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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for TEAD1 |
 Gene summary |
| Gene information | Gene symbol | TEAD1 | Gene ID | 7003 |
| Gene name | TEA domain transcription factor 1 | |
| Synonyms | AA|NTEF-1|REF1|TCF-13|TCF13|TEAD-1|TEF-1 | |
| Cytomap | 11p15.3 | |
| Type of gene | protein-coding | |
| Description | transcriptional enhancer factor TEF-1TEA domain family member 1 (SV40 transcriptional enhancer factor)protein GT-IICtranscription factor 13transcriptional enhancer factor 1 | |
| Modification date | 20200329 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| TEAD1 | GO:0035329 | hippo signaling | 18579750|19324877 |
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Gene structures and expression levels for TEAD1 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000187079
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | UP | ENST00000527376.1 | TEAD1-204:protein_coding:TEAD1 | 4.823824e+00 | 8.566382e-01 | 5.758826e-06 | 6.605984e-05 |
| TC | UP | ENST00000334310.10 | TEAD1-201:protein_coding:TEAD1 | 6.339030e+00 | 9.118296e-01 | 1.095197e-05 | 2.780229e-04 |
| TC | UP | ENST00000526600.1 | TEAD1-203:protein_coding:TEAD1 | 4.561291e+02 | 8.914200e-01 | 5.493937e-03 | 3.596631e-02 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for TEAD1 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_1021 | chr11 | 12862250:12862314:12864838:12864900:12878889:12878900 | 12864838:12864900 |
| exon_skip_133402 | chr11 | 12883001:12883125:12901940:12902113:12924912:12925052 | 12901940:12902113 |
| exon_skip_166541 | chr11 | 12864838:12864900:12878889:12878900:12879708:12879842 | 12878889:12878900 |
| exon_skip_33068 | chr11 | 12901940:12902113:12924912:12925052:12930174:12930326 | 12924912:12925052 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for TEAD1 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000638666 | 12901940 | 12902113 | In-frame |
| ENST00000638666 | 12924912 | 12925052 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000638666 | 12901940 | 12902113 | In-frame |
| ENST00000638666 | 12924912 | 12925052 | In-frame |
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Infer the effects of exon skipping event on protein functional features for TEAD1 |
p-ENSG00000187079_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000638666 | 1298 | 426 | 12901940 | 12902113 | 701 | 873 | 233 | 291 |
| ENST00000638666 | 1298 | 426 | 12924912 | 12925052 | 875 | 1014 | 291 | 338 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000638666 | 1298 | 426 | 12901940 | 12902113 | 701 | 873 | 233 | 291 |
| ENST00000638666 | 1298 | 426 | 12924912 | 12925052 | 875 | 1014 | 291 | 338 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P28347 | 233 | 291 | 234 | 291 | Alternative sequence | ID=VSP_056277;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| P28347 | 233 | 291 | 233 | 242 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RE1 |
| P28347 | 233 | 291 | 256 | 258 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RE1 |
| P28347 | 233 | 291 | 285 | 292 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RE1 |
| P28347 | 233 | 291 | 1 | 426 | Chain | ID=PRO_0000205930;Note=Transcriptional enhancer factor TEF-1 |
| P28347 | 233 | 291 | 259 | 261 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RE1 |
| P28347 | 233 | 291 | 263 | 265 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RE1 |
| P28347 | 233 | 291 | 273 | 279 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RE1 |
| P28347 | 233 | 291 | 282 | 284 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RE1 |
| P28347 | 233 | 291 | 167 | 426 | Region | Note=Transcriptional activation;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P28347 | 291 | 338 | 234 | 291 | Alternative sequence | ID=VSP_056277;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| P28347 | 291 | 338 | 285 | 292 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RE1 |
| P28347 | 291 | 338 | 304 | 316 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RE1 |
| P28347 | 291 | 338 | 319 | 328 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RE1 |
| P28347 | 291 | 338 | 331 | 341 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RE1 |
| P28347 | 291 | 338 | 1 | 426 | Chain | ID=PRO_0000205930;Note=Transcriptional enhancer factor TEF-1 |
| P28347 | 291 | 338 | 306 | 328 | Compositional bias | Note=Ser/Thr/Tyr-rich |
| P28347 | 291 | 338 | 167 | 426 | Region | Note=Transcriptional activation;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P28347 | 233 | 291 | 234 | 291 | Alternative sequence | ID=VSP_056277;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| P28347 | 233 | 291 | 233 | 242 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RE1 |
| P28347 | 233 | 291 | 256 | 258 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RE1 |
| P28347 | 233 | 291 | 285 | 292 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RE1 |
| P28347 | 233 | 291 | 1 | 426 | Chain | ID=PRO_0000205930;Note=Transcriptional enhancer factor TEF-1 |
| P28347 | 233 | 291 | 259 | 261 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RE1 |
| P28347 | 233 | 291 | 263 | 265 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RE1 |
| P28347 | 233 | 291 | 273 | 279 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RE1 |
| P28347 | 233 | 291 | 282 | 284 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RE1 |
| P28347 | 233 | 291 | 167 | 426 | Region | Note=Transcriptional activation;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P28347 | 291 | 338 | 234 | 291 | Alternative sequence | ID=VSP_056277;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| P28347 | 291 | 338 | 285 | 292 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RE1 |
| P28347 | 291 | 338 | 304 | 316 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RE1 |
| P28347 | 291 | 338 | 319 | 328 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RE1 |
| P28347 | 291 | 338 | 331 | 341 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RE1 |
| P28347 | 291 | 338 | 1 | 426 | Chain | ID=PRO_0000205930;Note=Transcriptional enhancer factor TEF-1 |
| P28347 | 291 | 338 | 306 | 328 | Compositional bias | Note=Ser/Thr/Tyr-rich |
| P28347 | 291 | 338 | 167 | 426 | Region | Note=Transcriptional activation;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
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3'-UTR located exon skipping events that lost miRNA binding sites in TEAD1 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for TEAD1 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for TEAD1 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TEAD1 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for TEAD1 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for TEAD1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TEAD1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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