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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for TIAM1 |
 Gene summary |
| Gene information | Gene symbol | TIAM1 | Gene ID | 7074 |
| Gene name | TIAM Rac1 associated GEF 1 | |
| Synonyms | TIAM-1 | |
| Cytomap | 21q22.11 | |
| Type of gene | protein-coding | |
| Description | T-lymphoma invasion and metastasis-inducing protein 1T cell lymphoma invasion and metastasis 1human T-lymphoma invasion and metastasis inducing TIAM1 protein | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| TIAM1 | GO:0008284 | positive regulation of cell proliferation | 25032858 |
| TIAM1 | GO:0010717 | regulation of epithelial to mesenchymal transition | 20826792 |
| TIAM1 | GO:0030335 | positive regulation of cell migration | 25032858 |
| TIAM1 | GO:0032092 | positive regulation of protein binding | 23109420 |
| TIAM1 | GO:0034622 | cellular protein-containing complex assembly | 23109420 |
| TIAM1 | GO:0090630 | activation of GTPase activity | 23109420 |
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Gene structures and expression levels for TIAM1 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000156299
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | DOWN | ENST00000423206.5 | TIAM1-202:protein_coding:TIAM1 | 3.699739e+02 | -2.027416e+00 | 1.568450e-13 | 3.267360e-11 |
| CB | UP | ENST00000541036.5 | TIAM1-206:protein_coding:TIAM1 | 1.198918e+03 | 1.628221e+00 | 1.231625e-11 | 1.164414e-09 |
| TC | DOWN | ENST00000423206.5 | TIAM1-202:protein_coding:TIAM1 | 9.744050e+01 | -8.301675e-01 | 5.300013e-06 | 1.561062e-04 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for TIAM1 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_11748 | chr21 | 31164962:31165065:31182421:31182645:31187001:31187087 | 31182421:31182645 |
| exon_skip_138172 | chr21 | 31146895:31147003:31152636:31152761:31153066:31153134 | 31152636:31152761 |
| exon_skip_15443 | chr21 | 31266814:31266983:31276732:31276908:31339243:31339422 | 31276732:31276908 |
| exon_skip_172298 | chr21 | 31210045:31210215:31213398:31213472:31217553:31217699 | 31213398:31213472 |
| exon_skip_188697 | chr21 | 31213398:31213472:31217553:31217699:31223406:31223591 | 31217553:31217699 |
| exon_skip_192433 | chr21 | 31195224:31195305:31202908:31203012:31210045:31210213 | 31202908:31203012 |
| exon_skip_20505 | chr21 | 31266296:31266983:31276732:31276908:31339243:31339422 | 31276732:31276908 |
| exon_skip_210255 | chr21 | 31154247:31154426:31164962:31165065:31182421:31182645 | 31164962:31165065 |
| exon_skip_216928 | chr21 | 31225726:31225950:31245488:31245660:31251742:31252189 | 31245488:31245660 |
| exon_skip_226448 | chr21 | 31225726:31225950:31245488:31245660:31251742:31252176 | 31245488:31245660 |
| exon_skip_230483 | chr21 | 31118458:31120837:31124522:31124694:31127065:31127152 | 31124522:31124694 |
| exon_skip_236650 | chr21 | 31141325:31141504:31146895:31147003:31152636:31152761 | 31146895:31147003 |
| exon_skip_246530 | chr21 | 31124681:31124694:31127065:31127152:31130213:31130221 | 31127065:31127152 |
| exon_skip_268464 | chr21 | 31339243:31339422:31463983:31464035:31558927:31558977 | 31463983:31464035 |
| exon_skip_280636 | chr21 | 31182421:31182645:31187001:31187087:31195224:31195305 | 31187001:31187087 |
| exon_skip_284919 | chr21 | 31130213:31130315:31130890:31130948:31135933:31136041 | 31130890:31130948 |
| exon_skip_38587 | chr21 | 31141118:31141236:31141325:31141504:31146895:31147003 | 31141325:31141504 |
| exon_skip_52833 | chr21 | 31276732:31276908:31339243:31339422:31463983:31464035 | 31339243:31339422 |
| exon_skip_87544 | chr21 | 31251742:31252189:31266010:31266983:31276732:31276908 | 31266010:31266983 |
| exon_skip_96470 | chr21 | 31195224:31195305:31202908:31203012:31210045:31210215 | 31202908:31203012 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for TIAM1 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000286827 | 31276732 | 31276908 | 3UTR-3UTR |
| ENST00000286827 | 31146895 | 31147003 | Frame-shift |
| ENST00000286827 | 31152636 | 31152761 | In-frame |
| ENST00000286827 | 31202908 | 31203012 | In-frame |
| ENST00000286827 | 31213398 | 31213472 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000286827 | 31276732 | 31276908 | 3UTR-3UTR |
| ENST00000286827 | 31146895 | 31147003 | Frame-shift |
| ENST00000286827 | 31202908 | 31203012 | In-frame |
| ENST00000286827 | 31213398 | 31213472 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000286827 | 31266010 | 31266983 | 3UTR-3CDS |
| ENST00000286827 | 31276732 | 31276908 | 3UTR-3UTR |
| ENST00000286827 | 31339243 | 31339422 | 3UTR-3UTR |
| ENST00000286827 | 31124522 | 31124694 | Frame-shift |
| ENST00000286827 | 31127065 | 31127152 | Frame-shift |
| ENST00000286827 | 31130890 | 31130948 | Frame-shift |
| ENST00000286827 | 31146895 | 31147003 | Frame-shift |
| ENST00000286827 | 31164962 | 31165065 | Frame-shift |
| ENST00000286827 | 31245488 | 31245660 | Frame-shift |
| ENST00000286827 | 31141325 | 31141504 | In-frame |
| ENST00000286827 | 31152636 | 31152761 | In-frame |
| ENST00000286827 | 31182421 | 31182645 | In-frame |
| ENST00000286827 | 31187001 | 31187087 | In-frame |
| ENST00000286827 | 31202908 | 31203012 | In-frame |
| ENST00000286827 | 31213398 | 31213472 | In-frame |
| ENST00000286827 | 31217553 | 31217699 | In-frame |
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Infer the effects of exon skipping event on protein functional features for TIAM1 |
p-ENSG00000156299_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000286827 | 7217 | 1591 | 31213398 | 31213472 | 2615 | 2688 | 714 | 738 |
| ENST00000286827 | 7217 | 1591 | 31202908 | 31203012 | 2861 | 2964 | 796 | 830 |
| ENST00000286827 | 7217 | 1591 | 31152636 | 31152761 | 3713 | 3837 | 1080 | 1121 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000286827 | 7217 | 1591 | 31213398 | 31213472 | 2615 | 2688 | 714 | 738 |
| ENST00000286827 | 7217 | 1591 | 31202908 | 31203012 | 2861 | 2964 | 796 | 830 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000286827 | 7217 | 1591 | 31217553 | 31217699 | 2468 | 2613 | 665 | 713 |
| ENST00000286827 | 7217 | 1591 | 31213398 | 31213472 | 2615 | 2688 | 714 | 738 |
| ENST00000286827 | 7217 | 1591 | 31202908 | 31203012 | 2861 | 2964 | 796 | 830 |
| ENST00000286827 | 7217 | 1591 | 31187001 | 31187087 | 3048 | 3133 | 858 | 887 |
| ENST00000286827 | 7217 | 1591 | 31182421 | 31182645 | 3135 | 3358 | 887 | 962 |
| ENST00000286827 | 7217 | 1591 | 31152636 | 31152761 | 3713 | 3837 | 1080 | 1121 |
