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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for TAF6 |
 Gene summary |
| Gene information | Gene symbol | TAF6 | Gene ID | 6878 |
| Gene name | TATA-box binding protein associated factor 6 | |
| Synonyms | ALYUS|MGC:8964|TAF(II)70|TAF(II)80|TAF2E|TAFII-70|TAFII-80|TAFII70|TAFII80|TAFII85 | |
| Cytomap | 7q22.1 | |
| Type of gene | protein-coding | |
| Description | transcription initiation factor TFIID subunit 6RNA polymerase II TBP-associated factor subunit ETAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDaTATA box binding protein (TBP)-associated factor, RNA polymerase II, E, 70/85 | |
| Modification date | 20200313 | |
| UniProtAcc | A0A1D5RMS5, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| TAF6 | GO:0006352 | DNA-templated transcription, initiation | 9603525 |
| TAF6 | GO:0006367 | transcription initiation from RNA polymerase II promoter | 9603525 |
| TAF6 | GO:0045786 | negative regulation of cell cycle | 15328371 |
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Gene structures and expression levels for TAF6 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000106290
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | DOWN | ENST00000452041.5 | TAF6-209:protein_coding:TAF6 | 2.977528e+02 | -9.083489e-01 | 5.428284e-06 | 6.285238e-05 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for TAF6 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_116535 | chr7 | 100113401:100113405:100113616:100113769:100113868:100113954 | 100113616:100113769 |
| exon_skip_118614 | chr7 | 100107926:100108123:100108367:100108540:100109948:100110073 | 100108367:100108540 |
| exon_skip_192481 | chr7 | 100112847:100112917:100113349:100113769:100113868:100113954 | 100113349:100113769 |
| exon_skip_216059 | chr7 | 100112847:100112917:100113349:100113405:100113616:100113769 | 100113349:100113405 |
| exon_skip_238216 | chr7 | 100113401:100113405:100113680:100113769:100113868:100113954 | 100113680:100113769 |
| exon_skip_274399 | chr7 | 100111799:100111829:100111922:100111999:100112108:100112253 | 100111922:100111999 |
| exon_skip_8405 | chr7 | 100107926:100108123:100108367:100108540:100109948:100110037 | 100108367:100108540 |
| exon_skip_91245 | chr7 | 100112847:100112917:100113616:100113769:100113868:100113954 | 100113616:100113769 |
| exon_skip_92831 | chr7 | 100107168:100107623:100107926:100108123:100108367:100108540 | 100107926:100108123 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for TAF6 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000344095 | 100107926 | 100108123 | In-frame |
| ENST00000452041 | 100107926 | 100108123 | In-frame |
| ENST00000453269 | 100107926 | 100108123 | In-frame |
| ENST00000344095 | 100108367 | 100108540 | In-frame |
| ENST00000452041 | 100108367 | 100108540 | In-frame |
| ENST00000453269 | 100108367 | 100108540 | In-frame |
| ENST00000344095 | 100111922 | 100111999 | In-frame |
| ENST00000452041 | 100111922 | 100111999 | In-frame |
| ENST00000453269 | 100111922 | 100111999 | In-frame |
| ENST00000344095 | 100113349 | 100113405 | In-frame |
| ENST00000452041 | 100113349 | 100113405 | In-frame |
| ENST00000453269 | 100113349 | 100113405 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000344095 | 100108367 | 100108540 | In-frame |
| ENST00000452041 | 100108367 | 100108540 | In-frame |
| ENST00000453269 | 100108367 | 100108540 | In-frame |
| ENST00000344095 | 100113349 | 100113405 | In-frame |
| ENST00000452041 | 100113349 | 100113405 | In-frame |
| ENST00000453269 | 100113349 | 100113405 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000344095 | 100113616 | 100113769 | Frame-shift |
| ENST00000452041 | 100113616 | 100113769 | Frame-shift |
| ENST00000453269 | 100113616 | 100113769 | Frame-shift |
| ENST00000344095 | 100107926 | 100108123 | In-frame |
| ENST00000452041 | 100107926 | 100108123 | In-frame |
| ENST00000453269 | 100107926 | 100108123 | In-frame |
| ENST00000344095 | 100108367 | 100108540 | In-frame |
| ENST00000452041 | 100108367 | 100108540 | In-frame |
| ENST00000453269 | 100108367 | 100108540 | In-frame |
| ENST00000344095 | 100111922 | 100111999 | In-frame |
