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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for ELOC |
 Gene summary |
| Gene information | Gene symbol | ELOC | Gene ID | 6921 |
| Gene name | elongin C | |
| Synonyms | SIII|TCEB1 | |
| Cytomap | 8q21.11 | |
| Type of gene | protein-coding | |
| Description | elongin-CRNA polymerase II transcription factor SIII subunit CSIII p15elongin 15 kDa subunittranscription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)transcription elongation factor B polypeptide 1transcription elongation factor B su | |
| Modification date | 20200327 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for ELOC |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000154582
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for ELOC |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
 |
| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_126999 | chr8 | 73955911:73956054:73959765:73959818:73972042:73972106 | 73959765:73959818 |
| exon_skip_156012 | chr8 | 73955911:73956054:73959765:73959818:73972077:73972170 | 73959765:73959818 |
| exon_skip_159610 | chr8 | 73959765:73959818:73970579:73970634:73971870:73971908 | 73970579:73970634 |
| exon_skip_181431 | chr8 | 73959765:73959818:73964487:73964625:73970579:73970603 | 73964487:73964625 |
| exon_skip_189855 | chr8 | 73964487:73964625:73970579:73970634:73971870:73971908 | 73970579:73970634 |
| exon_skip_220042 | chr8 | 73959765:73959818:73969560:73969673:73972077:73972170 | 73969560:73969673 |
| exon_skip_225499 | chr8 | 73946700:73946820:73955911:73956054:73959765:73959818 | 73955911:73956054 |
| exon_skip_227733 | chr8 | 73959765:73959818:73964487:73964625:73972077:73972170 | 73964487:73964625 |
| exon_skip_227882 | chr8 | 73959766:73959818:73964487:73964625:73972077:73972170 | 73964487:73964625 |
| exon_skip_239965 | chr8 | 73955911:73956054:73959765:73959818:73964487:73964625 | 73959765:73959818 |
| exon_skip_244825 | chr8 | 73959765:73959818:73964487:73964625:73970579:73970634 | 73964487:73964625 |
| exon_skip_249841 | chr8 | 73955911:73956054:73959765:73959818:73969560:73969673 | 73959765:73959818 |
| exon_skip_272887 | chr8 | 73955911:73956054:73959765:73959818:73972245:73972287 | 73959765:73959818 |
| exon_skip_46650 | chr8 | 73959766:73959818:73964487:73964625:73970579:73970634 | 73964487:73964625 |
| exon_skip_59517 | chr8 | 73955911:73956054:73959765:73959818:73970579:73970634 | 73959765:73959818 |
| exon_skip_61852 | chr8 | 73959765:73959818:73964487:73964625:73970579:73970631 | 73964487:73964625 |
| exon_skip_65103 | chr8 | 73959765:73959818:73969560:73969673:73972077:73972232 | 73969560:73969673 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for ELOC |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000284811 | 73959765 | 73959818 | 3UTR-3CDS |
| ENST00000518127 | 73959765 | 73959818 | 3UTR-3CDS |
| ENST00000519487 | 73959765 | 73959818 | 3UTR-3CDS |
| ENST00000520242 | 73959765 | 73959818 | 3UTR-3CDS |
| ENST00000522337 | 73959765 | 73959818 | 3UTR-3CDS |
| ENST00000523815 | 73959765 | 73959818 | 3UTR-3CDS |
| ENST00000622804 | 73959765 | 73959818 | 3UTR-3CDS |
| ENST00000523815 | 73964487 | 73964625 | 3UTR-3UTR |
| ENST00000522337 | 73969560 | 73969673 | 3UTR-3UTR |
| ENST00000523815 | 73970579 | 73970634 | 3UTR-3UTR |
| ENST00000622804 | 73970579 | 73970634 | 3UTR-3UTR |
