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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for SULT1A1 |
 Gene summary |
| Gene information | Gene symbol | SULT1A1 | Gene ID | 6817 |
| Gene name | sulfotransferase family 1A member 1 | |
| Synonyms | HAST1/HAST2|P-PST|PST|ST1A1|ST1A3|STP|STP1|TSPST1 | |
| Cytomap | 16p11.2 | |
| Type of gene | protein-coding | |
| Description | sulfotransferase 1A1P-PST 1aryl sulfotransferase 1phenol-sulfating phenol sulfotransferase 1sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1thermostable phenol sulfotransferase1ts-PST | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| SULT1A1 | GO:0006068 | ethanol catabolic process | 23207770 |
| SULT1A1 | GO:0006805 | xenobiotic metabolic process | 12471039|20056724 |
| SULT1A1 | GO:0008210 | estrogen metabolic process | 16221673 |
| SULT1A1 | GO:0009812 | flavonoid metabolic process | 20056724 |
| SULT1A1 | GO:0050427 | 3'-phosphoadenosine 5'-phosphosulfate metabolic process | 23207770 |
| SULT1A1 | GO:0051923 | sulfation | 19548878|20056724|23207770 |
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Gene structures and expression levels for SULT1A1 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000196502
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for SULT1A1 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_109650 | chr16 | 28608291:28608388:28608478:28608603:28608708:28608859 | 28608478:28608603 |
| exon_skip_155412 | chr16 | 28608708:28608859:28609363:28609435:28609931:28609989 | 28609363:28609435 |
| exon_skip_173549 | chr16 | 28608708:28608859:28609931:28610191:28620063:28620133 | 28609931:28610191 |
| exon_skip_201316 | chr16 | 28608297:28608388:28608478:28608603:28608708:28608859 | 28608478:28608603 |
| exon_skip_240159 | chr16 | 28606951:28607077:28608291:28608388:28608478:28608603 | 28608291:28608388 |
| exon_skip_25816 | chr16 | 28608291:28608388:28608478:28608603:28608708:28608779 | 28608478:28608603 |
| exon_skip_287914 | chr16 | 28606951:28607077:28608291:28608388:28608708:28608859 | 28608291:28608388 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for SULT1A1 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000395609 | 28609931 | 28610191 | 3UTR-3UTR |
| ENST00000314752 | 28608291 | 28608388 | Frame-shift |
| ENST00000395607 | 28608291 | 28608388 | Frame-shift |
| ENST00000395609 | 28608291 | 28608388 | Frame-shift |
| ENST00000569554 | 28608291 | 28608388 | Frame-shift |
| ENST00000314752 | 28608478 | 28608603 | In-frame |
| ENST00000395607 | 28608478 | 28608603 | In-frame |
| ENST00000395609 | 28608478 | 28608603 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000395609 | 28609931 | 28610191 | 3UTR-3UTR |
| ENST00000314752 | 28608478 | 28608603 | In-frame |
| ENST00000395607 | 28608478 | 28608603 | In-frame |
| ENST00000395609 | 28608478 | 28608603 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000395609 | 28609931 | 28610191 | 3UTR-3UTR |
| ENST00000314752 | 28608291 | 28608388 | Frame-shift |
| ENST00000395607 | 28608291 | 28608388 | Frame-shift |
| ENST00000395609 | 28608291 | 28608388 | Frame-shift |
| ENST00000569554 | 28608291 | 28608388 | Frame-shift |
| ENST00000314752 | 28608478 | 28608603 | In-frame |
| ENST00000395607 | 28608478 | 28608603 | In-frame |
| ENST00000395609 | 28608478 | 28608603 | In-frame |
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Infer the effects of exon skipping event on protein functional features for SULT1A1 |