| ENST00000286827 | 7217 | 1591 | 31141325 | 31141504 | 3948 | 4126 | 1158 | 1218 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q13009 | 714 | 738 | 715 | 739 | Alternative sequence | ID=VSP_055865;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| Q13009 | 714 | 738 | 2 | 1591 | Chain | ID=PRO_0000080976;Note=T-lymphoma invasion and metastasis-inducing protein 1 |
| Q13009 | 796 | 830 | 797 | 831 | Alternative sequence | ID=VSP_055866;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| Q13009 | 796 | 830 | 2 | 1591 | Chain | ID=PRO_0000080976;Note=T-lymphoma invasion and metastasis-inducing protein 1 |
| Q13009 | 796 | 830 | 765 | 832 | Domain | Note=RBD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00262 |
| Q13009 | 796 | 830 | 829 | 829 | Modified residue | Note=Phosphotyrosine%3B by NTRK2;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q60610 |
| Q13009 | 1080 | 1121 | 2 | 1591 | Chain | ID=PRO_0000080976;Note=T-lymphoma invasion and metastasis-inducing protein 1 |
| Q13009 | 1080 | 1121 | 1040 | 1234 | Domain | Note=DH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00062 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q13009 | 714 | 738 | 715 | 739 | Alternative sequence | ID=VSP_055865;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| Q13009 | 714 | 738 | 2 | 1591 | Chain | ID=PRO_0000080976;Note=T-lymphoma invasion and metastasis-inducing protein 1 |
| Q13009 | 796 | 830 | 797 | 831 | Alternative sequence | ID=VSP_055866;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| Q13009 | 796 | 830 | 2 | 1591 | Chain | ID=PRO_0000080976;Note=T-lymphoma invasion and metastasis-inducing protein 1 |
| Q13009 | 796 | 830 | 765 | 832 | Domain | Note=RBD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00262 |
| Q13009 | 796 | 830 | 829 | 829 | Modified residue | Note=Phosphotyrosine%3B by NTRK2;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q60610 |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q13009 | 665 | 713 | 2 | 1591 | Chain | ID=PRO_0000080976;Note=T-lymphoma invasion and metastasis-inducing protein 1 |
| Q13009 | 665 | 713 | 659 | 667 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4K2P |
| Q13009 | 665 | 713 | 695 | 695 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q60610 |
| Q13009 | 665 | 713 | 678 | 678 | Natural variant | ID=VAR_035977;Note=In a colorectal cancer sample%3B somatic mutation. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974 |
| Q13009 | 714 | 738 | 715 | 739 | Alternative sequence | ID=VSP_055865;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| Q13009 | 714 | 738 | 2 | 1591 | Chain | ID=PRO_0000080976;Note=T-lymphoma invasion and metastasis-inducing protein 1 |
| Q13009 | 796 | 830 | 797 | 831 | Alternative sequence | ID=VSP_055866;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| Q13009 | 796 | 830 | 2 | 1591 | Chain | ID=PRO_0000080976;Note=T-lymphoma invasion and metastasis-inducing protein 1 |
| Q13009 | 796 | 830 | 765 | 832 | Domain | Note=RBD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00262 |
| Q13009 | 796 | 830 | 829 | 829 | Modified residue | Note=Phosphotyrosine%3B by NTRK2;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q60610 |
| Q13009 | 858 | 887 | 859 | 865 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KZD |