| ENST00000284811 | 73955911 | 73956054 | In-frame |
| ENST00000518127 | 73955911 | 73956054 | In-frame |
| ENST00000519487 | 73955911 | 73956054 | In-frame |
| ENST00000520242 | 73955911 | 73956054 | In-frame |
| ENST00000522337 | 73955911 | 73956054 | In-frame |
| ENST00000523815 | 73955911 | 73956054 | In-frame |
| ENST00000622804 | 73955911 | 73956054 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000518127 | 73959765 | 73959818 | 3UTR-3CDS |
| ENST00000520242 | 73959765 | 73959818 | 3UTR-3CDS |
| ENST00000523815 | 73959765 | 73959818 | 3UTR-3CDS |
| ENST00000523815 | 73964487 | 73964625 | 3UTR-3UTR |
| ENST00000522337 | 73969560 | 73969673 | 3UTR-3UTR |
| ENST00000523815 | 73970579 | 73970634 | 3UTR-3UTR |
| ENST00000622804 | 73970579 | 73970634 | 3UTR-3UTR |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000284811 | 73959765 | 73959818 | 3UTR-3CDS |
| ENST00000518127 | 73959765 | 73959818 | 3UTR-3CDS |
| ENST00000520242 | 73959765 | 73959818 | 3UTR-3CDS |
| ENST00000522337 | 73959765 | 73959818 | 3UTR-3CDS |
| ENST00000523815 | 73959765 | 73959818 | 3UTR-3CDS |
| ENST00000523815 | 73964487 | 73964625 | 3UTR-3UTR |
| ENST00000523815 | 73970579 | 73970634 | 3UTR-3UTR |
| ENST00000622804 | 73970579 | 73970634 | 3UTR-3UTR |
| ENST00000284811 | 73955911 | 73956054 | In-frame |
| ENST00000518127 | 73955911 | 73956054 | In-frame |
| ENST00000519487 | 73955911 | 73956054 | In-frame |
| ENST00000520242 | 73955911 | 73956054 | In-frame |
| ENST00000522337 | 73955911 | 73956054 | In-frame |
| ENST00000523815 | 73955911 | 73956054 | In-frame |
| ENST00000622804 | 73955911 | 73956054 | In-frame |
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Infer the effects of exon skipping event on protein functional features for ELOC |
p-ENSG00000154582_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000284811 | 700 | 112 | 73955911 | 73956054 | 120 | 262 | 1 | 49 |
| ENST00000518127 | 1960 | 112 | 73955911 | 73956054 | 98 | 240 | 1 | 49 |
| ENST00000519487 | 831 | 112 | 73955911 | 73956054 | 114 | 256 | 1 | 49 |
| ENST00000520242 | 1590 | 112 | 73955911 | 73956054 | 226 | 368 | 1 | 49 |
| ENST00000522337 | 833 | 112 | 73955911 | 73956054 | 325 | 467 | 1 | 49 |
| ENST00000523815 | 736 | 112 | 73955911 | 73956054 | 289 | 431 | 1 | 49 |
| ENST00000622804 | 1993 | 112 | 73955911 | 73956054 | 150 | 292 | 1 | 49 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000284811 | 700 | 112 | 73955911 | 73956054 | 120 | 262 | 1 | 49 |
| ENST00000518127 | 1960 | 112 | 73955911 | 73956054 | 98 | 240 | 1 | 49 |
| ENST00000519487 | 831 | 112 | 73955911 | 73956054 | 114 | 256 | 1 | 49 |
| ENST00000520242 | 1590 | 112 | 73955911 | 73956054 | 226 | 368 | 1 | 49 |
| ENST00000522337 | 833 | 112 | 73955911 | 73956054 | 325 | 467 | 1 | 49 |
| ENST00000523815 | 736 | 112 | 73955911 | 73956054 | 289 | 431 | 1 | 49 |
| ENST00000622804 | 1993 | 112 | 73955911 | 73956054 | 150 | 292 | 1 | 49 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q15369 | 1 | 49 | 1 | 16 | Alternative sequence | ID=VSP_045955;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005 |
| Q15369 | 1 | 49 | 1 | 16 | Alternative sequence | ID=VSP_045955;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005 |
| Q15369 | 1 | 49 | 1 | 16 | Alternative sequence | ID=VSP_045955;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005 |
| Q15369 | 1 | 49 | 1 | 16 | Alternative sequence | ID=VSP_045955;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005 |
| Q15369 | 1 | 49 | 1 | 16 | Alternative sequence | ID=VSP_045955;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005 |
| Q15369 | 1 | 49 | 1 | 16 | Alternative sequence | ID=VSP_045955;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005 |
| Q15369 | 1 | 49 | 1 | 16 | Alternative sequence | ID=VSP_045955;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005 |
| Q15369 | 1 | 49 | 18 | 22 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AJY |
| Q15369 | 1 | 49 | 18 | 22 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AJY |
| Q15369 | 1 | 49 | 18 | 22 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AJY |
| Q15369 | 1 | 49 | 18 | 22 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AJY |
| Q15369 | 1 | 49 | 18 | 22 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AJY |
| Q15369 | 1 | 49 | 18 | 22 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AJY |
| Q15369 | 1 | 49 | 18 | 22 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AJY |
| Q15369 | 1 | 49 | 24 | 26 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZNG |
| Q15369 | 1 | 49 | 24 | 26 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZNG |
| Q15369 | 1 | 49 | 24 | 26 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZNG |
| Q15369 | 1 | 49 | 24 | 26 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZNG |
| Q15369 | 1 | 49 | 24 | 26 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZNG |
| Q15369 | 1 | 49 | 24 | 26 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZNG |
| Q15369 | 1 | 49 | 24 | 26 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZNG |
| Q15369 | 1 | 49 | 28 | 32 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AJY |
| Q15369 | 1 | 49 | 28 | 32 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AJY |
| Q15369 | 1 | 49 | 28 | 32 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AJY |
| Q15369 | 1 | 49 | 28 | 32 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AJY |
| Q15369 | 1 | 49 | 28 | 32 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AJY |
| Q15369 | 1 | 49 | 28 | 32 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AJY |
| Q15369 | 1 | 49 | 28 | 32 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AJY |
| Q15369 | 1 | 49 | 47 | 50 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2MA9 |
| Q15369 | 1 | 49 | 47 | 50 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2MA9 |
| Q15369 | 1 | 49 | 47 | 50 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2MA9 |
| Q15369 | 1 | 49 | 47 | 50 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2MA9 |
| Q15369 | 1 | 49 | 47 | 50 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2MA9 |
| Q15369 | 1 | 49 | 47 | 50 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2MA9 |
| Q15369 | 1 | 49 | 47 | 50 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2MA9 |
| Q15369 | 1 | 49 | 1 | 112 | Chain | ID=PRO_0000187258;Note=Elongin-C |
| Q15369 | 1 | 49 | 1 | 112 | Chain | ID=PRO_0000187258;Note=Elongin-C |
| Q15369 | 1 | 49 | 1 | 112 | Chain | ID=PRO_0000187258;Note=Elongin-C |
| Q15369 | 1 | 49 | 1 | 112 | Chain | ID=PRO_0000187258;Note=Elongin-C |
| Q15369 | 1 | 49 | 1 | 112 | Chain | ID=PRO_0000187258;Note=Elongin-C |
| Q15369 | 1 | 49 | 1 | 112 | Chain | ID=PRO_0000187258;Note=Elongin-C |
| Q15369 | 1 | 49 | 1 | 112 | Chain | ID=PRO_0000187258;Note=Elongin-C |
| Q15369 | 1 | 49 | 33 | 36 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AJY |
| Q15369 | 1 | 49 | 33 | 36 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AJY |
| Q15369 | 1 | 49 | 33 | 36 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AJY |
| Q15369 | 1 | 49 | 33 | 36 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AJY |
| Q15369 | 1 | 49 | 33 | 36 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AJY |
| Q15369 | 1 | 49 | 33 | 36 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AJY |
| Q15369 | 1 | 49 | 33 | 36 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AJY |
| Q15369 | 1 | 49 | 40 | 46 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AJY |
| Q15369 | 1 | 49 | 40 | 46 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AJY |
| Q15369 | 1 | 49 | 40 | 46 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AJY |
| Q15369 | 1 | 49 | 40 | 46 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AJY |
| Q15369 | 1 | 49 | 40 | 46 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AJY |
| Q15369 | 1 | 49 | 40 | 46 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AJY |
| Q15369 | 1 | 49 | 40 | 46 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AJY |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q15369 | 1 | 49 | 1 | 16 | Alternative sequence | ID=VSP_045955;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005 |
| Q15369 | 1 | 49 | 1 | 16 | Alternative sequence | ID=VSP_045955;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005 |
| Q15369 | 1 | 49 | 1 | 16 | Alternative sequence | ID=VSP_045955;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005 |
| Q15369 | 1 | 49 | 1 | 16 | Alternative sequence | ID=VSP_045955;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005 |
| Q15369 | 1 | 49 | 1 | 16 | Alternative sequence | ID=VSP_045955;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005 |
| Q15369 | 1 | 49 | 1 | 16 | Alternative sequence | ID=VSP_045955;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005 |
| Q15369 | 1 | 49 | 1 | 16 | Alternative sequence | ID=VSP_045955;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005 |
| Q15369 | 1 | 49 | 18 | 22 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AJY |
| Q15369 | 1 | 49 | 18 | 22 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AJY |
| Q15369 | 1 | 49 | 18 | 22 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AJY |
| Q15369 | 1 | 49 | 18 | 22 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AJY |
| Q15369 | 1 | 49 | 18 | 22 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AJY |
| Q15369 | 1 | 49 | 18 | 22 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AJY |
| Q15369 | 1 | 49 | 18 | 22 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AJY |
| Q15369 | 1 | 49 | 24 | 26 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZNG |
| Q15369 | 1 | 49 | 24 | 26 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZNG |
| Q15369 | 1 | 49 | 24 | 26 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZNG |
| Q15369 | 1 | 49 | 24 | 26 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZNG |
| Q15369 | 1 | 49 | 24 | 26 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZNG |
| Q15369 | 1 | 49 | 24 | 26 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZNG |
| Q15369 | 1 | 49 | 24 | 26 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ZNG |
| Q15369 | 1 | 49 | 28 | 32 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AJY |
| Q15369 | 1 | 49 | 28 | 32 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AJY |
| Q15369 | 1 | 49 | 28 | 32 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AJY |
| Q15369 | 1 | 49 | 28 | 32 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AJY |
| Q15369 | 1 | 49 | 28 | 32 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AJY |
| Q15369 | 1 | 49 | 28 | 32 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AJY |
| Q15369 | 1 | 49 | 28 | 32 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AJY |
| Q15369 | 1 | 49 | 47 | 50 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2MA9 |
| Q15369 | 1 | 49 | 47 | 50 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2MA9 |
| Q15369 | 1 | 49 | 47 | 50 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2MA9 |
| Q15369 | 1 | 49 | 47 | 50 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2MA9 |
| Q15369 | 1 | 49 | 47 | 50 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2MA9 |
| Q15369 | 1 | 49 | 47 | 50 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2MA9 |
| Q15369 | 1 | 49 | 47 | 50 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2MA9 |
| Q15369 | 1 | 49 | 1 | 112 | Chain | ID=PRO_0000187258;Note=Elongin-C |
| Q15369 | 1 | 49 | 1 | 112 | Chain | ID=PRO_0000187258;Note=Elongin-C |
| Q15369 | 1 | 49 | 1 | 112 | Chain | ID=PRO_0000187258;Note=Elongin-C |
| Q15369 | 1 | 49 | 1 | 112 | Chain | ID=PRO_0000187258;Note=Elongin-C |
| Q15369 | 1 | 49 | 1 | 112 | Chain | ID=PRO_0000187258;Note=Elongin-C |
| Q15369 | 1 | 49 | 1 | 112 | Chain | ID=PRO_0000187258;Note=Elongin-C |
| Q15369 | 1 | 49 | 1 | 112 | Chain | ID=PRO_0000187258;Note=Elongin-C |
| Q15369 | 1 | 49 | 33 | 36 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AJY |
| Q15369 | 1 | 49 | 33 | 36 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AJY |
| Q15369 | 1 | 49 | 33 | 36 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AJY |
| Q15369 | 1 | 49 | 33 | 36 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AJY |
| Q15369 | 1 | 49 | 33 | 36 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AJY |
| Q15369 | 1 | 49 | 33 | 36 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AJY |
| Q15369 | 1 | 49 | 33 | 36 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AJY |
| Q15369 | 1 | 49 | 40 | 46 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AJY |
| Q15369 | 1 | 49 | 40 | 46 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AJY |
| Q15369 | 1 | 49 | 40 | 46 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AJY |
| Q15369 | 1 | 49 | 40 | 46 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AJY |
| Q15369 | 1 | 49 | 40 | 46 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AJY |
| Q15369 | 1 | 49 | 40 | 46 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AJY |
| Q15369 | 1 | 49 | 40 | 46 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4AJY |
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3'-UTR located exon skipping events that lost miRNA binding sites in ELOC |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
