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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for TLR2 |
 Gene summary |
| Gene information | Gene symbol | TLR2 | Gene ID | 7097 |
| Gene name | toll like receptor 2 | |
| Synonyms | CD282|TIL4 | |
| Cytomap | 4q31.3 | |
| Type of gene | protein-coding | |
| Description | toll-like receptor 2toll/interleukin-1 receptor-like protein 4 | |
| Modification date | 20200329 | |
| UniProtAcc | A0A0S2Z4L7, | |
| Context | - 29990310(Selective Disruption of TLR2-MyD88 Interaction Inhibits Inflammation and Attenuates Alzheimer's Pathology) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| TLR2 | GO:0001775 | cell activation | 15294986 |
| TLR2 | GO:0007252 | I-kappaB phosphorylation | 19740627 |
| TLR2 | GO:0032613 | interleukin-10 production | 23826189 |
| TLR2 | GO:0032722 | positive regulation of chemokine production | 19740627 |
| TLR2 | GO:0032755 | positive regulation of interleukin-6 production | 19740627 |
| TLR2 | GO:0032757 | positive regulation of interleukin-8 production | 17128265|19740627 |
| TLR2 | GO:0034123 | positive regulation of toll-like receptor signaling pathway | 17128265 |
| TLR2 | GO:0042495 | detection of triacyl bacterial lipopeptide | 19931471 |
| TLR2 | GO:0042496 | detection of diacyl bacterial lipopeptide | 19931471 |
| TLR2 | GO:0050830 | defense response to Gram-positive bacterium | 11521063 |
| TLR2 | GO:0051092 | positive regulation of NF-kappaB transcription factor activity | 12594207|21618349 |
| TLR2 | GO:0071223 | cellular response to lipoteichoic acid | 12594207 |
| TLR2 | GO:0071346 | cellular response to interferon-gamma | 11672593 |
| TLR2 | GO:0071726 | cellular response to diacyl bacterial lipopeptide | 16880211|19931471 |
| TLR2 | GO:0071727 | cellular response to triacyl bacterial lipopeptide | 16880211|19931471 |
| TLR2 | GO:1901224 | positive regulation of NIK/NF-kappaB signaling | 19740627 |
| TLR2 | GO:1903974 | positive regulation of cellular response to macrophage colony-stimulating factor stimulus | 11672593 |
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Gene structures and expression levels for TLR2 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000137462
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for TLR2 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_114117 | chr4 | 153684290:153684360:153687902:153688047:153702892:153702962 | 153687902:153688047 |
| exon_skip_164798 | chr4 | 153687902:153688047:153702227:153702510:153702892:153702962 | 153702227:153702510 |
| exon_skip_180112 | chr4 | 153684290:153684360:153687917:153687988:153702892:153705702 | 153687917:153687988 |
| exon_skip_190550 | chr4 | 153687917:153688047:153702227:153702510:153702892:153702962 | 153702227:153702510 |
| exon_skip_268213 | chr4 | 153684338:153684360:153687917:153687988:153702892:153702962 | 153687917:153687988 |
| exon_skip_84209 | chr4 | 153684338:153684360:153687902:153688047:153702892:153702962 | 153687902:153688047 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for TLR2 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000642700 | 153687902 | 153688047 | 5UTR-5UTR |
| ENST00000642580 | 153687917 | 153687988 | 5UTR-5UTR |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000642700 | 153687902 | 153688047 | 5UTR-5UTR |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000642700 | 153687902 | 153688047 | 5UTR-5UTR |
| ENST00000642580 | 153687917 | 153687988 | 5UTR-5UTR |
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Infer the effects of exon skipping event on protein functional features for TLR2 |
p-ENSG00000137462_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in TLR2 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for TLR2 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for TLR2 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TLR2 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for TLR2 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for TLR2 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TLR2 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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