p-ENSG00000196502_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000314752 | 1179 | 295 | 28608478 | 28608603 | 230 | 354 | 49 | 91 |
| ENST00000395607 | 1403 | 295 | 28608478 | 28608603 | 423 | 547 | 49 | 91 |
| ENST00000395609 | 1888 | 295 | 28608478 | 28608603 | 908 | 1032 | 49 | 91 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000314752 | 1179 | 295 | 28608478 | 28608603 | 230 | 354 | 49 | 91 |
| ENST00000395607 | 1403 | 295 | 28608478 | 28608603 | 423 | 547 | 49 | 91 |
| ENST00000395609 | 1888 | 295 | 28608478 | 28608603 | 908 | 1032 | 49 | 91 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000314752 | 1179 | 295 | 28608478 | 28608603 | 230 | 354 | 49 | 91 |
| ENST00000395607 | 1403 | 295 | 28608478 | 28608603 | 423 | 547 | 49 | 91 |
| ENST00000395609 | 1888 | 295 | 28608478 | 28608603 | 908 | 1032 | 49 | 91 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P50225 | 49 | 91 | 1 | 124 | Alternative sequence | ID=VSP_040101;Note=In isoform 2. MELIQDTSRPPLEYVKGVPLIKYFAEALGPLQSFQARPDDLLISTYPKSGTTWVSQILDMIYQGGDLEKCHRAPIFMRVPFLEFKAPGIPSGMETLKDTPAPRLLKTHLPLALLPQTLLDQKVK->MLAKLLCDQVVGAPIAVSAFYAGMSILQGKDDIFLDLKQKFWNTYM;Ontology_term=ECO:0000303;evidence=ECO:0000303|Re |
| P50225 | 49 | 91 | 1 | 124 | Alternative sequence | ID=VSP_040101;Note=In isoform 2. MELIQDTSRPPLEYVKGVPLIKYFAEALGPLQSFQARPDDLLISTYPKSGTTWVSQILDMIYQGGDLEKCHRAPIFMRVPFLEFKAPGIPSGMETLKDTPAPRLLKTHLPLALLPQTLLDQKVK->MLAKLLCDQVVGAPIAVSAFYAGMSILQGKDDIFLDLKQKFWNTYM;Ontology_term=ECO:0000303;evidence=ECO:0000303|Re |
| P50225 | 49 | 91 | 1 | 124 | Alternative sequence | ID=VSP_040101;Note=In isoform 2. MELIQDTSRPPLEYVKGVPLIKYFAEALGPLQSFQARPDDLLISTYPKSGTTWVSQILDMIYQGGDLEKCHRAPIFMRVPFLEFKAPGIPSGMETLKDTPAPRLLKTHLPLALLPQTLLDQKVK->MLAKLLCDQVVGAPIAVSAFYAGMSILQGKDDIFLDLKQKFWNTYM;Ontology_term=ECO:0000303;evidence=ECO:0000303|Re |
| P50225 | 49 | 91 | 87 | 89 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GRA |
| P50225 | 49 | 91 | 87 | 89 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GRA |
| P50225 | 49 | 91 | 87 | 89 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GRA |
| P50225 | 49 | 91 | 1 | 295 | Chain | ID=PRO_0000085127;Note=Sulfotransferase 1A1 |
| P50225 | 49 | 91 | 1 | 295 | Chain | ID=PRO_0000085127;Note=Sulfotransferase 1A1 |
| P50225 | 49 | 91 | 1 | 295 | Chain | ID=PRO_0000085127;Note=Sulfotransferase 1A1 |
| P50225 | 49 | 91 | 51 | 62 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LS6 |
| P50225 | 49 | 91 | 51 | 62 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LS6 |
| P50225 | 49 | 91 | 51 | 62 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LS6 |
| P50225 | 49 | 91 | 67 | 70 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LS6 |
| P50225 | 49 | 91 | 67 | 70 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LS6 |
| P50225 | 49 | 91 | 67 | 70 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LS6 |
| P50225 | 49 | 91 | 75 | 78 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LS6 |
| P50225 | 49 | 91 | 75 | 78 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LS6 |
| P50225 | 49 | 91 | 75 | 78 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LS6 |
| P50225 | 49 | 91 | 70 | 70 | Mutagenesis | Note=Increased sensitivity of enzyme activity to heat inactivation. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8033270;Dbxref=PMID:8033270 |
