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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for TBX3 |
 Gene summary |
| Gene information | Gene symbol | TBX3 | Gene ID | 6926 |
| Gene name | T-box transcription factor 3 | |
| Synonyms | TBX3-ISO|UMS|XHL | |
| Cytomap | 12q24.21 | |
| Type of gene | protein-coding | |
| Description | T-box transcription factor TBX3T-box 3T-box protein 3bladder cancer related protein XHL | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| TBX3 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 11689487 |
| TBX3 | GO:0007569 | cell aging | 11689487|11748239 |
| TBX3 | GO:0008284 | positive regulation of cell proliferation | 11689487|11748239|12032820 |
| TBX3 | GO:0009887 | animal organ morphogenesis | 9207801 |
| TBX3 | GO:0035136 | forelimb morphogenesis | 9207801 |
| TBX3 | GO:0043066 | negative regulation of apoptotic process | 12032820 |
| TBX3 | GO:0045662 | negative regulation of myoblast differentiation | 12032820 |
| TBX3 | GO:0045787 | positive regulation of cell cycle | 12032820 |
| TBX3 | GO:0045892 | negative regulation of transcription, DNA-templated | 10468588|11689487 |
| TBX3 | GO:0090398 | cellular senescence | 22002537 |
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Gene structures and expression levels for TBX3 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000135111
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| STG | UP | 6.608832e+01 | 9.949758e-01 | 2.873820e-05 | 3.057961e-03 |
| PG | UP | 8.399917e+01 | 9.249873e-01 | 3.380708e-07 | 9.909825e-06 |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| PCC | UP | ENST00000552054.1 | TBX3-204:retained_intron:TBX3 | 8.544198e+00 | 8.004483e-01 | 1.594761e-04 | 8.063797e-03 |
| STG | UP | ENST00000349155.7 | TBX3-202:protein_coding:TBX3 | 4.952239e+01 | 8.796592e-01 | 5.193220e-04 | 2.755768e-02 |
| PG | UP | ENST00000349155.7 | TBX3-202:protein_coding:TBX3 | 6.571750e+01 | 1.054141e+00 | 1.173942e-06 | 1.000019e-04 |
| TC | UP | ENST00000552054.1 | TBX3-204:retained_intron:TBX3 | 1.343524e+01 | 8.021503e-01 | 9.834498e-05 | 1.591335e-03 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for TBX3 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_45012 | chr12 | 114679505:114679651:114679913:114679972:114680879:114681146 | 114679913:114679972 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |