201 | 847300 | 5UTR-5UTR |
| ENST00000397406 | 847201 | 847300 | 5UTR-5UTR |
| ENST00000397397 | 862550 | 862741 | In-frame |
| ENST00000397404 | 862550 | 862741 | In-frame |
| ENST00000397406 | 862550 | 862741 | In-frame |
| ENST00000397408 | 862550 | 862741 | In-frame |
| ENST00000397411 | 862550 | 862741 | In-frame |
| ENST00000409543 | 862550 | 862741 | In-frame |
| ENST00000397397 | 865513 | 865614 | In-frame |
| ENST00000397404 | 865513 | 865614 | In-frame |
| ENST00000397406 | 865513 | 865614 | In-frame |
| ENST00000397408 | 865513 | 865614 | In-frame |
| ENST00000397411 | 865513 | 865614 | In-frame |
| ENST00000409543 | 865513 | 865614 | In-frame |
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Infer the effects of exon skipping event on protein functional features for TSPAN4 |
p-ENSG00000214063_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000397397 | 1440 | 238 | 862550 | 862741 | 290 | 480 | 21 | 85 |
| ENST00000397404 | 1479 | 238 | 862550 | 862741 | 324 | 514 | 21 | 85 |
| ENST00000397406 | 1443 | 238 | 862550 | 862741 | 288 | 478 | 21 | 85 |
| ENST00000397408 | 1447 | 238 | 862550 | 862741 | 292 | 482 | 21 | 85 |
| ENST00000397411 | 1042 | 238 | 862550 | 862741 | 186 | 376 | 21 | 85 |
| ENST00000409543 | 1048 | 238 | 862550 | 862741 | 152 | 342 | 21 | 85 |
| ENST00000397397 | 1440 | 238 | 865513 | 865614 | 557 | 657 | 110 | 144 |
| ENST00000397404 | 1479 | 238 | 865513 | 865614 | 591 | 691 | 110 | 144 |
| ENST00000397406 | 1443 | 238 | 865513 | 865614 | 555 | 655 | 110 | 144 |
| ENST00000397408 | 1447 | 238 | 865513 | 865614 | 559 | 659 | 110 | 144 |
| ENST00000397411 | 1042 | 238 | 865513 | 865614 | 453 | 553 | 110 | 144 |
| ENST00000409543 | 1048 | 238 | 865513 | 865614 | 419 | 519 | 110 | 144 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000397397 | 1440 | 238 | 862550 | 862741 | 290 | 480 | 21 | 85 |
| ENST00000397404 | 1479 | 238 | 862550 | 862741 | 324 | 514 | 21 | 85 |
| ENST00000397406 | 1443 | 238 | 862550 | 862741 | 288 | 478 | 21 | 85 |
| ENST00000397408 | 1447 | 238 | 862550 | 862741 | 292 | 482 | 21 | 85 |
| ENST00000397411 | 1042 | 238 | 862550 | 862741 | 186 | 376 | 21 | 85 |
| ENST00000409543 | 1048 | 238 | 862550 | 862741 | 152 | 342 | 21 | 85 |
| ENST00000397397 | 1440 | 238 | 865513 | 865614 | 557 | 657 | 110 | 144 |
| ENST00000397404 | 1479 | 238 | 865513 | 865614 | 591 | 691 | 110 | 144 |
| ENST00000397406 | 1443 | 238 | 865513 | 865614 | 555 | 655 | 110 | 144 |
| ENST00000397408 | 1447 | 238 | 865513 | 865614 | 559 | 659 | 110 | 144 |
| ENST00000397411 | 1042 | 238 | 865513 | 865614 | 453 | 553 | 110 | 144 |
| ENST00000409543 | 1048 | 238 | 865513 | 865614 | 419 | 519 | 110 | 144 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| O14817 | 21 | 85 | 1 | 238 | Chain | ID=PRO_0000219241;Note=Tetraspanin-4 |
| O14817 | 21 | 85 | 1 | 238 | Chain | ID=PRO_0000219241;Note=Tetraspanin-4 |
| O14817 | 21 | 85 | 1 | 238 | Chain | ID=PRO_0000219241;Note=Tetraspanin-4 |
| O14817 | 21 | 85 | 1 | 238 | Chain | ID=PRO_0000219241;Note=Tetraspanin-4 |
| O14817 | 21 | 85 | 1 | 238 | Chain | ID=PRO_0000219241;Note=Tetraspanin-4 |
| O14817 | 21 | 85 | 1 | 238 | Chain | ID=PRO_0000219241;Note=Tetraspanin-4 |
| O14817 | 21 | 85 | 67 | 67 | Natural variant | ID=VAR_036616;Note=In a breast cancer sample%3B somatic mutation. I->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974 |
| O14817 | 21 | 85 | 67 | 67 | Natural variant | ID=VAR_036616;Note=In a breast cancer sample%3B somatic mutation. I->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974 |
| O14817 | 21 | 85 | 67 | 67 | Natural variant | ID=VAR_036616;Note=In a breast cancer sample%3B somatic mutation. I->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974 |
| O14817 | 21 | 85 | 67 | 67 | Natural variant | ID=VAR_036616;Note=In a breast cancer sample%3B somatic mutation. I->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974 |
| O14817 | 21 | 85 | 67 | 67 | Natural variant | ID=VAR_036616;Note=In a breast cancer sample%3B somatic mutation. I->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974 |