| P50225 | 49 | 91 | 70 | 70 | Mutagenesis | Note=Increased sensitivity of enzyme activity to heat inactivation. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8033270;Dbxref=PMID:8033270 |
| P50225 | 49 | 91 | 70 | 70 | Mutagenesis | Note=Increased sensitivity of enzyme activity to heat inactivation. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8033270;Dbxref=PMID:8033270 |
| P50225 | 49 | 91 | 48 | 53 | Nucleotide binding | Note=PAPS |
| P50225 | 49 | 91 | 48 | 53 | Nucleotide binding | Note=PAPS |
| P50225 | 49 | 91 | 48 | 53 | Nucleotide binding | Note=PAPS |
| P50225 | 49 | 91 | 90 | 90 | Sequence conflict | Note=P->L;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| P50225 | 49 | 91 | 90 | 90 | Sequence conflict | Note=P->L;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| P50225 | 49 | 91 | 90 | 90 | Sequence conflict | Note=P->L;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| P50225 | 49 | 91 | 63 | 65 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LS6 |
| P50225 | 49 | 91 | 63 | 65 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LS6 |
| P50225 | 49 | 91 | 63 | 65 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LS6 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P50225 | 49 | 91 | 1 | 124 | Alternative sequence | ID=VSP_040101;Note=In isoform 2. MELIQDTSRPPLEYVKGVPLIKYFAEALGPLQSFQARPDDLLISTYPKSGTTWVSQILDMIYQGGDLEKCHRAPIFMRVPFLEFKAPGIPSGMETLKDTPAPRLLKTHLPLALLPQTLLDQKVK->MLAKLLCDQVVGAPIAVSAFYAGMSILQGKDDIFLDLKQKFWNTYM;Ontology_term=ECO:0000303;evidence=ECO:0000303|Re |
| P50225 | 49 | 91 | 1 | 124 | Alternative sequence | ID=VSP_040101;Note=In isoform 2. MELIQDTSRPPLEYVKGVPLIKYFAEALGPLQSFQARPDDLLISTYPKSGTTWVSQILDMIYQGGDLEKCHRAPIFMRVPFLEFKAPGIPSGMETLKDTPAPRLLKTHLPLALLPQTLLDQKVK->MLAKLLCDQVVGAPIAVSAFYAGMSILQGKDDIFLDLKQKFWNTYM;Ontology_term=ECO:0000303;evidence=ECO:0000303|Re |
| P50225 | 49 | 91 | 1 | 124 | Alternative sequence | ID=VSP_040101;Note=In isoform 2. MELIQDTSRPPLEYVKGVPLIKYFAEALGPLQSFQARPDDLLISTYPKSGTTWVSQILDMIYQGGDLEKCHRAPIFMRVPFLEFKAPGIPSGMETLKDTPAPRLLKTHLPLALLPQTLLDQKVK->MLAKLLCDQVVGAPIAVSAFYAGMSILQGKDDIFLDLKQKFWNTYM;Ontology_term=ECO:0000303;evidence=ECO:0000303|Re |
| P50225 | 49 | 91 | 87 | 89 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GRA |
| P50225 | 49 | 91 | 87 | 89 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GRA |
| P50225 | 49 | 91 | 87 | 89 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GRA |
| P50225 | 49 | 91 | 1 | 295 | Chain | ID=PRO_0000085127;Note=Sulfotransferase 1A1 |
| P50225 | 49 | 91 | 1 | 295 | Chain | ID=PRO_0000085127;Note=Sulfotransferase 1A1 |
| P50225 | 49 | 91 | 1 | 295 | Chain | ID=PRO_0000085127;Note=Sulfotransferase 1A1 |
| P50225 | 49 | 91 | 51 | 62 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LS6 |
| P50225 | 49 | 91 | 51 | 62 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LS6 |
| P50225 | 49 | 91 | 51 | 62 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LS6 |
| P50225 | 49 | 91 | 67 | 70 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LS6 |
| P50225 | 49 | 91 | 67 | 70 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LS6 |
| P50225 | 49 | 91 | 67 | 70 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LS6 |
| P50225 | 49 | 91 | 75 | 78 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LS6 |
| P50225 | 49 | 91 | 75 | 78 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LS6 |
| P50225 | 49 | 91 | 75 | 78 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LS6 |
| P50225 | 49 | 91 | 70 | 70 | Mutagenesis | Note=Increased sensitivity of enzyme activity to heat inactivation. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8033270;Dbxref=PMID:8033270 |
| P50225 | 49 | 91 | 70 | 70 | Mutagenesis | Note=Increased sensitivity of enzyme activity to heat inactivation. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8033270;Dbxref=PMID:8033270 |
| P50225 | 49 | 91 | 70 | 70 | Mutagenesis | Note=Increased sensitivity of enzyme activity to heat inactivation. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8033270;Dbxref=PMID:8033270 |
| P50225 | 49 | 91 | 48 | 53 | Nucleotide binding | Note=PAPS |
| P50225 | 49 | 91 | 48 | 53 | Nucleotide binding | Note=PAPS |
| P50225 | 49 | 91 | 48 | 53 | Nucleotide binding | Note=PAPS |
| P50225 | 49 | 91 | 90 | 90 | Sequence conflict | Note=P->L;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| P50225 | 49 | 91 | 90 | 90 | Sequence conflict | Note=P->L;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| P50225 | 49 | 91 | 90 | 90 | Sequence conflict | Note=P->L;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| P50225 | 49 | 91 | 63 | 65 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LS6 |
| P50225 | 49 | 91 | 63 | 65 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LS6 |
| P50225 | 49 | 91 | 63 | 65 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LS6 |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P50225 | 49 | 91 | 1 | 124 | Alternative sequence | ID=VSP_040101;Note=In isoform 2. MELIQDTSRPPLEYVKGVPLIKYFAEALGPLQSFQARPDDLLISTYPKSGTTWVSQILDMIYQGGDLEKCHRAPIFMRVPFLEFKAPGIPSGMETLKDTPAPRLLKTHLPLALLPQTLLDQKVK->MLAKLLCDQVVGAPIAVSAFYAGMSILQGKDDIFLDLKQKFWNTYM;Ontology_term=ECO:0000303;evidence=ECO:0000303|Re |
| P50225 | 49 | 91 | 1 | 124 | Alternative sequence | ID=VSP_040101;Note=In isoform 2. MELIQDTSRPPLEYVKGVPLIKYFAEALGPLQSFQARPDDLLISTYPKSGTTWVSQILDMIYQGGDLEKCHRAPIFMRVPFLEFKAPGIPSGMETLKDTPAPRLLKTHLPLALLPQTLLDQKVK->MLAKLLCDQVVGAPIAVSAFYAGMSILQGKDDIFLDLKQKFWNTYM;Ontology_term=ECO:0000303;evidence=ECO:0000303|Re |
| P50225 | 49 | 91 | 1 | 124 | Alternative sequence | ID=VSP_040101;Note=In isoform 2. MELIQDTSRPPLEYVKGVPLIKYFAEALGPLQSFQARPDDLLISTYPKSGTTWVSQILDMIYQGGDLEKCHRAPIFMRVPFLEFKAPGIPSGMETLKDTPAPRLLKTHLPLALLPQTLLDQKVK->MLAKLLCDQVVGAPIAVSAFYAGMSILQGKDDIFLDLKQKFWNTYM;Ontology_term=ECO:0000303;evidence=ECO:0000303|Re |
| P50225 | 49 | 91 | 87 | 89 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GRA |
| P50225 | 49 | 91 | 87 | 89 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GRA |
| P50225 | 49 | 91 | 87 | 89 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GRA |
| P50225 | 49 | 91 | 1 | 295 | Chain | ID=PRO_0000085127;Note=Sulfotransferase 1A1 |
| P50225 | 49 | 91 | 1 | 295 | Chain | ID=PRO_0000085127;Note=Sulfotransferase 1A1 |
| P50225 | 49 | 91 | 1 | 295 | Chain | ID=PRO_0000085127;Note=Sulfotransferase 1A1 |
| P50225 | 49 | 91 | 51 | 62 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LS6 |
| P50225 | 49 | 91 | 51 | 62 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LS6 |
| P50225 | 49 | 91 | 51 | 62 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LS6 |
| P50225 | 49 | 91 | 67 | 70 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LS6 |
| P50225 | 49 | 91 | 67 | 70 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LS6 |
| P50225 | 49 | 91 | 67 | 70 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LS6 |
