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	Gene summary
	Gene structures and expression levels
	Exon skipping events with PSIs in RPSMAP, MSBB, and Mayo
	Open reading frame (ORF) annotation in the exon skipping event
	Exon skipping events in the canonical protein sequence
	3'-UTR located exon skipping events lost miRNA binding sites
	SNVs in the skipped exons with depth of coverage
	AD stage-associated exon skipping events
	Splicing Quantitative Trait Loci (sQTLs) in the skipped exons
	Correlation with RNA binding proteins (RBPs)
	Related drugs with this gene
	Related diseases with this gene

Gene summary for TCEA1

Gene summary

Gene information	Gene symbol	TCEA1
	Gene ID	6917
	Gene name	transcription elongation factor A1
	Synonyms	GTF2S|SII|TCEA|TF2S|TFIIS
	Cytomap	8q11.23
	Type of gene	protein-coding
	Description	transcription elongation factor A protein 1epididymis secretory sperm binding proteintranscription elongation factor A (SII), 1transcription elongation factor S-II protein 1transcription elongation factor TFIIS.otranscription factor IIS
	Modification date	20200313
	UniProtAcc	A0A1W2PPV7, A0A1W2PPZ5, A0A1W2PRL9, A0A1W2PS15, B7Z4S1, E5RFI1, E5RIS7, E5RJ93, E5RK46, P23193,
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene

GO ID

GO term

PubMed ID

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Gene structures and expression levels for TCEA1

Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

ENSG00000187735

Differentially expressed gene analysis across multiple brain tissues between AD and control.

Tissue type

DEG direction

Base mean exp.

log2FC(AD/control)

P-value

Adj. p-value

Differentially expressed isoform analysis across multiple brain tissues between AD and control.

Tissue type

DEG direction

ENST

Transcript info.

Base mean exp.

log2FC(AD/control)

P-value

Adjc. p-value

Landscape of isoform expressions across multiple brain tissues between AD and control.

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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for TCEA1

Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap).

All exon skipping events in AD cohorts.

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon
exon_skip_123076	chr8	54000010:54000050:54002892:54003086:54010430:54010491	54002892:54003086
exon_skip_14877	chr8	53970392:53970463:53979025:53979171:53984363:53984517	53979025:53979171
exon_skip_153079	chr8	54000010:54000050:54010430:54010492:54022063:54022125	54010430:54010492
exon_skip_163189	chr8	54000010:54000050:54010430:54010492:54022063:54022103	54010430:54010492
exon_skip_192279	chr8	54000010:54000050:54002892:54003086:54010430:54010492	54002892:54003086
exon_skip_195432	chr8	53993704:53993755:53999945:54000050:54010430:54010492	53999945:54000050
exon_skip_196239	chr8	54000010:54000050:54010430:54010492:54021526:54021586	54010430:54010492
exon_skip_201972	chr8	53993704:53993755:53999945:54000050:54022063:54022125	53999945:54000050
exon_skip_219910	chr8	54002892:54003086:54010430:54010492:54022063:54022125	54010430:54010492
exon_skip_232867	chr8	54000010:54000050:54002892:54003092:54010430:54010491	54002892:54003092
exon_skip_241964	chr8	54002892:54002940:54010430:54010492:54022063:54022103	54010430:54010492
exon_skip_24612	chr8	53970392:53970463:53979025:53979171:53984363:53984506	53979025:53979171
exon_skip_248583	chr8	54002892:54002940:54010430:54010492:54022063:54022125	54010430:54010492
exon_skip_252823	chr8	54010430:54010492:54021526:54021586:54022063:54022103	54021526:54021586
exon_skip_258288	chr8	54000010:54000050:54002892:54002940:54010430:54010492	54002892:54002940
exon_skip_268402	chr8	54000010:54000050:54002892:54002940:54010430:54010491	54002892:54002940
exon_skip_293495	chr8	54010430:54010492:54021526:54021586:54022063:54022310	54021526:54021586
exon_skip_3987	chr8	53970392:53970463:53979025:53979171:54010430:54010492	53979025:53979171
exon_skip_52377	chr8	53970392:53970463:53978523:53978697:53979025:53979171	53978523:53978697
exon_skip_53770	chr8	54000010:54000050:54002892:54003092:54010430:54010492	54002892:54003092
exon_skip_56493	chr8	53993704:53993755:53999945:54000050:54022063:54022103	53999945:54000050
exon_skip_66691	chr8	53967170:53968112:53970392:53970463:53979025:53979171	53970392:53970463
exon_skip_82819	chr8	53979025:53979171:54010430:54010492:54022063:54022125	54010430:54010492

Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control.