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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for TACC1 |
 Gene summary |
| Gene information | Gene symbol | TACC1 | Gene ID | 6867 |
| Gene name | transforming acidic coiled-coil containing protein 1 | |
| Synonyms | Ga55 | |
| Cytomap | 8p11.22 | |
| Type of gene | protein-coding | |
| Description | transforming acidic coiled-coil-containing protein 1gastric cancer antigen Ga55taxin-1 | |
| Modification date | 20200320 | |
| UniProtAcc | A0A0C4DGD3, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for TACC1 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000147526
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| PG | UP | ENST00000522544.5 | TACC1-220:lncRNA:TACC1 | 4.460128e+00 | 3.695030e+00 | 3.280122e-06 | 2.193430e-04 |
| PG | UP | ENST00000522474.1 | TACC1-219:lncRNA:TACC1 | 1.051407e+01 | 8.353166e-01 | 3.025575e-03 | 3.201854e-02 |
| CB | UP | ENST00000518415.5 | TACC1-204:protein_coding:TACC1 | 6.012283e+01 | 9.363971e-01 | 3.363999e-07 | 5.941676e-06 |
| CB | UP | ENST00000522474.1 | TACC1-219:lncRNA:TACC1 | 4.973557e+00 | 9.320149e-01 | 3.607571e-05 | 3.121560e-04 |
| CB | UP | ENST00000520615.5 | TACC1-210:protein_coding:TACC1 | 2.320405e+01 | 8.763993e-01 | 4.295375e-04 | 2.533352e-03 |
| TC | UP | ENST00000522474.1 | TACC1-219:lncRNA:TACC1 | 1.756153e+01 | 1.787872e+00 | 1.101940e-15 | 1.042728e-12 |
| TC | UP | ENST00000518415.5 | TACC1-204:protein_coding:TACC1 | 1.584024e+02 | 1.208485e+00 | 3.324569e-12 | 1.016254e-09 |
| TC | UP | ENST00000520615.5 | TACC1-210:protein_coding:TACC1 | 7.113746e+01 | 1.675124e+00 | 3.780278e-11 | 8.595040e-09 |
| TC | UP | ENST00000520340.5 | TACC1-208:protein_coding:TACC1 | 2.408037e+01 | 1.088977e+00 | 7.386154e-06 | 2.035794e-04 |
| TC | UP | ENST00000522983.1 | TACC1-225:lncRNA:TACC1 | 1.011336e+01 | 1.118193e+00 | 3.601199e-05 | 7.145053e-04 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for TACC1 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_109779 | chr8 | 38785682:38785736:38787557:38787743:38788704:38788819 | 38787557:38787743 |
| exon_skip_13389 | chr8 | 38785674:38785736:38787557:38787743:38788704:38788819 | 38787557:38787743 |
| exon_skip_163854 | chr8 | 38831125:38831177:38836162:38836287:38838470:38838507 | 38836162:38836287 |
| exon_skip_17437 | chr8 | 38820547:38820635:38825308:38825368:38827168:38827375 | 38825308:38825368 |
| exon_skip_18274 | chr8 | 38742351:38742451:38744895:38745493:38788704:38788819 | 38744895:38745493 |
| exon_skip_222567 | chr8 | 38836162:38836287:38838470:38838546:38840224:38840267 | 38838470:38838546 |
| exon_skip_224149 | chr8 | 38838470:38838546:38840224:38840267:38842287:38842447 | 38840224:38840267 |
| exon_skip_227490 | chr8 | 38742358:38742451:38744895:38745493:38788704:38788819 | 38744895:38745493 |
| exon_skip_253761 | chr8 | 38827168:38827288:38831125:38831177:38836162:38836287 | 38831125:38831177 |
| exon_skip_281064 | chr8 | 38820547:38820635:38825311:38825368:38827168:38827375 | 38825311:38825368 |
| exon_skip_45332 | chr8 | 38820547:38820635:38823990:38824025:38825308:38825368 | 38823990:38824025 |
| exon_skip_58921 | chr8 | 38785676:38785736:38787557:38787743:38788704:38788819 | 38787557:38787743 |
| exon_skip_61606 | chr8 | 38728190:38728671:38742351:38742451:38788704:38788819 | 38742351:38742451 |
| exon_skip_71097 | chr8 | 38827168:38827375:38831125:38831177:38836162:38836287 | 38831125:38831177 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
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| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
| exon_skip_45332 | MSBB_STG | 3.489231e-01 | 4.654167e-01 | -1.164936e-01 | 4.289039e-02 |
| exon_skip_45332 | MSBB_PG | 2.593333e-01 | 4.043636e-01 | -1.450303e-01 | 5.519105e-07 |