| O14817 | 21 | 85 | 67 | 67 | Natural variant | ID=VAR_036616;Note=In a breast cancer sample%3B somatic mutation. I->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974 |
| O14817 | 21 | 85 | 35 | 55 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O14817 | 21 | 85 | 35 | 55 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O14817 | 21 | 85 | 35 | 55 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O14817 | 21 | 85 | 35 | 55 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O14817 | 21 | 85 | 35 | 55 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O14817 | 21 | 85 | 35 | 55 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O14817 | 21 | 85 | 77 | 85 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O14817 | 21 | 85 | 77 | 85 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O14817 | 21 | 85 | 77 | 85 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O14817 | 21 | 85 | 77 | 85 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O14817 | 21 | 85 | 77 | 85 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O14817 | 21 | 85 | 77 | 85 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O14817 | 21 | 85 | 14 | 34 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O14817 | 21 | 85 | 14 | 34 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O14817 | 21 | 85 | 14 | 34 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O14817 | 21 | 85 | 14 | 34 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O14817 | 21 | 85 | 14 | 34 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O14817 | 21 | 85 | 14 | 34 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O14817 | 21 | 85 | 56 | 76 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O14817 | 21 | 85 | 56 | 76 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O14817 | 21 | 85 | 56 | 76 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O14817 | 21 | 85 | 56 | 76 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O14817 | 21 | 85 | 56 | 76 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O14817 | 21 | 85 | 56 | 76 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O14817 | 110 | 144 | 1 | 238 | Chain | ID=PRO_0000219241;Note=Tetraspanin-4 |
| O14817 | 110 | 144 | 1 | 238 | Chain | ID=PRO_0000219241;Note=Tetraspanin-4 |
| O14817 | 110 | 144 | 1 | 238 | Chain | ID=PRO_0000219241;Note=Tetraspanin-4 |
| O14817 | 110 | 144 | 1 | 238 | Chain | ID=PRO_0000219241;Note=Tetraspanin-4 |
| O14817 | 110 | 144 | 1 | 238 | Chain | ID=PRO_0000219241;Note=Tetraspanin-4 |
| O14817 | 110 | 144 | 1 | 238 | Chain | ID=PRO_0000219241;Note=Tetraspanin-4 |
| O14817 | 110 | 144 | 107 | 201 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O14817 | 110 | 144 | 107 | 201 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O14817 | 110 | 144 | 107 | 201 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O14817 | 110 | 144 | 107 | 201 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O14817 | 110 | 144 | 107 | 201 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O14817 | 110 | 144 | 107 | 201 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| O14817 | 21 | 85 | 1 | 238 | Chain | ID=PRO_0000219241;Note=Tetraspanin-4 |
| O14817 | 21 | 85 | 1 | 238 | Chain | ID=PRO_0000219241;Note=Tetraspanin-4 |
| O14817 | 21 | 85 | 1 | 238 | Chain | ID=PRO_0000219241;Note=Tetraspanin-4 |
| O14817 | 21 | 85 | 1 | 238 | Chain | ID=PRO_0000219241;Note=Tetraspanin-4 |
| O14817 | 21 | 85 | 1 | 238 | Chain | ID=PRO_0000219241;Note=Tetraspanin-4 |
| O14817 | 21 | 85 | 1 | 238 | Chain | ID=PRO_0000219241;Note=Tetraspanin-4 |
| O14817 | 21 | 85 | 67 | 67 | Natural variant | ID=VAR_036616;Note=In a breast cancer sample%3B somatic mutation. I->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974 |
| O14817 | 21 | 85 | 67 | 67 | Natural variant | ID=VAR_036616;Note=In a breast cancer sample%3B somatic mutation. I->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974 |
| O14817 | 21 | 85 | 67 | 67 | Natural variant | ID=VAR_036616;Note=In a breast cancer sample%3B somatic mutation. I->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974 |
| O14817 | 21 | 85 | 67 | 67 | Natural variant | ID=VAR_036616;Note=In a breast cancer sample%3B somatic mutation. I->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974 |
| O14817 | 21 | 85 | 67 | 67 | Natural variant | ID=VAR_036616;Note=In a breast cancer sample%3B somatic mutation. I->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974 |
| O14817 | 21 | 85 | 67 | 67 | Natural variant | ID=VAR_036616;Note=In a breast cancer sample%3B somatic mutation. I->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974 |
| O14817 | 21 | 85 | 35 | 55 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O14817 | 21 | 85 | 35 | 55 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O14817 | 21 | 85 | 35 | 55 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O14817 | 21 | 85 | 35 | 55 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O14817 | 21 | 85 | 35 | 55 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O14817 | 21 | 85 | 35 | 55 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O14817 | 21 | 85 | 77 | 85 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O14817 | 21 | 85 | 77 | 85 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O14817 | 21 | 85 | 77 | 85 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O14817 | 21 | 85 | 77 | 85 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O14817 | 21 | 85 | 77 | 85 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O14817 | 21 | 85 | 77 | 85 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O14817 | 21 | 85 | 14 | 34 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O14817 | 21 | 85 | 14 | 34 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O14817 | 21 | 85 | 14 | 34 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O14817 | 21 | 85 | 14 | 34 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O14817 | 21 | 85 | 14 | 34 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O14817 | 21 | 85 | 14 | 34 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O14817 | 21 | 85 | 56 | 76 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O14817 | 21 | 85 | 56 | 76 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O14817 | 21 | 85 | 56 | 76 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O14817 | 21 | 85 | 56 | 76 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O14817 | 21 | 85 | 56 | 76 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O14817 | 21 | 85 | 56 | 76 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O14817 | 110 | 144 | 1 | 238 | Chain | ID=PRO_0000219241;Note=Tetraspanin-4 |
| O14817 | 110 | 144 | 1 | 238 | Chain | ID=PRO_0000219241;Note=Tetraspanin-4 |
| O14817 | 110 | 144 | 1 | 238 | Chain | ID=PRO_0000219241;Note=Tetraspanin-4 |
| O14817 | 110 | 144 | 1 | 238 | Chain | ID=PRO_0000219241;Note=Tetraspanin-4 |
| O14817 | 110 | 144 | 1 | 238 | Chain | ID=PRO_0000219241;Note=Tetraspanin-4 |
| O14817 | 110 | 144 | 1 | 238 | Chain | ID=PRO_0000219241;Note=Tetraspanin-4 |
| O14817 | 110 | 144 | 107 | 201 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O14817 | 110 | 144 | 107 | 201 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O14817 | 110 | 144 | 107 | 201 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O14817 | 110 | 144 | 107 | 201 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O14817 | 110 | 144 | 107 | 201 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O14817 | 110 | 144 | 107 | 201 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
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3'-UTR located exon skipping events that lost miRNA binding sites in TSPAN4 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for TSPAN4 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for TSPAN4 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TSPAN4 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
| CB | exon_skip_294991 | rs11246327 | chr11:840034 | 2.743348e-07 | 1.186920e-04 |
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Correlation with RNA binding proteins (RBPs) for TSPAN4 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | TRA2A | exon_skip_294991 | -4.292105e-01 | 1.650757e-08 |
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RelatedDrugs for TSPAN4 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TSPAN4 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
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