| Mayo | ENST00000523815 | 73964487 | 73964625 | hsa-miR-186-3p | chr8:73964550-73964557 | 8mer-1a | chr8:73964541-73964562 | 148.00 | -24.27 |
| Mayo | ENST00000622804 | 73970579 | 73970634 | hsa-miR-664a-3p | chr8:73970610-73970617 | 8mer-1a | chr8:73970605-73970627 | 147.00 | -14.94 |
| Mayo | ENST00000622804 | 73970579 | 73970634 | hsa-miR-4666a-5p | chr8:73970623-73970630 | 8mer-1a | chr8:73970612-73970630 | 154.00 | -9.11 |
| Mayo | ENST00000523815 | 73964487 | 73964625 | hsa-miR-6762-3p | chr8:73964511-73964518 | 8mer-1a | chr8:73964506-73964529 | 170.00 | -29.85 |
| Mayo | ENST00000523815 | 73964487 | 73964625 | hsa-miR-3665 | chr8:73964533-73964540 | 8mer-1a | chr8:73964523-73964540 | 151.00 | -20.95 |
| Mayo | ENST00000523815 | 73964487 | 73964625 | hsa-miR-539-5p | chr8:73964504-73964511 | 8mer-1a | chr8:73964501-73964525 | 158.00 | -22.76 |
| Mayo | ENST00000622804 | 73970579 | 73970634 | hsa-miR-516b-5p | chr8:73970604-73970611 | 8mer-1a | chr8:73970589-73970611 | 157.00 | -17.47 |
| Mayo | ENST00000523815 | 73964487 | 73964625 | hsa-miR-372-5p | chr8:73964580-73964587 | 8mer-1a | chr8:73964572-73964591 | 156.00 | -21.17 |
| Mayo | ENST00000523815 | 73964487 | 73964625 | hsa-miR-6804-3p | chr8:73964517-73964524 | 8mer-1a | chr8:73964506-73964529 | 170.00 | -29.85 |
| Mayo | ENST00000523815 | 73964487 | 73964625 | hsa-miR-663b | chr8:73964608-73964615 | 8mer-1a | chr8:73964590-73964615 | 158.00 | -34.10 |
| Mayo | ENST00000523815 | 73964487 | 73964625 | hsa-miR-644a | chr8:73964610-73964617 | 8mer-1a | chr8:73964604-73964625 | 143.00 | -16.22 |
| Mayo | ENST00000523815 | 73964487 | 73964625 | hsa-miR-378a-5p | chr8:73964573-73964580 | 8mer-1a | chr8:73964559-73964580 | 160.00 | -19.13 |
| Mayo | ENST00000622804 | 73970579 | 73970634 | hsa-miR-8056 | chr8:73970618-73970625 | 8mer-1a | chr8:73970612-73970630 | 154.00 | -9.11 |
| Mayo | ENST00000523815 | 73964487 | 73964625 | hsa-miR-4469 | chr8:73964556-73964563 | 8mer-1a | chr8:73964551-73964569 | 156.00 | -18.35 |
| Mayo | ENST00000622804 | 73970579 | 73970634 | hsa-miR-12123 | chr8:73970611-73970618 | 8mer-1a | chr8:73970605-73970627 | 147.00 | -14.94 |
| Mayo | ENST00000523815 | 73964487 | 73964625 | hsa-miR-504-3p | chr8:73964596-73964603 | 8mer-1a | chr8:73964590-73964607 | 164.00 | -31.10 |
| MSBB | ENST00000523815 | 73964487 | 73964625 | hsa-miR-186-3p | chr8:73964550-73964557 | 8mer-1a | chr8:73964541-73964562 | 148.00 | -24.27 |
| MSBB | ENST00000622804 | 73970579 | 73970634 | hsa-miR-664a-3p | chr8:73970610-73970617 | 8mer-1a | chr8:73970605-73970627 | 147.00 | -14.94 |
| MSBB | ENST00000622804 | 73970579 | 73970634 | hsa-miR-4666a-5p | chr8:73970623-73970630 | 8mer-1a | chr8:73970612-73970630 | 154.00 | -9.11 |
| MSBB | ENST00000522337 | 73969560 | 73969673 | hsa-miR-619-3p | chr8:73969625-73969632 | 8mer-1a | chr8:73969609-73969632 | 150.00 | -16.09 |
| MSBB | ENST00000523815 | 73964487 | 73964625 | hsa-miR-6762-3p | chr8:73964511-73964518 | 8mer-1a | chr8:73964506-73964529 | 170.00 | -29.85 |
| MSBB | ENST00000523815 | 73964487 | 73964625 | hsa-miR-3665 | chr8:73964533-73964540 | 8mer-1a | chr8:73964523-73964540 | 151.00 | -20.95 |
| MSBB | ENST00000523815 | 73964487 | 73964625 | hsa-miR-539-5p | chr8:73964504-73964511 | 8mer-1a | chr8:73964501-73964525 | 158.00 | -22.76 |