| P50225 | 49 | 91 | 75 | 78 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LS6 |
| P50225 | 49 | 91 | 75 | 78 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LS6 |
| P50225 | 49 | 91 | 75 | 78 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LS6 |
| P50225 | 49 | 91 | 70 | 70 | Mutagenesis | Note=Increased sensitivity of enzyme activity to heat inactivation. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8033270;Dbxref=PMID:8033270 |
| P50225 | 49 | 91 | 70 | 70 | Mutagenesis | Note=Increased sensitivity of enzyme activity to heat inactivation. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8033270;Dbxref=PMID:8033270 |
| P50225 | 49 | 91 | 70 | 70 | Mutagenesis | Note=Increased sensitivity of enzyme activity to heat inactivation. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8033270;Dbxref=PMID:8033270 |
| P50225 | 49 | 91 | 48 | 53 | Nucleotide binding | Note=PAPS |
| P50225 | 49 | 91 | 48 | 53 | Nucleotide binding | Note=PAPS |
| P50225 | 49 | 91 | 48 | 53 | Nucleotide binding | Note=PAPS |
| P50225 | 49 | 91 | 90 | 90 | Sequence conflict | Note=P->L;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| P50225 | 49 | 91 | 90 | 90 | Sequence conflict | Note=P->L;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| P50225 | 49 | 91 | 90 | 90 | Sequence conflict | Note=P->L;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| P50225 | 49 | 91 | 63 | 65 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LS6 |
| P50225 | 49 | 91 | 63 | 65 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LS6 |
| P50225 | 49 | 91 | 63 | 65 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LS6 |
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3'-UTR located exon skipping events that lost miRNA binding sites in SULT1A1 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
| Mayo | ENST00000395609 | 28609931 | 28610191 | hsa-miR-4683 | chr16:28610166-28610173 | 8mer-1a | chr16:28610151-28610174 | 145.00 | -16.70 |
| Mayo | ENST00000395609 | 28609931 | 28610191 | hsa-miR-4691-3p | chr16:28609973-28609980 | 8mer-1a | chr16:28609955-28609980 | 152.00 | -23.15 |
| Mayo | ENST00000395609 | 28609931 | 28610191 | hsa-miR-100-3p | chr16:28610154-28610161 | 8mer-1a | chr16:28610139-28610161 | 163.00 | -17.55 |
| Mayo | ENST00000395609 | 28609931 | 28610191 | hsa-miR-4496 | chr16:28610027-28610034 | 8mer-1a | chr16:28610026-28610046 | 164.00 | -26.92 |
| Mayo | ENST00000395609 | 28609931 | 28610191 | hsa-miR-620 | chr16:28610167-28610174 | 8mer-1a | chr16:28610151-28610174 | 145.00 | -16.70 |
| Mayo | ENST00000395609 | 28609931 | 28610191 | hsa-miR-3173-3p | chr16:28610130-28610137 | 8mer-1a | chr16:28610119-28610137 | 161.00 | -24.73 |
| Mayo | ENST00000395609 | 28609931 | 28610191 | hsa-miR-4516 | chr16:28610118-28610125 | 8mer-1a | chr16:28610115-28610136 | 161.00 | -19.05 |
| Mayo | ENST00000395609 | 28609931 | 28610191 | hsa-miR-1270 | chr16:28610167-28610174 | 8mer-1a | chr16:28610151-28610174 | 145.00 | -16.70 |
| Mayo | ENST00000395609 | 28609931 | 28610191 | hsa-miR-4434 | chr16:28610118-28610125 | 8mer-1a | chr16:28610115-28610136 | 161.00 | -19.05 |
| Mayo | ENST00000395609 | 28609931 | 28610191 | hsa-miR-5703 | chr16:28610118-28610125 | 8mer-1a | chr16:28610115-28610136 | 161.00 | -19.05 |
| Mayo | ENST00000395609 | 28609931 | 28610191 | hsa-miR-3919 | chr16:28610012-28610019 | 8mer-1a | chr16:28610012-28610034 | 163.00 | -25.42 |