| ENST00000452041 | 100111922 | 100111999 | In-frame |
| ENST00000453269 | 100111922 | 100111999 | In-frame |
| ENST00000344095 | 100113349 | 100113405 | In-frame |
| ENST00000452041 | 100113349 | 100113405 | In-frame |
| ENST00000453269 | 100113349 | 100113405 | In-frame |
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Infer the effects of exon skipping event on protein functional features for TAF6 |
p-ENSG00000106290_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000344095 | 2744 | 677 | 100113349 | 100113405 | 924 | 979 | 132 | 151 |
| ENST00000452041 | 2314 | 677 | 100113349 | 100113405 | 493 | 548 | 132 | 151 |
| ENST00000453269 | 2481 | 677 | 100113349 | 100113405 | 652 | 707 | 132 | 151 |
| ENST00000344095 | 2744 | 677 | 100111922 | 100111999 | 1247 | 1323 | 240 | 265 |
| ENST00000452041 | 2314 | 677 | 100111922 | 100111999 | 816 | 892 | 240 | 265 |
| ENST00000453269 | 2481 | 677 | 100111922 | 100111999 | 975 | 1051 | 240 | 265 |
| ENST00000344095 | 2744 | 677 | 100108367 | 100108540 | 1811 | 1983 | 428 | 485 |
| ENST00000452041 | 2314 | 677 | 100108367 | 100108540 | 1380 | 1552 | 428 | 485 |
| ENST00000453269 | 2481 | 677 | 100108367 | 100108540 | 1539 | 1711 | 428 | 485 |
| ENST00000344095 | 2744 | 677 | 100107926 | 100108123 | 1985 | 2181 | 486 | 551 |
| ENST00000452041 | 2314 | 677 | 100107926 | 100108123 | 1554 | 1750 | 486 | 551 |
| ENST00000453269 | 2481 | 677 | 100107926 | 100108123 | 1713 | 1909 | 486 | 551 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000344095 | 2744 | 677 | 100113349 | 100113405 | 924 | 979 | 132 | 151 |
| ENST00000452041 | 2314 | 677 | 100113349 | 100113405 | 493 | 548 | 132 | 151 |
| ENST00000453269 | 2481 | 677 | 100113349 | 100113405 | 652 | 707 | 132 | 151 |
| ENST00000344095 | 2744 | 677 | 100108367 | 100108540 | 1811 | 1983 | 428 | 485 |
| ENST00000452041 | 2314 | 677 | 100108367 | 100108540 | 1380 | 1552 | 428 | 485 |
| ENST00000453269 | 2481 | 677 | 100108367 | 100108540 | 1539 | 1711 | 428 | 485 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000344095 | 2744 | 677 | 100113349 | 100113405 | 924 | 979 | 132 | 151 |
| ENST00000452041 | 2314 | 677 | 100113349 | 100113405 | 493 | 548 | 132 | 151 |
| ENST00000453269 | 2481 | 677 | 100113349 | 100113405 | 652 | 707 | 132 | 151 |
| ENST00000344095 | 2744 | 677 | 100111922 | 100111999 | 1247 | 1323 | 240 | 265 |
| ENST00000452041 | 2314 | 677 | 100111922 | 100111999 | 816 | 892 | 240 | 265 |
| ENST00000453269 | 2481 | 677 | 100111922 | 100111999 | 975 | 1051 | 240 | 265 |
| ENST00000344095 | 2744 | 677 | 100108367 | 100108540 | 1811 | 1983 | 428 | 485 |
| ENST00000452041 | 2314 | 677 | 100108367 | 100108540 | 1380 | 1552 | 428 | 485 |
| ENST00000453269 | 2481 | 677 | 100108367 | 100108540 | 1539 | 1711 | 428 | 485 |
| ENST00000344095 | 2744 | 677 | 100107926 | 100108123 | 1985 | 2181 | 486 | 551 |
| ENST00000452041 | 2314 | 677 | 100107926 | 100108123 | 1554 | 1750 | 486 | 551 |
| ENST00000453269 | 2481 | 677 | 100107926 | 100108123 | 1713 | 1909 | 486 | 551 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P49848 | 132 | 151 | 1 | 677 | Chain | ID=PRO_0000118873;Note=Transcription initiation factor TFIID subunit 6 |
| P49848 | 132 | 151 | 1 | 677 | Chain | ID=PRO_0000118873;Note=Transcription initiation factor TFIID subunit 6 |
| P49848 | 132 | 151 | 1 | 677 | Chain | ID=PRO_0000118873;Note=Transcription initiation factor TFIID subunit 6 |
| P49848 | 240 | 265 | 1 | 677 | Chain | ID=PRO_0000118873;Note=Transcription initiation factor TFIID subunit 6 |
| P49848 | 240 | 265 | 1 | 677 | Chain | ID=PRO_0000118873;Note=Transcription initiation factor TFIID subunit 6 |
| P49848 | 240 | 265 | 1 | 677 | Chain | ID=PRO_0000118873;Note=Transcription initiation factor TFIID subunit 6 |
| P49848 | 240 | 265 | 248 | 248 | Modified residue | Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q63801 |
| P49848 | 240 | 265 | 248 | 248 | Modified residue | Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q63801 |
| P49848 | 240 | 265 | 248 | 248 | Modified residue | Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q63801 |