| MSBB | ENST00000622804 | 73970579 | 73970634 | hsa-miR-516b-5p | chr8:73970604-73970611 | 8mer-1a | chr8:73970589-73970611 | 157.00 | -17.47 |
| MSBB | ENST00000523815 | 73964487 | 73964625 | hsa-miR-372-5p | chr8:73964580-73964587 | 8mer-1a | chr8:73964572-73964591 | 156.00 | -21.17 |
| MSBB | ENST00000523815 | 73964487 | 73964625 | hsa-miR-6804-3p | chr8:73964517-73964524 | 8mer-1a | chr8:73964506-73964529 | 170.00 | -29.85 |
| MSBB | ENST00000523815 | 73964487 | 73964625 | hsa-miR-663b | chr8:73964608-73964615 | 8mer-1a | chr8:73964590-73964615 | 158.00 | -34.10 |
| MSBB | ENST00000523815 | 73964487 | 73964625 | hsa-miR-644a | chr8:73964610-73964617 | 8mer-1a | chr8:73964604-73964625 | 143.00 | -16.22 |
| MSBB | ENST00000522337 | 73969560 | 73969673 | hsa-miR-3921 | chr8:73969645-73969652 | 8mer-1a | chr8:73969645-73969666 | 159.00 | -24.50 |
| MSBB | ENST00000523815 | 73964487 | 73964625 | hsa-miR-378a-5p | chr8:73964573-73964580 | 8mer-1a | chr8:73964559-73964580 | 160.00 | -19.13 |
| MSBB | ENST00000622804 | 73970579 | 73970634 | hsa-miR-8056 | chr8:73970618-73970625 | 8mer-1a | chr8:73970612-73970630 | 154.00 | -9.11 |
| MSBB | ENST00000522337 | 73969560 | 73969673 | hsa-miR-4653-5p | chr8:73969645-73969652 | 8mer-1a | chr8:73969645-73969666 | 159.00 | -24.50 |
| MSBB | ENST00000523815 | 73964487 | 73964625 | hsa-miR-4469 | chr8:73964556-73964563 | 8mer-1a | chr8:73964551-73964569 | 156.00 | -18.35 |
| MSBB | ENST00000622804 | 73970579 | 73970634 | hsa-miR-12123 | chr8:73970611-73970618 | 8mer-1a | chr8:73970605-73970627 | 147.00 | -14.94 |
| MSBB | ENST00000523815 | 73964487 | 73964625 | hsa-miR-504-3p | chr8:73964596-73964603 | 8mer-1a | chr8:73964590-73964607 | 164.00 | -31.10 |
| ROSMAP | ENST00000523815 | 73964487 | 73964625 | hsa-miR-186-3p | chr8:73964550-73964557 | 8mer-1a | chr8:73964541-73964562 | 148.00 | -24.27 |
| ROSMAP | ENST00000622804 | 73970579 | 73970634 | hsa-miR-664a-3p | chr8:73970610-73970617 | 8mer-1a | chr8:73970605-73970627 | 147.00 | -14.94 |
| ROSMAP | ENST00000622804 | 73970579 | 73970634 | hsa-miR-4666a-5p | chr8:73970623-73970630 | 8mer-1a | chr8:73970612-73970630 | 154.00 | -9.11 |
| ROSMAP | ENST00000522337 | 73969560 | 73969673 | hsa-miR-619-3p | chr8:73969625-73969632 | 8mer-1a | chr8:73969609-73969632 | 150.00 | -16.09 |
| ROSMAP | ENST00000523815 | 73964487 | 73964625 | hsa-miR-6762-3p | chr8:73964511-73964518 | 8mer-1a | chr8:73964506-73964529 | 170.00 | -29.85 |
| ROSMAP | ENST00000523815 | 73964487 | 73964625 | hsa-miR-3665 | chr8:73964533-73964540 | 8mer-1a | chr8:73964523-73964540 | 151.00 | -20.95 |
| ROSMAP | ENST00000523815 | 73964487 | 73964625 | hsa-miR-539-5p | chr8:73964504-73964511 | 8mer-1a | chr8:73964501-73964525 | 158.00 | -22.76 |
| ROSMAP | ENST00000622804 | 73970579 | 73970634 | hsa-miR-516b-5p | chr8:73970604-73970611 | 8mer-1a | chr8:73970589-73970611 | 157.00 | -17.47 |
| ROSMAP | ENST00000523815 | 73964487 | 73964625 | hsa-miR-372-5p | chr8:73964580-73964587 | 8mer-1a | chr8:73964572-73964591 | 156.00 | -21.17 |
| ROSMAP | ENST00000523815 | 73964487 | 73964625 | hsa-miR-6804-3p | chr8:73964517-73964524 | 8mer-1a | chr8:73964506-73964529 | 170.00 | -29.85 |
| ROSMAP | ENST00000523815 | 73964487 | 73964625 | hsa-miR-663b | chr8:73964608-73964615 | 8mer-1a | chr8:73964590-73964615 | 158.00 | -34.10 |
| ROSMAP | ENST00000523815 | 73964487 | 73964625 | hsa-miR-644a | chr8:73964610-73964617 | 8mer-1a | chr8:73964604-73964625 | 143.00 | -16.22 |