| Mayo | ENST00000395609 | 28609931 | 28610191 | hsa-miR-12118 | chr16:28610130-28610137 | 8mer-1a | chr16:28610119-28610137 | 161.00 | -24.73 |
| Mayo | ENST00000395609 | 28609931 | 28610191 | hsa-miR-6891-5p | chr16:28610130-28610137 | 8mer-1a | chr16:28610119-28610137 | 161.00 | -24.73 |
| Mayo | ENST00000395609 | 28609931 | 28610191 | hsa-miR-12131 | chr16:28610168-28610175 | 8mer-1a | chr16:28610167-28610184 | 144.00 | -16.47 |
| Mayo | ENST00000395609 | 28609931 | 28610191 | hsa-miR-4767 | chr16:28609965-28609972 | 8mer-1a | chr16:28609956-28609974 | 155.00 | -31.73 |
| Mayo | ENST00000395609 | 28609931 | 28610191 | hsa-miR-766-3p | chr16:28610146-28610153 | 8mer-1a | chr16:28610139-28610161 | 163.00 | -17.55 |
| MSBB | ENST00000395609 | 28609931 | 28610191 | hsa-miR-4683 | chr16:28610166-28610173 | 8mer-1a | chr16:28610151-28610174 | 145.00 | -16.70 |
| MSBB | ENST00000395609 | 28609931 | 28610191 | hsa-miR-4691-3p | chr16:28609973-28609980 | 8mer-1a | chr16:28609955-28609980 | 152.00 | -23.15 |
| MSBB | ENST00000395609 | 28609931 | 28610191 | hsa-miR-100-3p | chr16:28610154-28610161 | 8mer-1a | chr16:28610139-28610161 | 163.00 | -17.55 |
| MSBB | ENST00000395609 | 28609931 | 28610191 | hsa-miR-4496 | chr16:28610027-28610034 | 8mer-1a | chr16:28610026-28610046 | 164.00 | -26.92 |
| MSBB | ENST00000395609 | 28609931 | 28610191 | hsa-miR-620 | chr16:28610167-28610174 | 8mer-1a | chr16:28610151-28610174 | 145.00 | -16.70 |
| MSBB | ENST00000395609 | 28609931 | 28610191 | hsa-miR-3173-3p | chr16:28610130-28610137 | 8mer-1a | chr16:28610119-28610137 | 161.00 | -24.73 |
| MSBB | ENST00000395609 | 28609931 | 28610191 | hsa-miR-4516 | chr16:28610118-28610125 | 8mer-1a | chr16:28610115-28610136 | 161.00 | -19.05 |
| MSBB | ENST00000395609 | 28609931 | 28610191 | hsa-miR-1270 | chr16:28610167-28610174 | 8mer-1a | chr16:28610151-28610174 | 145.00 | -16.70 |
| MSBB | ENST00000395609 | 28609931 | 28610191 | hsa-miR-4434 | chr16:28610118-28610125 | 8mer-1a | chr16:28610115-28610136 | 161.00 | -19.05 |
| MSBB | ENST00000395609 | 28609931 | 28610191 | hsa-miR-5703 | chr16:28610118-28610125 | 8mer-1a | chr16:28610115-28610136 | 161.00 | -19.05 |
| MSBB | ENST00000395609 | 28609931 | 28610191 | hsa-miR-3919 | chr16:28610012-28610019 | 8mer-1a | chr16:28610012-28610034 | 163.00 | -25.42 |
| MSBB | ENST00000395609 | 28609931 | 28610191 | hsa-miR-12118 | chr16:28610130-28610137 | 8mer-1a | chr16:28610119-28610137 | 161.00 | -24.73 |
| MSBB | ENST00000395609 | 28609931 | 28610191 | hsa-miR-6891-5p | chr16:28610130-28610137 | 8mer-1a | chr16:28610119-28610137 | 161.00 | -24.73 |
| MSBB | ENST00000395609 | 28609931 | 28610191 | hsa-miR-12131 | chr16:28610168-28610175 | 8mer-1a | chr16:28610167-28610184 | 144.00 | -16.47 |
| MSBB | ENST00000395609 | 28609931 | 28610191 | hsa-miR-4767 | chr16:28609965-28609972 | 8mer-1a | chr16:28609956-28609974 | 155.00 | -31.73 |
| MSBB | ENST00000395609 | 28609931 | 28610191 | hsa-miR-766-3p | chr16:28610146-28610153 | 8mer-1a | chr16:28610139-28610161 | 163.00 | -17.55 |
| ROSMAP | ENST00000395609 | 28609931 | 28610191 | hsa-miR-4683 | chr16:28610166-28610173 | 8mer-1a | chr16:28610151-28610174 | 145.00 | -16.70 |
| ROSMAP | ENST00000395609 | 28609931 | 28610191 | hsa-miR-4691-3p | chr16:28609973-28609980 | 8mer-1a | chr16:28609955-28609980 | 152.00 | -23.15 |