| P49848 | 240 | 265 | 253 | 253 | Modified residue | Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q63801 |
| P49848 | 240 | 265 | 253 | 253 | Modified residue | Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q63801 |
| P49848 | 240 | 265 | 253 | 253 | Modified residue | Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q63801 |
| P49848 | 240 | 265 | 264 | 264 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q63801 |
| P49848 | 240 | 265 | 264 | 264 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q63801 |
| P49848 | 240 | 265 | 264 | 264 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q63801 |
| P49848 | 428 | 485 | 477 | 486 | Alternative sequence | ID=VSP_037476;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8262073;Dbxref=PMID:8262073 |
| P49848 | 428 | 485 | 477 | 486 | Alternative sequence | ID=VSP_037476;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8262073;Dbxref=PMID:8262073 |
| P49848 | 428 | 485 | 477 | 486 | Alternative sequence | ID=VSP_037476;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8262073;Dbxref=PMID:8262073 |
| P49848 | 428 | 485 | 1 | 677 | Chain | ID=PRO_0000118873;Note=Transcription initiation factor TFIID subunit 6 |
| P49848 | 428 | 485 | 1 | 677 | Chain | ID=PRO_0000118873;Note=Transcription initiation factor TFIID subunit 6 |
| P49848 | 428 | 485 | 1 | 677 | Chain | ID=PRO_0000118873;Note=Transcription initiation factor TFIID subunit 6 |
| P49848 | 486 | 551 | 477 | 486 | Alternative sequence | ID=VSP_037476;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8262073;Dbxref=PMID:8262073 |
| P49848 | 486 | 551 | 477 | 486 | Alternative sequence | ID=VSP_037476;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8262073;Dbxref=PMID:8262073 |
| P49848 | 486 | 551 | 477 | 486 | Alternative sequence | ID=VSP_037476;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8262073;Dbxref=PMID:8262073 |
| P49848 | 486 | 551 | 1 | 677 | Chain | ID=PRO_0000118873;Note=Transcription initiation factor TFIID subunit 6 |
| P49848 | 486 | 551 | 1 | 677 | Chain | ID=PRO_0000118873;Note=Transcription initiation factor TFIID subunit 6 |
| P49848 | 486 | 551 | 1 | 677 | Chain | ID=PRO_0000118873;Note=Transcription initiation factor TFIID subunit 6 |
| P49848 | 486 | 551 | 524 | 524 | Modified residue | Note=Omega-N-methylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315 |
| P49848 | 486 | 551 | 524 | 524 | Modified residue | Note=Omega-N-methylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315 |
| P49848 | 486 | 551 | 524 | 524 | Modified residue | Note=Omega-N-methylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P49848 | 132 | 151 | 1 | 677 | Chain | ID=PRO_0000118873;Note=Transcription initiation factor TFIID subunit 6 |
| P49848 | 132 | 151 | 1 | 677 | Chain | ID=PRO_0000118873;Note=Transcription initiation factor TFIID subunit 6 |
| P49848 | 132 | 151 | 1 | 677 | Chain | ID=PRO_0000118873;Note=Transcription initiation factor TFIID subunit 6 |
| P49848 | 428 | 485 | 477 | 486 | Alternative sequence | ID=VSP_037476;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8262073;Dbxref=PMID:8262073 |
| P49848 | 428 | 485 | 477 | 486 | Alternative sequence | ID=VSP_037476;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8262073;Dbxref=PMID:8262073 |
| P49848 | 428 | 485 | 477 | 486 | Alternative sequence | ID=VSP_037476;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8262073;Dbxref=PMID:8262073 |
| P49848 | 428 | 485 | 1 | 677 | Chain | ID=PRO_0000118873;Note=Transcription initiation factor TFIID subunit 6 |
| P49848 | 428 | 485 | 1 | 677 | Chain | ID=PRO_0000118873;Note=Transcription initiation factor TFIID subunit 6 |
| P49848 | 428 | 485 | 1 | 677 | Chain | ID=PRO_0000118873;Note=Transcription initiation factor TFIID subunit 6 |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P49848 | 132 | 151 | 1 | 677 | Chain | ID=PRO_0000118873;Note=Transcription initiation factor TFIID subunit 6 |
| P49848 | 132 | 151 | 1 | 677 | Chain | ID=PRO_0000118873;Note=Transcription initiation factor TFIID subunit 6 |
| P49848 | 132 | 151 | 1 | 677 | Chain | ID=PRO_0000118873;Note=Transcription initiation factor TFIID subunit 6 |