| Q13009 | 858 | 887 | 867 | 870 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KZD |
| Q13009 | 858 | 887 | 872 | 878 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KZD |
| Q13009 | 858 | 887 | 2 | 1591 | Chain | ID=PRO_0000080976;Note=T-lymphoma invasion and metastasis-inducing protein 1 |
| Q13009 | 858 | 887 | 845 | 908 | Domain | Note=PDZ;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00143 |
| Q13009 | 858 | 887 | 883 | 886 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KZD |
| Q13009 | 858 | 887 | 879 | 879 | Mutagenesis | Note=Strongly reduces affinity for SDC1. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23395182;Dbxref=PMID:23395182 |
| Q13009 | 858 | 887 | 881 | 881 | Sequence conflict | Note=T->I;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q13009 | 858 | 887 | 855 | 858 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KZE |
| Q13009 | 887 | 962 | 894 | 898 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KZD |
| Q13009 | 887 | 962 | 917 | 926 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KZD |
| Q13009 | 887 | 962 | 2 | 1591 | Chain | ID=PRO_0000080976;Note=T-lymphoma invasion and metastasis-inducing protein 1 |
| Q13009 | 887 | 962 | 845 | 908 | Domain | Note=PDZ;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00143 |
| Q13009 | 887 | 962 | 903 | 905 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KZD |
| Q13009 | 887 | 962 | 908 | 916 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KZD |
| Q13009 | 887 | 962 | 912 | 912 | Mutagenesis | Note=Strongly reduces affinity for SDC1. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23395182;Dbxref=PMID:23395182 |
| Q13009 | 887 | 962 | 951 | 951 | Sequence conflict | Note=G->D;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q13009 | 1080 | 1121 | 2 | 1591 | Chain | ID=PRO_0000080976;Note=T-lymphoma invasion and metastasis-inducing protein 1 |
| Q13009 | 1080 | 1121 | 1040 | 1234 | Domain | Note=DH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00062 |
| Q13009 | 1158 | 1218 | 2 | 1591 | Chain | ID=PRO_0000080976;Note=T-lymphoma invasion and metastasis-inducing protein 1 |
| Q13009 | 1158 | 1218 | 1040 | 1234 | Domain | Note=DH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00062 |
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3'-UTR located exon skipping events that lost miRNA binding sites in TIAM1 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
| Mayo | ENST00000286827 | 31276732 | 31276908 | hsa-miR-190b-3p | chr21:31276783-31276790 | 8mer-1a | chr21:31276769-31276791 | 164.00 | -17.81 |
| Mayo | ENST00000286827 | 31339243 | 31339422 | hsa-miR-5187-3p | chr21:31339326-31339333 | 8mer-1a | chr21:31339314-31339333 | 161.00 | -20.05 |
| Mayo | ENST00000286827 | 31276732 | 31276908 | hsa-miR-3620-5p | chr21:31276754-31276761 | 8mer-1a | chr21:31276744-31276764 | 165.00 | -24.46 |
| Mayo | ENST00000286827 | 31339243 | 31339422 | hsa-miR-4683 | chr21:31339272-31339279 | 8mer-1a | chr21:31339257-31339280 | 162.00 | -19.00 |
| Mayo | ENST00000286827 | 31276732 | 31276908 | hsa-miR-4687-3p | chr21:31276819-31276826 | 8mer-1a | chr21:31276808-31276829 | 166.00 | -24.95 |
| Mayo | ENST00000286827 | 31276732 | 31276908 | hsa-miR-4492 | chr21:31276753-31276760 | 8mer-1a | chr21:31276744-31276764 | 165.00 | -24.46 |
