|
Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for SYK |
Gene summary |
Gene information | Gene symbol | SYK | Gene ID | 6850 |
Gene name | spleen associated tyrosine kinase | |
Synonyms | p72-Syk | |
Cytomap | 9q22.2 | |
Type of gene | protein-coding | |
Description | tyrosine-protein kinase SYKspleen tyrosine kinase | |
Modification date | 20200329 | |
UniProtAcc | ||
Context | - 32334108(Neuronal Spleen tyrosine kinase SYK) mediates cytokine release in Transgenic Tau P301S mice organotypic brain slice cultures) |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
SYK | GO:0006468 | protein phosphorylation | 17681949 |
SYK | GO:0007159 | leukocyte cell-cell adhesion | 12885943 |
SYK | GO:0030593 | neutrophil chemotaxis | 12885943 |
Top |
Gene structures and expression levels for SYK |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
Top |
Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for SYK |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_207175 | chr9 | 90865048:90865097:90867131:90867199:90874204:90874291 | 90867131:90867199 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
Top |
Open reading frame (ORF) annotation in the exon skipping event for SYK |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000375746 | 90867131 | 90867199 | In-frame |
ENST00000375754 | 90867131 | 90867199 | In-frame |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000375746 | 90867131 | 90867199 | In-frame |
ENST00000375754 | 90867131 | 90867199 | In-frame |
Top |
Infer the effects of exon skipping event on protein functional features for SYK |
p-ENSG00000165025_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000375746 | 5007 | 635 | 90867131 | 90867199 | 981 | 1048 | 282 | 305 |
ENST00000375754 | 5022 | 635 | 90867131 | 90867199 | 996 | 1063 | 282 | 305 |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000375746 | 5007 | 635 | 90867131 | 90867199 | 981 | 1048 | 282 | 305 |
ENST00000375754 | 5022 | 635 | 90867131 | 90867199 | 996 | 1063 | 282 | 305 |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
P43405 | 282 | 305 | 283 | 305 | Alternative sequence | ID=VSP_005010;Note=In isoform Short. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
P43405 | 282 | 305 | 283 | 305 | Alternative sequence | ID=VSP_005010;Note=In isoform Short. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
P43405 | 282 | 305 | 1 | 635 | Chain | ID=PRO_0000088165;Note=Tyrosine-protein kinase SYK |
P43405 | 282 | 305 | 1 | 635 | Chain | ID=PRO_0000088165;Note=Tyrosine-protein kinase SYK |
P43405 | 282 | 305 | 295 | 295 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21469132;Dbxref=PMID:21469132 |
P43405 | 282 | 305 | 295 | 295 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21469132;Dbxref=PMID:21469132 |
P43405 | 282 | 305 | 296 | 296 | Modified residue | Note=Phosphotyrosine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21469132;Dbxref=PMID:21469132 |
P43405 | 282 | 305 | 296 | 296 | Modified residue | Note=Phosphotyrosine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21469132;Dbxref=PMID:21469132 |
P43405 | 282 | 305 | 297 | 297 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21469132;Dbxref=PMID:21469132 |
P43405 | 282 | 305 | 297 | 297 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21469132;Dbxref=PMID:21469132 |
P43405 | 282 | 305 | 297 | 297 | Mutagenesis | Note=Abolishes YWHAG binding. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21469132;Dbxref=PMID:21469132 |
P43405 | 282 | 305 | 297 | 297 | Mutagenesis | Note=Abolishes YWHAG binding. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21469132;Dbxref=PMID:21469132 |
P43405 | 282 | 305 | 260 | 370 | Region | Note=Interdomain B |
P43405 | 282 | 305 | 260 | 370 | Region | Note=Interdomain B |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
P43405 | 282 | 305 | 283 | 305 | Alternative sequence | ID=VSP_005010;Note=In isoform Short. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
P43405 | 282 | 305 | 283 | 305 | Alternative sequence | ID=VSP_005010;Note=In isoform Short. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
P43405 | 282 | 305 | 1 | 635 | Chain | ID=PRO_0000088165;Note=Tyrosine-protein kinase SYK |
P43405 | 282 | 305 | 1 | 635 | Chain | ID=PRO_0000088165;Note=Tyrosine-protein kinase SYK |
P43405 | 282 | 305 | 295 | 295 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21469132;Dbxref=PMID:21469132 |
P43405 | 282 | 305 | 295 | 295 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21469132;Dbxref=PMID:21469132 |
P43405 | 282 | 305 | 296 | 296 | Modified residue | Note=Phosphotyrosine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21469132;Dbxref=PMID:21469132 |
P43405 | 282 | 305 | 296 | 296 | Modified residue | Note=Phosphotyrosine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21469132;Dbxref=PMID:21469132 |
P43405 | 282 | 305 | 297 | 297 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21469132;Dbxref=PMID:21469132 |
P43405 | 282 | 305 | 297 | 297 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21469132;Dbxref=PMID:21469132 |
P43405 | 282 | 305 | 297 | 297 | Mutagenesis | Note=Abolishes YWHAG binding. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21469132;Dbxref=PMID:21469132 |
P43405 | 282 | 305 | 297 | 297 | Mutagenesis | Note=Abolishes YWHAG binding. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21469132;Dbxref=PMID:21469132 |
P43405 | 282 | 305 | 260 | 370 | Region | Note=Interdomain B |
P43405 | 282 | 305 | 260 | 370 | Region | Note=Interdomain B |
Top |
3'-UTR located exon skipping events that lost miRNA binding sites in SYK |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
Top |
SNVs in the skipped exons for SYK |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
Top |
AD stage-associated exon skippint events for SYK |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
Top |
Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for SYK |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
Top |
Correlation with RNA binding proteins (RBPs) for SYK |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
Top |
RelatedDrugs for SYK |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
P43405 | approved|investigational | DB12010 | Fostamatinib | small molecule | P43405 |
Top |
RelatedDiseases for SYK |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |