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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for TLR1 |
 Gene summary |
| Gene information | Gene symbol | TLR1 | Gene ID | 7096 |
| Gene name | toll like receptor 1 | |
| Synonyms | CD281|TIL|TIL. LPRS5|rsc786 | |
| Cytomap | 4p14 | |
| Type of gene | protein-coding | |
| Description | toll-like receptor 1toll/interleukin-1 receptor-like protein | |
| Modification date | 20200315 | |
| UniProtAcc | ||
| Context | - 25184331(The Oxidative Stress Product Carboxyethylpyrrole Potentiates TLR2/TLR1 Inflammatory Signaling in Macrophages) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| TLR1 | GO:0001775 | cell activation | 15294986 |
| TLR1 | GO:0042495 | detection of triacyl bacterial lipopeptide | 19931471 |
| TLR1 | GO:0071727 | cellular response to triacyl bacterial lipopeptide | 16880211|19931471 |
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Gene structures and expression levels for TLR1 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000174125
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| PG | UP | ENST00000510552.1 | TLR1-209:lncRNA:TLR1 | 4.985516e+00 | 1.326664e+00 | 6.817176e-08 | 1.110330e-05 |
| CB | UP | ENST00000505744.5 | TLR1-203:lncRNA:TLR1 | 8.554971e-01 | 9.437901e-01 | 1.199814e-02 | 4.031609e-02 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for TLR1 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_121367 | chr4 | 38804306:38804382:38804754:38804787:38805112:38805193 | 38804754:38804787 |
| exon_skip_157352 | chr4 | 38800870:38800948:38804306:38804382:38804754:38804787 | 38804306:38804382 |
| exon_skip_187064 | chr4 | 38798561:38798898:38800857:38800948:38804306:38804382 | 38800857:38800948 |
| exon_skip_194514 | chr4 | 38798561:38798898:38804306:38804382:38804754:38804787 | 38804306:38804382 |
| exon_skip_46583 | chr4 | 38798761:38798898:38800857:38800948:38804306:38804376 | 38800857:38800948 |
| exon_skip_61613 | chr4 | 38798761:38798898:38804306:38804382:38804754:38804787 | 38804306:38804382 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for TLR1 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000308979 | 38800857 | 38800948 | 3UTR-3UTR |
| ENST00000502213 | 38800857 | 38800948 | 3UTR-3UTR |
| ENST00000308979 | 38804306 | 38804382 | 3UTR-3UTR |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000308979 | 38800857 | 38800948 | 3UTR-3UTR |
| ENST00000502213 | 38800857 | 38800948 | 3UTR-3UTR |
| ENST00000308979 | 38804306 | 38804382 | 3UTR-3UTR |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000308979 | 38800857 | 38800948 | 3UTR-3UTR |
| ENST00000502213 | 38800857 | 38800948 | 3UTR-3UTR |
| ENST00000308979 | 38804306 | 38804382 | 3UTR-3UTR |
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Infer the effects of exon skipping event on protein functional features for TLR1 |
p-ENSG00000174125_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in TLR1 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
| Mayo | ENST00000502213 | 38800857 | 38800948 | hsa-miR-7154-5p | chr4:38800937-38800944 | 8mer-1a | chr4:38800922-38800944 | 145.00 | -15.99 |
| Mayo | ENST00000308979 | 38804306 | 38804382 | hsa-miR-935 | chr4:38804352-38804359 | 8mer-1a | chr4:38804347-38804375 | 158.00 | -17.66 |
| Mayo | ENST00000308979 | 38804306 | 38804382 | hsa-miR-10398-3p | chr4:38804344-38804351 | 8mer-1a | chr4:38804332-38804351 | 141.00 | -21.57 |
| Mayo | ENST00000502213 | 38800857 | 38800948 | hsa-miR-1911-3p | chr4:38800917-38800924 | 8mer-1a | chr4:38800905-38800924 | 145.00 | -18.62 |
| MSBB | ENST00000502213 | 38800857 | 38800948 | hsa-miR-7154-5p | chr4:38800937-38800944 | 8mer-1a | chr4:38800922-38800944 | 145.00 | -15.99 |
| MSBB | ENST00000308979 | 38804306 | 38804382 | hsa-miR-935 | chr4:38804352-38804359 | 8mer-1a | chr4:38804347-38804375 | 158.00 | -17.66 |
| MSBB | ENST00000308979 | 38804306 | 38804382 | hsa-miR-10398-3p | chr4:38804344-38804351 | 8mer-1a | chr4:38804332-38804351 | 141.00 | -21.57 |
| MSBB | ENST00000502213 | 38800857 | 38800948 | hsa-miR-1911-3p | chr4:38800917-38800924 | 8mer-1a | chr4:38800905-38800924 | 145.00 | -18.62 |
| ROSMAP | ENST00000502213 | 38800857 | 38800948 | hsa-miR-7154-5p | chr4:38800937-38800944 | 8mer-1a | chr4:38800922-38800944 | 145.00 | -15.99 |
| ROSMAP | ENST00000308979 | 38804306 | 38804382 | hsa-miR-935 | chr4:38804352-38804359 | 8mer-1a | chr4:38804347-38804375 | 158.00 | -17.66 |
| ROSMAP | ENST00000308979 | 38804306 | 38804382 | hsa-miR-10398-3p | chr4:38804344-38804351 | 8mer-1a | chr4:38804332-38804351 | 141.00 | -21.57 |
| ROSMAP | ENST00000502213 | 38800857 | 38800948 | hsa-miR-1911-3p | chr4:38800917-38800924 | 8mer-1a | chr4:38800905-38800924 | 145.00 | -18.62 |
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SNVs in the skipped exons for TLR1 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for TLR1 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TLR1 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for TLR1 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for TLR1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TLR1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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