| Mayo | ENST00000286827 | 31339243 | 31339422 | hsa-miR-620 | chr21:31339273-31339280 | 8mer-1a | chr21:31339257-31339280 | 162.00 | -19.00 |
| Mayo | ENST00000286827 | 31276732 | 31276908 | hsa-miR-4498 | chr21:31276753-31276760 | 8mer-1a | chr21:31276744-31276764 | 165.00 | -24.46 |
| Mayo | ENST00000286827 | 31276732 | 31276908 | hsa-miR-432-5p | chr21:31276766-31276773 | 8mer-1a | chr21:31276754-31276773 | 161.00 | -27.79 |
| Mayo | ENST00000286827 | 31276732 | 31276908 | hsa-miR-762 | chr21:31276753-31276760 | 8mer-1a | chr21:31276744-31276764 | 165.00 | -24.46 |
| Mayo | ENST00000286827 | 31276732 | 31276908 | hsa-miR-4738-3p | chr21:31276873-31276880 | 8mer-1a | chr21:31276869-31276891 | 152.00 | -19.80 |
| Mayo | ENST00000286827 | 31339243 | 31339422 | hsa-miR-4740-5p | chr21:31339403-31339410 | 8mer-1a | chr21:31339392-31339414 | 158.00 | -24.97 |
| Mayo | ENST00000286827 | 31339243 | 31339422 | hsa-miR-7153-3p | chr21:31339343-31339350 | 8mer-1a | chr21:31339332-31339354 | 170.00 | -21.63 |
| Mayo | ENST00000286827 | 31339243 | 31339422 | hsa-miR-1270 | chr21:31339273-31339280 | 8mer-1a | chr21:31339257-31339280 | 162.00 | -19.00 |
| Mayo | ENST00000286827 | 31276732 | 31276908 | hsa-miR-5001-5p | chr21:31276753-31276760 | 8mer-1a | chr21:31276744-31276764 | 165.00 | -24.46 |
| Mayo | ENST00000286827 | 31276732 | 31276908 | hsa-miR-4442 | chr21:31276809-31276816 | 8mer-1a | chr21:31276808-31276829 | 166.00 | -24.95 |
| Mayo | ENST00000286827 | 31339243 | 31339422 | hsa-miR-1263 | chr21:31339347-31339354 | 8mer-1a | chr21:31339332-31339354 | 170.00 | -21.63 |
| Mayo | ENST00000286827 | 31339243 | 31339422 | hsa-miR-3945 | chr21:31339338-31339345 | 8mer-1a | chr21:31339332-31339354 | 170.00 | -21.63 |
| Mayo | ENST00000286827 | 31339243 | 31339422 | hsa-miR-12125 | chr21:31339314-31339321 | 8mer-1a | chr21:31339298-31339321 | 167.00 | -25.28 |
| Mayo | ENST00000286827 | 31276732 | 31276908 | hsa-miR-3144-5p | chr21:31276748-31276755 | 8mer-1a | chr21:31276738-31276758 | 162.00 | -29.36 |
| Mayo | ENST00000286827 | 31339243 | 31339422 | hsa-miR-12131 | chr21:31339274-31339281 | 8mer-1a | chr21:31339262-31339281 | 143.00 | -13.14 |
| Mayo | ENST00000286827 | 31276732 | 31276908 | hsa-miR-1587 | chr21:31276754-31276761 | 8mer-1a | chr21:31276744-31276764 | 165.00 | -24.46 |
| MSBB | ENST00000286827 | 31276732 | 31276908 | hsa-miR-190b-3p | chr21:31276783-31276790 | 8mer-1a | chr21:31276769-31276791 | 164.00 | -17.81 |
| MSBB | ENST00000286827 | 31276732 | 31276908 | hsa-miR-3620-5p | chr21:31276754-31276761 | 8mer-1a | chr21:31276744-31276764 | 165.00 | -24.46 |
| MSBB | ENST00000286827 | 31276732 | 31276908 | hsa-miR-4687-3p | chr21:31276819-31276826 | 8mer-1a | chr21:31276808-31276829 | 166.00 | -24.95 |
| MSBB | ENST00000286827 | 31276732 | 31276908 | hsa-miR-4492 | chr21:31276753-31276760 | 8mer-1a | chr21:31276744-31276764 | 165.00 | -24.46 |
| MSBB | ENST00000286827 | 31276732 | 31276908 | hsa-miR-4498 | chr21:31276753-31276760 | 8mer-1a | chr21:31276744-31276764 | 165.00 | -24.46 |
| MSBB | ENST00000286827 | 31276732 | 31276908 | hsa-miR-432-5p | chr21:31276766-31276773 | 8mer-1a | chr21:31276754-31276773 | 161.00 | -27.79 |
| MSBB | ENST00000286827 | 31276732 | 31276908 | hsa-miR-762 | chr21:31276753-31276760 | 8mer-1a | chr21:31276744-31276764 | 165.00 | -24.46 |
