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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for TLN1 |
 Gene summary |
| Gene information | Gene symbol | TLN1 | Gene ID | 7094 |
| Gene name | talin 1 | |
| Synonyms | ILWEQ|TLN|talin-1 | |
| Cytomap | 9p13.3 | |
| Type of gene | protein-coding | |
| Description | talin-1 | |
| Modification date | 20200313 | |
| UniProtAcc | A0A1S5UZ07, Q9Y490, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for TLN1 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000137076
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| PG | UP | ENST00000378192.2 | TLN1-202:retained_intron:TLN1 | 2.374340e+01 | 9.348921e-01 | 3.580389e-08 | 6.676073e-06 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for TLN1 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_162443 | chr9 | 35699032:35699156:35699356:35699461:35699974:35700077 | 35699356:35699461 |
| exon_skip_17803 | chr9 | 35704332:35704498:35704669:35704815:35705551:35705670 | 35704669:35704815 |
| exon_skip_217081 | chr9 | 35707356:35707488:35707731:35707892:35708341:35708484 | 35707731:35707892 |
| exon_skip_21943 | chr9 | 35712005:35712124:35712835:35713043:35713196:35713298 | 35712835:35713043 |
| exon_skip_219620 | chr9 | 35699032:35699156:35699356:35699461:35699974:35700081 | 35699356:35699461 |
| exon_skip_22229 | chr9 | 35720039:35720219:35720433:35720509:35720812:35720913 | 35720433:35720509 |
| exon_skip_263562 | chr9 | 35704323:35704498:35704669:35704815:35705551:35705670 | 35704669:35704815 |
| exon_skip_35310 | chr9 | 35725224:35725321:35725565:35725727:35732075:35732104 | 35725565:35725727 |
| exon_skip_65251 | chr9 | 35722119:35722223:35722861:35722921:35723952:35724079 | 35722861:35722921 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for TLN1 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000314888 | 35699356 | 35699461 | Frame-shift |
| ENST00000314888 | 35712835 | 35713043 | Frame-shift |
| ENST00000314888 | 35722861 | 35722921 | Frame-shift |
| ENST00000314888 | 35704669 | 35704815 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000314888 | 35699356 | 35699461 | Frame-shift |
| ENST00000314888 | 35720433 | 35720509 | Frame-shift |
| ENST00000314888 | 35722861 | 35722921 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000314888 | 35699356 | 35699461 | Frame-shift |
| ENST00000314888 | 35712835 | 35713043 | Frame-shift |
| ENST00000314888 | 35722861 | 35722921 | Frame-shift |
| ENST00000314888 | 35704669 | 35704815 | In-frame |
| ENST00000314888 | 35707731 | 35707892 | In-frame |
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Infer the effects of exon skipping event on protein functional features for TLN1 |
p-ENSG00000137076_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000314888 | 8840 | 2541 | 35704669 | 35704815 | 6088 | 6233 | 1911 | 1959 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000314888 | 8840 | 2541 | 35707731 | 35707892 | 4825 | 4985 | 1490 | 1543 |
| ENST00000314888 | 8840 | 2541 | 35704669 | 35704815 | 6088 | 6233 | 1911 | 1959 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9Y490 | 1911 | 1959 | 1 | 2541 | Chain | ID=PRO_0000219428;Note=Talin-1 |
| Q9Y490 | 1911 | 1959 | 1919 | 1919 | Natural variant | ID=VAR_023752;Note=R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17854239,PMID:15489334 |
| Q9Y490 | 1911 | 1959 | 1327 | 1948 | Region | Note=Interaction with SYNM;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18342854;Dbxref=PMID:18342854 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9Y490 | 1490 | 1543 | 1 | 2541 | Chain | ID=PRO_0000219428;Note=Talin-1 |
| Q9Y490 | 1490 | 1543 | 1327 | 1948 | Region | Note=Interaction with SYNM;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18342854;Dbxref=PMID:18342854 |
| Q9Y490 | 1490 | 1543 | 1359 | 1659 | Region | Note=Interaction with VCL and F-actin;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P26039 |
| Q9Y490 | 1911 | 1959 | 1 | 2541 | Chain | ID=PRO_0000219428;Note=Talin-1 |
| Q9Y490 | 1911 | 1959 | 1919 | 1919 | Natural variant | ID=VAR_023752;Note=R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17854239,PMID:15489334 |
| Q9Y490 | 1911 | 1959 | 1327 | 1948 | Region | Note=Interaction with SYNM;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18342854;Dbxref=PMID:18342854 |
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3'-UTR located exon skipping events that lost miRNA binding sites in TLN1 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for TLN1 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for TLN1 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TLN1 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for TLN1 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | SRSF4 | exon_skip_162443 | -4.438477e-01 | 4.631255e-09 |
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RelatedDrugs for TLN1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TLN1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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