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Open reading frame (ORF) annotation in the exon skipping event for TACC1 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000317827 | 38825308 | 38825368 | Frame-shift |
| ENST00000317827 | 38831125 | 38831177 | Frame-shift |
| ENST00000317827 | 38838470 | 38838546 | Frame-shift |
| ENST00000317827 | 38840224 | 38840267 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000317827 | 38838470 | 38838546 | Frame-shift |
| ENST00000317827 | 38840224 | 38840267 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000317827 | 38825308 | 38825368 | Frame-shift |
| ENST00000317827 | 38831125 | 38831177 | Frame-shift |
| ENST00000317827 | 38838470 | 38838546 | Frame-shift |
| ENST00000317827 | 38840224 | 38840267 | Frame-shift |
| ENST00000317827 | 38836162 | 38836287 | In-frame |
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Infer the effects of exon skipping event on protein functional features for TACC1 |
p-ENSG00000147526_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000317827 | 7819 | 805 | 38836162 | 38836287 | 2094 | 2218 | 571 | 613 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| O75410 | 571 | 613 | 1 | 651 | Alternative sequence | ID=VSP_012640;Note=In isoform 8. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3 |
| O75410 | 571 | 613 | 2 | 805 | Chain | ID=PRO_0000179986;Note=Transforming acidic coiled-coil-containing protein 1 |
| O75410 | 571 | 613 | 610 | 805 | Coiled coil | . |
| O75410 | 571 | 613 | 591 | 591 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569 |
| O75410 | 571 | 613 | 588 | 588 | Sequence conflict | Note=G->V;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
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3'-UTR located exon skipping events that lost miRNA binding sites in TACC1 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for TACC1 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for TACC1 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TACC1 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for TACC1 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | ELAVL1 | exon_skip_45332 | 4.099062e-01 | 2.295973e-07 |
| CB | RALYL | exon_skip_45332 | 6.255035e-01 | 1.914867e-17 |
| FL | RALYL | exon_skip_45332 | 5.933745e-01 | 3.207776e-20 |
| FL | PTBP1 | exon_skip_45332 | -4.580463e-01 | 1.159649e-11 |
| HCC | RBM47 | exon_skip_45332 | -4.999744e-01 | 1.310724e-18 |
| HCC | FUBP1 | exon_skip_45332 | -5.069671e-01 | 3.619342e-19 |
| HCC | PUF60 | exon_skip_45332 | -4.847330e-01 | 1.959712e-17 |
| HCC | PTBP1 | exon_skip_45332 | -7.684261e-01 | 2.860745e-54 |
| IFG | RBM47 | exon_skip_45332 | -5.474531e-01 | 2.568023e-03 |
| IFG | RALYL | exon_skip_45332 | 5.142720e-01 | 5.115056e-03 |
| IFG | PTBP1 | exon_skip_45332 | -4.610967e-01 | 1.352693e-02 |
| PCC | RALYL | exon_skip_45332 | 4.759469e-01 | 1.932301e-13 |
| PCC | PTBP1 | exon_skip_45332 | -7.256894e-01 | 4.082022e-36 |
| PG | ELAVL1 | exon_skip_45332 | 4.547493e-01 | 7.406667e-12 |
| PG | PUF60 | exon_skip_45332 | 4.394823e-01 | 4.325452e-11 |
| PG | RALYL | exon_skip_45332 | 7.540045e-01 | 6.560114e-39 |
| PG | PTBP1 | exon_skip_45332 | -4.483369e-01 | 1.570976e-11 |
| PG | CELF1 | exon_skip_45332 | 5.180720e-01 | 1.784579e-15 |
| STG | RBM47 | exon_skip_45332 | -4.400789e-01 | 1.593407e-05 |
| STG | RALYL | exon_skip_45332 | 6.088956e-01 | 2.438678e-10 |
| STG | PTBP1 | exon_skip_45332 | -5.088949e-01 | 3.540404e-07 |
| TC | ELAVL1 | exon_skip_45332 | 4.100332e-01 | 7.986184e-08 |
| TC | RALYL | exon_skip_45332 | 8.654298e-01 | 5.543451e-49 |
| TC | CELF1 | exon_skip_45332 | 6.195649e-01 | 3.138521e-18 |
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RelatedDrugs for TACC1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TACC1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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