| MSBB | ENST00000286827 | 31276732 | 31276908 | hsa-miR-4738-3p | chr21:31276873-31276880 | 8mer-1a | chr21:31276869-31276891 | 152.00 | -19.80 |
| MSBB | ENST00000286827 | 31276732 | 31276908 | hsa-miR-5001-5p | chr21:31276753-31276760 | 8mer-1a | chr21:31276744-31276764 | 165.00 | -24.46 |
| MSBB | ENST00000286827 | 31276732 | 31276908 | hsa-miR-4442 | chr21:31276809-31276816 | 8mer-1a | chr21:31276808-31276829 | 166.00 | -24.95 |
| MSBB | ENST00000286827 | 31276732 | 31276908 | hsa-miR-3144-5p | chr21:31276748-31276755 | 8mer-1a | chr21:31276738-31276758 | 162.00 | -29.36 |
| MSBB | ENST00000286827 | 31276732 | 31276908 | hsa-miR-1587 | chr21:31276754-31276761 | 8mer-1a | chr21:31276744-31276764 | 165.00 | -24.46 |
| ROSMAP | ENST00000286827 | 31276732 | 31276908 | hsa-miR-190b-3p | chr21:31276783-31276790 | 8mer-1a | chr21:31276769-31276791 | 164.00 | -17.81 |
| ROSMAP | ENST00000286827 | 31276732 | 31276908 | hsa-miR-3620-5p | chr21:31276754-31276761 | 8mer-1a | chr21:31276744-31276764 | 165.00 | -24.46 |
| ROSMAP | ENST00000286827 | 31276732 | 31276908 | hsa-miR-4687-3p | chr21:31276819-31276826 | 8mer-1a | chr21:31276808-31276829 | 166.00 | -24.95 |
| ROSMAP | ENST00000286827 | 31276732 | 31276908 | hsa-miR-4492 | chr21:31276753-31276760 | 8mer-1a | chr21:31276744-31276764 | 165.00 | -24.46 |
| ROSMAP | ENST00000286827 | 31276732 | 31276908 | hsa-miR-4498 | chr21:31276753-31276760 | 8mer-1a | chr21:31276744-31276764 | 165.00 | -24.46 |
| ROSMAP | ENST00000286827 | 31276732 | 31276908 | hsa-miR-432-5p | chr21:31276766-31276773 | 8mer-1a | chr21:31276754-31276773 | 161.00 | -27.79 |
| ROSMAP | ENST00000286827 | 31276732 | 31276908 | hsa-miR-762 | chr21:31276753-31276760 | 8mer-1a | chr21:31276744-31276764 | 165.00 | -24.46 |
| ROSMAP | ENST00000286827 | 31276732 | 31276908 | hsa-miR-4738-3p | chr21:31276873-31276880 | 8mer-1a | chr21:31276869-31276891 | 152.00 | -19.80 |
| ROSMAP | ENST00000286827 | 31276732 | 31276908 | hsa-miR-5001-5p | chr21:31276753-31276760 | 8mer-1a | chr21:31276744-31276764 | 165.00 | -24.46 |
| ROSMAP | ENST00000286827 | 31276732 | 31276908 | hsa-miR-4442 | chr21:31276809-31276816 | 8mer-1a | chr21:31276808-31276829 | 166.00 | -24.95 |
| ROSMAP | ENST00000286827 | 31276732 | 31276908 | hsa-miR-3144-5p | chr21:31276748-31276755 | 8mer-1a | chr21:31276738-31276758 | 162.00 | -29.36 |
| ROSMAP | ENST00000286827 | 31276732 | 31276908 | hsa-miR-1587 | chr21:31276754-31276761 | 8mer-1a | chr21:31276744-31276764 | 165.00 | -24.46 |
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SNVs in the skipped exons for TIAM1 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for TIAM1 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TIAM1 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for TIAM1 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | NUP42 | exon_skip_172298 | 5.125327e-01 | 6.788868e-12 |
| CB | RBM4 | exon_skip_268464 | -4.763495e-01 | 8.225210e-10 |
| IFG | PABPC3 | exon_skip_96470 | 6.112573e-01 | 5.491616e-04 |
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RelatedDrugs for TIAM1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TIAM1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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