| P49848 | 240 | 265 | 1 | 677 | Chain | ID=PRO_0000118873;Note=Transcription initiation factor TFIID subunit 6 |
| P49848 | 240 | 265 | 1 | 677 | Chain | ID=PRO_0000118873;Note=Transcription initiation factor TFIID subunit 6 |
| P49848 | 240 | 265 | 1 | 677 | Chain | ID=PRO_0000118873;Note=Transcription initiation factor TFIID subunit 6 |
| P49848 | 240 | 265 | 248 | 248 | Modified residue | Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q63801 |
| P49848 | 240 | 265 | 248 | 248 | Modified residue | Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q63801 |
| P49848 | 240 | 265 | 248 | 248 | Modified residue | Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q63801 |
| P49848 | 240 | 265 | 253 | 253 | Modified residue | Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q63801 |
| P49848 | 240 | 265 | 253 | 253 | Modified residue | Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q63801 |
| P49848 | 240 | 265 | 253 | 253 | Modified residue | Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q63801 |
| P49848 | 240 | 265 | 264 | 264 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q63801 |
| P49848 | 240 | 265 | 264 | 264 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q63801 |
| P49848 | 240 | 265 | 264 | 264 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q63801 |
| P49848 | 428 | 485 | 477 | 486 | Alternative sequence | ID=VSP_037476;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8262073;Dbxref=PMID:8262073 |
| P49848 | 428 | 485 | 477 | 486 | Alternative sequence | ID=VSP_037476;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8262073;Dbxref=PMID:8262073 |
| P49848 | 428 | 485 | 477 | 486 | Alternative sequence | ID=VSP_037476;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8262073;Dbxref=PMID:8262073 |
| P49848 | 428 | 485 | 1 | 677 | Chain | ID=PRO_0000118873;Note=Transcription initiation factor TFIID subunit 6 |
| P49848 | 428 | 485 | 1 | 677 | Chain | ID=PRO_0000118873;Note=Transcription initiation factor TFIID subunit 6 |
| P49848 | 428 | 485 | 1 | 677 | Chain | ID=PRO_0000118873;Note=Transcription initiation factor TFIID subunit 6 |
| P49848 | 486 | 551 | 477 | 486 | Alternative sequence | ID=VSP_037476;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8262073;Dbxref=PMID:8262073 |
| P49848 | 486 | 551 | 477 | 486 | Alternative sequence | ID=VSP_037476;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8262073;Dbxref=PMID:8262073 |
| P49848 | 486 | 551 | 477 | 486 | Alternative sequence | ID=VSP_037476;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8262073;Dbxref=PMID:8262073 |
| P49848 | 486 | 551 | 1 | 677 | Chain | ID=PRO_0000118873;Note=Transcription initiation factor TFIID subunit 6 |
| P49848 | 486 | 551 | 1 | 677 | Chain | ID=PRO_0000118873;Note=Transcription initiation factor TFIID subunit 6 |
| P49848 | 486 | 551 | 1 | 677 | Chain | ID=PRO_0000118873;Note=Transcription initiation factor TFIID subunit 6 |
| P49848 | 486 | 551 | 524 | 524 | Modified residue | Note=Omega-N-methylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315 |
| P49848 | 486 | 551 | 524 | 524 | Modified residue | Note=Omega-N-methylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315 |
| P49848 | 486 | 551 | 524 | 524 | Modified residue | Note=Omega-N-methylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315 |
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3'-UTR located exon skipping events that lost miRNA binding sites in TAF6 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for TAF6 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for TAF6 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TAF6 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
| CB | exon_skip_216059 | rs1880949 | chr7:100124643 | 4.012363e-06 | 1.180939e-03 |
| CB | exon_skip_216059 | rs11771139 | chr7:100138436 | 4.012363e-06 | 1.180939e-03 |
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Correlation with RNA binding proteins (RBPs) for TAF6 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for TAF6 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TAF6 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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