| ROSMAP | ENST00000522337 | 73969560 | 73969673 | hsa-miR-3921 | chr8:73969645-73969652 | 8mer-1a | chr8:73969645-73969666 | 159.00 | -24.50 |
| ROSMAP | ENST00000523815 | 73964487 | 73964625 | hsa-miR-378a-5p | chr8:73964573-73964580 | 8mer-1a | chr8:73964559-73964580 | 160.00 | -19.13 |
| ROSMAP | ENST00000622804 | 73970579 | 73970634 | hsa-miR-8056 | chr8:73970618-73970625 | 8mer-1a | chr8:73970612-73970630 | 154.00 | -9.11 |
| ROSMAP | ENST00000522337 | 73969560 | 73969673 | hsa-miR-4653-5p | chr8:73969645-73969652 | 8mer-1a | chr8:73969645-73969666 | 159.00 | -24.50 |
| ROSMAP | ENST00000523815 | 73964487 | 73964625 | hsa-miR-4469 | chr8:73964556-73964563 | 8mer-1a | chr8:73964551-73964569 | 156.00 | -18.35 |
| ROSMAP | ENST00000622804 | 73970579 | 73970634 | hsa-miR-12123 | chr8:73970611-73970618 | 8mer-1a | chr8:73970605-73970627 | 147.00 | -14.94 |
| ROSMAP | ENST00000523815 | 73964487 | 73964625 | hsa-miR-504-3p | chr8:73964596-73964603 | 8mer-1a | chr8:73964590-73964607 | 164.00 | -31.10 |
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SNVs in the skipped exons for ELOC |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for ELOC |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
| CDR | MSBB | IFG | exon_skip_112156 | 3.741147e-01 | 4.984883e-02 | chr8 | - | 73946700 | 73946820 | 73955647 | 73955765 | 73955911 | 73956054 |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ELOC |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for ELOC |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | RBM3 | exon_skip_156012 | 4.039043e-01 | 1.295026e-07 |
| CB | NUP42 | exon_skip_156012 | 4.489255e-01 | 2.937822e-09 |
| CB | TRA2A | exon_skip_272887 | -4.205829e-01 | 8.385630e-08 |
| CB | TARDBP | exon_skip_227882 | 4.107271e-01 | 7.556228e-08 |
| CB | SAMD4A | exon_skip_227882 | 4.581229e-01 | 1.263645e-09 |
| CB | RBM23 | exon_skip_227882 | 4.442683e-01 | 4.461134e-09 |
| DLPFC | PCBP4 | exon_skip_227733 | -4.250888e-01 | 1.750575e-16 |
| HCC | SFPQ | exon_skip_227733 | 4.988009e-01 | 1.403284e-18 |
| HCC | SAMD4A | exon_skip_227733 | 5.501997e-01 | 5.280183e-23 |
| HCC | RBM5 | exon_skip_227733 | 4.847903e-01 | 1.694061e-17 |
| HCC | HNRNPF | exon_skip_227733 | 4.924957e-01 | 4.366385e-18 |
| IFG | TARDBP | exon_skip_227733 | 4.886832e-01 | 8.322542e-03 |
| IFG | SFPQ | exon_skip_227733 | 5.180426e-01 | 4.745984e-03 |
| IFG | RBM5 | exon_skip_227733 | 6.266999e-01 | 3.593248e-04 |
| IFG | MBNL1 | exon_skip_227733 | 5.753895e-01 | 1.358176e-03 |
| IFG | PCBP2 | exon_skip_227733 | 4.456045e-01 | 1.747997e-02 |
| IFG | CELF1 | exon_skip_227733 | 5.084391e-01 | 5.733907e-03 |
| IFG | PABPC5 | exon_skip_227733 | 5.079081e-01 | 5.793264e-03 |
| IFG | RBM23 | exon_skip_227733 | 4.513666e-01 | 1.591116e-02 |
| IFG | SRSF9 | exon_skip_227733 | 4.713887e-01 | 1.133590e-02 |
| TC | SRSF2 | exon_skip_156012 | 4.839207e-01 | 9.009994e-11 |
| TC | RBM3 | exon_skip_156012 | 4.489743e-01 | 2.605610e-09 |
| TC | ILF2 | exon_skip_156012 | 4.561503e-01 | 1.346335e-09 |
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RelatedDrugs for ELOC |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ELOC |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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