| ROSMAP | ENST00000395609 | 28609931 | 28610191 | hsa-miR-100-3p | chr16:28610154-28610161 | 8mer-1a | chr16:28610139-28610161 | 163.00 | -17.55 |
| ROSMAP | ENST00000395609 | 28609931 | 28610191 | hsa-miR-4496 | chr16:28610027-28610034 | 8mer-1a | chr16:28610026-28610046 | 164.00 | -26.92 |
| ROSMAP | ENST00000395609 | 28609931 | 28610191 | hsa-miR-620 | chr16:28610167-28610174 | 8mer-1a | chr16:28610151-28610174 | 145.00 | -16.70 |
| ROSMAP | ENST00000395609 | 28609931 | 28610191 | hsa-miR-3173-3p | chr16:28610130-28610137 | 8mer-1a | chr16:28610119-28610137 | 161.00 | -24.73 |
| ROSMAP | ENST00000395609 | 28609931 | 28610191 | hsa-miR-4516 | chr16:28610118-28610125 | 8mer-1a | chr16:28610115-28610136 | 161.00 | -19.05 |
| ROSMAP | ENST00000395609 | 28609931 | 28610191 | hsa-miR-1270 | chr16:28610167-28610174 | 8mer-1a | chr16:28610151-28610174 | 145.00 | -16.70 |
| ROSMAP | ENST00000395609 | 28609931 | 28610191 | hsa-miR-4434 | chr16:28610118-28610125 | 8mer-1a | chr16:28610115-28610136 | 161.00 | -19.05 |
| ROSMAP | ENST00000395609 | 28609931 | 28610191 | hsa-miR-5703 | chr16:28610118-28610125 | 8mer-1a | chr16:28610115-28610136 | 161.00 | -19.05 |
| ROSMAP | ENST00000395609 | 28609931 | 28610191 | hsa-miR-3919 | chr16:28610012-28610019 | 8mer-1a | chr16:28610012-28610034 | 163.00 | -25.42 |
| ROSMAP | ENST00000395609 | 28609931 | 28610191 | hsa-miR-12118 | chr16:28610130-28610137 | 8mer-1a | chr16:28610119-28610137 | 161.00 | -24.73 |
| ROSMAP | ENST00000395609 | 28609931 | 28610191 | hsa-miR-6891-5p | chr16:28610130-28610137 | 8mer-1a | chr16:28610119-28610137 | 161.00 | -24.73 |
| ROSMAP | ENST00000395609 | 28609931 | 28610191 | hsa-miR-12131 | chr16:28610168-28610175 | 8mer-1a | chr16:28610167-28610184 | 144.00 | -16.47 |
| ROSMAP | ENST00000395609 | 28609931 | 28610191 | hsa-miR-4767 | chr16:28609965-28609972 | 8mer-1a | chr16:28609956-28609974 | 155.00 | -31.73 |
| ROSMAP | ENST00000395609 | 28609931 | 28610191 | hsa-miR-766-3p | chr16:28610146-28610153 | 8mer-1a | chr16:28610139-28610161 | 163.00 | -17.55 |
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SNVs in the skipped exons for SULT1A1 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
Top |
AD stage-associated exon skippint events for SULT1A1 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
Top |
Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for SULT1A1 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
| HCC | exon_skip_109650 | rs17707300 | chr16:28582026 | 1.712636e-06 | 2.650124e-04 |
| HCC | exon_skip_109650 | rs4788074 | chr16:28582276 | 2.263100e-06 | 3.412445e-04 |
| HCC | exon_skip_109650 | rs4788076 | chr16:28558684 | 2.817372e-06 | 4.137476e-04 |
| HCC | exon_skip_109650 | rs7193402 | chr16:28574806 | 2.817372e-06 | 4.137476e-04 |
| HCC | exon_skip_109650 | rs1074631 | chr16:28542787 | 1.163576e-05 | 1.433929e-03 |
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Correlation with RNA binding proteins (RBPs) for SULT1A1 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | PCBP4 | exon_skip_290309 | 4.282040e-01 | 2.214606e-08 |
| CB | RBM45 | exon_skip_290309 | 4.860169e-01 | 1.099683e-10 |
| DLPFC | CELF1 | exon_skip_155412 | 4.123961e-01 | 4.063660e-14 |
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RelatedDrugs for SULT1A1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SULT1A1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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